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UniProtKB - Q5CZ29 (Q5CZ29_CRYPI)
Protein
Submitted name:
Calcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands
Gene
cgd7_40
Organism
Cryptosporidium parvum (strain Iowa II)
Status
Functioni
Caution
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 145 | ATP analog; via amide nitrogenCombined sources | 1 | |
Binding sitei | 164 | ATPPROSITE-ProRule annotation | 1 | |
Binding sitei | 164 | ATP analogCombined sources | 1 | |
Metal bindingi | 218 | Zinc; via pros nitrogenCombined sources | 1 | |
Binding sitei | 221 | ATP analogCombined sources | 1 | |
Metal bindingi | 247 | ZincCombined sources | 1 | |
Metal bindingi | 249 | ZincCombined sources | 1 | |
Metal bindingi | 252 | ZincCombined sources | 1 | |
Binding sitei | 320 | ATP analogCombined sources | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 215 – 217 | ATP analogCombined sources | 3 | |
Nucleotide bindingi | 450 – 452 | ATP analogCombined sources | 3 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- calcium ion binding Source: InterPro
- protein serine/threonine kinase activity Source: UniProt
Keywordsi
Molecular function | KinaseImported, Transferase |
Ligand | ATP-bindingPROSITE-ProRule annotationARBA annotation, CalciumARBA annotation, Metal-bindingCombined sourcesARBA annotation, Nucleotide-binding, ZincCombined sources |
Names & Taxonomyi
Protein namesi | Submitted name: Calcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF handsImported |
Gene namesi | ORF Names:cgd7_40Imported |
Organismi | Cryptosporidium parvum (strain Iowa II)Imported |
Taxonomic identifieri | 353152 [NCBI] |
Taxonomic lineagei | Eukaryota › Sar › Alveolata › Apicomplexa › Conoidasida › Coccidia › Eucoccidiorida › Eimeriorina › Cryptosporidiidae › Cryptosporidium › |
Proteomesi |
|
Structurei
3D structure databases
SMRi | Q5CZ29 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q5CZ29 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 135 – 441 | Protein kinaseInterPro annotationAdd BLAST | 307 | |
Domaini | 550 – 585 | EF-handInterPro annotationAdd BLAST | 36 | |
Domaini | 586 – 621 | EF-handInterPro annotationAdd BLAST | 36 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 48 | DisorderedSequence analysisAdd BLAST | 48 | |
Regioni | 64 – 90 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 761 – 788 | DisorderedSequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 21 – 45 | Polar residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 64 – 89 | Polar residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 761 – 778 | Basic and acidic residuesSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.ARBA annotation
Phylogenomic databases
InParanoidi | Q5CZ29 |
OMAi | TVIARYC |
Family and domain databases
CDDi | cd00051, EFh, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF13499, EF-hand_7, 1 hit PF00069, Pkinase, 2 hits |
SMARTi | View protein in SMART SM00054, EFh, 2 hits SM00220, S_TKc, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 2 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Fragment.
Q5CZ29-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
IRQGHIVNNN KMEKNRGKTR TPVSRQGSKP ASGLRSAQNL HSSERKGVSI
60 70 80 90 100
GFDKLRDGVT SSIENTPVRQ TSSRKVDQNS SCNRKCQSTE SYRTRTKLES
110 120 130 140 150
SERDKAMCFS PAFKLKFSHN AFVSLGSLLE LQKKYHLKGA IGQGSYGVVR
160 170 180 190 200
VAIENQTRAI RAIKIMNKNK IRQINPKDVE RIKTEVRLMK KLHHPNIARL
210 220 230 240 250
YEVYEDEQYI CLVMELCHGG HLLDKLNVFI DDSTGKCAMD VVKTQICPCP
260 270 280 290 300
ECNEEAINGS IHGFRESLDF VQREKLISNI MRQIFSALHY LHNQGICHRD
310 320 330 340 350
IKPENFLFST NKSFEIKLVD FGLSKEFYKL NNGEYYGMTT KAGTPYFVAP
360 370 380 390 400
EVLNTTNESY GPKCDAWSAG VLLHLLLMGA VPFPGVNDAD TISQVLNKKL
410 420 430 440 450
CFENPNYNVL SPLARDLLSN LLNRNVDERF DAMRALQHPW ISQFSDKIYK
460 470 480 490 500
MSPIAGIEAH ESHSSRRNIF GATEHSPVQI SMLKSLRRYY VSPLLKKIAL
510 520 530 540 550
TVIARYCPDK WIENLRNVFY KLDTRQIGKI NLYDLRVATQ QLVAQQKLKV
560 570 580 590 600
PQHHIDLLLD AVDSDGNGEI DYIEFVAAVI SPKLSCRKDV LTMAFKMLDQ
610 620 630 640 650
DEDGLISTRD IKKLVSSEKI RLSSATVLEA EEDSILEDLN VEVTKVIGKG
660 670 680 690 700
NENVTGISFQ AFEKLLNTSY DKVCRCYHGP REGETKGRLP VCGEDSMDTW
710 720 730 740 750
YDDLLSCNTE NENLTQLFAG SEPRRLQKNS LYVCRRTGFR DLLALSQGAG
760 770 780 790 800
QKDKFQVEMN RKRSLGNHQE REAYSTKGAK DEGQSSGEMN REYGLGIVGF
810 820
IGNGLGVRMG GNTKNPSKVL LCDS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAEE01000001 Genomic DNA Translation: EAK90662.1 |
RefSeqi | XP_628201.1, XM_628199.1 |
Genome annotation databases
EnsemblProtistsi | EAK90662; EAK90662; cgd7_40 |
GeneIDi | 3371759 |
KEGGi | cpv:cgd7_40 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAEE01000001 Genomic DNA Translation: EAK90662.1 |
RefSeqi | XP_628201.1, XM_628199.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3HKO | X-ray | 1.80 | A | 126-452 | [»] | |
SMRi | Q5CZ29 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Chemistry databases
BindingDBi | Q5CZ29 |
ChEMBLi | CHEMBL4295845 |
Genome annotation databases
EnsemblProtistsi | EAK90662; EAK90662; cgd7_40 |
GeneIDi | 3371759 |
KEGGi | cpv:cgd7_40 |
Phylogenomic databases
InParanoidi | Q5CZ29 |
OMAi | TVIARYC |
Miscellaneous databases
EvolutionaryTracei | Q5CZ29 |
Family and domain databases
CDDi | cd00051, EFh, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF13499, EF-hand_7, 1 hit PF00069, Pkinase, 2 hits |
SMARTi | View protein in SMART SM00054, EFh, 2 hits SM00220, S_TKc, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 2 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5CZ29_CRYPI | |
Accessioni | Q5CZ29Primary (citable) accession number: Q5CZ29 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 12, 2005 |
Last sequence update: | April 12, 2005 | |
Last modified: | May 25, 2022 | |
This is version 118 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |