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Entry version 124 (25 May 2022)
Sequence version 1 (12 Apr 2005)
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Protein
Submitted name:

Calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands

Gene

cgd5_820

Organism
Cryptosporidium parvum (strain Iowa II)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei95ATPPROSITE-ProRule annotation1
Binding sitei145ATP analogCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi379Calcium 1Combined sources1
Metal bindingi379Calcium 2Combined sources1
Metal bindingi381Calcium 1Combined sources1
Metal bindingi381Calcium 2Combined sources1
Metal bindingi383Calcium 1Combined sources1
Metal bindingi383Calcium 2Combined sources1
Metal bindingi385Calcium 1; via carbonyl oxygenCombined sources1
Metal bindingi385Calcium 2; via carbonyl oxygenCombined sources1
Metal bindingi390Calcium 1Combined sources1
Metal bindingi390Calcium 2Combined sources1
Metal bindingi423Calcium 3Combined sources1
Metal bindingi423Calcium 4Combined sources1
Metal bindingi423Calcium 5Combined sources1
Metal bindingi425Calcium 3Combined sources1
Metal bindingi425Calcium 4Combined sources1
Metal bindingi427Calcium 3Combined sources1
Metal bindingi427Calcium 4Combined sources1
Metal bindingi427Calcium 5Combined sources1
Metal bindingi429Calcium 3; via carbonyl oxygenCombined sources1
Metal bindingi429Calcium 5; via carbonyl oxygenCombined sources1
Metal bindingi431Calcium 3Combined sources1
Metal bindingi434Calcium 4Combined sources1
Metal bindingi434Calcium 5Combined sources1
Metal bindingi459Calcium 6Combined sources1
Metal bindingi459Calcium 7Combined sources1
Metal bindingi459Calcium 8Combined sources1
Metal bindingi461Calcium 6Combined sources1
Metal bindingi461Calcium 7Combined sources1
Metal bindingi461Calcium 8Combined sources1
Metal bindingi463Calcium 6Combined sources1
Metal bindingi463Calcium 7Combined sources1
Metal bindingi465Calcium 6; via carbonyl oxygenCombined sources1
Metal bindingi465Calcium 8; via carbonyl oxygenCombined sources1
Metal bindingi470Calcium 7Combined sources1
Metal bindingi470Calcium 8Combined sources1
Metal bindingi493Calcium 9Combined sources1
Metal bindingi495Calcium 9Combined sources1
Metal bindingi497Calcium 9Combined sources1
Metal bindingi499Calcium 9; via carbonyl oxygenCombined sources1
Metal bindingi504Calcium 9Combined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi139 – 141ATP analogCombined sources3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseImported, Transferase
LigandATP-bindingPROSITE-ProRule annotationARBA annotation, CalciumCombined sourcesARBA annotation, Metal-bindingCombined sourcesARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF handsImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:cgd5_820Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCryptosporidium parvum (strain Iowa II)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri353152 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaCryptosporidiidaeCryptosporidium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006726 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
353152.Q5CS01

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5CS01

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q5CS01

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini62 – 318Protein kinaseInterPro annotationAdd BLAST257
Domaini366 – 401EF-handInterPro annotationAdd BLAST36
Domaini410 – 445EF-handInterPro annotationAdd BLAST36
Domaini446 – 481EF-handInterPro annotationAdd BLAST36
Domaini483 – 515EF-handInterPro annotationAdd BLAST33

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.ARBA annotation

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5CS01

Identification of Orthologs from Complete Genome Data

More...
OMAi
CMELCAG

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00051, EFh, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00036, EF-hand_1, 2 hits
PF13499, EF-hand_7, 1 hit
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00054, EFh, 4 hits
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473, SSF47473, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018, EF_HAND_1, 4 hits
PS50222, EF_HAND_2, 4 hits
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q5CS01-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
ISLFIQKKMG CTPSKGKVEF TSRKREENEK EVEIKSVEIK NDLQATPGMF
60 70 80 90 100
ITSKKGHLSE MYQRVKKLGS GAYGEVLLCR DKVTHVERAI KIIRKTSVST
110 120 130 140 150
SSNSKLLEEV AVLKLLDHPN IMKLYDFFED KRNYYLVMEC YKGGELFDEI
160 170 180 190 200
IHRMKFNEVD AAVIIKQVLS GVTYLHKHNI VHRDLKPENL LLESKEKDAL
210 220 230 240 250
IKIVDFGLSA VFENQKKMKE RLGTAYYIAP EVLRKKYDEK CDVWSIGVIL
260 270 280 290 300
FILLAGYPPF GGQTDQEILR KVEKGKYTFD SPEWKNVSEG AKDLIKQMLQ
310 320 330 340 350
FDSQRRISAQ QALEHPWIKE MCSKKESGIE LPSLANAIEN MRKFQNSQKL
360 370 380 390 400
AQAALLYMAS KLTSQEETKE LTDIFRHIDK NGDGQLDRQE LIDGYSKLSG
410 420 430 440 450
EEVAVFDLPQ IESEVDAILG AADFDRNGYI DYSEFVTVAM DRKSLLSKDK
460 470 480 490 500
LESAFQKFDQ DGNGKISVDE LASVFGLDHL ESKTWKEMIS GIDSNNDGDV
510 520
DFEEFCKMIQ KLCSNNEPQL KKN
Length:523
Mass (Da):59,759
Last modified:April 12, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAD894F2FF9C53E1D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAEE01000007 Genomic DNA Translation: EAK88255.1

NCBI Reference Sequences

More...
RefSeqi
XP_626035.1, XM_626035.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAK88255; EAK88255; cgd5_820

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3373302

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cpv:cgd5_820

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEE01000007 Genomic DNA Translation: EAK88255.1
RefSeqiXP_626035.1, XM_626035.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3L19X-ray2.14A/B325-520[»]
3LIJX-ray1.90A42-517[»]
SMRiQ5CS01
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi353152.Q5CS01

Genome annotation databases

EnsemblProtistsiEAK88255; EAK88255; cgd5_820
GeneIDi3373302
KEGGicpv:cgd5_820

Phylogenomic databases

InParanoidiQ5CS01
OMAiCMELCAG

Miscellaneous databases

EvolutionaryTraceiQ5CS01

Family and domain databases

CDDicd00051, EFh, 2 hits
InterProiView protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00036, EF-hand_1, 2 hits
PF13499, EF-hand_7, 1 hit
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00054, EFh, 4 hits
SM00220, S_TKc, 1 hit
SUPFAMiSSF47473, SSF47473, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 4 hits
PS50222, EF_HAND_2, 4 hits
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ5CS01_CRYPI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5CS01
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2005
Last sequence update: April 12, 2005
Last modified: May 25, 2022
This is version 124 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Reference proteomeImported
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