NOM1

Functionⁱ

Plays a role in targeting PPP1CA to the nucleolus.1 Publication

GO - Molecular functionⁱ

RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22681889

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

hair follicle maturation Source: Ensembl
ribosomal small subunit biogenesis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Nucleolar MIF4G domain-containing protein 1 Alternative name(s): SGD1 homolog
Gene namesⁱ	Name:NOM1 Synonyms:C7orf3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000146909.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13244 NOM1
MIMⁱ	611269 gene
neXtProtⁱ	NX_Q5C9Z4

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	308	V → A: Loss of interaction with PPP1CA and loss of ability to relocalize PPP1CA to the nucleolus; when associated with A-310. 1 Publication		1
Mutagenesisⁱ	310	F → A: Loss of interaction with PPP1CA and loss of ability to relocalize PPP1CA to the nucleolus; when associated with A-308. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	64434
Open Targets More...OpenTargetsⁱ	ENSG00000146909
PharmGKBⁱ	PA25946

Polymorphism and mutation databases

BioMutaⁱ	NOM1
DMDMⁱ	74707675

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000286823	1 – 860	Nucleolar MIF4G domain-containing protein 1Add BLAST		860

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	57	PhosphoserineCombined sources	1
Modified residueⁱ	139	PhosphoserineCombined sources	1
Modified residueⁱ	317	PhosphoserineCombined sources	1
Modified residueⁱ	320	PhosphoserineCombined sources	1
Modified residueⁱ	321	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q5C9Z4
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q5C9Z4
PaxDbⁱ	Q5C9Z4
PeptideAtlas More...PeptideAtlasⁱ	Q5C9Z4
PRIDEⁱ	Q5C9Z4
ProteomicsDBⁱ	62725

PTM databases

iPTMnetⁱ	Q5C9Z4
PhosphoSitePlusⁱ	Q5C9Z4

Expressionⁱ

Tissue specificityⁱ

Expressed in heart and skeletal muscle.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000146909 Expressed in 196 organ(s), highest expression level in epithelial cell of pancreas
CleanExⁱ	HS_NOM1
Genevisibleⁱ	Q5C9Z4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA019866 HPA051624

HPAⁱ

HPA019866
HPA051624

Interactionⁱ

Subunit structureⁱ

May interact with EIF4A1, EIF4A2 and EIF4A3. Interacts with PPP1CA and PPP1CC.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
EIF4A3	P38919	3	EBI-2685618,EBI-299104

With

Entry

#Exp.

IntAct

Notes

EIF4A3

P38919

3

EBI-2685618,EBI-299104

Protein-protein interaction databases

BioGridⁱ	122182, 22 interactors
ELMⁱ	Q5C9Z4
IntActⁱ	Q5C9Z4, 42 interactors
Molecular INTeraction database More...MINTⁱ	Q5C9Z4
STRINGⁱ	9606.ENSP00000275820

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q5C9Z4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	362 – 559	MIF4GPROSITE-ProRule annotationAdd BLAST		198
Domainⁱ	654 – 770	MIPROSITE-ProRule annotationAdd BLAST		117

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 269	Necessary for nucleolar localization and for targeting PPP1CA to the nucleolusAdd BLAST		269

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	307 – 310	Required for efficient binding to PPP1CA and for targeting PPP1CA to the nucleolus		4

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	237 – 322	Glu-richAdd BLAST		86

Sequence similaritiesⁱ

Belongs to the CWC22 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2141 Eukaryota ENOG410XNNQ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000075087
HOGENOMⁱ	HOG000044155
HOVERGENⁱ	HBG098839
InParanoidⁱ	Q5C9Z4
KEGG Orthology (KO) More...KOⁱ	K17583
OMAⁱ	QEHMVLL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03TZ
PhylomeDBⁱ	Q5C9Z4
TreeFamⁱ	TF312808

Family and domain databases

Gene3Dⁱ	1.25.40.180, 1 hit
InterProⁱ	View protein in InterPro IPR016024 ARM-type_fold IPR003891 Initiation_fac_eIF4g_MI IPR016021 MIF4-like_sf IPR003890 MIF4G-like_typ-3
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02847 MA3, 1 hit PF02854 MIF4G, 1 hit
SMARTⁱ	View protein in SMART SM00544 MA3, 1 hit SM00543 MIF4G, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 1 hit
PROSITEⁱ	View protein in PROSITE PS51366 MI, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q5C9Z4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAASRSAGEA GPGGSQGRVV RMKRRGGRGP RRGPAGGGEK ALKRLKLAVE 
        60         70         80         90        100
EFVHATSEGE APGGCEGRGA PVSFRPGGRK SRKELRKEKR HLRKARRLQR 
       110        120        130        140        150
TAGPEQGPGL GGRSGAEEAS GHRQDTEERA RPAPSRDPSP PRKPRPSRVK 
       160        170        180        190        200
AKATAATAKT RPSAAATAAA RKRALLAANE EEDREIRKLE RCLGLNKRKK 
       210        220        230        240        250
KDGSSSVPLS FARDGLDYIL GALESGKNSG LYDSSGEEEE DAGQTLPESD 
       260        270        280        290        300
LESDSQDESE EEEEGDVEKE KKAQEAEAQS EDDDEDTEEE QGEEKEKGAQ 
       310        320        330        340        350
EKRRGKRVRF AEDEEKSENS SEDGDITDKS LCGSGEKYIP PHVRQAEETV 
       360        370        380        390        400
DFKKKEELER LKKHVKGLLN RLSEPNMASI SGQLEELYMA HSRKDMNDTL 
       410        420        430        440        450
TSALMGACVT ASAMPSRLMM EHVLLVSILH HTVGIEVGAH FLEAVVRKFD 
       460        470        480        490        500
AIYKYGSEGK ECDNLFTVIA HLYNFHVVQS LLIFDILKKL IGTFTEKDIE 
       510        520        530        540        550
LILLMLKNVG FSLRKDDALS LKELITEAQT KASGAGSEFQ DQTRIRFMLE 
       560        570        580        590        600
TMLALKNNDM RKIPGYDPEP VEKLRKLQRA LVRNAGSGSE TQLRVSWDSV 
       610        620        630        640        650
LSAEQTGRWW IVGSAWSGAP MIDNSHHTHL QKQLVGTVSS KILELARKQR 
       660        670        680        690        700
MNTDIRRNIF CTIMTSEDFL DAFEKLLKLG LKDQQEREII HVLMDCCLQE 
       710        720        730        740        750
KTYNPFYAFL ASKFCEYERR FQMTFQFSIW DKFRDLENLP ATNFSNLVHL 
       760        770        780        790        800
VAHLLKTKSL SLSILKVVEF SELDKPRVRF LRKVLSILLM ETEVEDLSLI 
       810        820        830        840        850
FTRVSDNPKL GVLREGLKLF ISHFLLKNAQ AHRSADEANV LREKADLATK 
       860
CLQGKASLRM

Length:860

Mass (Da):96,257

Last modified:April 12, 2005 - v1

Checksum:ⁱD4FAB8FB9AC3B5C9

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_061999	24	R → G. Corresponds to variant dbSNP:rs6969990Ensembl.	1
Natural variantⁱVAR_032187	122	H → P. Corresponds to variant dbSNP:rs6952214Ensembl.	1
Natural variantⁱVAR_053051	723	M → V. Corresponds to variant dbSNP:rs12919Ensembl.	1
Natural variantⁱVAR_032188	779	R → H. Corresponds to variant dbSNP:rs2302445Ensembl.	1
Natural variantⁱVAR_032189	804	V → L. Corresponds to variant dbSNP:rs2302443Ensembl.	1
Natural variantⁱVAR_032190	812	V → M. Corresponds to variant dbSNP:rs12919Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY576779 mRNA Translation: AAT39521.1 AF107455 mRNA No translation available. BC007902 mRNA Translation: AAH07902.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34787.1
NCBI Reference Sequences More...RefSeqⁱ	NP_612409.1, NM_138400.1
UniGeneⁱ	Hs.15825

Genome annotation databases

Ensemblⁱ	ENST00000275820; ENSP00000275820; ENSG00000146909
GeneIDⁱ	64434
KEGGⁱ	hsa:64434
UCSC genome browser More...UCSCⁱ	uc003wmy.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q5C9Z4	Nucleolar protein with MIF4G domain 1		GORGO		929	UniRef90_Q5C9Z4
Uncharacterized protein		CERAT		865
Uncharacterized protein		PAPAN		864
Uncharacterized protein		RHIRO		863
Uncharacterized protein		RHIBE		863
+16

Protein	Similar proteins		Species	Score	Length	Source
Q5C9Z4	Nucleolar MIF4G domain-containing protein 1		MOUSE		854	UniRef50_Q5C9Z4
Nucleolar protein with MIF4G domain 1		GORGO		929
Uncharacterized protein		CERAT		865
Uncharacterized protein		PAPAN		864
Uncharacterized protein		MACNE		863
+117

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY576779 mRNA Translation: AAT39521.1 AF107455 mRNA No translation available. BC007902 mRNA Translation: AAH07902.2
CCDSⁱ	CCDS34787.1
RefSeqⁱ	NP_612409.1, NM_138400.1
UniGeneⁱ	Hs.15825

3D structure databases

ProteinModelPortalⁱ	Q5C9Z4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	122182, 22 interactors
ELMⁱ	Q5C9Z4
IntActⁱ	Q5C9Z4, 42 interactors
MINTⁱ	Q5C9Z4
STRINGⁱ	9606.ENSP00000275820

PTM databases

iPTMnetⁱ	Q5C9Z4
PhosphoSitePlusⁱ	Q5C9Z4

Polymorphism and mutation databases

BioMutaⁱ	NOM1
DMDMⁱ	74707675

Proteomic databases

EPDⁱ	Q5C9Z4
MaxQBⁱ	Q5C9Z4
PaxDbⁱ	Q5C9Z4
PeptideAtlasⁱ	Q5C9Z4
PRIDEⁱ	Q5C9Z4
ProteomicsDBⁱ	62725

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	64434
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000275820; ENSP00000275820; ENSG00000146909
GeneIDⁱ	64434
KEGGⁱ	hsa:64434
UCSCⁱ	uc003wmy.3 human

Organism-specific databases

CTDⁱ	64434
DisGeNETⁱ	64434
EuPathDBⁱ	HostDB:ENSG00000146909.7
GeneCardsⁱ	NOM1
HGNCⁱ	HGNC:13244 NOM1
HPAⁱ	HPA019866 HPA051624
MIMⁱ	611269 gene
neXtProtⁱ	NX_Q5C9Z4
OpenTargetsⁱ	ENSG00000146909
PharmGKBⁱ	PA25946
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2141 Eukaryota ENOG410XNNQ LUCA
GeneTreeⁱ	ENSGT00550000075087
HOGENOMⁱ	HOG000044155
HOVERGENⁱ	HBG098839
InParanoidⁱ	Q5C9Z4
KOⁱ	K17583
OMAⁱ	QEHMVLL
OrthoDBⁱ	EOG091G03TZ
PhylomeDBⁱ	Q5C9Z4
TreeFamⁱ	TF312808

Miscellaneous databases

ChiTaRSⁱ	NOM1 human
GeneWikiⁱ	NOM1
GenomeRNAiⁱ	64434
Protein Ontology More...PROⁱ	PR:Q5C9Z4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000146909 Expressed in 196 organ(s), highest expression level in epithelial cell of pancreas
CleanExⁱ	HS_NOM1
Genevisibleⁱ	Q5C9Z4 HS

Family and domain databases

Gene3Dⁱ	1.25.40.180, 1 hit
InterProⁱ	View protein in InterPro IPR016024 ARM-type_fold IPR003891 Initiation_fac_eIF4g_MI IPR016021 MIF4-like_sf IPR003890 MIF4G-like_typ-3
Pfamⁱ	View protein in Pfam PF02847 MA3, 1 hit PF02854 MIF4G, 1 hit
SMARTⁱ	View protein in SMART SM00544 MA3, 1 hit SM00543 MIF4G, 1 hit
SUPFAMⁱ	SSF48371 SSF48371, 1 hit
PROSITEⁱ	View protein in PROSITE PS51366 MI, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NOM1_HUMAN
Accessionⁱ	Q5C9Z4Primary (citable) accession number: Q5C9Z4 Secondary accession number(s): Q96I08
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
	Last sequence update:	April 12, 2005
	Last modified:	November 7, 2018
	This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM

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UniProtKB - Q5C9Z4 (NOM1_HUMAN)

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Nucleolar MIF4G domain-containing protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ