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Protein

Nucleolar MIF4G domain-containing protein 1

Gene

NOM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in targeting PPP1CA to the nucleolus.1 Publication

GO - Molecular functioni

GO - Biological processi

  • hair follicle maturation Source: Ensembl
  • ribosomal small subunit biogenesis Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar MIF4G domain-containing protein 1
Alternative name(s):
SGD1 homolog
Gene namesi
Name:NOM1
Synonyms:C7orf3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000146909.7
HGNCiHGNC:13244 NOM1
MIMi611269 gene
neXtProtiNX_Q5C9Z4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi308V → A: Loss of interaction with PPP1CA and loss of ability to relocalize PPP1CA to the nucleolus; when associated with A-310. 1 Publication1
Mutagenesisi310F → A: Loss of interaction with PPP1CA and loss of ability to relocalize PPP1CA to the nucleolus; when associated with A-308. 1 Publication1

Organism-specific databases

DisGeNETi64434
OpenTargetsiENSG00000146909
PharmGKBiPA25946

Polymorphism and mutation databases

BioMutaiNOM1
DMDMi74707675

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002868231 – 860Nucleolar MIF4G domain-containing protein 1Add BLAST860

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei57PhosphoserineCombined sources1
Modified residuei139PhosphoserineCombined sources1
Modified residuei317PhosphoserineCombined sources1
Modified residuei320PhosphoserineCombined sources1
Modified residuei321PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5C9Z4
MaxQBiQ5C9Z4
PaxDbiQ5C9Z4
PeptideAtlasiQ5C9Z4
PRIDEiQ5C9Z4
ProteomicsDBi62725

PTM databases

iPTMnetiQ5C9Z4
PhosphoSitePlusiQ5C9Z4

Expressioni

Tissue specificityi

Expressed in heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000146909 Expressed in 196 organ(s), highest expression level in epithelial cell of pancreas
CleanExiHS_NOM1
GenevisibleiQ5C9Z4 HS

Organism-specific databases

HPAiHPA019866
HPA051624

Interactioni

Subunit structurei

May interact with EIF4A1, EIF4A2 and EIF4A3. Interacts with PPP1CA and PPP1CC.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
EIF4A3P389193EBI-2685618,EBI-299104

Protein-protein interaction databases

BioGridi122182, 22 interactors
ELMiQ5C9Z4
IntActiQ5C9Z4, 42 interactors
MINTiQ5C9Z4
STRINGi9606.ENSP00000275820

Structurei

3D structure databases

ProteinModelPortaliQ5C9Z4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini362 – 559MIF4GPROSITE-ProRule annotationAdd BLAST198
Domaini654 – 770MIPROSITE-ProRule annotationAdd BLAST117

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 269Necessary for nucleolar localization and for targeting PPP1CA to the nucleolusAdd BLAST269

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi307 – 310Required for efficient binding to PPP1CA and for targeting PPP1CA to the nucleolus4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi237 – 322Glu-richAdd BLAST86

Sequence similaritiesi

Belongs to the CWC22 family.Curated

Phylogenomic databases

eggNOGiKOG2141 Eukaryota
ENOG410XNNQ LUCA
GeneTreeiENSGT00550000075087
HOGENOMiHOG000044155
HOVERGENiHBG098839
InParanoidiQ5C9Z4
KOiK17583
OMAiQEHMVLL
OrthoDBiEOG091G03TZ
PhylomeDBiQ5C9Z4
TreeFamiTF312808

Family and domain databases

Gene3Di1.25.40.180, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR003891 Initiation_fac_eIF4g_MI
IPR016021 MIF4-like_sf
IPR003890 MIF4G-like_typ-3
PfamiView protein in Pfam
PF02847 MA3, 1 hit
PF02854 MIF4G, 1 hit
SMARTiView protein in SMART
SM00544 MA3, 1 hit
SM00543 MIF4G, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51366 MI, 1 hit

Sequencei

Sequence statusi: Complete.

Q5C9Z4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAASRSAGEA GPGGSQGRVV RMKRRGGRGP RRGPAGGGEK ALKRLKLAVE
60 70 80 90 100
EFVHATSEGE APGGCEGRGA PVSFRPGGRK SRKELRKEKR HLRKARRLQR
110 120 130 140 150
TAGPEQGPGL GGRSGAEEAS GHRQDTEERA RPAPSRDPSP PRKPRPSRVK
160 170 180 190 200
AKATAATAKT RPSAAATAAA RKRALLAANE EEDREIRKLE RCLGLNKRKK
210 220 230 240 250
KDGSSSVPLS FARDGLDYIL GALESGKNSG LYDSSGEEEE DAGQTLPESD
260 270 280 290 300
LESDSQDESE EEEEGDVEKE KKAQEAEAQS EDDDEDTEEE QGEEKEKGAQ
310 320 330 340 350
EKRRGKRVRF AEDEEKSENS SEDGDITDKS LCGSGEKYIP PHVRQAEETV
360 370 380 390 400
DFKKKEELER LKKHVKGLLN RLSEPNMASI SGQLEELYMA HSRKDMNDTL
410 420 430 440 450
TSALMGACVT ASAMPSRLMM EHVLLVSILH HTVGIEVGAH FLEAVVRKFD
460 470 480 490 500
AIYKYGSEGK ECDNLFTVIA HLYNFHVVQS LLIFDILKKL IGTFTEKDIE
510 520 530 540 550
LILLMLKNVG FSLRKDDALS LKELITEAQT KASGAGSEFQ DQTRIRFMLE
560 570 580 590 600
TMLALKNNDM RKIPGYDPEP VEKLRKLQRA LVRNAGSGSE TQLRVSWDSV
610 620 630 640 650
LSAEQTGRWW IVGSAWSGAP MIDNSHHTHL QKQLVGTVSS KILELARKQR
660 670 680 690 700
MNTDIRRNIF CTIMTSEDFL DAFEKLLKLG LKDQQEREII HVLMDCCLQE
710 720 730 740 750
KTYNPFYAFL ASKFCEYERR FQMTFQFSIW DKFRDLENLP ATNFSNLVHL
760 770 780 790 800
VAHLLKTKSL SLSILKVVEF SELDKPRVRF LRKVLSILLM ETEVEDLSLI
810 820 830 840 850
FTRVSDNPKL GVLREGLKLF ISHFLLKNAQ AHRSADEANV LREKADLATK
860
CLQGKASLRM
Length:860
Mass (Da):96,257
Last modified:April 12, 2005 - v1
Checksum:iD4FAB8FB9AC3B5C9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06199924R → G. Corresponds to variant dbSNP:rs6969990Ensembl.1
Natural variantiVAR_032187122H → P. Corresponds to variant dbSNP:rs6952214Ensembl.1
Natural variantiVAR_053051723M → V. Corresponds to variant dbSNP:rs12919Ensembl.1
Natural variantiVAR_032188779R → H. Corresponds to variant dbSNP:rs2302445Ensembl.1
Natural variantiVAR_032189804V → L. Corresponds to variant dbSNP:rs2302443Ensembl.1
Natural variantiVAR_032190812V → M. Corresponds to variant dbSNP:rs12919Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY576779 mRNA Translation: AAT39521.1
AF107455 mRNA No translation available.
BC007902 mRNA Translation: AAH07902.2
CCDSiCCDS34787.1
RefSeqiNP_612409.1, NM_138400.1
UniGeneiHs.15825

Genome annotation databases

EnsembliENST00000275820; ENSP00000275820; ENSG00000146909
GeneIDi64434
KEGGihsa:64434
UCSCiuc003wmy.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY576779 mRNA Translation: AAT39521.1
AF107455 mRNA No translation available.
BC007902 mRNA Translation: AAH07902.2
CCDSiCCDS34787.1
RefSeqiNP_612409.1, NM_138400.1
UniGeneiHs.15825

3D structure databases

ProteinModelPortaliQ5C9Z4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122182, 22 interactors
ELMiQ5C9Z4
IntActiQ5C9Z4, 42 interactors
MINTiQ5C9Z4
STRINGi9606.ENSP00000275820

PTM databases

iPTMnetiQ5C9Z4
PhosphoSitePlusiQ5C9Z4

Polymorphism and mutation databases

BioMutaiNOM1
DMDMi74707675

Proteomic databases

EPDiQ5C9Z4
MaxQBiQ5C9Z4
PaxDbiQ5C9Z4
PeptideAtlasiQ5C9Z4
PRIDEiQ5C9Z4
ProteomicsDBi62725

Protocols and materials databases

DNASUi64434
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275820; ENSP00000275820; ENSG00000146909
GeneIDi64434
KEGGihsa:64434
UCSCiuc003wmy.3 human

Organism-specific databases

CTDi64434
DisGeNETi64434
EuPathDBiHostDB:ENSG00000146909.7
GeneCardsiNOM1
HGNCiHGNC:13244 NOM1
HPAiHPA019866
HPA051624
MIMi611269 gene
neXtProtiNX_Q5C9Z4
OpenTargetsiENSG00000146909
PharmGKBiPA25946
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2141 Eukaryota
ENOG410XNNQ LUCA
GeneTreeiENSGT00550000075087
HOGENOMiHOG000044155
HOVERGENiHBG098839
InParanoidiQ5C9Z4
KOiK17583
OMAiQEHMVLL
OrthoDBiEOG091G03TZ
PhylomeDBiQ5C9Z4
TreeFamiTF312808

Miscellaneous databases

ChiTaRSiNOM1 human
GeneWikiiNOM1
GenomeRNAii64434
PROiPR:Q5C9Z4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000146909 Expressed in 196 organ(s), highest expression level in epithelial cell of pancreas
CleanExiHS_NOM1
GenevisibleiQ5C9Z4 HS

Family and domain databases

Gene3Di1.25.40.180, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR003891 Initiation_fac_eIF4g_MI
IPR016021 MIF4-like_sf
IPR003890 MIF4G-like_typ-3
PfamiView protein in Pfam
PF02847 MA3, 1 hit
PF02854 MIF4G, 1 hit
SMARTiView protein in SMART
SM00544 MA3, 1 hit
SM00543 MIF4G, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51366 MI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNOM1_HUMAN
AccessioniPrimary (citable) accession number: Q5C9Z4
Secondary accession number(s): Q96I08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: April 12, 2005
Last modified: November 7, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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