UniProtKB - Q5C9Z4 (NOM1_HUMAN)
Protein
Nucleolar MIF4G domain-containing protein 1
Gene
NOM1
Organism
Homo sapiens (Human)
Status
Functioni
Plays a role in targeting PPP1CA to the nucleolus.1 Publication
GO - Molecular functioni
- RNA binding Source: UniProtKB
GO - Biological processi
- hair follicle maturation Source: Ensembl
- ribosomal small subunit biogenesis Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q5C9Z4 |
Names & Taxonomyi
Protein namesi | Recommended name: Nucleolar MIF4G domain-containing protein 1Alternative name(s): SGD1 homolog |
Gene namesi | Name:NOM1 Synonyms:C7orf3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13244, NOM1 |
MIMi | 611269, gene |
neXtProti | NX_Q5C9Z4 |
VEuPathDBi | HostDB:ENSG00000146909.7 |
Subcellular locationi
Nucleus
- nucleolus 2 Publications
Nucleus
- nucleolus Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 308 | V → A: Loss of interaction with PPP1CA and loss of ability to relocalize PPP1CA to the nucleolus; when associated with A-310. 1 Publication | 1 | |
Mutagenesisi | 310 | F → A: Loss of interaction with PPP1CA and loss of ability to relocalize PPP1CA to the nucleolus; when associated with A-308. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 64434 |
OpenTargetsi | ENSG00000146909 |
PharmGKBi | PA25946 |
Miscellaneous databases
Pharosi | Q5C9Z4, Tdark |
Genetic variation databases
BioMutai | NOM1 |
DMDMi | 74707675 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000286823 | 1 – 860 | Nucleolar MIF4G domain-containing protein 1Add BLAST | 860 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 57 | PhosphoserineCombined sources | 1 | |
Modified residuei | 139 | PhosphoserineCombined sources | 1 | |
Modified residuei | 317 | PhosphoserineCombined sources | 1 | |
Modified residuei | 320 | PhosphoserineCombined sources | 1 | |
Modified residuei | 321 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q5C9Z4 |
jPOSTi | Q5C9Z4 |
MassIVEi | Q5C9Z4 |
MaxQBi | Q5C9Z4 |
PaxDbi | Q5C9Z4 |
PeptideAtlasi | Q5C9Z4 |
PRIDEi | Q5C9Z4 |
ProteomicsDBi | 62725 |
PTM databases
iPTMneti | Q5C9Z4 |
PhosphoSitePlusi | Q5C9Z4 |
Expressioni
Tissue specificityi
Expressed in heart and skeletal muscle.1 Publication
Gene expression databases
Bgeei | ENSG00000146909, Expressed in epithelial cell of pancreas and 209 other tissues |
Genevisiblei | Q5C9Z4, HS |
Organism-specific databases
HPAi | ENSG00000146909, Low tissue specificity |
Interactioni
Subunit structurei
May interact with EIF4A1, EIF4A2 and EIF4A3.
Interacts with PPP1CA and PPP1CC.
1 PublicationBinary interactionsi
Hide detailsQ5C9Z4
With | #Exp. | IntAct |
---|---|---|
EIF4A3 [P38919] | 3 | EBI-2685618,EBI-299104 |
NGDN [Q8NEJ9] | 3 | EBI-2685618,EBI-9995414 |
SRPK2 [P78362] | 3 | EBI-2685618,EBI-593303 |
Protein-protein interaction databases
BioGRIDi | 122182, 45 interactors |
ELMi | Q5C9Z4 |
IntActi | Q5C9Z4, 48 interactors |
MINTi | Q5C9Z4 |
STRINGi | 9606.ENSP00000275820 |
Miscellaneous databases
RNActi | Q5C9Z4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 362 – 559 | MIF4GPROSITE-ProRule annotationAdd BLAST | 198 | |
Domaini | 654 – 770 | MIPROSITE-ProRule annotationAdd BLAST | 117 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 269 | Necessary for nucleolar localization and for targeting PPP1CA to the nucleolusAdd BLAST | 269 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 307 – 310 | Required for efficient binding to PPP1CA and for targeting PPP1CA to the nucleolus | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 237 – 322 | Glu-richAdd BLAST | 86 |
Sequence similaritiesi
Belongs to the CWC22 family.Curated
Phylogenomic databases
eggNOGi | KOG2141, Eukaryota |
GeneTreei | ENSGT00940000153458 |
HOGENOMi | CLU_006786_0_1_1 |
InParanoidi | Q5C9Z4 |
OMAi | ASWDRIN |
OrthoDBi | 307186at2759 |
PhylomeDBi | Q5C9Z4 |
TreeFami | TF312808 |
Family and domain databases
Gene3Di | 1.25.40.180, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR003891, Initiation_fac_eIF4g_MI IPR016021, MIF4-like_sf IPR003890, MIF4G-like_typ-3 |
Pfami | View protein in Pfam PF02847, MA3, 1 hit PF02854, MIF4G, 1 hit |
SMARTi | View protein in SMART SM00544, MA3, 1 hit SM00543, MIF4G, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS51366, MI, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5C9Z4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAASRSAGEA GPGGSQGRVV RMKRRGGRGP RRGPAGGGEK ALKRLKLAVE
60 70 80 90 100
EFVHATSEGE APGGCEGRGA PVSFRPGGRK SRKELRKEKR HLRKARRLQR
110 120 130 140 150
TAGPEQGPGL GGRSGAEEAS GHRQDTEERA RPAPSRDPSP PRKPRPSRVK
160 170 180 190 200
AKATAATAKT RPSAAATAAA RKRALLAANE EEDREIRKLE RCLGLNKRKK
210 220 230 240 250
KDGSSSVPLS FARDGLDYIL GALESGKNSG LYDSSGEEEE DAGQTLPESD
260 270 280 290 300
LESDSQDESE EEEEGDVEKE KKAQEAEAQS EDDDEDTEEE QGEEKEKGAQ
310 320 330 340 350
EKRRGKRVRF AEDEEKSENS SEDGDITDKS LCGSGEKYIP PHVRQAEETV
360 370 380 390 400
DFKKKEELER LKKHVKGLLN RLSEPNMASI SGQLEELYMA HSRKDMNDTL
410 420 430 440 450
TSALMGACVT ASAMPSRLMM EHVLLVSILH HTVGIEVGAH FLEAVVRKFD
460 470 480 490 500
AIYKYGSEGK ECDNLFTVIA HLYNFHVVQS LLIFDILKKL IGTFTEKDIE
510 520 530 540 550
LILLMLKNVG FSLRKDDALS LKELITEAQT KASGAGSEFQ DQTRIRFMLE
560 570 580 590 600
TMLALKNNDM RKIPGYDPEP VEKLRKLQRA LVRNAGSGSE TQLRVSWDSV
610 620 630 640 650
LSAEQTGRWW IVGSAWSGAP MIDNSHHTHL QKQLVGTVSS KILELARKQR
660 670 680 690 700
MNTDIRRNIF CTIMTSEDFL DAFEKLLKLG LKDQQEREII HVLMDCCLQE
710 720 730 740 750
KTYNPFYAFL ASKFCEYERR FQMTFQFSIW DKFRDLENLP ATNFSNLVHL
760 770 780 790 800
VAHLLKTKSL SLSILKVVEF SELDKPRVRF LRKVLSILLM ETEVEDLSLI
810 820 830 840 850
FTRVSDNPKL GVLREGLKLF ISHFLLKNAQ AHRSADEANV LREKADLATK
860
CLQGKASLRM
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_061999 | 24 | R → G. Corresponds to variant dbSNP:rs6969990Ensembl. | 1 | |
Natural variantiVAR_032187 | 122 | H → P. Corresponds to variant dbSNP:rs6952214Ensembl. | 1 | |
Natural variantiVAR_053051 | 723 | M → V. Corresponds to variant dbSNP:rs12919Ensembl. | 1 | |
Natural variantiVAR_032188 | 779 | R → H. Corresponds to variant dbSNP:rs2302445Ensembl. | 1 | |
Natural variantiVAR_032189 | 804 | V → L. Corresponds to variant dbSNP:rs2302443Ensembl. | 1 | |
Natural variantiVAR_032190 | 812 | V → M. Corresponds to variant dbSNP:rs12919Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY576779 mRNA Translation: AAT39521.1 AF107455 mRNA No translation available. BC007902 mRNA Translation: AAH07902.2 |
CCDSi | CCDS34787.1 |
RefSeqi | NP_612409.1, NM_138400.1 |
Genome annotation databases
Ensembli | ENST00000275820; ENSP00000275820; ENSG00000146909 |
GeneIDi | 64434 |
KEGGi | hsa:64434 |
UCSCi | uc003wmy.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY576779 mRNA Translation: AAT39521.1 AF107455 mRNA No translation available. BC007902 mRNA Translation: AAH07902.2 |
CCDSi | CCDS34787.1 |
RefSeqi | NP_612409.1, NM_138400.1 |
3D structure databases
SMRi | Q5C9Z4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122182, 45 interactors |
ELMi | Q5C9Z4 |
IntActi | Q5C9Z4, 48 interactors |
MINTi | Q5C9Z4 |
STRINGi | 9606.ENSP00000275820 |
PTM databases
iPTMneti | Q5C9Z4 |
PhosphoSitePlusi | Q5C9Z4 |
Genetic variation databases
BioMutai | NOM1 |
DMDMi | 74707675 |
Proteomic databases
EPDi | Q5C9Z4 |
jPOSTi | Q5C9Z4 |
MassIVEi | Q5C9Z4 |
MaxQBi | Q5C9Z4 |
PaxDbi | Q5C9Z4 |
PeptideAtlasi | Q5C9Z4 |
PRIDEi | Q5C9Z4 |
ProteomicsDBi | 62725 |
Protocols and materials databases
Antibodypediai | 56748, 62 antibodies |
DNASUi | 64434 |
Genome annotation databases
Ensembli | ENST00000275820; ENSP00000275820; ENSG00000146909 |
GeneIDi | 64434 |
KEGGi | hsa:64434 |
UCSCi | uc003wmy.3, human |
Organism-specific databases
CTDi | 64434 |
DisGeNETi | 64434 |
GeneCardsi | NOM1 |
HGNCi | HGNC:13244, NOM1 |
HPAi | ENSG00000146909, Low tissue specificity |
MIMi | 611269, gene |
neXtProti | NX_Q5C9Z4 |
OpenTargetsi | ENSG00000146909 |
PharmGKBi | PA25946 |
VEuPathDBi | HostDB:ENSG00000146909.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2141, Eukaryota |
GeneTreei | ENSGT00940000153458 |
HOGENOMi | CLU_006786_0_1_1 |
InParanoidi | Q5C9Z4 |
OMAi | ASWDRIN |
OrthoDBi | 307186at2759 |
PhylomeDBi | Q5C9Z4 |
TreeFami | TF312808 |
Enzyme and pathway databases
PathwayCommonsi | Q5C9Z4 |
Miscellaneous databases
BioGRID-ORCSi | 64434, 598 hits in 1006 CRISPR screens |
ChiTaRSi | NOM1, human |
GeneWikii | NOM1 |
GenomeRNAii | 64434 |
Pharosi | Q5C9Z4, Tdark |
PROi | PR:Q5C9Z4 |
RNActi | Q5C9Z4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000146909, Expressed in epithelial cell of pancreas and 209 other tissues |
Genevisiblei | Q5C9Z4, HS |
Family and domain databases
Gene3Di | 1.25.40.180, 1 hit |
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR003891, Initiation_fac_eIF4g_MI IPR016021, MIF4-like_sf IPR003890, MIF4G-like_typ-3 |
Pfami | View protein in Pfam PF02847, MA3, 1 hit PF02854, MIF4G, 1 hit |
SMARTi | View protein in SMART SM00544, MA3, 1 hit SM00543, MIF4G, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS51366, MI, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NOM1_HUMAN | |
Accessioni | Q5C9Z4Primary (citable) accession number: Q5C9Z4 Secondary accession number(s): Q96I08 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | April 12, 2005 | |
Last modified: | April 7, 2021 | |
This is version 129 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families