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UniProtKB - Q5BVD1 (TTMP_HUMAN)

Entry version 122 (07 Apr 2021)
Sequence version 2 (11 Jan 2011)
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Protein

TPA-induced transmembrane protein

Gene

TTMP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q5BVD1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TPA-induced transmembrane protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TTMP
Synonyms:C3orf52
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:26255, C3orf52

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611956, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5BVD1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000114529.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei66 – 86HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		79669

Open Targets

More...OpenTargetsi		ENSG00000114529

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA143485328

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5BVD1, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		C3orf52

Domain mapping of disease mutations (DMDM)

More...DMDMi		317373287

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002480241 – 217TPA-induced transmembrane proteinAdd BLAST217

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q5BVD1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5BVD1

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q5BVD1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5BVD1

PeptideAtlas

More...PeptideAtlasi		Q5BVD1

PRoteomics IDEntifications database

More...PRIDEi		Q5BVD1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		62722 [Q5BVD1-1]
62723 [Q5BVD1-2]
62724 [Q5BVD1-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5BVD1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5BVD1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated following treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) in the pancreatic cancer cell line HPAF-II. The up-regulation by TPA is triggered at the promoter level.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000114529, Expressed in stomach and 153 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q5BVD1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5BVD1, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000114529, Tissue enhanced (pancreas)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q5BVD1
With#Exp.IntAct
ADGRG3 [Q86Y34]3EBI-10243654,EBI-17979264
AGER [Q15109]3EBI-10243654,EBI-1646426
AHNAK2 - isoform 3 [Q8IVF2-3]3EBI-10243654,EBI-12078468
AMIGO1 [Q86WK6]3EBI-10243654,EBI-19125216
AQP6 [Q13520]3EBI-10243654,EBI-13059134
ATP1B4 [Q9UN42]3EBI-10243654,EBI-12894731
BIK [Q13323]3EBI-10243654,EBI-700794
CCL21 [O00585]3EBI-10243654,EBI-953695
CCL26 [Q9Y258]3EBI-10243654,EBI-7783416
CD33 [P20138]3EBI-10243654,EBI-3906571
CHST13 [Q8NET6]3EBI-10243654,EBI-11599701
CLDN7 [O95471]3EBI-10243654,EBI-740744
CLEC10A [Q8IUN9]3EBI-10243654,EBI-2873246
CNMD - isoform 2 [O75829-2]3EBI-10243654,EBI-10696063
CPLX4 [Q7Z7G2]3EBI-10243654,EBI-18013275
DEXI [O95424]3EBI-10243654,EBI-724515
ERGIC3 [Q9Y282]3EBI-10243654,EBI-781551
ERP29 [P30040]3EBI-10243654,EBI-946830
ESAM [Q96AP7]3EBI-10243654,EBI-4314670
FAM209A [Q5JX71]3EBI-10243654,EBI-18304435
FFAR2 [O15552]3EBI-10243654,EBI-2833872
FNDC9 [Q8TBE3]3EBI-10243654,EBI-12142257
FOLH1 - isoform PSMA-8 [Q04609-8]3EBI-10243654,EBI-13060980
FUT3 [P21217]3EBI-10243654,EBI-12839380
GJA8 [P48165]3EBI-10243654,EBI-17458373
GJB1 [P08034]3EBI-10243654,EBI-17565645
GORAB [Q5T7V8]3EBI-10243654,EBI-3917143
HHLA2 [Q9UM44]3EBI-10243654,EBI-2867874
HSD17B13 [Q7Z5P4]3EBI-10243654,EBI-18053395
KEL [P23276]3EBI-10243654,EBI-746662
KIR2DL3 [P43628]3EBI-10243654,EBI-8632435
KLRC1 [P26715]3EBI-10243654,EBI-9018187
LEUTX [A8MZ59]3EBI-10243654,EBI-17490413
LHFPL5 [Q8TAF8]3EBI-10243654,EBI-2820517
LRRC25 [Q8N386]3EBI-10243654,EBI-11304917
MFF - isoform 5 [Q9GZY8-5]3EBI-10243654,EBI-11956541
MGST2 [Q99735]3EBI-10243654,EBI-11324706
MGST3 [O14880]3EBI-10243654,EBI-724754
MRGPRX3 [Q96LB0]3EBI-10243654,EBI-17958655
MUC1 - isoform Y-LSP [P15941-11]3EBI-10243654,EBI-17263240
NCR3LG1 [Q68D85]3EBI-10243654,EBI-14061804
NEMP1 - isoform 2 [O14524-2]3EBI-10243654,EBI-10969203
NPDC1 [Q9NQX5]3EBI-10243654,EBI-748927
NSG2 [Q9Y328]3EBI-10243654,EBI-7101695
PVR [P15151]3EBI-10243654,EBI-3919694
QPCTL - isoform 2 [Q9NXS2-3]3EBI-10243654,EBI-13336719
REEP3 [Q6NUK4]3EBI-10243654,EBI-7545786
RNF150 - isoform 3 [Q9ULK6-3]3EBI-10243654,EBI-23640835
SAR1A [Q9NR31]3EBI-10243654,EBI-3920694
SGTA [O43765]6EBI-10243654,EBI-347996
SIGLECL1 [Q8N7X8]3EBI-10243654,EBI-18052611
SLC10A2 [Q12908]3EBI-10243654,EBI-18114847
SLC39A2 [Q9NP94]3EBI-10243654,EBI-12898013
SPRING1 [Q9H741]3EBI-10243654,EBI-2836158
ST6GALNAC3 [Q8NDV1]3EBI-10243654,EBI-12947081
STOM [P27105]3EBI-10243654,EBI-1211440
SYNE4 [Q8N205]3EBI-10243654,EBI-7131783
TIMMDC1 [Q9NPL8]3EBI-10243654,EBI-6268651
TMEM179B [Q7Z7N9]3EBI-10243654,EBI-11724423
TMEM237 - isoform 2 [Q96Q45-2]3EBI-10243654,EBI-10982110
TMEM45B [Q96B21]3EBI-10243654,EBI-3923061
TMEM52B [Q4KMG9]3EBI-10243654,EBI-18178701
TMEM80 [Q96HE8]3EBI-10243654,EBI-11742770
TMPRSS2 - isoform 2 [O15393-2]5EBI-10243654,EBI-12345267
TMX2 [Q9Y320]3EBI-10243654,EBI-6447886
UPK2 [O00526]3EBI-10243654,EBI-10179682
ZNRF3 [Q9ULT6]3EBI-10243654,EBI-949772

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122794, 79 interactors

Protein interaction database and analysis system

More...IntActi		Q5BVD1, 74 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000399392

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5BVD1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5BVD1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S6A0, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000014574

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_1815206_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5BVD1

Identification of Orthologs from Complete Genome Data

More...OMAi		ITYHLQF

Database of Orthologous Groups

More...OrthoDBi		1078323at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5BVD1

TreeFam database of animal gene trees

More...TreeFami		TF330754

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR033223, TTMP

The PANTHER Classification System

More...PANTHERi		PTHR14636, PTHR14636, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5BVD1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDLAQPSQPV DELELSVLER QPEENTPLNG ADKVFPSLDE EVPPAEANKE 
        60         70         80         90        100
SPWSSCNKNV VGRCKLWMII TSIFLGVITV IIIGLCLAAV TYVDEDENEI 
       110        120        130        140        150
LELSSNKTFF IMLKIPEECV AEEELPHLLT ERLTDVYSTS PSLGRYFTSV 
       160        170        180        190        200
EIVDFSGENA TVTYDLQFGV PSDDENFMKY MMSEELVLGI LLQDFRDQNI 
       210 
PGCESLGLDP TSLLLYE
Length:217
Mass (Da):24,295
Last modified:January 11, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9240342865DBD743
GO
Isoform 2 (identifier: Q5BVD1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-217: LTDVYSTSPS...LDPTSLLLYE → EVGLKPNPEALVGFE

Show »
Length:147
Mass (Da):16,351
Checksum:i04506CED6912B373
GO
Isoform 3 (identifier: Q5BVD1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-217: LTDVYSTSPS...LDPTSLLLYE → NEVMEAGLCL...FFETGSRSVA

Show »
Length:250
Mass (Da):27,722
Checksum:i63C1D2E1BA69B742
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C5J7H7C5J7_HUMAN
Chromosome 3 open reading frame 52
C3orf52
241Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH17064 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB15569 differs from that shown. Reason: Frameshift.Curated
The sequence BAG60364 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1M → V in BAB15569 (PubMed:14702039).Curated1
Sequence conflicti123E → K in BAB15569 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05973666L → P. Corresponds to variant dbSNP:rs16859172Ensembl.1
Natural variantiVAR_027203111I → V. Corresponds to variant dbSNP:rs16859190Ensembl.1
Natural variantiVAR_027204144G → S3 PublicationsCorresponds to variant dbSNP:rs340167Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_036120133 – 217LTDVY…LLLYE → EVGLKPNPEALVGFE in isoform 2. 1 PublicationAdd BLAST85
Alternative sequenceiVSP_036121133 – 217LTDVY…LLLYE → NEVMEAGLCLKAVLYQVLEM KGIHSVLQKRFCGLIQKHQQ HQRGGDSFLSRFYSLALSPV KQLPSTASAGSSLDKGRKPA RVGAIGSAGMSHCWRSLVFC LFLFCFVLFFETGSRSVA in isoform 3. 1 PublicationAdd BLAST85

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY830714 mRNA Translation: AAX21411.1
AK026839 mRNA Translation: BAB15569.1 Frameshift.
AK298076 mRNA Translation: BAG60364.1 Different initiation.
AK303588 mRNA Translation: BAG64604.1
AC024887 Genomic DNA No translation available.
BC017064 mRNA Translation: AAH17064.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS46887.1 [Q5BVD1-1]
CCDS54620.1 [Q5BVD1-3]

NCBI Reference Sequences

More...RefSeqi		NP_001165218.1, NM_001171747.1 [Q5BVD1-3]
NP_078892.2, NM_024616.2 [Q5BVD1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000264848; ENSP00000264848; ENSG00000114529 [Q5BVD1-1]
ENST00000431717; ENSP00000399392; ENSG00000114529 [Q5BVD1-3]
ENST00000480282; ENSP00000420539; ENSG00000114529 [Q5BVD1-2]
ENST00000642661; ENSP00000495747; ENSG00000285394 [Q5BVD1-2]
ENST00000643248; ENSP00000495807; ENSG00000285394 [Q5BVD1-1]
ENST00000646545; ENSP00000493652; ENSG00000285394 [Q5BVD1-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		79669

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:79669

UCSC genome browser

More...UCSCi		uc003dyq.5, human [Q5BVD1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY830714 mRNA Translation: AAX21411.1
AK026839 mRNA Translation: BAB15569.1 Frameshift.
AK298076 mRNA Translation: BAG60364.1 Different initiation.
AK303588 mRNA Translation: BAG64604.1
AC024887 Genomic DNA No translation available.
BC017064 mRNA Translation: AAH17064.1 Different initiation.
CCDSiCCDS46887.1 [Q5BVD1-1]
CCDS54620.1 [Q5BVD1-3]
RefSeqiNP_001165218.1, NM_001171747.1 [Q5BVD1-3]
NP_078892.2, NM_024616.2 [Q5BVD1-1]

3D structure databases

SMRiQ5BVD1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122794, 79 interactors
IntActiQ5BVD1, 74 interactors
STRINGi9606.ENSP00000399392

PTM databases

iPTMnetiQ5BVD1
PhosphoSitePlusiQ5BVD1

Genetic variation databases

BioMutaiC3orf52
DMDMi317373287

Proteomic databases

jPOSTiQ5BVD1
MassIVEiQ5BVD1
MaxQBiQ5BVD1
PaxDbiQ5BVD1
PeptideAtlasiQ5BVD1
PRIDEiQ5BVD1
ProteomicsDBi62722 [Q5BVD1-1]
62723 [Q5BVD1-2]
62724 [Q5BVD1-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2367, 19 antibodies

The DNASU plasmid repository

More...DNASUi		79669

Genome annotation databases

EnsembliENST00000264848; ENSP00000264848; ENSG00000114529 [Q5BVD1-1]
ENST00000431717; ENSP00000399392; ENSG00000114529 [Q5BVD1-3]
ENST00000480282; ENSP00000420539; ENSG00000114529 [Q5BVD1-2]
ENST00000642661; ENSP00000495747; ENSG00000285394 [Q5BVD1-2]
ENST00000643248; ENSP00000495807; ENSG00000285394 [Q5BVD1-1]
ENST00000646545; ENSP00000493652; ENSG00000285394 [Q5BVD1-3]
GeneIDi79669
KEGGihsa:79669
UCSCiuc003dyq.5, human [Q5BVD1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79669
DisGeNETi79669

GeneCards: human genes, protein and diseases

More...GeneCardsi		C3orf52
HGNCiHGNC:26255, C3orf52
HPAiENSG00000114529, Tissue enhanced (pancreas)
MIMi611956, gene
neXtProtiNX_Q5BVD1
OpenTargetsiENSG00000114529
PharmGKBiPA143485328
VEuPathDBiHostDB:ENSG00000114529.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S6A0, Eukaryota
GeneTreeiENSGT00390000014574
HOGENOMiCLU_1815206_0_0_1
InParanoidiQ5BVD1
OMAiITYHLQF
OrthoDBi1078323at2759
PhylomeDBiQ5BVD1
TreeFamiTF330754

Enzyme and pathway databases

PathwayCommonsiQ5BVD1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		79669, 5 hits in 999 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		79669
PharosiQ5BVD1, Tdark

Protein Ontology

More...PROi		PR:Q5BVD1
RNActiQ5BVD1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000114529, Expressed in stomach and 153 other tissues
ExpressionAtlasiQ5BVD1, baseline and differential
GenevisibleiQ5BVD1, HS

Family and domain databases

InterProiView protein in InterPro
IPR033223, TTMP
PANTHERiPTHR14636, PTHR14636, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTTMP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5BVD1
Secondary accession number(s): B4DNV2
, B4E0Z2, Q96AJ4, Q9H5Q1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: January 11, 2011
Last modified: April 7, 2021
This is version 122 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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