UniProtKB - Q5BVD1 (TTMP_HUMAN)
Protein
TPA-induced transmembrane protein
Gene
TTMP
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: TPA-induced transmembrane protein |
Gene namesi | Name:TTMP Synonyms:C3orf52 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000114529.12 |
HGNCi | HGNC:26255, C3orf52 |
MIMi | 611956, gene |
neXtProti | NX_Q5BVD1 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 66 – 86 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 79669 |
OpenTargetsi | ENSG00000114529 |
PharmGKBi | PA143485328 |
Miscellaneous databases
Pharosi | Q5BVD1, Tdark |
Polymorphism and mutation databases
BioMutai | C3orf52 |
DMDMi | 317373287 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000248024 | 1 – 217 | TPA-induced transmembrane proteinAdd BLAST | 217 |
Proteomic databases
jPOSTi | Q5BVD1 |
MassIVEi | Q5BVD1 |
MaxQBi | Q5BVD1 |
PaxDbi | Q5BVD1 |
PeptideAtlasi | Q5BVD1 |
PRIDEi | Q5BVD1 |
ProteomicsDBi | 62722 [Q5BVD1-1] 62723 [Q5BVD1-2] 62724 [Q5BVD1-3] |
PTM databases
iPTMneti | Q5BVD1 |
PhosphoSitePlusi | Q5BVD1 |
Expressioni
Inductioni
Up-regulated following treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA) in the pancreatic cancer cell line HPAF-II. The up-regulation by TPA is triggered at the promoter level.1 Publication
Gene expression databases
Bgeei | ENSG00000114529, Expressed in stomach and 153 other tissues |
ExpressionAtlasi | Q5BVD1, baseline and differential |
Genevisiblei | Q5BVD1, HS |
Organism-specific databases
HPAi | ENSG00000114529, Tissue enhanced (pancreas) |
Interactioni
Binary interactionsi
Q5BVD1
Protein-protein interaction databases
BioGRIDi | 122794, 79 interactors |
IntActi | Q5BVD1, 74 interactors |
STRINGi | 9606.ENSP00000399392 |
Miscellaneous databases
RNActi | Q5BVD1, protein |
Family & Domainsi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S6A0, Eukaryota |
GeneTreei | ENSGT00390000014574 |
HOGENOMi | CLU_1815206_0_0_1 |
InParanoidi | Q5BVD1 |
OMAi | ITYHLQF |
OrthoDBi | 1078323at2759 |
PhylomeDBi | Q5BVD1 |
TreeFami | TF330754 |
Family and domain databases
InterProi | View protein in InterPro IPR033223, TTMP |
PANTHERi | PTHR14636, PTHR14636, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q5BVD1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDLAQPSQPV DELELSVLER QPEENTPLNG ADKVFPSLDE EVPPAEANKE
60 70 80 90 100
SPWSSCNKNV VGRCKLWMII TSIFLGVITV IIIGLCLAAV TYVDEDENEI
110 120 130 140 150
LELSSNKTFF IMLKIPEECV AEEELPHLLT ERLTDVYSTS PSLGRYFTSV
160 170 180 190 200
EIVDFSGENA TVTYDLQFGV PSDDENFMKY MMSEELVLGI LLQDFRDQNI
210
PGCESLGLDP TSLLLYE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH7C5J7 | H7C5J7_HUMAN | Chromosome 3 open reading frame 52 | C3orf52 | 241 | Annotation score: |
Sequence cautioni
The sequence AAH17064 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAB15569 differs from that shown. Reason: Frameshift.Curated
The sequence BAG60364 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1 | M → V in BAB15569 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 123 | E → K in BAB15569 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_059736 | 66 | L → P. Corresponds to variant dbSNP:rs16859172Ensembl. | 1 | |
Natural variantiVAR_027203 | 111 | I → V. Corresponds to variant dbSNP:rs16859190Ensembl. | 1 | |
Natural variantiVAR_027204 | 144 | G → S3 PublicationsCorresponds to variant dbSNP:rs340167Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_036120 | 133 – 217 | LTDVY…LLLYE → EVGLKPNPEALVGFE in isoform 2. 1 PublicationAdd BLAST | 85 | |
Alternative sequenceiVSP_036121 | 133 – 217 | LTDVY…LLLYE → NEVMEAGLCLKAVLYQVLEM KGIHSVLQKRFCGLIQKHQQ HQRGGDSFLSRFYSLALSPV KQLPSTASAGSSLDKGRKPA RVGAIGSAGMSHCWRSLVFC LFLFCFVLFFETGSRSVA in isoform 3. 1 PublicationAdd BLAST | 85 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY830714 mRNA Translation: AAX21411.1 AK026839 mRNA Translation: BAB15569.1 Frameshift. AK298076 mRNA Translation: BAG60364.1 Different initiation. AK303588 mRNA Translation: BAG64604.1 AC024887 Genomic DNA No translation available. BC017064 mRNA Translation: AAH17064.1 Different initiation. |
CCDSi | CCDS46887.1 [Q5BVD1-1] CCDS54620.1 [Q5BVD1-3] |
RefSeqi | NP_001165218.1, NM_001171747.1 [Q5BVD1-3] NP_078892.2, NM_024616.2 [Q5BVD1-1] |
Genome annotation databases
Ensembli | ENST00000264848; ENSP00000264848; ENSG00000114529 [Q5BVD1-1] ENST00000431717; ENSP00000399392; ENSG00000114529 [Q5BVD1-3] ENST00000480282; ENSP00000420539; ENSG00000114529 [Q5BVD1-2] ENST00000642661; ENSP00000495747; ENSG00000285394 [Q5BVD1-2] ENST00000643248; ENSP00000495807; ENSG00000285394 [Q5BVD1-1] ENST00000646545; ENSP00000493652; ENSG00000285394 [Q5BVD1-3] |
GeneIDi | 79669 |
KEGGi | hsa:79669 |
UCSCi | uc003dyq.5, human [Q5BVD1-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY830714 mRNA Translation: AAX21411.1 AK026839 mRNA Translation: BAB15569.1 Frameshift. AK298076 mRNA Translation: BAG60364.1 Different initiation. AK303588 mRNA Translation: BAG64604.1 AC024887 Genomic DNA No translation available. BC017064 mRNA Translation: AAH17064.1 Different initiation. |
CCDSi | CCDS46887.1 [Q5BVD1-1] CCDS54620.1 [Q5BVD1-3] |
RefSeqi | NP_001165218.1, NM_001171747.1 [Q5BVD1-3] NP_078892.2, NM_024616.2 [Q5BVD1-1] |
3D structure databases
SMRi | Q5BVD1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122794, 79 interactors |
IntActi | Q5BVD1, 74 interactors |
STRINGi | 9606.ENSP00000399392 |
PTM databases
iPTMneti | Q5BVD1 |
PhosphoSitePlusi | Q5BVD1 |
Polymorphism and mutation databases
BioMutai | C3orf52 |
DMDMi | 317373287 |
Proteomic databases
jPOSTi | Q5BVD1 |
MassIVEi | Q5BVD1 |
MaxQBi | Q5BVD1 |
PaxDbi | Q5BVD1 |
PeptideAtlasi | Q5BVD1 |
PRIDEi | Q5BVD1 |
ProteomicsDBi | 62722 [Q5BVD1-1] 62723 [Q5BVD1-2] 62724 [Q5BVD1-3] |
Protocols and materials databases
Antibodypediai | 2367, 19 antibodies |
DNASUi | 79669 |
Genome annotation databases
Ensembli | ENST00000264848; ENSP00000264848; ENSG00000114529 [Q5BVD1-1] ENST00000431717; ENSP00000399392; ENSG00000114529 [Q5BVD1-3] ENST00000480282; ENSP00000420539; ENSG00000114529 [Q5BVD1-2] ENST00000642661; ENSP00000495747; ENSG00000285394 [Q5BVD1-2] ENST00000643248; ENSP00000495807; ENSG00000285394 [Q5BVD1-1] ENST00000646545; ENSP00000493652; ENSG00000285394 [Q5BVD1-3] |
GeneIDi | 79669 |
KEGGi | hsa:79669 |
UCSCi | uc003dyq.5, human [Q5BVD1-1] |
Organism-specific databases
CTDi | 79669 |
DisGeNETi | 79669 |
EuPathDBi | HostDB:ENSG00000114529.12 |
GeneCardsi | C3orf52 |
HGNCi | HGNC:26255, C3orf52 |
HPAi | ENSG00000114529, Tissue enhanced (pancreas) |
MIMi | 611956, gene |
neXtProti | NX_Q5BVD1 |
OpenTargetsi | ENSG00000114529 |
PharmGKBi | PA143485328 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S6A0, Eukaryota |
GeneTreei | ENSGT00390000014574 |
HOGENOMi | CLU_1815206_0_0_1 |
InParanoidi | Q5BVD1 |
OMAi | ITYHLQF |
OrthoDBi | 1078323at2759 |
PhylomeDBi | Q5BVD1 |
TreeFami | TF330754 |
Enzyme and pathway databases
PathwayCommonsi | Q5BVD1 |
Miscellaneous databases
BioGRID-ORCSi | 79669, 4 hits in 850 CRISPR screens |
GenomeRNAii | 79669 |
Pharosi | Q5BVD1, Tdark |
PROi | PR:Q5BVD1 |
RNActi | Q5BVD1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000114529, Expressed in stomach and 153 other tissues |
ExpressionAtlasi | Q5BVD1, baseline and differential |
Genevisiblei | Q5BVD1, HS |
Family and domain databases
InterProi | View protein in InterPro IPR033223, TTMP |
PANTHERi | PTHR14636, PTHR14636, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TTMP_HUMAN | |
Accessioni | Q5BVD1Primary (citable) accession number: Q5BVD1 Secondary accession number(s): B4DNV2 Q9H5Q1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 5, 2006 |
Last sequence update: | January 11, 2011 | |
Last modified: | December 2, 2020 | |
This is version 120 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations