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Entry version 90 (16 Jan 2019)
Sequence version 1 (12 Apr 2005)
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Protein
Submitted name:

Ribeye a protein

Gene

ctbp2a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • camera-type eye development Source: ZFIN
  • clustering of voltage-gated calcium channels Source: ZFIN
  • regulation of gliogenesis Source: ZFIN
  • regulation of melanocyte differentiation Source: ZFIN
  • synapse assembly Source: ZFIN
  • synapse assembly involved in innervation Source: ZFIN

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ribeye a proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ctbp2aImported
Synonyms:ctbp2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-010130-2 ctbp2a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q5BU19

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini787 – 11002-Hacid_dhInterPro annotationAdd BLAST314
Domaini883 – 10662-Hacid_dh_CInterPro annotationAdd BLAST184

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili301 – 321Sequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0067 Eukaryota
COG0111 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000168252

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG096985

KEGG Orthology (KO)

More...
KOi
K04496

Database of Orthologous Groups

More...
OrthoDBi
700058at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5BU19

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006139 D-isomer_2_OHA_DH_cat_dom
IPR029753 D-isomer_DH_CS
IPR006140 D-isomer_DH_NAD-bd
IPR036291 NAD(P)-bd_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00389 2-Hacid_dh, 1 hit
PF02826 2-Hacid_dh_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51735 SSF51735, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00671 D_2_HYDROXYACID_DH_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5BU19-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLISSKQLPI GRSQSWDTLG GNEGHWERSD SVYEQQARMA GRRNPLSYGA
60 70 80 90 100
DAGGGWYEPA PGVRPPDLDL KREPEAYQES LYNQGYLDRP DPRNIRKSSV
110 120 130 140 150
PELNSHYDRP PIAHRGTLPP HDYYQQDPGM PSRPTEGFYR GEQPHSLNRS
160 170 180 190 200
SSHYGMMAGP RQIWGQGSGG RPGSVAPTPG VPPPPPPTVH DMGRIYRDPM
210 220 230 240 250
LSGPLPATPG TKMMHEGQRI PSRAQSPARY IMEPNSPRYA AEPPASLTSH
260 270 280 290 300
TVYSDVNGRP IDPHQPTATC LVVDPVAQGM DGTSRGMVMH PENPSPYTIQ
310 320 330 340 350
QQQQAQQQQQ MQQQIQQQQM QQVQPVQQMQ QVQPVQQMQQ AQPVQQMQQA
360 370 380 390 400
QPVQQMQPVQ PVQQMQPVQQ VQQVPQVQPV QQVPHVQPVA SPNPIYTPVP
410 420 430 440 450
PVAPAPVTTP GVAVIPAPLP QLPAQPLTAA PPPSVPQTPV APVDPKKNAD
460 470 480 490 500
PEFLALLHKE GLSESTINSL LQQGFDSTAM LAVMEENDVR SVAPNLGQAR
510 520 530 540 550
VLSRVVLCCK RPPEIVPATP LHPSAPARGR SNSFSHRSDI YVHQPPPLTP
560 570 580 590 600
GWESQYIQPP STPMQTMSPR IGDGYSRRPS SAPSQQLLET SGYPGPRVSG
610 620 630 640 650
VYSGAMVPVQ PRPLSGYNPH SGLPVTAMSQ HVAIPAHLPG IQQQMAALPP
660 670 680 690 700
QIHAMPLPAL PAVPQSMTVP ALAPQQAPKA YTTNYTVPME LMKRDRSLAT
710 720 730 740 750
MSPMPSPHLS PQVMREAGVS SDGALAPIGG AVPGQNMNLA NQKLSRRTGP
760 770 780 790 800
PVIVSTMASP DTSIRPQIMN GPMHPRPLVA LLDGRDCTVE MPILKDLATV
810 820 830 840 850
AFCDAQSTQE IHEKVLNEAV GAMMYHTITL TREDLEKFKA LRIIIRIGSG
860 870 880 890 900
YDNIDIKAAG EMGIAVCNIP SAAVEETADS TLCHILNLYR RNTWLYQAMR
910 920 930 940 950
EGTRVQSVEQ IREVASGAAR IRGETLGLIG FGRSGQAVAV RAKAFGFNVI
960 970 980 990 1000
FYDPYLQDGL ERSLGVQRVY TLQDLLYQSD CVSLHCNLNE HNHHLINDFT
1010 1020 1030 1040 1050
IKQMRQGAFL VNTARGGLVD EKALAQALKE GRIRGAALDV HESEPFSFTQ
1060 1070 1080 1090 1100
GPLKDAPNLI CTPHTAWYSE QASLEMREAA ATEIRRAITG RIPDSLRNCV
1110 1120 1130 1140
NKEFFVTTAP WGVMEQQVHP ELNGGAYRVA QPLPAVSPGG LQDKMYT
Length:1,147
Mass (Da):125,297
Last modified:April 12, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDC7915A37EE43B07
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY878349 mRNA Translation: AAX20023.1

NCBI Reference Sequences

More...
RefSeqi
NP_001182420.1, NM_001195491.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Dr.77714

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
65230

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:65230

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY878349 mRNA Translation: AAX20023.1
RefSeqiNP_001182420.1, NM_001195491.1
UniGeneiDr.77714

3D structure databases

ProteinModelPortaliQ5BU19
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi65230
KEGGidre:65230

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
65230
ZFINiZDB-GENE-010130-2 ctbp2a

Phylogenomic databases

eggNOGiKOG0067 Eukaryota
COG0111 LUCA
HOGENOMiHOG000168252
HOVERGENiHBG096985
KOiK04496
OrthoDBi700058at2759
PhylomeDBiQ5BU19

Family and domain databases

InterProiView protein in InterPro
IPR006139 D-isomer_2_OHA_DH_cat_dom
IPR029753 D-isomer_DH_CS
IPR006140 D-isomer_DH_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF00389 2-Hacid_dh, 1 hit
PF02826 2-Hacid_dh_C, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00671 D_2_HYDROXYACID_DH_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ5BU19_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5BU19
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2005
Last sequence update: April 12, 2005
Last modified: January 16, 2019
This is version 90 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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