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Protein

E2F-associated phosphoprotein

Gene

Eapp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression (By similarity).By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
E2F-associated phosphoprotein
Short name:
EAPP
Gene namesi
Name:Eapp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1913516 Eapp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000869051 – 281E2F-associated phosphoproteinAdd BLAST281

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei17PhosphoserineBy similarity1
Modified residuei37PhosphothreonineBy similarity1
Modified residuei109PhosphoserineCombined sources1
Modified residuei111PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5BU09
PRIDEiQ5BU09

PTM databases

iPTMnetiQ5BU09
PhosphoSitePlusiQ5BU09

Expressioni

Gene expression databases

BgeeiENSMUSG00000054302 Expressed in 275 organ(s), highest expression level in heart left ventricle
CleanExiMM_EAPP
ExpressionAtlasiQ5BU09 baseline and differential
GenevisibleiQ5BU09 MM

Interactioni

Subunit structurei

Interacts with E2F1. The C-terminal half binds the N-terminal of E2F1. Also interacts with E2F2 and E2F3, but not E2F4.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000123698

Structurei

3D structure databases

ProteinModelPortaliQ5BU09
SMRiQ5BU09
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi120 – 125Poly-Lys6

Phylogenomic databases

eggNOGiKOG3395 Eukaryota
ENOG4110B8Q LUCA
GeneTreeiENSGT00390000001332
HOGENOMiHOG000068005
HOVERGENiHBG054593
InParanoidiQ5BU09
OMAiKYRTQYR
OrthoDBiEOG091G0BO0
PhylomeDBiQ5BU09
TreeFamiTF328497

Family and domain databases

InterProiView protein in InterPro
IPR019370 E2F-assoc_phosphoprotein
PANTHERiPTHR15967 PTHR15967, 1 hit
PfamiView protein in Pfam
PF10238 Eapp_C, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5BU09-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNRLQDDYDP YAVEEPSDEE PALSSSEDEL DVLLHGTPDQ KRKLIRECLT
60 70 80 90 100
GESESSSEDE FEKEMEAELN STMKTMEDQL SSLGTGSSSG VAKVGGVTEK
110 120 130 140 150
FYDEIYFDSD SEDEDKTVTK KKKKKQHRIP TNDELLYDPE KDNRDQAWVD
160 170 180 190 200
AKRRGYHAFG LQRPRQKQQP VPNSDAVLNC PACMTTLCLD CQRHESYKTQ
210 220 230 240 250
YRAMFVMNCS INREEVLRYK NPENRRKRRS AKKMRSNPED PAEREAEEIY
260 270 280
HPVMCTECST EVAVYDKDEV FHFFNVLASH S
Length:281
Mass (Da):32,494
Last modified:August 30, 2005 - v2
Checksum:i269C664CA3E3C401
GO
Isoform 2 (identifier: Q5BU09-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-193: Missing.

Note: No experimental confirmation available.
Show »
Length:243
Mass (Da):28,208
Checksum:i5701DEB71ABCEC22
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CXF0E0CXF0_MOUSE
E2F-associated phosphoprotein
Eapp
156Annotation score:
E0CYG0E0CYG0_MOUSE
E2F-associated phosphoprotein
Eapp
128Annotation score:
F8WGY8F8WGY8_MOUSE
E2F-associated phosphoprotein
Eapp
56Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti116K → R in AAX20161 (PubMed:15716352).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_015331156 – 193Missing in isoform 2. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY882557 mRNA Translation: AAX20161.1
AK007442 mRNA Translation: BAB25042.1
AK012800 mRNA Translation: BAB28479.1
BC037622 mRNA Translation: AAH37622.1
CCDSiCCDS25910.1 [Q5BU09-1]
RefSeqiNP_001318091.1, NM_001331162.1 [Q5BU09-2]
NP_079732.1, NM_025456.4 [Q5BU09-1]
XP_006516205.1, XM_006516142.3 [Q5BU09-1]
UniGeneiMm.156440

Genome annotation databases

EnsembliENSMUST00000110713; ENSMUSP00000106341; ENSMUSG00000054302 [Q5BU09-2]
ENSMUST00000161592; ENSMUSP00000123698; ENSMUSG00000054302 [Q5BU09-1]
ENSMUST00000163433; ENSMUSP00000130251; ENSMUSG00000054302 [Q5BU09-1]
GeneIDi66266
KEGGimmu:66266
UCSCiuc007nnu.1 mouse [Q5BU09-1]
uc011ylx.1 mouse [Q5BU09-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY882557 mRNA Translation: AAX20161.1
AK007442 mRNA Translation: BAB25042.1
AK012800 mRNA Translation: BAB28479.1
BC037622 mRNA Translation: AAH37622.1
CCDSiCCDS25910.1 [Q5BU09-1]
RefSeqiNP_001318091.1, NM_001331162.1 [Q5BU09-2]
NP_079732.1, NM_025456.4 [Q5BU09-1]
XP_006516205.1, XM_006516142.3 [Q5BU09-1]
UniGeneiMm.156440

3D structure databases

ProteinModelPortaliQ5BU09
SMRiQ5BU09
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000123698

PTM databases

iPTMnetiQ5BU09
PhosphoSitePlusiQ5BU09

Proteomic databases

PaxDbiQ5BU09
PRIDEiQ5BU09

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000110713; ENSMUSP00000106341; ENSMUSG00000054302 [Q5BU09-2]
ENSMUST00000161592; ENSMUSP00000123698; ENSMUSG00000054302 [Q5BU09-1]
ENSMUST00000163433; ENSMUSP00000130251; ENSMUSG00000054302 [Q5BU09-1]
GeneIDi66266
KEGGimmu:66266
UCSCiuc007nnu.1 mouse [Q5BU09-1]
uc011ylx.1 mouse [Q5BU09-2]

Organism-specific databases

CTDi55837
MGIiMGI:1913516 Eapp

Phylogenomic databases

eggNOGiKOG3395 Eukaryota
ENOG4110B8Q LUCA
GeneTreeiENSGT00390000001332
HOGENOMiHOG000068005
HOVERGENiHBG054593
InParanoidiQ5BU09
OMAiKYRTQYR
OrthoDBiEOG091G0BO0
PhylomeDBiQ5BU09
TreeFamiTF328497

Miscellaneous databases

PROiPR:Q5BU09
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000054302 Expressed in 275 organ(s), highest expression level in heart left ventricle
CleanExiMM_EAPP
ExpressionAtlasiQ5BU09 baseline and differential
GenevisibleiQ5BU09 MM

Family and domain databases

InterProiView protein in InterPro
IPR019370 E2F-assoc_phosphoprotein
PANTHERiPTHR15967 PTHR15967, 1 hit
PfamiView protein in Pfam
PF10238 Eapp_C, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEAPP_MOUSE
AccessioniPrimary (citable) accession number: Q5BU09
Secondary accession number(s): Q9CZB5, Q9D914
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 30, 2005
Last modified: November 7, 2018
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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