UniProtKB - Q5BU09 (EAPP_MOUSE)
Protein
E2F-associated phosphoprotein
Gene
Eapp
Organism
Mus musculus (Mouse)
Status
Functioni
May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression (By similarity).By similarity
GO - Biological processi
Names & Taxonomyi
Protein namesi | Recommended name: E2F-associated phosphoproteinShort name: EAPP |
Gene namesi | Name:Eapp |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1913516, Eapp |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086905 | 1 – 281 | E2F-associated phosphoproteinAdd BLAST | 281 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 17 | PhosphoserineBy similarity | 1 | |
Modified residuei | 37 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 109 | PhosphoserineCombined sources | 1 | |
Modified residuei | 111 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
PaxDbi | Q5BU09 |
PRIDEi | Q5BU09 |
PTM databases
iPTMneti | Q5BU09 |
PhosphoSitePlusi | Q5BU09 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000054302, Expressed in heart left ventricle and 291 other tissues |
ExpressionAtlasi | Q5BU09, baseline and differential |
Genevisiblei | Q5BU09, MM |
Interactioni
Subunit structurei
Interacts with E2F1. The C-terminal half binds the N-terminal of E2F1.
Also interacts with E2F2 and E2F3, but not E2F4.
1 PublicationProtein-protein interaction databases
STRINGi | 10090.ENSMUSP00000123698 |
Miscellaneous databases
RNActi | Q5BU09, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 120 – 125 | Poly-Lys | 6 |
Phylogenomic databases
eggNOGi | KOG3395, Eukaryota |
GeneTreei | ENSGT00390000001332 |
HOGENOMi | CLU_075202_0_0_1 |
InParanoidi | Q5BU09 |
OMAi | YHPVLCT |
OrthoDBi | 1484224at2759 |
PhylomeDBi | Q5BU09 |
TreeFami | TF328497 |
Family and domain databases
InterProi | View protein in InterPro IPR019370, E2F-assoc_phosphoprotein |
PANTHERi | PTHR15967, PTHR15967, 1 hit |
Pfami | View protein in Pfam PF10238, Eapp_C, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q5BU09-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNRLQDDYDP YAVEEPSDEE PALSSSEDEL DVLLHGTPDQ KRKLIRECLT
60 70 80 90 100
GESESSSEDE FEKEMEAELN STMKTMEDQL SSLGTGSSSG VAKVGGVTEK
110 120 130 140 150
FYDEIYFDSD SEDEDKTVTK KKKKKQHRIP TNDELLYDPE KDNRDQAWVD
160 170 180 190 200
AKRRGYHAFG LQRPRQKQQP VPNSDAVLNC PACMTTLCLD CQRHESYKTQ
210 220 230 240 250
YRAMFVMNCS INREEVLRYK NPENRRKRRS AKKMRSNPED PAEREAEEIY
260 270 280
HPVMCTECST EVAVYDKDEV FHFFNVLASH S
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE0CXF0 | E0CXF0_MOUSE | E2F-associated phosphoprotein | Eapp | 156 | Annotation score: | ||
E0CYG0 | E0CYG0_MOUSE | E2F-associated phosphoprotein | Eapp | 128 | Annotation score: | ||
F8WGY8 | F8WGY8_MOUSE | E2F-associated phosphoprotein | Eapp | 56 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 116 | K → R in AAX20161 (PubMed:15716352).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_015331 | 156 – 193 | Missing in isoform 2. 1 PublicationAdd BLAST | 38 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY882557 mRNA Translation: AAX20161.1 AK007442 mRNA Translation: BAB25042.1 AK012800 mRNA Translation: BAB28479.1 BC037622 mRNA Translation: AAH37622.1 |
CCDSi | CCDS25910.1 [Q5BU09-1] CCDS88337.1 [Q5BU09-2] |
RefSeqi | NP_001318091.1, NM_001331162.1 [Q5BU09-2] NP_079732.1, NM_025456.4 [Q5BU09-1] XP_006516205.1, XM_006516142.3 [Q5BU09-1] |
Genome annotation databases
Ensembli | ENSMUST00000110713; ENSMUSP00000106341; ENSMUSG00000054302 [Q5BU09-2] ENSMUST00000161592; ENSMUSP00000123698; ENSMUSG00000054302 [Q5BU09-1] ENSMUST00000163433; ENSMUSP00000130251; ENSMUSG00000054302 [Q5BU09-1] |
GeneIDi | 66266 |
KEGGi | mmu:66266 |
UCSCi | uc007nnu.1, mouse [Q5BU09-1] uc011ylx.1, mouse [Q5BU09-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY882557 mRNA Translation: AAX20161.1 AK007442 mRNA Translation: BAB25042.1 AK012800 mRNA Translation: BAB28479.1 BC037622 mRNA Translation: AAH37622.1 |
CCDSi | CCDS25910.1 [Q5BU09-1] CCDS88337.1 [Q5BU09-2] |
RefSeqi | NP_001318091.1, NM_001331162.1 [Q5BU09-2] NP_079732.1, NM_025456.4 [Q5BU09-1] XP_006516205.1, XM_006516142.3 [Q5BU09-1] |
3D structure databases
SMRi | Q5BU09 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000123698 |
PTM databases
iPTMneti | Q5BU09 |
PhosphoSitePlusi | Q5BU09 |
Proteomic databases
PaxDbi | Q5BU09 |
PRIDEi | Q5BU09 |
Protocols and materials databases
Antibodypediai | 128, 123 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000110713; ENSMUSP00000106341; ENSMUSG00000054302 [Q5BU09-2] ENSMUST00000161592; ENSMUSP00000123698; ENSMUSG00000054302 [Q5BU09-1] ENSMUST00000163433; ENSMUSP00000130251; ENSMUSG00000054302 [Q5BU09-1] |
GeneIDi | 66266 |
KEGGi | mmu:66266 |
UCSCi | uc007nnu.1, mouse [Q5BU09-1] uc011ylx.1, mouse [Q5BU09-2] |
Organism-specific databases
CTDi | 55837 |
MGIi | MGI:1913516, Eapp |
Phylogenomic databases
eggNOGi | KOG3395, Eukaryota |
GeneTreei | ENSGT00390000001332 |
HOGENOMi | CLU_075202_0_0_1 |
InParanoidi | Q5BU09 |
OMAi | YHPVLCT |
OrthoDBi | 1484224at2759 |
PhylomeDBi | Q5BU09 |
TreeFami | TF328497 |
Miscellaneous databases
BioGRID-ORCSi | 66266, 4 hits in 17 CRISPR screens |
ChiTaRSi | Eapp, mouse |
PROi | PR:Q5BU09 |
RNActi | Q5BU09, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000054302, Expressed in heart left ventricle and 291 other tissues |
ExpressionAtlasi | Q5BU09, baseline and differential |
Genevisiblei | Q5BU09, MM |
Family and domain databases
InterProi | View protein in InterPro IPR019370, E2F-assoc_phosphoprotein |
PANTHERi | PTHR15967, PTHR15967, 1 hit |
Pfami | View protein in Pfam PF10238, Eapp_C, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EAPP_MOUSE | |
Accessioni | Q5BU09Primary (citable) accession number: Q5BU09 Secondary accession number(s): Q9CZB5, Q9D914 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 30, 2005 |
Last sequence update: | August 30, 2005 | |
Last modified: | December 2, 2020 | |
This is version 109 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot