Eapp

Functionⁱ

May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression (By similarity).By similarity

GO - Biological processⁱ

negative regulation of transcription elongation from RNA polymerase II promoter
Source: MGI
Inferred from sequence orthologyⁱ
- 15716352
positive regulation of cell proliferation
Source: MGI
Inferred from sequence orthologyⁱ
- 15716352
positive regulation of transcription elongation from RNA polymerase II promoter
Source: MGI
Inferred from sequence orthologyⁱ
- 15716352

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: E2F-associated phosphoprotein Short name: EAPP
Gene namesⁱ	Name:Eapp
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 12

Organism-specific databases

MGIⁱ	MGI:1913516 Eapp

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000086905	1 – 281	E2F-associated phosphoproteinAdd BLAST		281

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineBy similarity	1
Modified residueⁱ	17	PhosphoserineBy similarity	1
Modified residueⁱ	37	PhosphothreonineBy similarity	1
Modified residueⁱ	109	PhosphoserineCombined sources	1
Modified residueⁱ	111	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q5BU09
PRIDEⁱ	Q5BU09

PTM databases

iPTMnetⁱ	Q5BU09
PhosphoSitePlusⁱ	Q5BU09

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000054302 Expressed in 275 organ(s), highest expression level in heart left ventricle
CleanExⁱ	MM_EAPP
ExpressionAtlasⁱ	Q5BU09 baseline and differential
Genevisibleⁱ	Q5BU09 MM

Interactionⁱ

Subunit structureⁱ

Interacts with E2F1. The C-terminal half binds the N-terminal of E2F1. Also interacts with E2F2 and E2F3, but not E2F4.1 Publication

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000123698

STRINGⁱ

10090.ENSMUSP00000123698

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q5BU09
SMRⁱ	Q5BU09
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	120 – 125	Poly-Lys		6

Phylogenomic databases

eggNOGⁱ	KOG3395 Eukaryota ENOG4110B8Q LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000001332
HOGENOMⁱ	HOG000068005
HOVERGENⁱ	HBG054593
InParanoidⁱ	Q5BU09
OMAⁱ	KYRTQYR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BO0
PhylomeDBⁱ	Q5BU09
TreeFamⁱ	TF328497

Family and domain databases

InterProⁱ	View protein in InterPro IPR019370 E2F-assoc_phosphoprotein
PANTHERⁱ	PTHR15967 PTHR15967, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10238 Eapp_C, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q5BU09-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNRLQDDYDP YAVEEPSDEE PALSSSEDEL DVLLHGTPDQ KRKLIRECLT 
        60         70         80         90        100
GESESSSEDE FEKEMEAELN STMKTMEDQL SSLGTGSSSG VAKVGGVTEK 
       110        120        130        140        150
FYDEIYFDSD SEDEDKTVTK KKKKKQHRIP TNDELLYDPE KDNRDQAWVD 
       160        170        180        190        200
AKRRGYHAFG LQRPRQKQQP VPNSDAVLNC PACMTTLCLD CQRHESYKTQ 
       210        220        230        240        250
YRAMFVMNCS INREEVLRYK NPENRRKRRS AKKMRSNPED PAEREAEEIY 
       260        270        280 
HPVMCTECST EVAVYDKDEV FHFFNVLASH S

Length:281

Mass (Da):32,494

Last modified:August 30, 2005 - v2

Checksum:ⁱ269C664CA3E3C401

GO

Isoform 2 (identifier: Q5BU09-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
156-193: Missing.

« Hide

        10         20         30         40         50
MNRLQDDYDP YAVEEPSDEE PALSSSEDEL DVLLHGTPDQ KRKLIRECLT 
        60         70         80         90        100
GESESSSEDE FEKEMEAELN STMKTMEDQL SSLGTGSSSG VAKVGGVTEK 
       110        120        130        140        150
FYDEIYFDSD SEDEDKTVTK KKKKKQHRIP TNDELLYDPE KDNRDQAWVD 
       160        170        180        190        200
AKRRGHESYK TQYRAMFVMN CSINREEVLR YKNPENRRKR RSAKKMRSNP 
       210        220        230        240 
EDPAEREAEE IYHPVMCTEC STEVAVYDKD EVFHFFNVLA SHS

Note: No experimental confirmation available.

Show »

Length:243

Mass (Da):28,208

Checksum:ⁱ5701DEB71ABCEC22

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E0CXF0	E0CXF0_MOUSE	E2F-associated phosphoprotein E2F-associated phosphoprotein	Eapp	156	Annotation score:
E0CYG0	E0CYG0_MOUSE	E2F-associated phosphoprotein E2F-associated phosphoprotein	Eapp	128	Annotation score:
F8WGY8	F8WGY8_MOUSE	E2F-associated phosphoprotein E2F-associated phosphoprotein	Eapp	56	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	116	K → R in AAX20161 (PubMed:15716352).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_015331	156 – 193	Missing in isoform 2. 1 PublicationAdd BLAST		38

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY882557 mRNA Translation: AAX20161.1 AK007442 mRNA Translation: BAB25042.1 AK012800 mRNA Translation: BAB28479.1 BC037622 mRNA Translation: AAH37622.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS25910.1 [Q5BU09-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001318091.1, NM_001331162.1 [Q5BU09-2] NP_079732.1, NM_025456.4 [Q5BU09-1] XP_006516205.1, XM_006516142.3 [Q5BU09-1]
UniGeneⁱ	Mm.156440

Genome annotation databases

Ensemblⁱ	ENSMUST00000110713; ENSMUSP00000106341; ENSMUSG00000054302 [Q5BU09-2] ENSMUST00000161592; ENSMUSP00000123698; ENSMUSG00000054302 [Q5BU09-1] ENSMUST00000163433; ENSMUSP00000130251; ENSMUSG00000054302 [Q5BU09-1]
GeneIDⁱ	66266
KEGGⁱ	mmu:66266
UCSC genome browser More...UCSCⁱ	uc007nnu.1 mouse [Q5BU09-1] uc011ylx.1 mouse [Q5BU09-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q5BU09	E2F-associated phosphoprotein		CRIGR		283	UniRef90_Q5BU09
E2F-associated phosphoprotein		RAT		280
UPI0004ED157D		NANGA		286
UPI00042AAF62		PERMB		283
UPI00038BB97D		MICOH		282
+5

Protein	Similar proteins		Species	Score	Length	Source
Q5BU09	E2F-associated phosphoprotein		CRIGR		283	UniRef50_Q5BU09
E2F-associated phosphoprotein		RAT		280
E2F-associated phosphoprotein		ERIEU		285
E2F-associated phosphoprotein		ICTPU		310
E2F-associated phosphoprotein		Asian bonytongue		292
+177
Q5BU09-2	EAPP isoform 3 (Fragment)		PONAB		205	UniRef50_Q5BU09-2
E2F-associated phosphoprotein		HUMAN		231
EAPP isoform 2		PANTR		231
Uncharacterized protein		PANPA		218
Uncharacterized protein		ICTTR		208
+8

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY882557 mRNA Translation: AAX20161.1 AK007442 mRNA Translation: BAB25042.1 AK012800 mRNA Translation: BAB28479.1 BC037622 mRNA Translation: AAH37622.1
CCDSⁱ	CCDS25910.1 [Q5BU09-1]
RefSeqⁱ	NP_001318091.1, NM_001331162.1 [Q5BU09-2] NP_079732.1, NM_025456.4 [Q5BU09-1] XP_006516205.1, XM_006516142.3 [Q5BU09-1]
UniGeneⁱ	Mm.156440

3D structure databases

ProteinModelPortalⁱ	Q5BU09
SMRⁱ	Q5BU09
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000123698

STRINGⁱ

10090.ENSMUSP00000123698

PTM databases

iPTMnetⁱ	Q5BU09
PhosphoSitePlusⁱ	Q5BU09

Proteomic databases

PaxDbⁱ	Q5BU09
PRIDEⁱ	Q5BU09

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000110713; ENSMUSP00000106341; ENSMUSG00000054302 [Q5BU09-2] ENSMUST00000161592; ENSMUSP00000123698; ENSMUSG00000054302 [Q5BU09-1] ENSMUST00000163433; ENSMUSP00000130251; ENSMUSG00000054302 [Q5BU09-1]
GeneIDⁱ	66266
KEGGⁱ	mmu:66266
UCSCⁱ	uc007nnu.1 mouse [Q5BU09-1] uc011ylx.1 mouse [Q5BU09-2]

Organism-specific databases

CTDⁱ	55837
MGIⁱ	MGI:1913516 Eapp

Phylogenomic databases

eggNOGⁱ	KOG3395 Eukaryota ENOG4110B8Q LUCA
GeneTreeⁱ	ENSGT00390000001332
HOGENOMⁱ	HOG000068005
HOVERGENⁱ	HBG054593
InParanoidⁱ	Q5BU09
OMAⁱ	KYRTQYR
OrthoDBⁱ	EOG091G0BO0
PhylomeDBⁱ	Q5BU09
TreeFamⁱ	TF328497

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q5BU09
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000054302 Expressed in 275 organ(s), highest expression level in heart left ventricle
CleanExⁱ	MM_EAPP
ExpressionAtlasⁱ	Q5BU09 baseline and differential
Genevisibleⁱ	Q5BU09 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR019370 E2F-assoc_phosphoprotein
PANTHERⁱ	PTHR15967 PTHR15967, 1 hit
Pfamⁱ	View protein in Pfam PF10238 Eapp_C, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EAPP_MOUSE
Accessionⁱ	Q5BU09Primary (citable) accession number: Q5BU09 Secondary accession number(s): Q9CZB5, Q9D914
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
	Last sequence update:	August 30, 2005
	Last modified:	November 7, 2018
	This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q5BU09 (EAPP_MOUSE)

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E2F-associated phosphoprotein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ