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Protein

UPF0691 protein C9orf116

Gene

C9orf116

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0691 protein C9orf116
Alternative name(s):
p53-induced expression in RB-null cells protein 1
Short name:
Pierce1
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000160345.12
HGNCiHGNC:28435 C9orf116
MIMi614502 gene
neXtProtiNX_Q5BN46

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000160345
PharmGKBiPA134878696

Polymorphism and mutation databases

BioMutaiC9orf116

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000897281 – 136UPF0691 protein C9orf116Add BLAST136

Proteomic databases

PaxDbiQ5BN46
PeptideAtlasiQ5BN46
PRIDEiQ5BN46
ProteomicsDBi62718
62719 [Q5BN46-2]

PTM databases

iPTMnetiQ5BN46
PhosphoSitePlusiQ5BN46

Expressioni

Developmental stagei

May be up-regulated during progression from G1 to S phase of the cell cycle. Maximal expression in S or G2 phase.1 Publication

Gene expression databases

BgeeiENSG00000160345
CleanExiHS_C9orf116
ExpressionAtlasiQ5BN46 baseline and differential
GenevisibleiQ5BN46 HS

Organism-specific databases

HPAiHPA021439
HPA065287

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FHL3Q136433EBI-10243636,EBI-741101

Protein-protein interaction databases

BioGridi126503, 2 interactors
IntActiQ5BN46, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ5BN46
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0691 family.Curated

Phylogenomic databases

eggNOGiENOG410IX5S Eukaryota
ENOG4111ZK1 LUCA
GeneTreeiENSGT00510000049377
HOGENOMiHOG000111655
HOVERGENiHBG055120
InParanoidiQ5BN46
OMAiFHPSYNV
OrthoDBiEOG091G15IX
PhylomeDBiQ5BN46
TreeFamiTF323876

Family and domain databases

InterProiView protein in InterPro
IPR026507 UPF0691
PANTHERiPTHR20899 PTHR20899, 1 hit
PfamiView protein in Pfam
PF14892 DUF4490, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5BN46-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEECPRACA EPVAPKATAP PERTSDYYRV SADLPGRFNN PGWFRGYRTQ
60 70 80 90 100
KAVSVYRTSN QAYGSRAPTV HEMPKVFYPN SNKFSQQLAA GGMFRNNTLN
110 120 130
VYLEKSIVTG PDNCITSCDR LNFHPSYNIN RPSICD
Length:136
Mass (Da):15,260
Last modified:April 12, 2005 - v1
Checksum:i40EF2889FC52E775
GO
Isoform 2 (identifier: Q5BN46-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     75-92: KVFYPNSNKFSQQLAAGG → RVECSGTILSMFTWRKAS
     93-136: Missing.

Show »
Length:92
Mass (Da):10,318
Checksum:iCC7E80830492B1AC
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01446675 – 92KVFYP…LAAGG → RVECSGTILSMFTWRKAS in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_01446793 – 136Missing in isoform 2. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY927868 mRNA Translation: AAX22217.1
AL161452 Genomic DNA No translation available.
BC021261 mRNA Translation: AAH21261.1
CCDSiCCDS43899.1 [Q5BN46-1]
CCDS6989.1 [Q5BN46-2]
RefSeqiNP_001041730.1, NM_001048265.1 [Q5BN46-1]
NP_653255.1, NM_144654.2 [Q5BN46-2]
UniGeneiHs.414028

Genome annotation databases

EnsembliENST00000371789; ENSP00000360854; ENSG00000160345 [Q5BN46-2]
ENST00000371791; ENSP00000360856; ENSG00000160345 [Q5BN46-2]
ENST00000429260; ENSP00000395281; ENSG00000160345 [Q5BN46-1]
GeneIDi138162
KEGGihsa:138162
UCSCiuc004cfs.2 human [Q5BN46-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCI116_HUMAN
AccessioniPrimary (citable) accession number: Q5BN46
Secondary accession number(s): Q5T897, Q8WU44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: April 12, 2005
Last modified: June 20, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

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