UniProtKB - Q5BLY5 (ACPH1_APIME)
Protein
Venom acid phosphatase Acph-1
Gene
N/A
Organism
Apis mellifera (Honeybee)
Status
Functioni
Catalytic activityi
- EC:3.1.3.2
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 26 | NucleophileBy similarity | 1 | |
Active sitei | 273 | Proton donorBy similarity | 1 |
GO - Molecular functioni
- acid phosphatase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Hydrolase |
Enzyme and pathway databases
BRENDAi | 3.1.3.2 387 |
Names & Taxonomyi
Protein namesi | |
Organismi | Apis mellifera (Honeybee) |
Taxonomic identifieri | 7460 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Hymenoptera › Apocrita › Aculeata › Apoidea › Apidae › Apis |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPathology & Biotechi
Allergenic propertiesi
Causes an allergic reaction in human.2 Publications
Keywords - Diseasei
AllergenProtein family/group databases
Allergomei | 2778 Api m A1-A2-A3 3090 Api m 3.0101 47 Api m 3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 15 | Sequence analysisAdd BLAST | 15 | |
ChainiPRO_5000095341 | 16 – 388 | Venom acid phosphatase Acph-1Add BLAST | 373 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 145 ↔ 355 | By similarity | ||
Glycosylationi | 182 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 228 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 330 ↔ 334 | By similarity | ||
Glycosylationi | 366 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q5BLY5 |
Expressioni
Tissue specificityi
Expressed by the venom gland.
Structurei
3D structure databases
ProteinModelPortali | Q5BLY5 |
SMRi | Q5BLY5 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the histidine acid phosphatase family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3720 Eukaryota ENOG410ZVBQ LUCA |
InParanoidi | Q5BLY5 |
KOi | K19283 |
OMAi | LIFEVFR |
Family and domain databases
CDDi | cd07061 HP_HAP_like, 1 hit |
Gene3Di | 3.40.50.1240, 1 hit |
InterProi | View protein in InterPro IPR033379 Acid_Pase_AS IPR029630 Api_m_3 IPR000560 His_Pase_clade-2 IPR029033 His_PPase_superfam |
PANTHERi | PTHR11567:SF22 PTHR11567:SF22, 1 hit |
Pfami | View protein in Pfam PF00328 His_Phos_2, 2 hits |
SUPFAMi | SSF53254 SSF53254, 1 hit |
PROSITEi | View protein in PROSITE PS00616 HIS_ACID_PHOSPHAT_1, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q5BLY5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSVIAILAMV VGVQAELKQI NVIFRHGDRI PDEKNEMYPK DPYLYYDFYP
60 70 80 90 100
LERGELTNSG KMREYQLGQF LRERYGDFLG DIYTEESVSA LSSFYDRTKM
110 120 130 140 150
SLQLVLAALY PPNKLQQWNE DLNWQPIATK YLRRYEDNIF LPEDCLLFTI
160 170 180 190 200
ELDRVLESPR GKYEFSKYDK LKKKLEEWTG KNITTPWDYY YIYHTLVAEQ
210 220 230 240 250
SYGLTLPSWT NNIFPRGELF DATVFTYNIT NSTPLLKKLY GGPLLRIFTK
260 270 280 290 300
HMLDVVSGTQ KKKRKIYLFS GHESNIASVL HALQLYYPHV PEYSSSIIME
310 320 330 340 350
LHNIEGTHYV KIVYYLGIPS EARELQLPGC EVLCPLYKYL QLIENVIPSN
360 370 380
EELICDKRFV DESANNLSIE ELDFVKLNLI RIAGTENK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 152 | L → F in ACI25605 (Ref. 2) Curated | 1 | |
Sequence conflicti | 278 | S → A in ACI25605 (Ref. 2) Curated | 1 | |
Sequence conflicti | 323 | R → G in ACI25605 (Ref. 2) Curated | 1 | |
Sequence conflicti | 360 | V → A in ACI25605 (Ref. 2) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY939855 mRNA Translation: AAX33235.1 FJ200211 mRNA Translation: ACI25605.1 DQ058012 mRNA Translation: AAY57281.1 |
RefSeqi | NP_001013377.2, NM_001013359.2 |
UniGenei | Ame.7483 |
Genome annotation databases
GeneIDi | 411830 |
KEGGi | ame:411830 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY939855 mRNA Translation: AAX33235.1 FJ200211 mRNA Translation: ACI25605.1 DQ058012 mRNA Translation: AAY57281.1 |
RefSeqi | NP_001013377.2, NM_001013359.2 |
UniGenei | Ame.7483 |
3D structure databases
ProteinModelPortali | Q5BLY5 |
SMRi | Q5BLY5 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
STRINGi | 7460.GB12546-PA |
Protein family/group databases
Allergomei | 2778 Api m A1-A2-A3 3090 Api m 3.0101 47 Api m 3 |
Proteomic databases
PaxDbi | Q5BLY5 |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Genome annotation databases
GeneIDi | 411830 |
KEGGi | ame:411830 |
Organism-specific databases
CTDi | 48445 |
Phylogenomic databases
eggNOGi | KOG3720 Eukaryota ENOG410ZVBQ LUCA |
InParanoidi | Q5BLY5 |
KOi | K19283 |
OMAi | LIFEVFR |
Enzyme and pathway databases
BRENDAi | 3.1.3.2 387 |
Family and domain databases
CDDi | cd07061 HP_HAP_like, 1 hit |
Gene3Di | 3.40.50.1240, 1 hit |
InterProi | View protein in InterPro IPR033379 Acid_Pase_AS IPR029630 Api_m_3 IPR000560 His_Pase_clade-2 IPR029033 His_PPase_superfam |
PANTHERi | PTHR11567:SF22 PTHR11567:SF22, 1 hit |
Pfami | View protein in Pfam PF00328 His_Phos_2, 2 hits |
SUPFAMi | SSF53254 SSF53254, 1 hit |
PROSITEi | View protein in PROSITE PS00616 HIS_ACID_PHOSPHAT_1, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | ACPH1_APIME | |
Accessioni | Q5BLY5Primary (citable) accession number: Q5BLY5 Secondary accession number(s): B6E2X9, Q4TUB9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 30, 2010 |
Last sequence update: | April 12, 2005 | |
Last modified: | December 5, 2018 | |
This is version 69 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Allergens
Nomenclature of allergens and list of entries