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Entry version 110 (16 Oct 2019)
Sequence version 3 (22 Sep 2009)
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Protein

Terminal uridylyltransferase 7

Gene

Tut7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:28792939). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (PubMed:28792939). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of miRNA precursors, including that of let-7 (pre-let-7) (PubMed:22898984). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A. Due to functional redundancy between ZCCHC6 and ZCCHC11, the identification of the specific role of each of these proteins is difficult (By similarity) (PubMed:22898984). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (By similarity). Also functions as an integral regulator of microRNA biogenesiS using 3 different uridylation mechanisms (By similarity). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 oligouridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (By similarity). Add oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (By similarity). Does not play a role in replication-dependent histone mRNA degradation (By similarity). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (PubMed:28792939, PubMed:22898984). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (By similarity).By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1054Magnesium or manganese; catalyticBy similarity1
Metal bindingi1056Magnesium or manganese; catalyticBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei1126UTPBy similarity1
Binding sitei1148UTPBy similarity1
Binding sitei1282UTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri244 – 274Matrin-typePROSITE-ProRule annotationAdd BLAST31
Zinc fingeri959 – 976CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri1341 – 1358CCHC-type 2PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri1447 – 1464CCHC-type 3PROSITE-ProRule annotationAdd BLAST18

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, Transferase
LigandMagnesium, Manganese, Metal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-429947 Deadenylation of mRNA

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Terminal uridylyltransferase 7Curated (EC:2.7.7.52By similarity)
Short name:
TUTase 7
Alternative name(s):
Zinc finger CCHC domain-containing protein 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tut7Imported
Synonyms:Kiaa1711, Zcchc6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2387179 Tut7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Double conditional knockouts that have deleted both TUT4 and TUT7 at the secondary oocyte stage are infertile. Females ovulate normal numbers of oocytes with normal morphology of antral follicles but with a slight decrease in the frequency of surrounded nucleolus state oocytes. Mutant oocytes are unable to support early embryonic development, they fail to complete meiosis I properly.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001509581 – 1491Terminal uridylyltransferase 7Add BLAST1491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei64PhosphothreonineBy similarity1
Modified residuei132PhosphoserineCombined sources1
Modified residuei172PhosphoserineCombined sources1
Modified residuei600PhosphoserineBy similarity1
Modified residuei747PhosphoserineCombined sources1
Modified residuei865PhosphothreonineCombined sources1
Modified residuei891PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5BLK4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5BLK4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5BLK4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5BLK4

PRoteomics IDEntifications database

More...
PRIDEi
Q5BLK4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5BLK4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5BLK4

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q5BLK4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
229511, 1 interactor

Database of interacting proteins

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DIPi
DIP-60223N

Protein interaction database and analysis system

More...
IntActi
Q5BLK4, 3 interactors

Molecular INTeraction database

More...
MINTi
Q5BLK4

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000071623

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q5BLK4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini551 – 600PAP-associated 1Add BLAST50
Domaini1230 – 1282PAP-associated 2Add BLAST53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni947 – 1491Sufficient for monouridylation activityBy similarityAdd BLAST545
Regioni1043 – 1046UTP bindingBy similarity4
Regioni1053 – 1056UTP bindingBy similarity4
Regioni1166 – 1170UTP bindingBy similarity5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi20 – 23Poly-Asp4
Compositional biasi791 – 933Glu-richAdd BLAST143
Compositional biasi1363 – 1366Poly-Arg4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Utilizes two multidomain functional modules during the switch from monouridylation to oligouridylation. The catalytic module (containing the 3 CCHC-type Zinc finger domains) is essential for both activites while the Lin28-interacting module (LIM) at the N-termail part is indispensable for oligouridylation.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-B-like family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri244 – 274Matrin-typePROSITE-ProRule annotationAdd BLAST31
Zinc fingeri959 – 976CCHC-type 1PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri1341 – 1358CCHC-type 2PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri1447 – 1464CCHC-type 3PROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2277 Eukaryota
COG5260 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000155767

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5BLK4

KEGG Orthology (KO)

More...
KOi
K13291

Database of Orthologous Groups

More...
OrthoDBi
803033at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q5BLK4

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002058 PAP_assoc
IPR002934 Polymerase_NTP_transf_dom
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01909 NTP_transf_2, 1 hit
PF03828 PAP_assoc, 2 hits
PF00098 zf-CCHC, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00343 ZnF_C2HC, 3 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF57756 SSF57756, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50158 ZF_CCHC, 3 hits
PS00028 ZINC_FINGER_C2H2_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q5BLK4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDTAKPYFV KRTKDRGIID DDDFRRGHPQ QDYLIMDDYA KGHSSKMEKG
60 70 80 90 100
LPKKKISPGN YGNTPRKGLY GVSSNPYAFK NPIYSQPAWM NDNHKDQNKK
110 120 130 140 150
WLSDELAGNA DSWREFKPGP RIPVISRSRK ESFQESDDAY RWQEGRGCRA
160 170 180 190 200
VRRLFQKDLS SLEAMSEMEA GSPENKKQRS RPRKPRRTRT EDSEQDGDLD
210 220 230 240 250
GPVIDESVLS TKELLGLQQA EERLKRDCID RLKRRPRNCP TAKYTCKLCD
260 270 280 290 300
ALIDSIPFAH KHIKEKRHKK NLKEKQEEEL LTTLPPPAPS QIHAVGSAID
310 320 330 340 350
RVVQEFGLHS ENLDQRLEIK RVMESVFRHK LPDCSLRLYG SSCSRLGFRD
360 370 380 390 400
SDVNIDVQFP AVMSQPDVLL LVQECLKNSD SFIDVDADFH ARVPVVVCRD
410 420 430 440 450
KQSGLLCKVS AGNENAWLTT KHLTALGKLE PRLVPLVIAF RYWAKLCSID
460 470 480 490 500
RPEEGGLPPY VFALMAVFFL QQRKEPLLPV YLGSWIEEFS LNKLGNFSLK
510 520 530 540 550
DVEKDSVVWE YTDNSTGDTS SAKEEAPKET AAKKGQVPLT FNIKHQPSVP
560 570 580 590 600
VGQLWVELLR FYALEFNLAD LVISIRVKEL ISRESKDWPK KRIAIEDPYS
610 620 630 640 650
VKRNVARTLN NQPVFEYILH CLRTTYKYFA LPHKVTKPNL TKPPSPVTCV
660 670 680 690 700
SDPYREAKNG GPEPQATNID KLGNAAVAQD PGVQTSGDCR AQLVTLKNTT
710 720 730 740 750
EEVGSPAKEK TGGVHIPAHQ ESSGCVQAEV SCEGLEDATA ELPETGSDNE
760 770 780 790 800
EVRRKTKHPL STDDQGLSSS KHPELQNCGS LCGLQADNTL ELVAEECNSC
810 820 830 840 850
ASLDNKAEVN EERIEGAEEL EEAAALSCFS PSVQSRTSAA MHFDDEEEEE
860 870 880 890 900
EEEEEEEPRL SINLTEDEEG VANEHQVDSR YAGSGEEDAL SEEDDLAEPA
910 920 930 940 950
KGEDTGECGE NVGGTLLIDL NRITLKEESF PEEDLPGDQS EFFYEFRKLT
960 970 980 990 1000
FTKGKSPTVV CSLCKREGHL KKDCPEDFKR VQLEPLPPLT PKFSNILDQV
1010 1020 1030 1040 1050
CVQCYKDFSP TIVEDQAREH IRQNLESFIK QDFPGTKLSL FGSSKNGFGF
1060 1070 1080 1090 1100
KQSDLDVCMT INGHETAEGL DCVRTIEELA RVLRKHSGLR NILPITTAKV
1110 1120 1130 1140 1150
PIVKFFHLRS GLEVDISLYN TLALHNTRLL SAYSAIDPRV KYLCYTMKVF
1160 1170 1180 1190 1200
TKMCDIGDAS RGSLSSYAYT LMVLYFLQQR SPPVIPVLQE IYKGEKKPEI
1210 1220 1230 1240 1250
LVDGWNIYFF DQINELPTCW PEYGKNTEPV GQLWLGLLRF YTEEFDFKEH
1260 1270 1280 1290 1300
VISIRRKSLL TTFKKQWTSK YIVIEDPFDL NHNLGAGLSR KMTNFIMKAF
1310 1320 1330 1340 1350
INGRRVFGIP VKGFPKDNPS KLAYFFDPDV LTEGELAPND RCCRICGKIG
1360 1370 1380 1390 1400
HFMKDCPMRR KVRRRRDQED TPNQRYSESK EKRSKEDKEI QNKYTEKEVS
1410 1420 1430 1440 1450
TKEDKLTPCA AAKAKPVRAA VDLGREKLLR TPTEKWKRQD DRDSREKRCF
1460 1470 1480 1490
ICGREGHIKK ECPQFKGSPG SLSSKYMTQG RASVKRTQQE S
Length:1,491
Mass (Da):169,103
Last modified:September 22, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC574FCAC3781B3CC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PUA2E9PUA2_MOUSE
Terminal uridylyltransferase 7
Tut7 Zcchc6
1,474Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YDD7A0A286YDD7_MOUSE
Terminal uridylyltransferase 7
Tut7 Zcchc6
1,089Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YDR9A0A286YDR9_MOUSE
Terminal uridylyltransferase 7
Tut7 Zcchc6
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YCY9A0A286YCY9_MOUSE
Terminal uridylyltransferase 7
Tut7 Zcchc6
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YD79A0A286YD79_MOUSE
Terminal uridylyltransferase 7
Tut7 Zcchc6
210Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YDH2A0A286YDH2_MOUSE
Terminal uridylyltransferase 7
Tut7 Zcchc6
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH23438 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH23880 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAE20473 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti960V → L in AAH23438 (PubMed:15489334).Curated1
Sequence conflicti982Q → R in BAE20473 (PubMed:16141072).Curated1
Sequence conflicti1338P → L in AAH43111 (PubMed:15489334).Curated1
Sequence conflicti1343C → Y in BAE20473 (PubMed:16141072).Curated1
Sequence conflicti1472 – 1491LSSKY…TQQES → AFT in AAH43111 (PubMed:15489334).CuratedAdd BLAST20

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BC023880 mRNA Translation: AAH23880.1 Different initiation.
BC043111 mRNA Translation: AAH43111.1
BC023438 mRNA Translation: AAH23438.1 Sequence problems.
AK031043 mRNA Translation: BAE20473.1 Different initiation.

NCBI Reference Sequences

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RefSeqi
NP_705766.3, NM_153538.3
XP_006517271.1, XM_006517208.1
XP_017170969.1, XM_017315480.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
214290

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:214290

UCSC genome browser

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UCSCi
uc007qvf.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC023880 mRNA Translation: AAH23880.1 Different initiation.
BC043111 mRNA Translation: AAH43111.1
BC023438 mRNA Translation: AAH23438.1 Sequence problems.
AK031043 mRNA Translation: BAE20473.1 Different initiation.
RefSeqiNP_705766.3, NM_153538.3
XP_006517271.1, XM_006517208.1
XP_017170969.1, XM_017315480.1

3D structure databases

SMRiQ5BLK4
ModBaseiSearch...

Protein-protein interaction databases

BioGridi229511, 1 interactor
DIPiDIP-60223N
IntActiQ5BLK4, 3 interactors
MINTiQ5BLK4
STRINGi10090.ENSMUSP00000071623

PTM databases

iPTMnetiQ5BLK4
PhosphoSitePlusiQ5BLK4
SwissPalmiQ5BLK4

Proteomic databases

EPDiQ5BLK4
jPOSTiQ5BLK4
MaxQBiQ5BLK4
PaxDbiQ5BLK4
PRIDEiQ5BLK4

Genome annotation databases

GeneIDi214290
KEGGimmu:214290
UCSCiuc007qvf.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
79670
MGIiMGI:2387179 Tut7

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG2277 Eukaryota
COG5260 LUCA
HOGENOMiHOG000155767
InParanoidiQ5BLK4
KOiK13291
OrthoDBi803033at2759
PhylomeDBiQ5BLK4

Enzyme and pathway databases

ReactomeiR-MMU-429947 Deadenylation of mRNA

Miscellaneous databases

Protein Ontology

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PROi
PR:Q5BLK4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Family and domain databases

InterProiView protein in InterPro
IPR002058 PAP_assoc
IPR002934 Polymerase_NTP_transf_dom
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PfamiView protein in Pfam
PF01909 NTP_transf_2, 1 hit
PF03828 PAP_assoc, 2 hits
PF00098 zf-CCHC, 3 hits
SMARTiView protein in SMART
SM00343 ZnF_C2HC, 3 hits
SUPFAMiSSF57756 SSF57756, 3 hits
PROSITEiView protein in PROSITE
PS50158 ZF_CCHC, 3 hits
PS00028 ZINC_FINGER_C2H2_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTUT7_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5BLK4
Secondary accession number(s): A1A4B1, Q3V3V7, Q8CIH3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: September 22, 2009
Last modified: October 16, 2019
This is version 110 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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