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Protein

Ceramide glucosyltransferase

Gene

ugcg

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. Glycosphingolipids are required for convergence extension movements during early development.By similarity

Catalytic activityi

UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine.By similarity

Pathwayi: sphingolipid metabolism

This protein is involved in the pathway sphingolipid metabolism, which is part of Lipid metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway sphingolipid metabolism and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei236Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Glycosyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Sphingolipid metabolism

Enzyme and pathway databases

ReactomeiR-XTR-1660662 Glycosphingolipid metabolism
UniPathwayi
UPA00222

Protein family/group databases

CAZyiGT21 Glycosyltransferase Family 21

Names & Taxonomyi

Protein namesi
Recommended name:
Ceramide glucosyltransferaseBy similarity (EC:2.4.1.80)
Alternative name(s):
UDP-glucose ceramide glucosyltransferaseImported
Gene namesi
Name:ugcg
ORF Names:TEgg030g03.1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-944694 ugcg

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10LumenalSequence analysis10
Transmembranei11 – 32HelicalSequence analysisAdd BLAST22
Topological domaini33 – 195CytoplasmicSequence analysisAdd BLAST163
Transmembranei196 – 215HelicalSequence analysisAdd BLAST20
Topological domaini216 – 287LumenalSequence analysisAdd BLAST72
Transmembranei288 – 304HelicalSequence analysisAdd BLAST17
Topological domaini305 – 309CytoplasmicSequence analysis5
Transmembranei310 – 328HelicalSequence analysisAdd BLAST19
Topological domaini329 – 348LumenalSequence analysisAdd BLAST20
Transmembranei349 – 369HelicalSequence analysisAdd BLAST21
Topological domaini370 – 394CytoplasmicSequence analysisAdd BLAST25

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003768561 – 394Ceramide glucosyltransferaseAdd BLAST394

Proteomic databases

PaxDbiQ5BL38
PRIDEiQ5BL38

Expressioni

Gene expression databases

BgeeiENSXETG00000010219 Expressed in 19 organ(s), highest expression level in embryo

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000005911

Structurei

3D structure databases

ProteinModelPortaliQ5BL38
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi92D1Curated1
Motifi144D2Curated1
Motifi236D3Curated1
Motifi272 – 276(Q/R)XXRWCurated5

Domaini

The D1, D2, D3, (Q/R)XXRW motif is a critical part of the GCS active site, involved in catalysis and UDP-sugar binding.By similarity

Sequence similaritiesi

Belongs to the glycosyltransferase 2 family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2547 Eukaryota
COG1215 LUCA
GeneTreeiENSGT00390000012898
HOGENOMiHOG000039663
InParanoidiQ5BL38
KOiK00720
OMAiNPKLNNC
OrthoDBiEOG091G0G3M
TreeFamiTF314564

Family and domain databases

Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR025993 Ceramide_glucosylTrfase
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR12726 PTHR12726, 1 hit
PfamiView protein in Pfam
PF13506 Glyco_transf_21, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

Sequencei

Sequence statusi: Complete.

Q5BL38-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVLDLALQG LAIFGCVLFF VLWFMHFLSI VYTRLHLNKK VSDKQPYSKL
60 70 80 90 100
PGVSLLKPLK GVDPNLINNL ETFFELDYPK FEILLCVQDL DDPAVDVCKK
110 120 130 140 150
LLGKYPSVDA KLFIGGKKVG INPKINNLMP GYEVAKYDLI WICDSGIKVK
160 170 180 190 200
PDTLTDMANQ MTEKVGLVHG LPYVADRQGF AATLEQVYFG TSHPRSYISA
210 220 230 240 250
NVTGFKCVTG MSCLMRKEVL DQAGGLIAFA QYIAEDYFMA KAIADRGWKF
260 270 280 290 300
SMATQVAMQN SGCYSISQFQ SRMIRWAKLR INMLPATIIC EPISECFVAS
310 320 330 340 350
LIIGWAAHHI FRWDIMVFFM CHCLAWFIFD YIQLRGVQGG PLNFSKLDYA
360 370 380 390
VAWFIRESMT IYIFLSALWD PTISWRTGRY RLRCGGTAEE ILDV
Length:394
Mass (Da):44,638
Last modified:April 12, 2005 - v1
Checksum:i1CF7077F02358BD0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR762041 mRNA Translation: CAJ81500.1
BC090614 mRNA Translation: AAH90614.1
RefSeqiNP_001016133.1, NM_001016133.2
UniGeneiStr.20419

Genome annotation databases

EnsembliENSXETT00000005911; ENSXETP00000005911; ENSXETG00000010219
GeneIDi548887
KEGGixtr:548887

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR762041 mRNA Translation: CAJ81500.1
BC090614 mRNA Translation: AAH90614.1
RefSeqiNP_001016133.1, NM_001016133.2
UniGeneiStr.20419

3D structure databases

ProteinModelPortaliQ5BL38
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000005911

Protein family/group databases

CAZyiGT21 Glycosyltransferase Family 21

Proteomic databases

PaxDbiQ5BL38
PRIDEiQ5BL38

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000005911; ENSXETP00000005911; ENSXETG00000010219
GeneIDi548887
KEGGixtr:548887

Organism-specific databases

CTDi7357
XenbaseiXB-GENE-944694 ugcg

Phylogenomic databases

eggNOGiKOG2547 Eukaryota
COG1215 LUCA
GeneTreeiENSGT00390000012898
HOGENOMiHOG000039663
InParanoidiQ5BL38
KOiK00720
OMAiNPKLNNC
OrthoDBiEOG091G0G3M
TreeFamiTF314564

Enzyme and pathway databases

UniPathwayi
UPA00222

ReactomeiR-XTR-1660662 Glycosphingolipid metabolism

Gene expression databases

BgeeiENSXETG00000010219 Expressed in 19 organ(s), highest expression level in embryo

Family and domain databases

Gene3Di3.90.550.10, 1 hit
InterProiView protein in InterPro
IPR025993 Ceramide_glucosylTrfase
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR12726 PTHR12726, 1 hit
PfamiView protein in Pfam
PF13506 Glyco_transf_21, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCEGT_XENTR
AccessioniPrimary (citable) accession number: Q5BL38
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: April 12, 2005
Last modified: November 7, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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