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Protein

Peroxisome biogenesis factor 1

Gene

Pex1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi600 – 607ATPSequence analysis8
Nucleotide bindingi882 – 889ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processPeroxisome biogenesis, Protein transport, Transport
LigandATP-binding, Lipid-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-9033241 Peroxisomal protein import

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome biogenesis factor 1
Alternative name(s):
Peroxin-1
Gene namesi
Name:Pex1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1918632 Pex1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Peroxisome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi135R → A: Loss of phospholipid-binding. 1 Publication1
Mutagenesisi174K → A: No effect on phospholipid-binding. 1 Publication1

Keywords - Diseasei

Peroxisome biogenesis disorder

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003049311 – 1284Peroxisome biogenesis factor 1Add BLAST1284

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1182PhosphoserineBy similarity1
Modified residuei1210PhosphoserineBy similarity1
Modified residuei1212PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5BL07
PaxDbiQ5BL07
PeptideAtlasiQ5BL07
PRIDEiQ5BL07

PTM databases

iPTMnetiQ5BL07
PhosphoSitePlusiQ5BL07

Expressioni

Gene expression databases

BgeeiENSMUSG00000005907 Expressed in 240 organ(s), highest expression level in embryo
CleanExiMM_PEX1
ExpressionAtlasiQ5BL07 baseline and differential
GenevisibleiQ5BL07 MM

Interactioni

Subunit structurei

Interacts directly with PEX6. Interacts indirectly with PEX26, via its interaction with PEX6 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi214674, 1 interactor
IntActiQ5BL07, 3 interactors
STRINGi10090.ENSMUSP00000006061

Structurei

Secondary structure

11284
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ5BL07
SMRiQ5BL07
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5BL07

Family & Domainsi

Domaini

The N-terminal domain shows evolutionary conservation with that of VCP, and is able to bind phospholipids with a preference for phosphatidylinositol monophosphates.

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0735 Eukaryota
COG0464 LUCA
GeneTreeiENSGT00550000075032
HOGENOMiHOG000252959
HOVERGENiHBG008169
InParanoidiQ5BL07
KOiK13338
OMAiSMEHITH
OrthoDBiEOG091G08H7
PhylomeDBiQ5BL07
TreeFamiTF106447

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR009010 Asp_de-COase-like_dom_sf
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR029067 CDC48_domain_2-like_sf
IPR027417 P-loop_NTPase
IPR015343 PEX-N_a/b
IPR015342 PEX-N_psi_beta-barrel
IPR025653 Pex1
PANTHERiPTHR23077:SF12 PTHR23077:SF12, 2 hits
PfamiView protein in Pfam
PF00004 AAA, 2 hits
PF09262 PEX-1N, 1 hit
PF09263 PEX-2N, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF50692 SSF50692, 1 hit
SSF52540 SSF52540, 2 hits
SSF54585 SSF54585, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5BL07-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MWSSDRLAGA GSGGAVVTVA FTNARDCFLH LPRRLVAQLH LLQNQAIEVA
60 70 80 90 100
SDHQPTYLSW VEGRHFNDQS ENVAEINRQV GQKLGLSSGD QVFLRPCSHV
110 120 130 140 150
VSCQQVEVEP LSADDWEILE LHAISLEQHL LDQIRIVFPK AVVPIWVDQQ
160 170 180 190 200
TYIFIQIVTL MPAAPYGRLE TNTKLLIQPK TRQAKESTFP KEGDAHGQVH
210 220 230 240 250
SYGREQKGLS KELQTRQLHT NSEGITASNG RDPKVPGGPL KPSWWAVLGS
260 270 280 290 300
MLSFGPDSKQ ESAWGSLELG AFKNMQSQAA PLEGTFRVCQ VQPPSARTTT
310 320 330 340 350
ATSVFHKHCT AHVFPWDQEY FDVEPSFTVT YGKLVKLHSP KQQQDKSKQG
360 370 380 390 400
VLLPDKEKQL SKSPDHKQIS SNRSEEAAEA CVLKVVWNGL EELKNATEFT
410 420 430 440 450
ESLELLHRGK VWIPDDLRKR LNIEMHAVVR ITPLETTPKI PRSLKLQPRE
460 470 480 490 500
NLPKDVNEET IKTVFSSWVQ QSATTMLPLV ISKEERIKLE IKDGLREFSL
510 520 530 540 550
STVHSQEKEK EEGKTVFVLS SILLQKISVQ VLLEPMIKEE QSAEIDFLLP
560 570 580 590 600
SLTLSSLGGV SALGASAMEH ITHSLLGRPL SRQLMALVAG LRNGALLITG
610 620 630 640 650
GKGSGKSTFA KAICKEAQDT LDARVETVDC KALRGKRLES IQKALEVAFS
660 670 680 690 700
EAAWRQPSVI LLDDLDLIAG LPSVPEQEHS PEAVQSQRLA HALNDMIKEF
710 720 730 740 750
VSTGSLVALI ATSQLQQSLH PSLVSAQGIH TFQCVQHLQP PNPEQRCEIL
760 770 780 790 800
HSVVKNKLGC DISNFPDLDL QCIAKDTEAF VARDFTVLVD RAIHSSLSRQ
810 820 830 840 850
HSSSREDLTL TTSDFQKALR GFLPASLRNV NLHKPRDLGW DKIGGLHEVR
860 870 880 890 900
QILMDTIQLP AKYPELFANL PIRQRTGILL YGPPGTGKTL LAGVVARESG
910 920 930 940 950
MNFISIKGPE LLSKYIGASE QAVRDVFIRA QAAKPCILFF DEFESIAPRR
960 970 980 990 1000
GHDNTGVTDR VVNQLLTQLD GVEGLQGVYV LAATSRPDLI DPALLRPGRL
1010 1020 1030 1040 1050
DKCVYCPPPD QVSRLEILTV LSKSLALADD VDLQHVASVT DSFTGADLKA
1060 1070 1080 1090 1100
LLYNAQLEAL QGRLLPSGLP DGGSSSDSDL SLSSMVFLNH SSGSDDSAGD
1110 1120 1130 1140 1150
GECGLEQSLL SLEMSEILPD ESKFNMYRLY FGSSYESELG NGTPSDLSSH
1160 1170 1180 1190 1200
CLSAPSSVTQ DLPAAPGKDP LFTQHPVFRT PSQEGCQDLT QEQRDQLRAE
1210 1220 1230 1240 1250
ISIIKGRYRS QSGEDESLNQ PGPIKTTFAI SQAHLMTALA HTRPSISEDE
1260 1270 1280
GKEFAELYEN FQNPKKRKNQ SGTVFRTGQK VTLA
Length:1,284
Mass (Da):141,428
Last modified:October 2, 2007 - v2
Checksum:i29B6C9B6E93FA6EF
GO
Isoform 2 (identifier: Q5BL07-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     413-452: Missing.

Note: No experimental confirmation available.
Show »
Length:1,244
Mass (Da):136,743
Checksum:i9B1073BBA4CC4106
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6RUH9F6RUH9_MOUSE
Peroxisome biogenesis factor 1
Pex1
213Annotation score:
F7CF88F7CF88_MOUSE
Peroxisome biogenesis factor 1
Pex1
76Annotation score:
A0A0G2JE39A0A0G2JE39_MOUSE
Peroxisome biogenesis factor 1
Pex1
143Annotation score:
D3Z5A7D3Z5A7_MOUSE
Peroxisome biogenesis factor 1
Pex1
69Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_028131413 – 452Missing in isoform 2. 1 PublicationAdd BLAST40

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC090845 mRNA Translation: AAH90845.1
AK017309 mRNA Translation: BAB30684.1
AK149599 mRNA Translation: BAE28984.1
CCDSiCCDS19065.1 [Q5BL07-2]
CCDS80201.1 [Q5BL07-1]
RefSeqiNP_001280735.1, NM_001293806.1 [Q5BL07-1]
NP_082053.1, NM_027777.2 [Q5BL07-2]
UniGeneiMm.379196

Genome annotation databases

EnsembliENSMUST00000006061; ENSMUSP00000006061; ENSMUSG00000005907 [Q5BL07-2]
ENSMUST00000121291; ENSMUSP00000113304; ENSMUSG00000005907 [Q5BL07-1]
GeneIDi71382
KEGGimmu:71382
UCSCiuc008whe.2 mouse [Q5BL07-1]
uc008whf.2 mouse [Q5BL07-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC090845 mRNA Translation: AAH90845.1
AK017309 mRNA Translation: BAB30684.1
AK149599 mRNA Translation: BAE28984.1
CCDSiCCDS19065.1 [Q5BL07-2]
CCDS80201.1 [Q5BL07-1]
RefSeqiNP_001280735.1, NM_001293806.1 [Q5BL07-1]
NP_082053.1, NM_027777.2 [Q5BL07-2]
UniGeneiMm.379196

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WLFX-ray2.05A3-181[»]
ProteinModelPortaliQ5BL07
SMRiQ5BL07
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214674, 1 interactor
IntActiQ5BL07, 3 interactors
STRINGi10090.ENSMUSP00000006061

PTM databases

iPTMnetiQ5BL07
PhosphoSitePlusiQ5BL07

Proteomic databases

EPDiQ5BL07
PaxDbiQ5BL07
PeptideAtlasiQ5BL07
PRIDEiQ5BL07

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006061; ENSMUSP00000006061; ENSMUSG00000005907 [Q5BL07-2]
ENSMUST00000121291; ENSMUSP00000113304; ENSMUSG00000005907 [Q5BL07-1]
GeneIDi71382
KEGGimmu:71382
UCSCiuc008whe.2 mouse [Q5BL07-1]
uc008whf.2 mouse [Q5BL07-2]

Organism-specific databases

CTDi5189
MGIiMGI:1918632 Pex1

Phylogenomic databases

eggNOGiKOG0735 Eukaryota
COG0464 LUCA
GeneTreeiENSGT00550000075032
HOGENOMiHOG000252959
HOVERGENiHBG008169
InParanoidiQ5BL07
KOiK13338
OMAiSMEHITH
OrthoDBiEOG091G08H7
PhylomeDBiQ5BL07
TreeFamiTF106447

Enzyme and pathway databases

ReactomeiR-MMU-9033241 Peroxisomal protein import

Miscellaneous databases

EvolutionaryTraceiQ5BL07
PROiPR:Q5BL07
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005907 Expressed in 240 organ(s), highest expression level in embryo
CleanExiMM_PEX1
ExpressionAtlasiQ5BL07 baseline and differential
GenevisibleiQ5BL07 MM

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR009010 Asp_de-COase-like_dom_sf
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR029067 CDC48_domain_2-like_sf
IPR027417 P-loop_NTPase
IPR015343 PEX-N_a/b
IPR015342 PEX-N_psi_beta-barrel
IPR025653 Pex1
PANTHERiPTHR23077:SF12 PTHR23077:SF12, 2 hits
PfamiView protein in Pfam
PF00004 AAA, 2 hits
PF09262 PEX-1N, 1 hit
PF09263 PEX-2N, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF50692 SSF50692, 1 hit
SSF52540 SSF52540, 2 hits
SSF54585 SSF54585, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPEX1_MOUSE
AccessioniPrimary (citable) accession number: Q5BL07
Secondary accession number(s): Q3UEC7, Q9CU85
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: November 7, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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