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Entry version 139 (25 May 2022)
Sequence version 1 (12 Apr 2005)
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Protein

Homeobox protein cut-like

Gene

Cux1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi1150 – 1209HomeoboxPROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationARBA annotation
Biological processTranscription, Transcription regulationUniRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Homeobox protein cut-likeUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cux1Imported
Synonyms:Cutl1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:88568, Cux1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5BL05

PeptideAtlas

More...
PeptideAtlasi
Q5BL05

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5BL05, MM

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini451 – 538CUTInterPro annotationAdd BLAST88
Domaini840 – 927CUTInterPro annotationAdd BLAST88
Domaini1023 – 1110CUTInterPro annotationAdd BLAST88
Domaini1148 – 1208HomeoboxInterPro annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni410 – 457DisorderedSequence analysisAdd BLAST48
Regioni555 – 577DisorderedSequence analysisAdd BLAST23
Regioni591 – 613DisorderedSequence analysisAdd BLAST23
Regioni680 – 782DisorderedSequence analysisAdd BLAST103
Regioni795 – 834DisorderedSequence analysisAdd BLAST40
Regioni943 – 1016DisorderedSequence analysisAdd BLAST74
Regioni1118 – 1153DisorderedSequence analysisAdd BLAST36
Regioni1218 – 1381DisorderedSequence analysisAdd BLAST164

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili17 – 37Sequence analysisAdd BLAST21
Coiled coili68 – 88Sequence analysisAdd BLAST21
Coiled coili112 – 196Sequence analysisAdd BLAST85
Coiled coili201 – 228Sequence analysisAdd BLAST28
Coiled coili237 – 274Sequence analysisAdd BLAST38
Coiled coili296 – 355Sequence analysisAdd BLAST60

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi410 – 455Polar residuesSequence analysisAdd BLAST46
Compositional biasi559 – 573Polar residuesSequence analysisAdd BLAST15
Compositional biasi595 – 613Polar residuesSequence analysisAdd BLAST19
Compositional biasi744 – 758Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi759 – 780Polar residuesSequence analysisAdd BLAST22
Compositional biasi795 – 816Polar residuesSequence analysisAdd BLAST22
Compositional biasi817 – 834Pro residuesSequence analysisAdd BLAST18
Compositional biasi943 – 984Polar residuesSequence analysisAdd BLAST42
Compositional biasi1218 – 1239Polar residuesSequence analysisAdd BLAST22
Compositional biasi1360 – 1378Polar residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CUT homeobox family.UniRule annotationARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, HomeoboxPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
181575at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00086, homeodomain, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.260.40, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003350, CUT_dom
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR010982, Lambda_DNA-bd_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02376, CUT, 3 hits
PF00046, Homeodomain, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01109, CUT, 3 hits
SM00389, HOX, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 1 hit
SSF47413, SSF47413, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51042, CUT, 3 hits
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5BL05-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAANVGSMFQ YWKRFDLQQL QRELDATATV LANRQDESEQ SRKRLIEQSR
60 70 80 90 100
EFKKNTPEDL RKQVAPLLKS FQGEIDALSK RSKEAEAAFL TVYKRLIDVP
110 120 130 140 150
DPVPALDVGQ QLEIKVQRLH DIETENQKLR ETLEEYNKEF AEVKNQEVTI
160 170 180 190 200
KALKEKIREY EQTLKSQAET IALEKEQKLQ NDFAEKERKL QETQMSTTSK
210 220 230 240 250
LEEAEHKLQT LQTALEKTRT ELFDLKTKYD EETTAKADEI EMIMTDLERA
260 270 280 290 300
NQRAEVAQRE AETLREQLSS ANHSLQLASQ IQKAPDVEQA IEVLTRSSLE
310 320 330 340 350
VELAAKEREI AQLVEDVQRL QASLTKLREN SASQISQLEQ QLNAKNSTLK
360 370 380 390 400
QLEEKLKGQA DYEEVKKELN TLKSMEFAPS EGAGTQDSTK PLEVLLLEKN
410 420 430 440 450
RSLQSENATL RISNSDLSGP YSTNSISSPS PLQQSPDVNG MAPSPSQSES
460 470 480 490 500
AGSISEGEEI DTAEIARQVK EQLIKHNIGQ RIFGHYVLGL SQGSVSEILA
510 520 530 540 550
RPKPWNKLTV RGKEPFHKMK QFLSDEQNIL ALRSIQGRQR ENPGQSLNRL
560 570 580 590 600
FQEVPKRRNG SEGNITTRIR ASETGSDEAI KSILEQAKRE LQVQKTAEPV
610 620 630 640 650
QTSSTSSSGN SDDAIRSILQ QARREMEAQQ AALDPALKPA PLSQPDLTIL
660 670 680 690 700
TPKHLSASPM STVSTYPPLA ISLKKTPAAP ETSTAALPSA PALKKEAQDV
710 720 730 740 750
PTLDPPGSAD AAQGVLRPMK SELVRGSTWK DPWWSPIQPE RRNLTSSEET
760 770 780 790 800
KADETTASGK ERAGSSQPRA ERSQLQGPSA SAEYWKEWPS AESPYSQSSE
810 820 830 840 850
LSLTGASRSE TPQNSPLPSS PIVPMAKPAK PSVPPLTPEQ YEVYMYQEVD
860 870 880 890 900
TIELTRQVKE KLAKNGICQR IFGEKVLGLS QGSVSDMLSR PKPWSKLTQK
910 920 930 940 950
GREPFIRMQL WLNGELGQGV LPVQGQQQGP VLHSVASLQD PLQQGCVSSE
960 970 980 990 1000
STPKTSASCS PAPESPMSSS ESVKSLTELV QQPCPAIETS KEGKPPEPSD
1010 1020 1030 1040 1050
PPASDSQPTT PLPLSGHSAL SIQELVAMSP ELDTYGITKR VKEVLTDNNL
1060 1070 1080 1090 1100
GQRLFGETIL GLTQGSVSDL LARPKPWHKL SLKGREPFVR MQLWLNDPNN
1110 1120 1130 1140 1150
VEKLMDMKRM EKKAYMKRRH SSVSDSQPCE PPSVGIDYSQ GASPHPQHQL
1160 1170 1180 1190 1200
KKPRVVLAPE EKEALKRAYQ QKPYPSPKTI EELATQLNLK TSTVINWFHN
1210 1220 1230 1240 1250
YRSRIRRELF IEEIQAGSQG QAGASDSPSA RSSRAAPSSE GDSCDGVEAT
1260 1270 1280 1290 1300
DAEEPGGNIV ATKSQGGLAE VAAAPADREE ATQPAEKAKA QPLCSGTPGQ
1310 1320 1330 1340 1350
DDGEDASRPR PLPEGLADAP APVPSLAAPA AGEDAATSAT APATATEAPG
1360 1370 1380 1390 1400
AARAGPAERS SALPSTSAPA NAPARRPSSL QSLFGLPEAA GARDNLVRKK
1410 1420
KAANLNSIIH RLEKAASREE PIEWEF
Length:1,426
Mass (Da):156,408
Last modified:April 12, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i373175EE0CD6001F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC090847 mRNA Translation: AAH90847.1

NCBI Reference Sequences

More...
RefSeqi
NP_001278162.1, NM_001291233.1
NP_001278163.1, NM_001291234.1
NP_001278167.1, NM_001291238.1
NP_034116.3, NM_009986.4
NP_941004.2, NM_198602.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
13047

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:13047

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC090847 mRNA Translation: AAH90847.1
RefSeqiNP_001278162.1, NM_001291233.1
NP_001278163.1, NM_001291234.1
NP_001278167.1, NM_001291238.1
NP_034116.3, NM_009986.4
NP_941004.2, NM_198602.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

EPDiQ5BL05
PeptideAtlasiQ5BL05

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
13047

Genome annotation databases

GeneIDi13047
KEGGimmu:13047

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1523
MGIiMGI:88568, Cux1

Phylogenomic databases

OrthoDBi181575at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
13047, 6 hits in 73 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Cux1, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

GenevisibleiQ5BL05, MM

Family and domain databases

CDDicd00086, homeodomain, 1 hit
Gene3Di1.10.260.40, 3 hits
InterProiView protein in InterPro
IPR003350, CUT_dom
IPR009057, Homeobox-like_sf
IPR017970, Homeobox_CS
IPR001356, Homeobox_dom
IPR010982, Lambda_DNA-bd_dom_sf
PfamiView protein in Pfam
PF02376, CUT, 3 hits
PF00046, Homeodomain, 1 hit
SMARTiView protein in SMART
SM01109, CUT, 3 hits
SM00389, HOX, 1 hit
SUPFAMiSSF46689, SSF46689, 1 hit
SSF47413, SSF47413, 3 hits
PROSITEiView protein in PROSITE
PS51042, CUT, 3 hits
PS00027, HOMEOBOX_1, 1 hit
PS50071, HOMEOBOX_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ5BL05_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5BL05
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2005
Last sequence update: April 12, 2005
Last modified: May 25, 2022
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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