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Entry version 141 (16 Oct 2019)
Sequence version 2 (16 Aug 2005)
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Protein

DBIRD complex subunit ZNF326

Gene

ZNF326

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. May play a role in neuronal differentiation and is able to bind DNA and activate expression in vitro.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri314 – 336C2H2 AKAP95-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri407 – 430C2H2 AKAP95-type 2PROSITE-ProRule annotationAdd BLAST24

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processmRNA processing, mRNA splicing, Transcription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DBIRD complex subunit ZNF326
Alternative name(s):
Zinc finger protein 326
Zinc finger protein interacting with mRNPs and DBC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF326
Synonyms:ZIRD
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14104 ZNF326

Online Mendelian Inheritance in Man (OMIM)

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MIMi
614601 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5BKZ1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
284695

Open Targets

More...
OpenTargetsi
ENSG00000162664

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37842

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5BKZ1

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF326

Domain mapping of disease mutations (DMDM)

More...
DMDMi
73622105

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000753861 – 582DBIRD complex subunit ZNF326Add BLAST582

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei48PhosphoserineCombined sources1
Modified residuei56PhosphoserineCombined sources1
Modified residuei63PhosphoserineCombined sources1
Modified residuei69PhosphoserineCombined sources1
Modified residuei81PhosphoserineCombined sources1
Modified residuei82PhosphoserineCombined sources1
Modified residuei91PhosphoserineCombined sources1
Modified residuei106PhosphoserineCombined sources1
Modified residuei114PhosphoserineCombined sources1
Modified residuei118PhosphoserineCombined sources1
Modified residuei121PhosphoserineCombined sources1
Modified residuei137PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki140Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei173Omega-N-methylarginineCombined sources1
Modified residuei212PhosphoserineCombined sources1
Modified residuei235Omega-N-methylarginineCombined sources1
Cross-linki240Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei247N6-acetyllysine; alternateCombined sources1
Cross-linki247Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei249PhosphoserineCombined sources1
Modified residuei251PhosphothreonineCombined sources1
Cross-linki254Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki264Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei270PhosphoserineCombined sources1
Cross-linki401Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki459Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki467Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q5BKZ1

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q5BKZ1

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q5BKZ1

MaxQB - The MaxQuant DataBase

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MaxQBi
Q5BKZ1

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q5BKZ1

PeptideAtlas

More...
PeptideAtlasi
Q5BKZ1

PRoteomics IDEntifications database

More...
PRIDEi
Q5BKZ1

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
62713 [Q5BKZ1-1]
62714 [Q5BKZ1-2]
62715 [Q5BKZ1-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5BKZ1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5BKZ1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000162664 Expressed in 200 organ(s), highest expression level in C1 segment of cervical spinal cord

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q5BKZ1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5BKZ1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA028450
HPA028461
HPA028466

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the DBIRD complex.

Interacts with CCAR2; the interaction is direct.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
BRINP1O604775EBI-2560158,EBI-3904864

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
129936, 82 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q5BKZ1

Protein interaction database and analysis system

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IntActi
Q5BKZ1, 45 interactors

Molecular INTeraction database

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MINTi
Q5BKZ1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000340796

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 124Mediates transcriptional activationBy similarityAdd BLAST124

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi238 – 260Bipartite nuclear localization signalBy similarityAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi18 – 211Gly-richAdd BLAST194
Compositional biasi484 – 581Glu-richAdd BLAST98

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AKAP95 family.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri314 – 336C2H2 AKAP95-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri407 – 430C2H2 AKAP95-type 2PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IGVY Eukaryota
ENOG4111H5U LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063777

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000234349

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q5BKZ1

KEGG Orthology (KO)

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KOi
K13204

Identification of Orthologs from Complete Genome Data

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OMAi
DYHNKPS

Database of Orthologous Groups

More...
OrthoDBi
902224at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5BKZ1

TreeFam database of animal gene trees

More...
TreeFami
TF105407

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007071 AKAP95
IPR034736 ZF_C2H2_AKAP95

The PANTHER Classification System

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PANTHERi
PTHR12190 PTHR12190, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF04988 AKAP95, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51799 ZF_C2H2_AKAP95, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5BKZ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDFEDDYTHS ACRNTYQGFN GMDRDYGPGS YGGMDRDYGH GSYGGQRSMD
60 70 80 90 100
SYLNQSYGMD NHSGGGGGSR FGPYESYDSR SSLGGRDLYR SGYGFNEPEQ
110 120 130 140 150
SRFGGSYGGR FESSYRNSLD SFGGRNQGGS SWEAPYSRSK LRPGFMEDRG
160 170 180 190 200
RENYSSYSSF SSPHMKPAPV GSRGRGTPAY PESTFGSRNY DAFGGPSTGR
210 220 230 240 250
GRGRGHMGDF GSIHRPGIVV DYQNKSTNVT VAAARGIKRK MMQPFNKPSG
260 270 280 290 300
TFIKKPKLAK PMEKISLSKS PTKTDPKNEE EEKRRIEARR EKQRRRREKN
310 320 330 340 350
SEKYGDGYRM AFTCSFCKFR TFEEKDIELH LESSSHQETL DHIQKQTKFD
360 370 380 390 400
KVVMEFLHEC MVNKFKKTSI RKQQTNNQTE VVKIIEKDVM EGVTVDDHMM
410 420 430 440 450
KVETVHCSAC SVYIPALHSS VQQHLKSPDH IKGKQAYKEQ IKRESVLTAT
460 470 480 490 500
SILNNPIVKA RYERFVKGEN PFEIQDHSQD QQIEGDEEDE EKIDEPIEEE
510 520 530 540 550
EDEDEEEEAE EVGEVEEVEE VEEVREGGIE GEGNIQGVGE GGEVGVVGEV
560 570 580
EGVGEVEEVE ELEEETAKEE PADFPVEQPE EN
Length:582
Mass (Da):65,654
Last modified:August 16, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7F513DA0C5B7F3CD
GO
Isoform 2 (identifier: Q5BKZ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     71-582: Missing.

Note: No experimental confirmation available.
Show »
Length:70
Mass (Da):7,668
Checksum:iFF2BDBA284F6BE1A
GO
Isoform 3 (identifier: Q5BKZ1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-206: Missing.

Note: No experimental confirmation available.
Show »
Length:376
Mass (Da):43,101
Checksum:iA9F9CB75B1BBEB29
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MRN4A0A0A0MRN4_HUMAN
DBIRD complex subunit ZNF326
ZNF326 hCG_22859
493Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E2QRN4E2QRN4_HUMAN
DBIRD complex subunit ZNF326
ZNF326
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH52645 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH70341 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti471P → S in AAH90866 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0437721 – 206Missing in isoform 3. 1 PublicationAdd BLAST206
Alternative sequenceiVSP_01495671 – 582Missing in isoform 2. 1 PublicationAdd BLAST512

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK297073 mRNA Translation: BAG59592.1
AK303707 mRNA Translation: BAG64691.1
AL161797 Genomic DNA No translation available.
AL391497 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73125.1
CH471097 Genomic DNA Translation: EAW73128.1
BC052645 mRNA Translation: AAH52645.1 Sequence problems.
BC053888 mRNA Translation: AAH53888.1
BC070341 mRNA Translation: AAH70341.1 Sequence problems.
BC090866 mRNA Translation: AAH90866.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS727.1 [Q5BKZ1-1]
CCDS728.1 [Q5BKZ1-2]

NCBI Reference Sequences

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RefSeqi
NP_001307114.1, NM_001320185.1
NP_861446.2, NM_181781.3 [Q5BKZ1-3]
NP_892020.1, NM_182975.3 [Q5BKZ1-2]
NP_892021.1, NM_182976.3 [Q5BKZ1-1]
XP_005270836.1, XM_005270779.4 [Q5BKZ1-3]
XP_011539592.1, XM_011541290.2 [Q5BKZ1-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000340281; ENSP00000340796; ENSG00000162664 [Q5BKZ1-1]
ENST00000361911; ENSP00000355318; ENSG00000162664 [Q5BKZ1-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
284695

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:284695

UCSC genome browser

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UCSCi
uc001dnp.5 human [Q5BKZ1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK297073 mRNA Translation: BAG59592.1
AK303707 mRNA Translation: BAG64691.1
AL161797 Genomic DNA No translation available.
AL391497 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73125.1
CH471097 Genomic DNA Translation: EAW73128.1
BC052645 mRNA Translation: AAH52645.1 Sequence problems.
BC053888 mRNA Translation: AAH53888.1
BC070341 mRNA Translation: AAH70341.1 Sequence problems.
BC090866 mRNA Translation: AAH90866.1
CCDSiCCDS727.1 [Q5BKZ1-1]
CCDS728.1 [Q5BKZ1-2]
RefSeqiNP_001307114.1, NM_001320185.1
NP_861446.2, NM_181781.3 [Q5BKZ1-3]
NP_892020.1, NM_182975.3 [Q5BKZ1-2]
NP_892021.1, NM_182976.3 [Q5BKZ1-1]
XP_005270836.1, XM_005270779.4 [Q5BKZ1-3]
XP_011539592.1, XM_011541290.2 [Q5BKZ1-3]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi129936, 82 interactors
CORUMiQ5BKZ1
IntActiQ5BKZ1, 45 interactors
MINTiQ5BKZ1
STRINGi9606.ENSP00000340796

PTM databases

iPTMnetiQ5BKZ1
PhosphoSitePlusiQ5BKZ1

Polymorphism and mutation databases

BioMutaiZNF326
DMDMi73622105

Proteomic databases

EPDiQ5BKZ1
jPOSTiQ5BKZ1
MassIVEiQ5BKZ1
MaxQBiQ5BKZ1
PaxDbiQ5BKZ1
PeptideAtlasiQ5BKZ1
PRIDEiQ5BKZ1
ProteomicsDBi62713 [Q5BKZ1-1]
62714 [Q5BKZ1-2]
62715 [Q5BKZ1-3]

Genome annotation databases

EnsembliENST00000340281; ENSP00000340796; ENSG00000162664 [Q5BKZ1-1]
ENST00000361911; ENSP00000355318; ENSG00000162664 [Q5BKZ1-2]
GeneIDi284695
KEGGihsa:284695
UCSCiuc001dnp.5 human [Q5BKZ1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
284695
DisGeNETi284695

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF326
HGNCiHGNC:14104 ZNF326
HPAiHPA028450
HPA028461
HPA028466
MIMi614601 gene
neXtProtiNX_Q5BKZ1
OpenTargetsiENSG00000162664
PharmGKBiPA37842

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IGVY Eukaryota
ENOG4111H5U LUCA
GeneTreeiENSGT00530000063777
HOGENOMiHOG000234349
InParanoidiQ5BKZ1
KOiK13204
OMAiDYHNKPS
OrthoDBi902224at2759
PhylomeDBiQ5BKZ1
TreeFamiTF105407

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF326 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
284695
PharosiQ5BKZ1

Protein Ontology

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PROi
PR:Q5BKZ1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000162664 Expressed in 200 organ(s), highest expression level in C1 segment of cervical spinal cord
ExpressionAtlasiQ5BKZ1 baseline and differential
GenevisibleiQ5BKZ1 HS

Family and domain databases

InterProiView protein in InterPro
IPR007071 AKAP95
IPR034736 ZF_C2H2_AKAP95
PANTHERiPTHR12190 PTHR12190, 1 hit
PfamiView protein in Pfam
PF04988 AKAP95, 1 hit
PROSITEiView protein in PROSITE
PS51799 ZF_C2H2_AKAP95, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN326_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5BKZ1
Secondary accession number(s): A8MYX1
, B4DLN0, B4E179, Q5VW93, Q5VW94, Q5VW96, Q5VW97, Q6NSA2, Q7Z638, Q7Z6C2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: October 16, 2019
This is version 141 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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