UniProtKB - Q5BKY9 (F133B_HUMAN)
Protein
Protein FAM133B
Gene
FAM133B
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- RNA binding Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q5BKY9 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein FAM133B |
Gene namesi | Name:FAM133B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000234545.7 |
HGNCi | HGNC:28629, FAM133B |
neXtProti | NX_Q5BKY9 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 257415 |
OpenTargetsi | ENSG00000234545 |
PharmGKBi | PA162386138 |
Miscellaneous databases
Pharosi | Q5BKY9, Tdark |
Polymorphism and mutation databases
BioMutai | FAM133B |
DMDMi | 74736047 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000287616 | 1 – 247 | Protein FAM133BAdd BLAST | 247 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 82 | PhosphoserineCombined sources | 1 | |
Modified residuei | 191 | PhosphoserineCombined sources | 1 | |
Modified residuei | 192 | PhosphoserineCombined sources | 1 | |
Modified residuei | 194 | PhosphoserineCombined sources | 1 | |
Modified residuei | 196 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q5BKY9 |
jPOSTi | Q5BKY9 |
MassIVEi | Q5BKY9 |
MaxQBi | Q5BKY9 |
PaxDbi | Q5BKY9 |
PeptideAtlasi | Q5BKY9 |
PRIDEi | Q5BKY9 |
ProteomicsDBi | 62711 [Q5BKY9-1] 62712 [Q5BKY9-2] |
PTM databases
iPTMneti | Q5BKY9 |
PhosphoSitePlusi | Q5BKY9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000234545, Expressed in frontal cortex and 120 other tissues |
ExpressionAtlasi | Q5BKY9, baseline and differential |
Genevisiblei | Q5BKY9, HS |
Organism-specific databases
HPAi | ENSG00000234545, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 129218, 12 interactors |
IntActi | Q5BKY9, 5 interactors |
STRINGi | 9606.ENSP00000398401 |
Miscellaneous databases
RNActi | Q5BKY9, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 45 – 238 | Lys-richAdd BLAST | 194 | |
Compositional biasi | 82 – 157 | Ser-richAdd BLAST | 76 |
Sequence similaritiesi
Belongs to the FAM133 family.Curated
Phylogenomic databases
eggNOGi | ENOG502QWN4, Eukaryota |
GeneTreei | ENSGT00730000111097 |
HOGENOMi | CLU_108741_0_0_1 |
InParanoidi | Q5BKY9 |
OMAi | PTWDDLK |
OrthoDBi | 1561261at2759 |
TreeFami | TF350193 |
Family and domain databases
InterProi | View protein in InterPro IPR026766, Fam133 |
PANTHERi | PTHR31911, PTHR31911, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q5BKY9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGKRDNRVAY MNPIAMARSR GPIQSSGPTI QDYLNRPRPT WEEVKEQLEK
60 70 80 90 100
KKKGSKALAE FEEKMNENWK KELEKHREKL LSGSESSSKK RQRKKKEKKK
110 120 130 140 150
SGRYSSSSSS SSDSSSSSSD SEDEDKKQGK RRKKKKNRSH KSSESSMSET
160 170 180 190 200
ESDSKDSLKK KKKSKDGTEK EKDIKGLSKK RKMYSEDKPL SSESLSESEY
210 220 230 240
IEEVRAKKKK SSEEREKATE KTKKKKKHKK HSKKKKKKAA SSSPDSP
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3XAI9 | G3XAI9_HUMAN | Protein FAM133B | FAM133B MGC40405, hCG_19545 | 105 | Annotation score: | ||
H0YH72 | H0YH72_HUMAN | Protein FAM133B | FAM133B | 120 | Annotation score: | ||
C9JUX2 | C9JUX2_HUMAN | Protein FAM133B | FAM133B | 30 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_025571 | 1 – 10 | Missing in isoform 2. 3 Publications | 10 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK313692 mRNA Translation: BAG36441.1 AL833918 mRNA Translation: CAD38774.1 CH236949 Genomic DNA Translation: EAL24147.1 CH471091 Genomic DNA Translation: EAW76831.1 BC017874 mRNA Translation: AAH17874.1 Different termination. BC032461 mRNA Translation: AAH32461.1 BC057771 mRNA Translation: AAH57771.1 BC062706 mRNA Translation: AAH62706.1 Different termination. BC090868 mRNA Translation: AAH90868.1 |
CCDSi | CCDS47640.1 [Q5BKY9-1] CCDS47641.1 [Q5BKY9-2] |
RefSeqi | NP_001035146.1, NM_001040057.2 [Q5BKY9-2] NP_001275513.1, NM_001288584.1 [Q5BKY9-2] NP_690002.2, NM_152789.3 [Q5BKY9-1] XP_011514306.1, XM_011516004.2 [Q5BKY9-2] |
Genome annotation databases
Ensembli | ENST00000427372; ENSP00000402843; ENSG00000234545 [Q5BKY9-2] ENST00000438306; ENSP00000389783; ENSG00000234545 [Q5BKY9-2] ENST00000445716; ENSP00000398401; ENSG00000234545 [Q5BKY9-1] |
GeneIDi | 257415 |
KEGGi | hsa:257415 |
UCSCi | uc003umb.5, human [Q5BKY9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK313692 mRNA Translation: BAG36441.1 AL833918 mRNA Translation: CAD38774.1 CH236949 Genomic DNA Translation: EAL24147.1 CH471091 Genomic DNA Translation: EAW76831.1 BC017874 mRNA Translation: AAH17874.1 Different termination. BC032461 mRNA Translation: AAH32461.1 BC057771 mRNA Translation: AAH57771.1 BC062706 mRNA Translation: AAH62706.1 Different termination. BC090868 mRNA Translation: AAH90868.1 |
CCDSi | CCDS47640.1 [Q5BKY9-1] CCDS47641.1 [Q5BKY9-2] |
RefSeqi | NP_001035146.1, NM_001040057.2 [Q5BKY9-2] NP_001275513.1, NM_001288584.1 [Q5BKY9-2] NP_690002.2, NM_152789.3 [Q5BKY9-1] XP_011514306.1, XM_011516004.2 [Q5BKY9-2] |
3D structure databases
SMRi | Q5BKY9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 129218, 12 interactors |
IntActi | Q5BKY9, 5 interactors |
STRINGi | 9606.ENSP00000398401 |
PTM databases
iPTMneti | Q5BKY9 |
PhosphoSitePlusi | Q5BKY9 |
Polymorphism and mutation databases
BioMutai | FAM133B |
DMDMi | 74736047 |
Proteomic databases
EPDi | Q5BKY9 |
jPOSTi | Q5BKY9 |
MassIVEi | Q5BKY9 |
MaxQBi | Q5BKY9 |
PaxDbi | Q5BKY9 |
PeptideAtlasi | Q5BKY9 |
PRIDEi | Q5BKY9 |
ProteomicsDBi | 62711 [Q5BKY9-1] 62712 [Q5BKY9-2] |
Protocols and materials databases
Antibodypediai | 58077, 36 antibodies |
DNASUi | 257415 |
Genome annotation databases
Ensembli | ENST00000427372; ENSP00000402843; ENSG00000234545 [Q5BKY9-2] ENST00000438306; ENSP00000389783; ENSG00000234545 [Q5BKY9-2] ENST00000445716; ENSP00000398401; ENSG00000234545 [Q5BKY9-1] |
GeneIDi | 257415 |
KEGGi | hsa:257415 |
UCSCi | uc003umb.5, human [Q5BKY9-1] |
Organism-specific databases
CTDi | 257415 |
DisGeNETi | 257415 |
EuPathDBi | HostDB:ENSG00000234545.7 |
GeneCardsi | FAM133B |
HGNCi | HGNC:28629, FAM133B |
HPAi | ENSG00000234545, Low tissue specificity |
neXtProti | NX_Q5BKY9 |
OpenTargetsi | ENSG00000234545 |
PharmGKBi | PA162386138 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QWN4, Eukaryota |
GeneTreei | ENSGT00730000111097 |
HOGENOMi | CLU_108741_0_0_1 |
InParanoidi | Q5BKY9 |
OMAi | PTWDDLK |
OrthoDBi | 1561261at2759 |
TreeFami | TF350193 |
Enzyme and pathway databases
PathwayCommonsi | Q5BKY9 |
Miscellaneous databases
BioGRID-ORCSi | 257415, 303 hits in 822 CRISPR screens |
ChiTaRSi | FAM133B, human |
GenomeRNAii | 257415 |
Pharosi | Q5BKY9, Tdark |
PROi | PR:Q5BKY9 |
RNActi | Q5BKY9, protein |
Gene expression databases
Bgeei | ENSG00000234545, Expressed in frontal cortex and 120 other tissues |
ExpressionAtlasi | Q5BKY9, baseline and differential |
Genevisiblei | Q5BKY9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR026766, Fam133 |
PANTHERi | PTHR31911, PTHR31911, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F133B_HUMAN | |
Accessioni | Q5BKY9Primary (citable) accession number: Q5BKY9 Secondary accession number(s): B2R994 Q8N0W8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 29, 2007 |
Last sequence update: | April 12, 2005 | |
Last modified: | December 2, 2020 | |
This is version 114 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families