UniProtKB - Q5BKX8 (CAVN4_HUMAN)
Protein
Caveolae-associated protein 4
Gene
CAVIN4
Organism
Homo sapiens (Human)
Status
Functioni
Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation. Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes (By similarity). Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway (PubMed:18332105).By similarity1 Publication
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- muscle organ development Source: UniProtKB-KW
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- regulation of gene expression Source: CACAO
- regulation of Rho protein signal transduction Source: InterPro
Keywordsi
Molecular function | Activator, Developmental protein |
Biological process | Differentiation, Myogenesis, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q5BKX8 |
Names & Taxonomyi
Protein namesi | Recommended name: Caveolae-associated protein 4ImportedAlternative name(s): Muscle-related coiled-coil protein Muscle-restricted coiled-coil protein |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:33742, CAVIN4 |
MIMi | 617714, gene |
neXtProti | NX_Q5BKX8 |
VEuPathDBi | HostDB:ENSG00000170681.6 |
Subcellular locationi
Plasma membrane
- sarcolemma By similarity
- Cell membrane 1 Publication
Cytoplasm and Cytosol
Other locations
Note: In cardiomyocytes, accumulates in the Z-line of the sarcomere. In vascular smooth muscle cells, detected diffusely throughout the cytoplasm. Localizes in the caveolae in a caveolin-dependent manner.By similarity
Cytosol
- cytosol Source: UniProtKB-SubCell
Plasma Membrane
- caveola Source: UniProtKB
- plasma membrane Source: UniProtKB
- sarcolemma Source: UniProtKB-SubCell
Other locations
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 347273 |
OpenTargetsi | ENSG00000170681 |
PharmGKBi | PA164723237 |
Miscellaneous databases
Pharosi | Q5BKX8, Tbio |
Genetic variation databases
BioMutai | CAVIN4 |
DMDMi | 172045939 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000325763 | 1 – 364 | Caveolae-associated protein 4Add BLAST | 364 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 172 | PhosphoserineBy similarity | 1 | |
Modified residuei | 173 | PhosphoserineBy similarity | 1 | |
Modified residuei | 326 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 336 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 355 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MassIVEi | Q5BKX8 |
PaxDbi | Q5BKX8 |
PeptideAtlasi | Q5BKX8 |
PRIDEi | Q5BKX8 |
ProteomicsDBi | 62708 |
PTM databases
iPTMneti | Q5BKX8 |
PhosphoSitePlusi | Q5BKX8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000170681, Expressed in quadriceps femoris and 133 other tissues |
Genevisiblei | Q5BKX8, HS |
Organism-specific databases
HPAi | ENSG00000170681, Group enriched (skeletal muscle, tongue) |
Interactioni
Subunit structurei
Component of the CAVIN complex composed of CAVIN1, CAVIN2, CAVIN3 and CAVIN4 (By similarity).
Interacts with CAVIN1, ADRA1A and ADRA1B (PubMed:24567387).
Interacts with CAVIN2; this augments the transactivation of NPPA (PubMed:18332105, PubMed:24567387).
Interacts with CAV3 (PubMed:26497963, PubMed:24567387).
Interacts with MAPK1 and MAPK3 (By similarity).
By similarity3 PublicationsBinary interactionsi
Hide detailsQ5BKX8
With | #Exp. | IntAct |
---|---|---|
BYSL [Q13895] | 3 | EBI-12836558,EBI-358049 |
NTAQ1 [Q96HA8] | 3 | EBI-12836558,EBI-741158 |
ZGPAT - isoform 2 [Q8N5A5-2] | 3 | EBI-12836558,EBI-10183064 |
Protein-protein interaction databases
BioGRIDi | 131419, 6 interactors |
IntActi | Q5BKX8, 5 interactors |
STRINGi | 9606.ENSP00000418668 |
Miscellaneous databases
RNActi | Q5BKX8, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 44 – 77 | Sequence analysisAdd BLAST | 34 | |
Coiled coili | 202 – 226 | Sequence analysisAdd BLAST | 25 |
Domaini
The coiled coil domain (residues 44-77) is essential for membrane-targeting in cardiomyocytes.1 Publication
Sequence similaritiesi
Belongs to the CAVIN family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QQ9A, Eukaryota |
GeneTreei | ENSGT00950000182910 |
HOGENOMi | CLU_065589_1_0_1 |
InParanoidi | Q5BKX8 |
OMAi | YQEETEC |
OrthoDBi | 991901at2759 |
PhylomeDBi | Q5BKX8 |
TreeFami | TF331031 |
Family and domain databases
InterProi | View protein in InterPro IPR033299, Cavin4 IPR026752, Cavin_fam |
PANTHERi | PTHR15240, PTHR15240, 1 hit PTHR15240:SF4, PTHR15240:SF4, 1 hit |
Pfami | View protein in Pfam PF15237, PTRF_SDPR, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5BKX8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEHNGSASNA DKIHQNRLSS VTEDEDQDAA LTIVTVLDKV ASIVDSVQAS
60 70 80 90 100
QKRIEERHRE MENAIKSVQI DLLKLSQSHS NTGHIINKLF EKTRKVSAHI
110 120 130 140 150
KDVKARVEKQ QIHVKKVEVK QEEIMKKNKF RVVIFQEKFR CPTSLSVVKD
160 170 180 190 200
RNLTENQEED DDDIFDPPVD LSSDEEYYVE ESRSARLRKS GKEHIDNIKK
210 220 230 240 250
AFSKENMQKT RQNLDKKVNR IRTRIVTPER RERLRQSGER LRQSGERLRQ
260 270 280 290 300
SGERFKKSIS NAAPSKEAFK MRSLRKGKDR TVAEGEECAR EMGVDIIARS
310 320 330 340 350
ESLGPISELY SDELSEPEHE AARPVYPPHE GREIPTPEPL KVTFKSQVKV
360
EDDESLLLDL KHSS
Sequence cautioni
The sequence AAH90888 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 34 | V → A in BAG61900 (PubMed:14702039).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU487253 mRNA Translation: ACA62935.1 AK300099 mRNA Translation: BAG61900.1 AL354917 Genomic DNA No translation available. BC090888 mRNA Translation: AAH90888.1 Different initiation. |
CCDSi | CCDS35083.1 |
RefSeqi | NP_001018126.1, NM_001018116.2 |
Genome annotation databases
Ensembli | ENST00000307584; ENSP00000418668; ENSG00000170681 |
GeneIDi | 347273 |
KEGGi | hsa:347273 |
UCSCi | uc004bba.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EU487253 mRNA Translation: ACA62935.1 AK300099 mRNA Translation: BAG61900.1 AL354917 Genomic DNA No translation available. BC090888 mRNA Translation: AAH90888.1 Different initiation. |
CCDSi | CCDS35083.1 |
RefSeqi | NP_001018126.1, NM_001018116.2 |
3D structure databases
SMRi | Q5BKX8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 131419, 6 interactors |
IntActi | Q5BKX8, 5 interactors |
STRINGi | 9606.ENSP00000418668 |
PTM databases
iPTMneti | Q5BKX8 |
PhosphoSitePlusi | Q5BKX8 |
Genetic variation databases
BioMutai | CAVIN4 |
DMDMi | 172045939 |
Proteomic databases
MassIVEi | Q5BKX8 |
PaxDbi | Q5BKX8 |
PeptideAtlasi | Q5BKX8 |
PRIDEi | Q5BKX8 |
ProteomicsDBi | 62708 |
Protocols and materials databases
Antibodypediai | 14631, 85 antibodies |
Genome annotation databases
Ensembli | ENST00000307584; ENSP00000418668; ENSG00000170681 |
GeneIDi | 347273 |
KEGGi | hsa:347273 |
UCSCi | uc004bba.5, human |
Organism-specific databases
CTDi | 347273 |
DisGeNETi | 347273 |
GeneCardsi | CAVIN4 |
HGNCi | HGNC:33742, CAVIN4 |
HPAi | ENSG00000170681, Group enriched (skeletal muscle, tongue) |
MIMi | 617714, gene |
neXtProti | NX_Q5BKX8 |
OpenTargetsi | ENSG00000170681 |
PharmGKBi | PA164723237 |
VEuPathDBi | HostDB:ENSG00000170681.6 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQ9A, Eukaryota |
GeneTreei | ENSGT00950000182910 |
HOGENOMi | CLU_065589_1_0_1 |
InParanoidi | Q5BKX8 |
OMAi | YQEETEC |
OrthoDBi | 991901at2759 |
PhylomeDBi | Q5BKX8 |
TreeFami | TF331031 |
Enzyme and pathway databases
PathwayCommonsi | Q5BKX8 |
Miscellaneous databases
BioGRID-ORCSi | 347273, 5 hits in 984 CRISPR screens |
ChiTaRSi | MURC, human |
GenomeRNAii | 347273 |
Pharosi | Q5BKX8, Tbio |
PROi | PR:Q5BKX8 |
RNActi | Q5BKX8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000170681, Expressed in quadriceps femoris and 133 other tissues |
Genevisiblei | Q5BKX8, HS |
Family and domain databases
InterProi | View protein in InterPro IPR033299, Cavin4 IPR026752, Cavin_fam |
PANTHERi | PTHR15240, PTHR15240, 1 hit PTHR15240:SF4, PTHR15240:SF4, 1 hit |
Pfami | View protein in Pfam PF15237, PTRF_SDPR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CAVN4_HUMAN | |
Accessioni | Q5BKX8Primary (citable) accession number: Q5BKX8 Secondary accession number(s): B1PRL3, B4DT88 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | March 18, 2008 | |
Last modified: | April 7, 2021 | |
This is version 123 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families