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Entry version 112 (26 Feb 2020)
Sequence version 2 (20 May 2008)
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Protein

Solute carrier family 45 member 4

Gene

SLC45A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.2.4.7 the glycoside-pentoside-hexuronide (gph):cation symporter family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 45 member 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC45A4
Synonyms:KIAA1126
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29196 SLC45A4

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5BKX6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei63 – 83HelicalSequence analysisAdd BLAST21
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Transmembranei518 – 538HelicalSequence analysisAdd BLAST21
Transmembranei560 – 580HelicalSequence analysisAdd BLAST21
Transmembranei592 – 612HelicalSequence analysisAdd BLAST21
Transmembranei614 – 634HelicalSequence analysisAdd BLAST21
Transmembranei666 – 686HelicalSequence analysisAdd BLAST21
Transmembranei695 – 715HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57210

Open Targets

More...
OpenTargetsi
ENSG00000022567

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5BKX6 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC45A4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
189046188

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003338031 – 768Solute carrier family 45 member 4Add BLAST768

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei424PhosphoserineCombined sources1
Modified residuei454PhosphoserineCombined sources1
Modified residuei485PhosphoserineBy similarity1
Modified residuei732PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5BKX6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5BKX6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5BKX6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5BKX6

PeptideAtlas

More...
PeptideAtlasi
Q5BKX6

PRoteomics IDEntifications database

More...
PRIDEi
Q5BKX6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
62705 [Q5BKX6-1]
62706 [Q5BKX6-2]
62707 [Q5BKX6-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5BKX6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5BKX6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000022567 Expressed in endothelial cell and 175 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5BKX6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5BKX6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA023154

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121448, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q5BKX6, 2 interactors

Molecular INTeraction database

More...
MINTi
Q5BKX6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000428137

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5BKX6 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0637 Eukaryota
ENOG410XPTR LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182914

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5BKX6

KEGG Orthology (KO)

More...
KOi
K15378

Database of Orthologous Groups

More...
OrthoDBi
1230185at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5BKX6

TreeFam database of animal gene trees

More...
TreeFami
TF325412

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036259 MFS_trans_sf

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473 SSF103473, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5BKX6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKMAPQNADP ESMQVQELSV PLPDPQKAGG AEAENCETIS EGSIDRIPMR
60 70 80 90 100
LWVMHGAVMF GREFCYAMET ALVTPILLQI GLPEQYYSLT WFLSPILGLI
110 120 130 140 150
FTPLIGSASD RCTLSWGRRR PFILALCVGV LFGVALFLNG SAIGLALGDV
160 170 180 190 200
PNRQPIGIVL TVLGVVVLDF SADATEGPIR AYLLDVVDSE EQDMALNIHA
210 220 230 240 250
FSAGLGGAIG YVLGGLDWTQ TFLGSWFRTQ NQVLFFFAAI IFTVSVALHL
260 270 280 290 300
FSIDEEQYSP QQERSAEEPG ALDGGEPHGV PAFPDEVQSE HELALDYPDV
310 320 330 340 350
DIMRSKSDSA LHVPDTALDL EPELLFLHDI EPSIFHDASY PATPRSTSQE
360 370 380 390 400
LAKTKLPRLA TFLKEAAKED ETLLDNHLNE AKVPNGSGSP TKDALGGYTR
410 420 430 440 450
VDTKPSATSS SMRRRRHAFR RQASSTFSYY GKLGSHCYRY RRANAVVLIK
460 470 480 490 500
PSRSMSDLYD MQKRQRQHRH RNQSGATTSS GDTESEEGEG ETTVRLLWLS
510 520 530 540 550
MLKMPRELMR LCLCHLLTWF SVIAEAVFYT DFMGQVIFEG DPKAPSNSTA
560 570 580 590 600
WQAYNAGVKM GCWGLVIYAA TGAICSALLQ KYLDNYDLSV RVIYVLGTLG
610 620 630 640 650
FSVGTAVMAM FPNVYVAMVT ISTMGIVSMS ISYCPYALLG QYHDIKQYIH
660 670 680 690 700
HSPGNSKRGF GIDCAILSCQ VYISQILVAS ALGGVVDAVG TVRVIPMVAS
710 720 730 740 750
VGSFLGFLTA TFLVIYPNVS EEAKEEQKGL SSPLAGEGRA GGNSEKPTVL
760
KLTRKEGLQG PVETESVV
Length:768
Mass (Da):83,878
Last modified:May 20, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8FAC1B4D0B918363
GO
Isoform 2 (identifier: Q5BKX6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-51: Missing.
     52-80: WVMHGAVMFGREFCYAMETALVTPILLQI → MGKASPASGLSRPKTLVSPLRSNQWSLQK

Show »
Length:717
Mass (Da):78,182
Checksum:i6FD092AE5EDABDCE
GO
Isoform 3 (identifier: Q5BKX6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-51: Missing.
     52-80: WVMHGAVMFGREFCYAMETALVTPILLQI → MGKASPASGLSRPKTLVSPLRSNQWSLQK
     766-768: SVV → RLQVLTSVRS...AGPGGLGRRQ

Show »
Length:798
Mass (Da):87,626
Checksum:i85AB7BB52564C5CD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EV90E7EV90_HUMAN
Solute carrier family 45 member 4
SLC45A4
808Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJM7E5RJM7_HUMAN
Solute carrier family 45 member 4
SLC45A4
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGN5E5RGN5_HUMAN
Solute carrier family 45 member 4
SLC45A4
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH90891 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 3 (identifier: Q5BKX6-3)
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti787E → K in BAC87328 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_043164277P → L. Corresponds to variant dbSNP:rs753778Ensembl.1
Natural variantiVAR_043165718N → D1 PublicationCorresponds to variant dbSNP:rs3739238Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0335401 – 51Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST51
Alternative sequenceiVSP_03354152 – 80WVMHG…ILLQI → MGKASPASGLSRPKTLVSPL RSNQWSLQK in isoform 2 and isoform 3. 2 PublicationsAdd BLAST29
Alternative sequenceiVSP_033542766 – 768SVV → RLQVLTSVRSRHIGWCRSCW RVFFFMIILEKKFSFPQCGS LRRMTYLLFLSELDTLCPGQ PCPWAATAHQSWEEAGPGGL GRRQ in isoform 3. 1 Publication3

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK128212 mRNA Translation: BAC87328.1
AC011676 Genomic DNA No translation available.
BC090891 mRNA Translation: AAH90891.1 Different initiation.
AB032952 mRNA Translation: BAA86440.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34948.1 [Q5BKX6-3]
CCDS69550.1 [Q5BKX6-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001073900.1, NM_001080431.2 [Q5BKX6-3]
NP_001273575.1, NM_001286646.1
NP_001273577.1, NM_001286648.1 [Q5BKX6-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000024061; ENSP00000024061; ENSG00000022567 [Q5BKX6-3]
ENST00000519067; ENSP00000429059; ENSG00000022567 [Q5BKX6-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57210

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57210

UCSC genome browser

More...
UCSCi
uc003ywc.3 human [Q5BKX6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK128212 mRNA Translation: BAC87328.1
AC011676 Genomic DNA No translation available.
BC090891 mRNA Translation: AAH90891.1 Different initiation.
AB032952 mRNA Translation: BAA86440.1
CCDSiCCDS34948.1 [Q5BKX6-3]
CCDS69550.1 [Q5BKX6-2]
RefSeqiNP_001073900.1, NM_001080431.2 [Q5BKX6-3]
NP_001273575.1, NM_001286646.1
NP_001273577.1, NM_001286648.1 [Q5BKX6-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi121448, 2 interactors
IntActiQ5BKX6, 2 interactors
MINTiQ5BKX6
STRINGi9606.ENSP00000428137

Protein family/group databases

TCDBi2.A.2.4.7 the glycoside-pentoside-hexuronide (gph):cation symporter family

PTM databases

iPTMnetiQ5BKX6
PhosphoSitePlusiQ5BKX6

Polymorphism and mutation databases

BioMutaiSLC45A4
DMDMi189046188

Proteomic databases

jPOSTiQ5BKX6
MassIVEiQ5BKX6
MaxQBiQ5BKX6
PaxDbiQ5BKX6
PeptideAtlasiQ5BKX6
PRIDEiQ5BKX6
ProteomicsDBi62705 [Q5BKX6-1]
62706 [Q5BKX6-2]
62707 [Q5BKX6-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
57210

Genome annotation databases

EnsembliENST00000024061; ENSP00000024061; ENSG00000022567 [Q5BKX6-3]
ENST00000519067; ENSP00000429059; ENSG00000022567 [Q5BKX6-2]
GeneIDi57210
KEGGihsa:57210
UCSCiuc003ywc.3 human [Q5BKX6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57210
DisGeNETi57210

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC45A4
HGNCiHGNC:29196 SLC45A4
HPAiHPA023154
neXtProtiNX_Q5BKX6
OpenTargetsiENSG00000022567

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0637 Eukaryota
ENOG410XPTR LUCA
GeneTreeiENSGT00950000182914
InParanoidiQ5BKX6
KOiK15378
OrthoDBi1230185at2759
PhylomeDBiQ5BKX6
TreeFamiTF325412

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SLC45A4 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57210
PharosiQ5BKX6 Tdark

Protein Ontology

More...
PROi
PR:Q5BKX6
RNActiQ5BKX6 protein

Gene expression databases

BgeeiENSG00000022567 Expressed in endothelial cell and 175 other tissues
ExpressionAtlasiQ5BKX6 baseline and differential
GenevisibleiQ5BKX6 HS

Family and domain databases

InterProiView protein in InterPro
IPR036259 MFS_trans_sf
SUPFAMiSSF103473 SSF103473, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS45A4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5BKX6
Secondary accession number(s): Q6ZRI2, Q9ULU3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: February 26, 2020
This is version 112 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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