Solute carrier family 45 member 4

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• sucrose:proton symporter activity Source: ParkinsonsUK-UCL

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• sucrose transport Source: ParkinsonsUK-UCL

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsⁱ produced by alternative splicing. AlignAdd to basketAdded to basket

        10         20         30         40         50
MKMAPQNADP ESMQVQELSV PLPDPQKAGG AEAENCETIS EGSIDRIPMR 
        60         70         80         90        100
LWVMHGAVMF GREFCYAMET ALVTPILLQI GLPEQYYSLT WFLSPILGLI 
       110        120        130        140        150
FTPLIGSASD RCTLSWGRRR PFILALCVGV LFGVALFLNG SAIGLALGDV 
       160        170        180        190        200
PNRQPIGIVL TVLGVVVLDF SADATEGPIR AYLLDVVDSE EQDMALNIHA 
       210        220        230        240        250
FSAGLGGAIG YVLGGLDWTQ TFLGSWFRTQ NQVLFFFAAI IFTVSVALHL 
       260        270        280        290        300
FSIDEEQYSP QQERSAEEPG ALDGGEPHGV PAFPDEVQSE HELALDYPDV 
       310        320        330        340        350
DIMRSKSDSA LHVPDTALDL EPELLFLHDI EPSIFHDASY PATPRSTSQE 
       360        370        380        390        400
LAKTKLPRLA TFLKEAAKED ETLLDNHLNE AKVPNGSGSP TKDALGGYTR 
       410        420        430        440        450
VDTKPSATSS SMRRRRHAFR RQASSTFSYY GKLGSHCYRY RRANAVVLIK 
       460        470        480        490        500
PSRSMSDLYD MQKRQRQHRH RNQSGATTSS GDTESEEGEG ETTVRLLWLS 
       510        520        530        540        550
MLKMPRELMR LCLCHLLTWF SVIAEAVFYT DFMGQVIFEG DPKAPSNSTA 
       560        570        580        590        600
WQAYNAGVKM GCWGLVIYAA TGAICSALLQ KYLDNYDLSV RVIYVLGTLG 
       610        620        630        640        650
FSVGTAVMAM FPNVYVAMVT ISTMGIVSMS ISYCPYALLG QYHDIKQYIH 
       660        670        680        690        700
HSPGNSKRGF GIDCAILSCQ VYISQILVAS ALGGVVDAVG TVRVIPMVAS 
       710        720        730        740        750
VGSFLGFLTA TFLVIYPNVS EEAKEEQKGL SSPLAGEGRA GGNSEKPTVL 
       760 
KLTRKEGLQG PVETESVV                                    

        10         20         30         40         50
MGKASPASGL SRPKTLVSPL RSNQWSLQKG LPEQYYSLTW FLSPILGLIF 
        60         70         80         90        100
TPLIGSASDR CTLSWGRRRP FILALCVGVL FGVALFLNGS AIGLALGDVP 
       110        120        130        140        150
NRQPIGIVLT VLGVVVLDFS ADATEGPIRA YLLDVVDSEE QDMALNIHAF 
       160        170        180        190        200
SAGLGGAIGY VLGGLDWTQT FLGSWFRTQN QVLFFFAAII FTVSVALHLF 
       210        220        230        240        250
SIDEEQYSPQ QERSAEEPGA LDGGEPHGVP AFPDEVQSEH ELALDYPDVD 
       260        270        280        290        300
IMRSKSDSAL HVPDTALDLE PELLFLHDIE PSIFHDASYP ATPRSTSQEL 
       310        320        330        340        350
AKTKLPRLAT FLKEAAKEDE TLLDNHLNEA KVPNGSGSPT KDALGGYTRV 
       360        370        380        390        400
DTKPSATSSS MRRRRHAFRR QASSTFSYYG KLGSHCYRYR RANAVVLIKP 
       410        420        430        440        450
SRSMSDLYDM QKRQRQHRHR NQSGATTSSG DTESEEGEGE TTVRLLWLSM 
       460        470        480        490        500
LKMPRELMRL CLCHLLTWFS VIAEAVFYTD FMGQVIFEGD PKAPSNSTAW 
       510        520        530        540        550
QAYNAGVKMG CWGLVIYAAT GAICSALLQK YLDNYDLSVR VIYVLGTLGF 
       560        570        580        590        600
SVGTAVMAMF PNVYVAMVTI STMGIVSMSI SYCPYALLGQ YHDIKQYIHH 
       610        620        630        640        650
SPGNSKRGFG IDCAILSCQV YISQILVASA LGGVVDAVGT VRVIPMVASV 
       660        670        680        690        700
GSFLGFLTAT FLVIYPNVSE EAKEEQKGLS SPLAGEGRAG GNSEKPTVLK 
       710 
LTRKEGLQGP VETESVV                                     

        10         20         30         40         50
MGKASPASGL SRPKTLVSPL RSNQWSLQKG LPEQYYSLTW FLSPILGLIF 
        60         70         80         90        100
TPLIGSASDR CTLSWGRRRP FILALCVGVL FGVALFLNGS AIGLALGDVP 
       110        120        130        140        150
NRQPIGIVLT VLGVVVLDFS ADATEGPIRA YLLDVVDSEE QDMALNIHAF 
       160        170        180        190        200
SAGLGGAIGY VLGGLDWTQT FLGSWFRTQN QVLFFFAAII FTVSVALHLF 
       210        220        230        240        250
SIDEEQYSPQ QERSAEEPGA LDGGEPHGVP AFPDEVQSEH ELALDYPDVD 
       260        270        280        290        300
IMRSKSDSAL HVPDTALDLE PELLFLHDIE PSIFHDASYP ATPRSTSQEL 
       310        320        330        340        350
AKTKLPRLAT FLKEAAKEDE TLLDNHLNEA KVPNGSGSPT KDALGGYTRV 
       360        370        380        390        400
DTKPSATSSS MRRRRHAFRR QASSTFSYYG KLGSHCYRYR RANAVVLIKP 
       410        420        430        440        450
SRSMSDLYDM QKRQRQHRHR NQSGATTSSG DTESEEGEGE TTVRLLWLSM 
       460        470        480        490        500
LKMPRELMRL CLCHLLTWFS VIAEAVFYTD FMGQVIFEGD PKAPSNSTAW 
       510        520        530        540        550
QAYNAGVKMG CWGLVIYAAT GAICSALLQK YLDNYDLSVR VIYVLGTLGF 
       560        570        580        590        600
SVGTAVMAMF PNVYVAMVTI STMGIVSMSI SYCPYALLGQ YHDIKQYIHH 
       610        620        630        640        650
SPGNSKRGFG IDCAILSCQV YISQILVASA LGGVVDAVGT VRVIPMVASV 
       660        670        680        690        700
GSFLGFLTAT FLVIYPNVSE EAKEEQKGLS SPLAGEGRAG GNSEKPTVLK 
       710        720        730        740        750
LTRKEGLQGP VETERLQVLT SVRSRHIGWC RSCWRVFFFM IILEKKFSFP 
       760        770        780        790 
QCGSLRRMTY LLFLSELDTL CPGQPCPWAA TAHQSWEEAG PGGLGRRQ   

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

Documents

1. Human chromosome 8
   Human chromosome 8: entries, gene names and cross-references to MIM
2. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
3. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
4. SIMILARITY comments
   Index of protein domains and families