UniProtKB - Q5BKX6 (S45A4_HUMAN)
Protein
Solute carrier family 45 member 4
Gene
SLC45A4
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- sucrose:proton symporter activity Source: ParkinsonsUK-UCL
GO - Biological processi
- sucrose transport Source: ParkinsonsUK-UCL
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
PathwayCommonsi | Q5BKX6 |
Protein family/group databases
TCDBi | 2.A.2.4.7, the glycoside-pentoside-hexuronide (gph):cation symporter family |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 45 member 4 |
Gene namesi | Name:SLC45A4 Synonyms:KIAA1126 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000022567.9 |
HGNCi | HGNC:29196, SLC45A4 |
neXtProti | NX_Q5BKX6 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 63 – 83 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 86 – 106 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 123 – 143 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 155 – 175 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 196 – 216 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 233 – 253 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 518 – 538 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 560 – 580 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 592 – 612 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 614 – 634 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 666 – 686 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 695 – 715 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 57210 |
OpenTargetsi | ENSG00000022567 |
Miscellaneous databases
Pharosi | Q5BKX6, Tdark |
Polymorphism and mutation databases
BioMutai | SLC45A4 |
DMDMi | 189046188 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000333803 | 1 – 768 | Solute carrier family 45 member 4Add BLAST | 768 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 424 | PhosphoserineCombined sources | 1 | |
Modified residuei | 454 | PhosphoserineCombined sources | 1 | |
Modified residuei | 485 | PhosphoserineBy similarity | 1 | |
Modified residuei | 732 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q5BKX6 |
MassIVEi | Q5BKX6 |
MaxQBi | Q5BKX6 |
PaxDbi | Q5BKX6 |
PeptideAtlasi | Q5BKX6 |
PRIDEi | Q5BKX6 |
ProteomicsDBi | 62705 [Q5BKX6-1] 62706 [Q5BKX6-2] 62707 [Q5BKX6-3] |
PTM databases
iPTMneti | Q5BKX6 |
PhosphoSitePlusi | Q5BKX6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000022567, Expressed in endothelial cell and 193 other tissues |
ExpressionAtlasi | Q5BKX6, baseline and differential |
Genevisiblei | Q5BKX6, HS |
Organism-specific databases
HPAi | ENSG00000022567, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 121448, 2 interactors |
IntActi | Q5BKX6, 2 interactors |
MINTi | Q5BKX6 |
STRINGi | 9606.ENSP00000428137 |
Miscellaneous databases
RNActi | Q5BKX6, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0637, Eukaryota |
GeneTreei | ENSGT00950000182914 |
InParanoidi | Q5BKX6 |
PhylomeDBi | Q5BKX6 |
TreeFami | TF325412 |
Family and domain databases
InterProi | View protein in InterPro IPR036259, MFS_trans_sf |
SUPFAMi | SSF103473, SSF103473, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q5BKX6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKMAPQNADP ESMQVQELSV PLPDPQKAGG AEAENCETIS EGSIDRIPMR
60 70 80 90 100
LWVMHGAVMF GREFCYAMET ALVTPILLQI GLPEQYYSLT WFLSPILGLI
110 120 130 140 150
FTPLIGSASD RCTLSWGRRR PFILALCVGV LFGVALFLNG SAIGLALGDV
160 170 180 190 200
PNRQPIGIVL TVLGVVVLDF SADATEGPIR AYLLDVVDSE EQDMALNIHA
210 220 230 240 250
FSAGLGGAIG YVLGGLDWTQ TFLGSWFRTQ NQVLFFFAAI IFTVSVALHL
260 270 280 290 300
FSIDEEQYSP QQERSAEEPG ALDGGEPHGV PAFPDEVQSE HELALDYPDV
310 320 330 340 350
DIMRSKSDSA LHVPDTALDL EPELLFLHDI EPSIFHDASY PATPRSTSQE
360 370 380 390 400
LAKTKLPRLA TFLKEAAKED ETLLDNHLNE AKVPNGSGSP TKDALGGYTR
410 420 430 440 450
VDTKPSATSS SMRRRRHAFR RQASSTFSYY GKLGSHCYRY RRANAVVLIK
460 470 480 490 500
PSRSMSDLYD MQKRQRQHRH RNQSGATTSS GDTESEEGEG ETTVRLLWLS
510 520 530 540 550
MLKMPRELMR LCLCHLLTWF SVIAEAVFYT DFMGQVIFEG DPKAPSNSTA
560 570 580 590 600
WQAYNAGVKM GCWGLVIYAA TGAICSALLQ KYLDNYDLSV RVIYVLGTLG
610 620 630 640 650
FSVGTAVMAM FPNVYVAMVT ISTMGIVSMS ISYCPYALLG QYHDIKQYIH
660 670 680 690 700
HSPGNSKRGF GIDCAILSCQ VYISQILVAS ALGGVVDAVG TVRVIPMVAS
710 720 730 740 750
VGSFLGFLTA TFLVIYPNVS EEAKEEQKGL SSPLAGEGRA GGNSEKPTVL
760
KLTRKEGLQG PVETESVV
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7EV90 | E7EV90_HUMAN | Solute carrier family 45 member 4 | SLC45A4 | 808 | Annotation score: | ||
E5RJM7 | E5RJM7_HUMAN | Solute carrier family 45 member 4 | SLC45A4 | 95 | Annotation score: | ||
E5RGN5 | E5RGN5_HUMAN | Solute carrier family 45 member 4 | SLC45A4 | 102 | Annotation score: |
Sequence cautioni
The sequence AAH90891 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Isoform 3 (identifier: Q5BKX6-3) | |||||
Sequence conflicti | 787 | E → K in BAC87328 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_043164 | 277 | P → L. Corresponds to variant dbSNP:rs753778Ensembl. | 1 | |
Natural variantiVAR_043165 | 718 | N → D1 PublicationCorresponds to variant dbSNP:rs3739238Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_033540 | 1 – 51 | Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST | 51 | |
Alternative sequenceiVSP_033541 | 52 – 80 | WVMHG…ILLQI → MGKASPASGLSRPKTLVSPL RSNQWSLQK in isoform 2 and isoform 3. 2 PublicationsAdd BLAST | 29 | |
Alternative sequenceiVSP_033542 | 766 – 768 | SVV → RLQVLTSVRSRHIGWCRSCW RVFFFMIILEKKFSFPQCGS LRRMTYLLFLSELDTLCPGQ PCPWAATAHQSWEEAGPGGL GRRQ in isoform 3. 1 Publication | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK128212 mRNA Translation: BAC87328.1 AC011676 Genomic DNA No translation available. BC090891 mRNA Translation: AAH90891.1 Different initiation. AB032952 mRNA Translation: BAA86440.1 |
CCDSi | CCDS34948.1 [Q5BKX6-3] CCDS69550.1 [Q5BKX6-2] |
RefSeqi | NP_001073900.1, NM_001080431.2 [Q5BKX6-3] NP_001273575.1, NM_001286646.1 NP_001273577.1, NM_001286648.1 [Q5BKX6-2] |
Genome annotation databases
Ensembli | ENST00000024061; ENSP00000024061; ENSG00000022567 [Q5BKX6-3] ENST00000519067; ENSP00000429059; ENSG00000022567 [Q5BKX6-2] |
GeneIDi | 57210 |
KEGGi | hsa:57210 |
UCSCi | uc003ywc.3, human [Q5BKX6-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK128212 mRNA Translation: BAC87328.1 AC011676 Genomic DNA No translation available. BC090891 mRNA Translation: AAH90891.1 Different initiation. AB032952 mRNA Translation: BAA86440.1 |
CCDSi | CCDS34948.1 [Q5BKX6-3] CCDS69550.1 [Q5BKX6-2] |
RefSeqi | NP_001073900.1, NM_001080431.2 [Q5BKX6-3] NP_001273575.1, NM_001286646.1 NP_001273577.1, NM_001286648.1 [Q5BKX6-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 121448, 2 interactors |
IntActi | Q5BKX6, 2 interactors |
MINTi | Q5BKX6 |
STRINGi | 9606.ENSP00000428137 |
Protein family/group databases
TCDBi | 2.A.2.4.7, the glycoside-pentoside-hexuronide (gph):cation symporter family |
PTM databases
iPTMneti | Q5BKX6 |
PhosphoSitePlusi | Q5BKX6 |
Polymorphism and mutation databases
BioMutai | SLC45A4 |
DMDMi | 189046188 |
Proteomic databases
jPOSTi | Q5BKX6 |
MassIVEi | Q5BKX6 |
MaxQBi | Q5BKX6 |
PaxDbi | Q5BKX6 |
PeptideAtlasi | Q5BKX6 |
PRIDEi | Q5BKX6 |
ProteomicsDBi | 62705 [Q5BKX6-1] 62706 [Q5BKX6-2] 62707 [Q5BKX6-3] |
Protocols and materials databases
Antibodypediai | 14508, 17 antibodies |
DNASUi | 57210 |
Genome annotation databases
Ensembli | ENST00000024061; ENSP00000024061; ENSG00000022567 [Q5BKX6-3] ENST00000519067; ENSP00000429059; ENSG00000022567 [Q5BKX6-2] |
GeneIDi | 57210 |
KEGGi | hsa:57210 |
UCSCi | uc003ywc.3, human [Q5BKX6-1] |
Organism-specific databases
CTDi | 57210 |
DisGeNETi | 57210 |
EuPathDBi | HostDB:ENSG00000022567.9 |
GeneCardsi | SLC45A4 |
HGNCi | HGNC:29196, SLC45A4 |
HPAi | ENSG00000022567, Low tissue specificity |
neXtProti | NX_Q5BKX6 |
OpenTargetsi | ENSG00000022567 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0637, Eukaryota |
GeneTreei | ENSGT00950000182914 |
InParanoidi | Q5BKX6 |
PhylomeDBi | Q5BKX6 |
TreeFami | TF325412 |
Enzyme and pathway databases
PathwayCommonsi | Q5BKX6 |
Miscellaneous databases
BioGRID-ORCSi | 57210, 3 hits in 842 CRISPR screens |
ChiTaRSi | SLC45A4, human |
GenomeRNAii | 57210 |
Pharosi | Q5BKX6, Tdark |
PROi | PR:Q5BKX6 |
RNActi | Q5BKX6, protein |
Gene expression databases
Bgeei | ENSG00000022567, Expressed in endothelial cell and 193 other tissues |
ExpressionAtlasi | Q5BKX6, baseline and differential |
Genevisiblei | Q5BKX6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036259, MFS_trans_sf |
SUPFAMi | SSF103473, SSF103473, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S45A4_HUMAN | |
Accessioni | Q5BKX6Primary (citable) accession number: Q5BKX6 Secondary accession number(s): Q6ZRI2, Q9ULU3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 20, 2008 |
Last sequence update: | May 20, 2008 | |
Last modified: | December 2, 2020 | |
This is version 116 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations