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Entry version 105 (02 Dec 2020)
Sequence version 2 (05 Oct 2010)
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Protein

UPF0692 protein C19orf54

Gene

C19orf54

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q5BKX5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UPF0692 protein C19orf54
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

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EuPathDBi
HostDB:ENSG00000188493.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24758, C19orf54

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5BKX5

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
284325

Open Targets

More...
OpenTargetsi
ENSG00000188493

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA147358417

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5BKX5, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C19orf54

Domain mapping of disease mutations (DMDM)

More...
DMDMi
308153429

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002976591 – 351UPF0692 protein C19orf54Add BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei316PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q5BKX5

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q5BKX5

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q5BKX5

MaxQB - The MaxQuant DataBase

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MaxQBi
Q5BKX5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5BKX5

PeptideAtlas

More...
PeptideAtlasi
Q5BKX5

PRoteomics IDEntifications database

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PRIDEi
Q5BKX5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
62702 [Q5BKX5-1]
62703 [Q5BKX5-2]
62704 [Q5BKX5-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5BKX5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5BKX5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000188493, Expressed in epithelium of mammary gland and 218 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5BKX5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5BKX5, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000188493, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Isoform 3 [Q5BKX5-3]
With#Exp.IntAct
A1CF [Q9NQ94]3EBI-11976299,EBI-2809489
ABI2 - isoform 2 [Q9NYB9-2]5EBI-11976299,EBI-11096309
AGXT [P21549]3EBI-11976299,EBI-727098
ANKS1A [Q49AR9]3EBI-11976299,EBI-11954519
ARID5A [Q03989]3EBI-11976299,EBI-948603
COL8A1 [P27658]3EBI-11976299,EBI-747133
CYSRT1 [A8MQ03]3EBI-11976299,EBI-3867333
DTX2 [Q86UW9]3EBI-11976299,EBI-740376
ENKD1 [Q9H0I2]3EBI-11976299,EBI-744099
FAM222B [Q8WU58]3EBI-11976299,EBI-2807642
FANCL [Q9NW38]3EBI-11976299,EBI-2339898
FBLIM1 [Q8WUP2]3EBI-11976299,EBI-3864120
FNDC3B - isoform 3 [Q53EP0-3]3EBI-11976299,EBI-10242151
FOXH1 [O75593]3EBI-11976299,EBI-1759806
FRS3 [O43559]3EBI-11976299,EBI-725515
GLIS2 [Q9BZE0]5EBI-11976299,EBI-7251368
GLYCTK [Q8IVS8]3EBI-11976299,EBI-748515
GPS2 [Q13227]3EBI-11976299,EBI-713355
HOXC8 [P31273]3EBI-11976299,EBI-1752118
HR [O43593]3EBI-11976299,EBI-2880706
HSF4 - isoform HSF4A [Q9ULV5-2]3EBI-11976299,EBI-12056251
IGFN1 - isoform 5 [Q86VF2-5]3EBI-11976299,EBI-11955401
INCA1 [Q0VD86]3EBI-11976299,EBI-6509505
KCTD9 [Q7L273]3EBI-11976299,EBI-4397613
KPRP [Q5T749]3EBI-11976299,EBI-10981970
KRTAP23-1 [A1A580]3EBI-11976299,EBI-10171734
KRTAP26-1 [Q6PEX3]3EBI-11976299,EBI-3957672
LASP1 - isoform 2 [Q14847-2]3EBI-11976299,EBI-9088686
LMO3 - isoform 4 [Q8TAP4-4]3EBI-11976299,EBI-11742507
MISP [Q8IVT2]3EBI-11976299,EBI-2555085
NEDD9 - isoform 2 [Q14511-2]3EBI-11976299,EBI-11746523
NOXA1 - isoform 2 [Q86UR1-2]5EBI-11976299,EBI-12025760
PATZ1 - isoform 4 [Q9HBE1-4]3EBI-11976299,EBI-11022007
PITX1 [P78337]3EBI-11976299,EBI-748265
PLSCR3 [Q9NRY6]3EBI-11976299,EBI-750734
POGZ [Q7Z3K3]3EBI-11976299,EBI-1389308
PRKAB2 [O43741]3EBI-11976299,EBI-1053424
PROP1 [O75360]3EBI-11976299,EBI-9027467
PRR35 [P0CG20]3EBI-11976299,EBI-11986293
QRICH1 [Q2TAL8]3EBI-11976299,EBI-2798044
RBPMS - isoform C [Q93062-3]3EBI-11976299,EBI-740343
RBPMS2 [Q6ZRY4]3EBI-11976299,EBI-11987469
ROR2 [Q01974]3EBI-11976299,EBI-6422642
SAXO1 [Q8IYX7]3EBI-11976299,EBI-3957636
SMARCD1 [Q96GM5]3EBI-11976299,EBI-358489
SNRPC [P09234]3EBI-11976299,EBI-766589
SPAG8 - isoform 2 [Q99932-2]4EBI-11976299,EBI-11959123
TBX6 [O95947]3EBI-11976299,EBI-2824328
TCAP [O15273]3EBI-11976299,EBI-954089
TCF7L2 - isoform 10 [Q9NQB0-10]3EBI-11976299,EBI-11746252
TEKT5 [Q96M29]3EBI-11976299,EBI-10239812
TFG [Q92734]3EBI-11976299,EBI-357061
TLE5 - isoform 2 [Q08117-2]3EBI-11976299,EBI-11741437
TLX3 [O43711]3EBI-11976299,EBI-3939165
TOLLIP [Q9H0E2]3EBI-11976299,EBI-74615
TRAF4 [Q9BUZ4]3EBI-11976299,EBI-3650647
TRIP13 [Q15645]3EBI-11976299,EBI-358993
TROAP [Q12815]3EBI-11976299,EBI-2349743
VAC14 [Q08AM6]3EBI-11976299,EBI-2107455
VENTX [O95231]3EBI-11976299,EBI-10191303
WDR25 - isoform 2 [Q64LD2-2]3EBI-11976299,EBI-12032042
WWOX - isoform 5 [Q9NZC7-5]3EBI-11976299,EBI-12040603
ZC2HC1C - isoform 2 [Q53FD0-2]3EBI-11976299,EBI-14104088
ZC3H10 [Q96K80]3EBI-11976299,EBI-742550
ZMYND19 [Q96E35]3EBI-11976299,EBI-746595
Q96EJ43EBI-11976299,EBI-750454

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
129828, 72 interactors

Protein interaction database and analysis system

More...
IntActi
Q5BKX5, 70 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000367564

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5BKX5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5BKX5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4 – 69Pro-richAdd BLAST66

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UPF0692 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502QQQD, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000012368

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_077492_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5BKX5

Identification of Orthologs from Complete Genome Data

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OMAi
LQDGPQC

Database of Orthologous Groups

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OrthoDBi
1549432at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5BKX5

TreeFam database of animal gene trees

More...
TreeFami
TF314051

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040043, UPF0692

The PANTHER Classification System

More...
PANTHERi
PTHR28631, PTHR28631, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5BKX5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTSPCSPPLK PPISPPKTPV PQASSIPSPP LPPSPLDFSA LPSPPWSQQT
60 70 80 90 100
PVPPPLPLPP PPAATGPAPR HVFGLEKSQL LKEAFDKAGP VPKGREDVKR
110 120 130 140 150
LLKLHKDRFR GDLRWILFCA DLPSLIQEGP QCGLVALWMA GTLLSPPSGV
160 170 180 190 200
PLERLIRVAT ERGYTAQGEM FSVADMGRLA QEVLGCQAKL LSGGLGGPNR
210 220 230 240 250
DLVLQHLVTG HPLLIPYDED FNHEPCQRKG HKAHWAVSAG VLLGVRAVPS
260 270 280 290 300
LGYTEDPELP GLFHPVLGTP CQPPSLPEEG SPGAVYLLSK QGKSWHYQLW
310 320 330 340 350
DYDQVRESNL QLTDFSPSRA TDGRVYVVPV GGVRAGLCGQ ALLLTPQDCS

H
Length:351
Mass (Da):37,779
Last modified:October 5, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB1CE78515DC3A553
GO
Isoform 2 (identifier: Q5BKX5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-216: MTSPCSPPLK...LVTGHPLLIP → MRAGGLVDGR...GPGRDVLSTS
     305-351: VRESNLQLTDFSPSRATDGRVYVVPVGGVRAGLCGQALLLTPQDCSH → GPPLSSH

Show »
Length:139
Mass (Da):15,107
Checksum:i82E3B29750E4BA53
GO
Isoform 3 (identifier: Q5BKX5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-216: MTSPCSPPLK...LVTGHPLLIP → MRAGGLVDGR...GPGRDVLSTS

Show »
Length:179
Mass (Da):19,398
Checksum:i1318759D86E77445
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R2U9M0R2U9_HUMAN
UPF0692 protein C19orf54
C19orf54
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q6ZWG5Q6ZWG5_HUMAN
FLJ41131 protein
C19orf54 FLJ41131, hCG_20793
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXR4M0QXR4_HUMAN
UPF0692 protein C19orf54
C19orf54
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R0A6M0R0A6_HUMAN
UPF0692 protein C19orf54
C19orf54
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R368M0R368_HUMAN
UPF0692 protein C19orf54
C19orf54
182Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R322M0R322_HUMAN
UPF0692 protein C19orf54
C19orf54
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti70R → P in BC020262 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0398841 – 216MTSPC…PLLIP → MRAGGLVDGRYSPVAPQWRP PGETHTGGHGKRLHGPGRDV LSTS in isoform 2 and isoform 3. 2 PublicationsAdd BLAST216
Alternative sequenceiVSP_039885305 – 351VRESN…QDCSH → GPPLSSH in isoform 2. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK298068 mRNA Translation: BAG60359.1
AC020945 Genomic DNA No translation available.
BC020262 mRNA No translation available.
BC090894 mRNA Translation: AAH90894.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12564.2 [Q5BKX5-1]

NCBI Reference Sequences

More...
RefSeqi
NP_940878.3, NM_198476.3 [Q5BKX5-1]
XP_005258835.1, XM_005258778.4
XP_016882116.1, XM_017026627.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000378313; ENSP00000367564; ENSG00000188493 [Q5BKX5-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
284325

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:284325

UCSC genome browser

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UCSCi
uc002oou.1, human [Q5BKX5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK298068 mRNA Translation: BAG60359.1
AC020945 Genomic DNA No translation available.
BC020262 mRNA No translation available.
BC090894 mRNA Translation: AAH90894.1
CCDSiCCDS12564.2 [Q5BKX5-1]
RefSeqiNP_940878.3, NM_198476.3 [Q5BKX5-1]
XP_005258835.1, XM_005258778.4
XP_016882116.1, XM_017026627.1

3D structure databases

SMRiQ5BKX5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi129828, 72 interactors
IntActiQ5BKX5, 70 interactors
STRINGi9606.ENSP00000367564

PTM databases

iPTMnetiQ5BKX5
PhosphoSitePlusiQ5BKX5

Polymorphism and mutation databases

BioMutaiC19orf54
DMDMi308153429

Proteomic databases

EPDiQ5BKX5
jPOSTiQ5BKX5
MassIVEiQ5BKX5
MaxQBiQ5BKX5
PaxDbiQ5BKX5
PeptideAtlasiQ5BKX5
PRIDEiQ5BKX5
ProteomicsDBi62702 [Q5BKX5-1]
62703 [Q5BKX5-2]
62704 [Q5BKX5-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
45214, 69 antibodies

Genome annotation databases

EnsembliENST00000378313; ENSP00000367564; ENSG00000188493 [Q5BKX5-1]
GeneIDi284325
KEGGihsa:284325
UCSCiuc002oou.1, human [Q5BKX5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
284325
DisGeNETi284325
EuPathDBiHostDB:ENSG00000188493.14

GeneCards: human genes, protein and diseases

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GeneCardsi
C19orf54
HGNCiHGNC:24758, C19orf54
HPAiENSG00000188493, Low tissue specificity
neXtProtiNX_Q5BKX5
OpenTargetsiENSG00000188493
PharmGKBiPA147358417

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QQQD, Eukaryota
GeneTreeiENSGT00390000012368
HOGENOMiCLU_077492_1_0_1
InParanoidiQ5BKX5
OMAiLQDGPQC
OrthoDBi1549432at2759
PhylomeDBiQ5BKX5
TreeFamiTF314051

Enzyme and pathway databases

PathwayCommonsiQ5BKX5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
284325, 7 hits in 833 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
284325
PharosiQ5BKX5, Tdark

Protein Ontology

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PROi
PR:Q5BKX5
RNActiQ5BKX5, protein

Gene expression databases

BgeeiENSG00000188493, Expressed in epithelium of mammary gland and 218 other tissues
ExpressionAtlasiQ5BKX5, baseline and differential
GenevisibleiQ5BKX5, HS

Family and domain databases

InterProiView protein in InterPro
IPR040043, UPF0692
PANTHERiPTHR28631, PTHR28631, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCS054_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5BKX5
Secondary accession number(s): A8MSZ5, B4DNU7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: October 5, 2010
Last modified: December 2, 2020
This is version 105 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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