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Protein

UPF0692 protein C19orf54

Gene

C19orf54

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
UPF0692 protein C19orf54
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000188493.14
HGNCiHGNC:24758 C19orf54
neXtProtiNX_Q5BKX5

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188493
PharmGKBiPA147358417

Polymorphism and mutation databases

BioMutaiC19orf54
DMDMi308153429

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002976591 – 351UPF0692 protein C19orf54Add BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei316PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5BKX5
MaxQBiQ5BKX5
PaxDbiQ5BKX5
PeptideAtlasiQ5BKX5
PRIDEiQ5BKX5
ProteomicsDBi62702
62703 [Q5BKX5-2]
62704 [Q5BKX5-3]

PTM databases

iPTMnetiQ5BKX5
PhosphoSitePlusiQ5BKX5

Expressioni

Gene expression databases

BgeeiENSG00000188493 Expressed in 205 organ(s), highest expression level in epithelium of mammary gland
CleanExiHS_C19orf54
ExpressionAtlasiQ5BKX5 baseline and differential
GenevisibleiQ5BKX5 HS

Organism-specific databases

HPAiHPA059043
HPA059628

Interactioni

Protein-protein interaction databases

BioGridi129828, 4 interactors
IntActiQ5BKX5, 65 interactors
STRINGi9606.ENSP00000367564

Structurei

3D structure databases

ProteinModelPortaliQ5BKX5
SMRiQ5BKX5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 69Pro-richAdd BLAST66

Sequence similaritiesi

Belongs to the UPF0692 family.Curated

Phylogenomic databases

eggNOGiENOG410IJKK Eukaryota
ENOG410XSMD LUCA
GeneTreeiENSGT00390000012368
HOGENOMiHOG000015241
HOVERGENiHBG107765
InParanoidiQ5BKX5
OMAiQDGPQCG
OrthoDBiEOG091G0KWQ
PhylomeDBiQ5BKX5
TreeFamiTF314051

Family and domain databases

InterProiView protein in InterPro
IPR040043 UPF0692
PANTHERiPTHR28631 PTHR28631, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5BKX5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTSPCSPPLK PPISPPKTPV PQASSIPSPP LPPSPLDFSA LPSPPWSQQT
60 70 80 90 100
PVPPPLPLPP PPAATGPAPR HVFGLEKSQL LKEAFDKAGP VPKGREDVKR
110 120 130 140 150
LLKLHKDRFR GDLRWILFCA DLPSLIQEGP QCGLVALWMA GTLLSPPSGV
160 170 180 190 200
PLERLIRVAT ERGYTAQGEM FSVADMGRLA QEVLGCQAKL LSGGLGGPNR
210 220 230 240 250
DLVLQHLVTG HPLLIPYDED FNHEPCQRKG HKAHWAVSAG VLLGVRAVPS
260 270 280 290 300
LGYTEDPELP GLFHPVLGTP CQPPSLPEEG SPGAVYLLSK QGKSWHYQLW
310 320 330 340 350
DYDQVRESNL QLTDFSPSRA TDGRVYVVPV GGVRAGLCGQ ALLLTPQDCS

H
Note: No experimental confirmation available.
Length:351
Mass (Da):37,779
Last modified:October 5, 2010 - v2
Checksum:iB1CE78515DC3A553
GO
Isoform 2 (identifier: Q5BKX5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-216: MTSPCSPPLK...LVTGHPLLIP → MRAGGLVDGR...GPGRDVLSTS
     305-351: VRESNLQLTDFSPSRATDGRVYVVPVGGVRAGLCGQALLLTPQDCSH → GPPLSSH

Note: No experimental confirmation available.
Show »
Length:139
Mass (Da):15,107
Checksum:i82E3B29750E4BA53
GO
Isoform 3 (identifier: Q5BKX5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-216: MTSPCSPPLK...LVTGHPLLIP → MRAGGLVDGR...GPGRDVLSTS

Note: No experimental confirmation available.
Show »
Length:179
Mass (Da):19,398
Checksum:i1318759D86E77445
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6ZWG5Q6ZWG5_HUMAN
FLJ41131 protein
C19orf54 FLJ41131, hCG_20793
170Annotation score:
M0R368M0R368_HUMAN
UPF0692 protein C19orf54
C19orf54
182Annotation score:
M0R2U9M0R2U9_HUMAN
UPF0692 protein C19orf54
C19orf54
112Annotation score:
M0R322M0R322_HUMAN
UPF0692 protein C19orf54
C19orf54
65Annotation score:
M0R0A6M0R0A6_HUMAN
UPF0692 protein C19orf54
C19orf54
57Annotation score:
M0QXR4M0QXR4_HUMAN
UPF0692 protein C19orf54
C19orf54
67Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti70R → P in BC020262 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0398841 – 216MTSPC…PLLIP → MRAGGLVDGRYSPVAPQWRP PGETHTGGHGKRLHGPGRDV LSTS in isoform 2 and isoform 3. 2 PublicationsAdd BLAST216
Alternative sequenceiVSP_039885305 – 351VRESN…QDCSH → GPPLSSH in isoform 2. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK298068 mRNA Translation: BAG60359.1
AC020945 Genomic DNA No translation available.
BC020262 mRNA No translation available.
BC090894 mRNA Translation: AAH90894.1
CCDSiCCDS12564.2 [Q5BKX5-1]
RefSeqiNP_940878.3, NM_198476.3 [Q5BKX5-1]
XP_005258835.1, XM_005258778.4
XP_016882116.1, XM_017026627.1
UniGeneiHs.585105

Genome annotation databases

EnsembliENST00000378313; ENSP00000367564; ENSG00000188493 [Q5BKX5-1]
GeneIDi284325
KEGGihsa:284325
UCSCiuc002oou.1 human [Q5BKX5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK298068 mRNA Translation: BAG60359.1
AC020945 Genomic DNA No translation available.
BC020262 mRNA No translation available.
BC090894 mRNA Translation: AAH90894.1
CCDSiCCDS12564.2 [Q5BKX5-1]
RefSeqiNP_940878.3, NM_198476.3 [Q5BKX5-1]
XP_005258835.1, XM_005258778.4
XP_016882116.1, XM_017026627.1
UniGeneiHs.585105

3D structure databases

ProteinModelPortaliQ5BKX5
SMRiQ5BKX5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129828, 4 interactors
IntActiQ5BKX5, 65 interactors
STRINGi9606.ENSP00000367564

PTM databases

iPTMnetiQ5BKX5
PhosphoSitePlusiQ5BKX5

Polymorphism and mutation databases

BioMutaiC19orf54
DMDMi308153429

Proteomic databases

EPDiQ5BKX5
MaxQBiQ5BKX5
PaxDbiQ5BKX5
PeptideAtlasiQ5BKX5
PRIDEiQ5BKX5
ProteomicsDBi62702
62703 [Q5BKX5-2]
62704 [Q5BKX5-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378313; ENSP00000367564; ENSG00000188493 [Q5BKX5-1]
GeneIDi284325
KEGGihsa:284325
UCSCiuc002oou.1 human [Q5BKX5-1]

Organism-specific databases

CTDi284325
EuPathDBiHostDB:ENSG00000188493.14
GeneCardsiC19orf54
H-InvDBiHIX0027474
HGNCiHGNC:24758 C19orf54
HPAiHPA059043
HPA059628
neXtProtiNX_Q5BKX5
OpenTargetsiENSG00000188493
PharmGKBiPA147358417
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJKK Eukaryota
ENOG410XSMD LUCA
GeneTreeiENSGT00390000012368
HOGENOMiHOG000015241
HOVERGENiHBG107765
InParanoidiQ5BKX5
OMAiQDGPQCG
OrthoDBiEOG091G0KWQ
PhylomeDBiQ5BKX5
TreeFamiTF314051

Miscellaneous databases

ChiTaRSiC19orf54 human
GenomeRNAii284325
PROiPR:Q5BKX5

Gene expression databases

BgeeiENSG00000188493 Expressed in 205 organ(s), highest expression level in epithelium of mammary gland
CleanExiHS_C19orf54
ExpressionAtlasiQ5BKX5 baseline and differential
GenevisibleiQ5BKX5 HS

Family and domain databases

InterProiView protein in InterPro
IPR040043 UPF0692
PANTHERiPTHR28631 PTHR28631, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCS054_HUMAN
AccessioniPrimary (citable) accession number: Q5BKX5
Secondary accession number(s): A8MSZ5, B4DNU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: October 5, 2010
Last modified: November 7, 2018
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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