UniProtKB - Q5BKQ4 (LIPR1_MOUSE)
Protein
Inactive pancreatic lipase-related protein 1
Gene
Pnliprp1
Organism
Mus musculus (Mouse)
Status
Functioni
May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity (in vitro) (By similarity).By similarity
Miscellaneous
Expression is gender and species-specific.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 171 | NucleophileBy similarity | 1 | |
Active sitei | 194 | Charge relay systemPROSITE-ProRule annotation | 1 | |
Metal bindingi | 205 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 208 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 210 | CalciumBy similarity | 1 | |
Metal bindingi | 213 | CalciumBy similarity | 1 | |
Active sitei | 281 | Charge relay systemPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- calcium ion binding Source: UniProtKB
- lipase activity Source: MGI
- triglyceride lipase activity Source: InterPro
GO - Biological processi
- lipid metabolic process Source: InterPro
Keywordsi
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
Reactomei | R-MMU-192456, Digestion of dietary lipid |
Protein family/group databases
ESTHERi | mouse-1plrp, Pancreatic_lipase |
Names & Taxonomyi
Protein namesi | Recommended name: Inactive pancreatic lipase-related protein 1Short name: PL-RP1 |
Gene namesi | Name:Pnliprp1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97723, Pnliprp1 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Note: Secreted in acinar cells.
Extracellular region or secreted
- extracellular space Source: MGI
Keywords - Cellular componenti
SecretedPathology & Biotechi
Disruption phenotypei
Mice have no visible phenotype during the first 10 weeks after birth and are fertile. Adult mice have normal body weight, but higher than normal body fat and lower than normal lean mass. They display impaired glucose tolerance and decreased insulin sensitivity, and obesity and insulin resistance are exacerbated by high-fat diet. Their pancreatic juice has greater ability to hydrolyze triglycerides than that from wild-type littermates.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_0000017791 | 18 – 473 | Inactive pancreatic lipase-related protein 1Add BLAST | 456 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 21 ↔ 27 | PROSITE-ProRule annotation | ||
Disulfide bondi | 109 ↔ 120 | PROSITE-ProRule annotation | ||
Disulfide bondi | 255 ↔ 279 | PROSITE-ProRule annotation | ||
Disulfide bondi | 303 ↔ 314 | PROSITE-ProRule annotation | ||
Disulfide bondi | 317 ↔ 322 | PROSITE-ProRule annotation | ||
Disulfide bondi | 451 ↔ 467 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondProteomic databases
CPTACi | non-CPTAC-3721 |
MaxQBi | Q5BKQ4 |
PaxDbi | Q5BKQ4 |
PeptideAtlasi | Q5BKQ4 |
PRIDEi | Q5BKQ4 |
Expressioni
Tissue specificityi
Expressed in female, but not in male, lacrimal gland. Expressed in male and female sublingual gland and pancreas.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000042179, Expressed in dorsal pancreas and 93 other tissues |
ExpressionAtlasi | Q5BKQ4, baseline and differential |
Genevisiblei | Q5BKQ4, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000045465 |
Miscellaneous databases
RNActi | Q5BKQ4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 356 – 467 | PLATPROSITE-ProRule annotationAdd BLAST | 112 |
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QUK7, Eukaryota |
GeneTreei | ENSGT00940000162375 |
HOGENOMi | CLU_027171_0_2_1 |
InParanoidi | Q5BKQ4 |
OMAi | KGNTHQY |
OrthoDBi | 534956at2759 |
PhylomeDBi | Q5BKQ4 |
TreeFami | TF324997 |
Family and domain databases
CDDi | cd00707, Pancreat_lipase_like, 1 hit |
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR013818, Lipase/vitellogenin IPR016272, Lipase_LIPH IPR033906, Lipase_N IPR002331, Lipase_panc IPR001024, PLAT/LH2_dom IPR036392, PLAT/LH2_dom_sf IPR000734, TAG_lipase |
PANTHERi | PTHR11610, PTHR11610, 1 hit |
Pfami | View protein in Pfam PF00151, Lipase, 1 hit PF01477, PLAT, 1 hit |
PIRSFi | PIRSF000865, Lipoprotein_lipase_LIPH, 1 hit |
PRINTSi | PR00823, PANCLIPASE PR00821, TAGLIPASE |
SMARTi | View protein in SMART SM00308, LH2, 1 hit |
SUPFAMi | SSF49723, SSF49723, 1 hit SSF53474, SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS00120, LIPASE_SER, 1 hit PS50095, PLAT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q5BKQ4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLILWTIPLF LLGAAQGKEV CYDNLGCFSD AEPWAGTAIR PLKLLPWSPE
60 70 80 90 100
KINTRFLLYT NENPTAFQTL QLSDPSTIEA SNFQVARKTR FIIHGFIDKG
110 120 130 140 150
EENWVVDMCK NMFQVEEVNC ICVDWKRGSQ TTYTQAANNV RVVGAQVAQM
160 170 180 190 200
IDILVRNFNY SASKVHLIGH SLGAHVAGEA GSRTPGLGRI TGLDPVEANF
210 220 230 240 250
EGTPEEVRLD PSDADFVDVI HTDAAPLIPF LGFGTNQMVG HFDFFPNGGQ
260 270 280 290 300
YMPGCKKNAL SQIVDIDGIW SGTRDFVACN HLRSYKYYLE SILNPDGFAA
310 320 330 340 350
YPCASYRDFE SNKCFPCPDQ GCPQMGHYAD KFANNTSVEP QKFFLNTGEA
360 370 380 390 400
KNFARWRYRV SLTFSGRTVT GQVKVSLFGS NGNTRQCDIF RGIIKPGATH
410 420 430 440 450
SNEFDAKLDV GTIEKVKFLW NNHVVNPSFP KVGAAKITVQ KGEERTEHNF
460 470
CSEETVREDI LLTLLPCKTS DTM
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A494BA59 | A0A494BA59_MOUSE | Inactive pancreatic lipase-related ... | Pnliprp1 | 252 | Annotation score: | ||
A0A494B903 | A0A494B903_MOUSE | Inactive pancreatic lipase-related ... | Pnliprp1 | 35 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 59 | Y → H in AAH90985 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 97 – 115 | IDKGE…NMFQV → RPTSWPPGPSSGNNAEYAG in AAH68266 (PubMed:16141072).CuratedAdd BLAST | 19 | |
Sequence conflicti | 159 – 161 | NYS → KYY in AAH68266 (PubMed:16141072).Curated | 3 | |
Sequence conflicti | 159 | N → D in AAH90985 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 282 | L → P in AAH68266 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 351 | K → R in AAH68266 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 407 | K → E in AAH68266 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF061274 mRNA Translation: AAC15774.1 AK028105 mRNA Translation: BAC25750.1 BC068266 mRNA Translation: AAH68266.1 BC090985 mRNA Translation: AAH90985.1 |
CCDSi | CCDS29931.1 |
RefSeqi | NP_061362.1, NM_018874.2 |
Genome annotation databases
Ensembli | ENSMUST00000048644; ENSMUSP00000045465; ENSMUSG00000042179 |
GeneIDi | 18946 |
KEGGi | mmu:18946 |
UCSCi | uc008iat.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF061274 mRNA Translation: AAC15774.1 AK028105 mRNA Translation: BAC25750.1 BC068266 mRNA Translation: AAH68266.1 BC090985 mRNA Translation: AAH90985.1 |
CCDSi | CCDS29931.1 |
RefSeqi | NP_061362.1, NM_018874.2 |
3D structure databases
SMRi | Q5BKQ4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000045465 |
Protein family/group databases
ESTHERi | mouse-1plrp, Pancreatic_lipase |
Proteomic databases
CPTACi | non-CPTAC-3721 |
MaxQBi | Q5BKQ4 |
PaxDbi | Q5BKQ4 |
PeptideAtlasi | Q5BKQ4 |
PRIDEi | Q5BKQ4 |
Protocols and materials databases
Antibodypediai | 35303, 71 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000048644; ENSMUSP00000045465; ENSMUSG00000042179 |
GeneIDi | 18946 |
KEGGi | mmu:18946 |
UCSCi | uc008iat.1, mouse |
Organism-specific databases
CTDi | 5407 |
MGIi | MGI:97723, Pnliprp1 |
Phylogenomic databases
eggNOGi | ENOG502QUK7, Eukaryota |
GeneTreei | ENSGT00940000162375 |
HOGENOMi | CLU_027171_0_2_1 |
InParanoidi | Q5BKQ4 |
OMAi | KGNTHQY |
OrthoDBi | 534956at2759 |
PhylomeDBi | Q5BKQ4 |
TreeFami | TF324997 |
Enzyme and pathway databases
Reactomei | R-MMU-192456, Digestion of dietary lipid |
Miscellaneous databases
BioGRID-ORCSi | 18946, 0 hits in 17 CRISPR screens |
ChiTaRSi | Pnliprp1, mouse |
PROi | PR:Q5BKQ4 |
RNActi | Q5BKQ4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000042179, Expressed in dorsal pancreas and 93 other tissues |
ExpressionAtlasi | Q5BKQ4, baseline and differential |
Genevisiblei | Q5BKQ4, MM |
Family and domain databases
CDDi | cd00707, Pancreat_lipase_like, 1 hit |
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR013818, Lipase/vitellogenin IPR016272, Lipase_LIPH IPR033906, Lipase_N IPR002331, Lipase_panc IPR001024, PLAT/LH2_dom IPR036392, PLAT/LH2_dom_sf IPR000734, TAG_lipase |
PANTHERi | PTHR11610, PTHR11610, 1 hit |
Pfami | View protein in Pfam PF00151, Lipase, 1 hit PF01477, PLAT, 1 hit |
PIRSFi | PIRSF000865, Lipoprotein_lipase_LIPH, 1 hit |
PRINTSi | PR00823, PANCLIPASE PR00821, TAGLIPASE |
SMARTi | View protein in SMART SM00308, LH2, 1 hit |
SUPFAMi | SSF49723, SSF49723, 1 hit SSF53474, SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS00120, LIPASE_SER, 1 hit PS50095, PLAT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LIPR1_MOUSE | |
Accessioni | Q5BKQ4Primary (citable) accession number: Q5BKQ4 Secondary accession number(s): O70478, Q6NV82 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 21, 2005 |
Last sequence update: | June 21, 2005 | |
Last modified: | December 2, 2020 | |
This is version 120 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families