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UniProtKB - Q5BKL0 (HPPD_XENTR)
Protein
4-hydroxyphenylpyruvate dioxygenase
Gene
hpd
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Functioni
Key enzyme in the degradation of tyrosine.
By similarityCatalytic activityi
- EC:1.13.11.27
Cofactori
Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity
: L-phenylalanine degradation Pathwayi
This protein is involved in step 3 of the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine. This subpathway is part of the pathway L-phenylalanine degradation, which is itself part of Amino-acid degradation.View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine, the pathway L-phenylalanine degradation and in Amino-acid degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 184 | IronBy similarity | 1 | |
Metal bindingi | 267 | IronBy similarity | 1 | |
Metal bindingi | 350 | IronBy similarity | 1 |
GO - Molecular functioni
- 4-hydroxyphenylpyruvate dioxygenase activity Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- L-phenylalanine catabolic process Source: UniProtKB-UniPathway
- tyrosine catabolic process Source: UniProtKB
Keywordsi
Molecular function | Dioxygenase, Oxidoreductase |
Biological process | Phenylalanine catabolism, Tyrosine catabolism |
Ligand | Iron, Metal-binding |
Enzyme and pathway databases
UniPathwayi | UPA00139;UER00362 |
Names & Taxonomyi
Protein namesi | Recommended name: 4-hydroxyphenylpyruvate dioxygenase (EC:1.13.11.27)Alternative name(s): 4-hydroxyphenylpyruvic acid oxidase Short name: 4HPPD Short name: HPD Short name: HPPDase |
Gene namesi | Name:hpd |
Organismi | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
Taxonomic identifieri | 8364 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana |
Proteomesi |
|
Organism-specific databases
Xenbasei | XB-GENE-986330, hpd-like.2 |
Subcellular locationi
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: GO_Central
Golgi apparatus
- Golgi membrane Source: GO_Central
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000088393 | 1 – 394 | 4-hydroxyphenylpyruvate dioxygenaseAdd BLAST | 394 |
Proteomic databases
PaxDbi | Q5BKL0 |
Expressioni
Gene expression databases
Bgeei | ENSXETG00000007789, Expressed in liver and 9 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 18 – 149 | VOC 1PROSITE-ProRule annotationAdd BLAST | 132 | |
Domaini | 181 – 339 | VOC 2PROSITE-ProRule annotationAdd BLAST | 159 |
Sequence similaritiesi
Belongs to the 4HPPD family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0638, Eukaryota |
GeneTreei | ENSGT00530000063474 |
HOGENOMi | CLU_034004_3_1_1 |
InParanoidi | Q5BKL0 |
OrthoDBi | 1087836at2759 |
PhylomeDBi | Q5BKL0 |
Family and domain databases
CDDi | cd07250, HPPD_C_like, 1 hit cd08342, HPPD_N_like, 1 hit |
Gene3Di | 3.10.180.10, 2 hits |
InterProi | View protein in InterPro IPR005956, 4OHPhenylPyrv_dOase IPR041735, 4OHPhenylPyrv_dOase_C IPR041736, 4OHPhenylPyrv_dOase_N IPR029068, Glyas_Bleomycin-R_OHBP_Dase IPR004360, Glyas_Fos-R_dOase_dom IPR037523, VOC |
PANTHERi | PTHR11959, PTHR11959, 1 hit |
Pfami | View protein in Pfam PF00903, Glyoxalase, 2 hits |
PIRSFi | PIRSF009283, HPP_dOase, 1 hit |
SUPFAMi | SSF54593, SSF54593, 1 hit |
TIGRFAMsi | TIGR01263, 4HPPD, 1 hit |
PROSITEi | View protein in PROSITE PS51819, VOC, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q5BKL0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTSYTDKGEK HARGRFLSFH HLTFWVGNAK QAASFYCDKF GFEPCAYKGL
60 70 80 90 100
ETGSRDVVSH AIKQDKIIFV FQSPLNPGNQ EMGQHMIKHG DGVKDVAFQV
110 120 130 140 150
EDCDFLFQKA KDHGAVVVRE PWIEEDEGGK VKYAVLQTYG DTTHTLLEYL
160 170 180 190 200
GPYRGVFLPG YKEPLFRDPL LPTLPSGCLS FIDHIVGNQP DNEMVPIVEW
210 220 230 240 250
YQKCLLFHRF WSVDDKQIHT EYSSLRSIVV TNYEETIKMP INEPAAGKKK
260 270 280 290 300
SQIQEYVDYY GSAGVQHIAL NTSNIIKAVK NLKSRGIEFL SAPDTYYEEL
310 320 330 340 350
RKKLKTAKIT VKEDLNVLQE LKILVDYDDK GYLLQIFTKP MQDRPTLFLE
360 370 380 390
VIQRYNHFGF GAGNFKSLFE AIETDQDARG NLTIYAANGE HQVL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A6I8SJR1 | A0A6I8SJR1_XENTR | 4-hydroxyphenylpyruvate dioxygenase | hpd-like.2 | 369 | Annotation score: | ||
A0A5S6L615 | A0A5S6L615_XENTR | 4-hydroxyphenylpyruvate dioxygenase | hpd-like.2 | 413 | Annotation score: | ||
A0A6I8PY96 | A0A6I8PY96_XENTR | 4-hydroxyphenylpyruvate dioxygenase | hpd-like.2 | 396 | Annotation score: | ||
A0A6I8PUH6 | A0A6I8PUH6_XENTR | 4-hydroxyphenylpyruvate dioxygenase | hpd-like.2 | 395 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC091035 mRNA Translation: AAH91035.1 |
RefSeqi | NP_001025588.1, NM_001030417.1 |
Genome annotation databases
Ensembli | ENSXETT00000085370; ENSXETP00000064696; ENSXETG00000007789 ENSXETT00000097642; ENSXETP00000097666; ENSXETG00000007789 |
GeneIDi | 594976 |
KEGGi | xtr:594976 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC091035 mRNA Translation: AAH91035.1 |
RefSeqi | NP_001025588.1, NM_001030417.1 |
3D structure databases
SMRi | Q5BKL0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 8364.ENSXETP00000062603 |
Proteomic databases
PaxDbi | Q5BKL0 |
Protocols and materials databases
DNASUi | 594976 |
Genome annotation databases
Ensembli | ENSXETT00000085370; ENSXETP00000064696; ENSXETG00000007789 ENSXETT00000097642; ENSXETP00000097666; ENSXETG00000007789 |
GeneIDi | 594976 |
KEGGi | xtr:594976 |
Organism-specific databases
CTDi | 594976 |
Xenbasei | XB-GENE-986330, hpd-like.2 |
Phylogenomic databases
eggNOGi | KOG0638, Eukaryota |
GeneTreei | ENSGT00530000063474 |
HOGENOMi | CLU_034004_3_1_1 |
InParanoidi | Q5BKL0 |
OrthoDBi | 1087836at2759 |
PhylomeDBi | Q5BKL0 |
Enzyme and pathway databases
UniPathwayi | UPA00139;UER00362 |
Gene expression databases
Bgeei | ENSXETG00000007789, Expressed in liver and 9 other tissues |
Family and domain databases
CDDi | cd07250, HPPD_C_like, 1 hit cd08342, HPPD_N_like, 1 hit |
Gene3Di | 3.10.180.10, 2 hits |
InterProi | View protein in InterPro IPR005956, 4OHPhenylPyrv_dOase IPR041735, 4OHPhenylPyrv_dOase_C IPR041736, 4OHPhenylPyrv_dOase_N IPR029068, Glyas_Bleomycin-R_OHBP_Dase IPR004360, Glyas_Fos-R_dOase_dom IPR037523, VOC |
PANTHERi | PTHR11959, PTHR11959, 1 hit |
Pfami | View protein in Pfam PF00903, Glyoxalase, 2 hits |
PIRSFi | PIRSF009283, HPP_dOase, 1 hit |
SUPFAMi | SSF54593, SSF54593, 1 hit |
TIGRFAMsi | TIGR01263, 4HPPD, 1 hit |
PROSITEi | View protein in PROSITE PS51819, VOC, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | HPPD_XENTR | |
Accessioni | Q5BKL0Primary (citable) accession number: Q5BKL0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2005 |
Last sequence update: | April 12, 2005 | |
Last modified: | February 23, 2022 | |
This is version 88 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families