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Protein

FAS-associated factor 2

Gene

Faf2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis.By similarity

GO - Biological processi

Keywordsi

Biological processUnfolded protein response

Enzyme and pathway databases

ReactomeiR-RNO-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
FAS-associated factor 2
Alternative name(s):
UBX domain-containing protein 8
Gene namesi
Name:Faf2
Synonyms:Ubxd8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi1306577 Faf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Lipid droplet

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002440661 – 346FAS-associated factor 2Add BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei68N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ5BK32
PRIDEiQ5BK32

PTM databases

iPTMnetiQ5BK32
PhosphoSitePlusiQ5BK32

Expressioni

Gene expression databases

BgeeiENSRNOG00000017607 Expressed in 10 organ(s), highest expression level in liver
ExpressionAtlasiQ5BK32 baseline and differential
GenevisibleiQ5BK32 RN

Interactioni

Subunit structurei

Identified in a complex that contains SEL1L, OS9, FAF2/UBXD8, UBE2J1/UBC6E and AUP1. Interacts with YOD1. Interacts (via N-terminus) with UBQLN2 (via C-terminus). Interacts with PNPLA2 and UBAC2. Interacts with ZFAND2B; probably through VCP.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063246

Structurei

3D structure databases

ProteinModelPortaliQ5BK32
SMRiQ5BK32
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini258 – 340UBXPROSITE-ProRule annotationAdd BLAST83

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili176 – 251Sequence analysisAdd BLAST76

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1363 Eukaryota
ENOG410XSFS LUCA
GeneTreeiENSGT00530000063422
HOGENOMiHOG000007539
HOVERGENiHBG101311
InParanoidiQ5BK32
KOiK18726
PhylomeDBiQ5BK32

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
IPR006577 UAS
IPR029071 Ubiquitin-like_domsf
IPR001012 UBX_dom
PfamiView protein in Pfam
PF00789 UBX, 1 hit
SMARTiView protein in SMART
SM00594 UAS, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50033 UBX, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q5BK32-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPFRFTYYT ILDIFRFALR FIRPDPRSRV TDPVGDIVSF MHSFEEKYGR
60 70 80 90 100
AHPVFYQGTY SQALSDAKRE LRFLLVYLHG DDHQDSDEFC RNALCAPEVI
110 120 130 140 150
SLINSRMLFW ACSTNKPEGY RVSQALRENT YPFLAMIMLK DRRMTVVGRL
160 170 180 190 200
EGLIQPDDLI NQLTFIMDAN QTYLVSERLE REERNQTQVL RQQQDEAYLA
210 220 230 240 250
SLRADQEKER KKREERERKR RKEEEVQQQK LAEERRRQNL QEEKERKLEC
260 270 280 290 300
LPPEPSPDDP DSVKIIFKLP NDSRVERRFH FSQSLTVIHD FLFSLKESPE
310 320 330 340
KFQIEANFPR RVLPCVPSEE WPNPPTLQEA GLSHTEVLFV QDLTDE
Length:346
Mass (Da):41,080
Last modified:April 12, 2005 - v1
Checksum:i3852DEB92B939F44
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JTA0A0A0G2JTA0_RAT
FAS-associated factor 2
Faf2 rCG_24095
445Annotation score:
B2GV65B2GV65_RAT
HIG1 domain family, member 2A
Higd2a rCG_24095
106Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091224 mRNA Translation: AAH91224.1
RefSeqiNP_001017445.1, NM_001017445.1
UniGeneiRn.111214
Rn.199132

Genome annotation databases

EnsembliENSRNOT00000064477; ENSRNOP00000063246; ENSRNOG00000017607
GeneIDi291000
KEGGirno:291000
UCSCiRGD:1306577 rat

Similar proteinsi

Entry informationi

Entry nameiFAF2_RAT
AccessioniPrimary (citable) accession number: Q5BK32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: April 12, 2005
Last modified: September 12, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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