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Protein

Calpain-13

Gene

Capn13

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable non-lysosomal thiol-protease.By similarity

Caution

It is unlikely that this protein binds calcium as none of the 2 EF-hand domains seem to contain a canonical calcium-binding site.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei93By similarity1
Active sitei249By similarity1
Active sitei273By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

ReactomeiR-RNO-1474228 Degradation of the extracellular matrix

Protein family/group databases

MEROPSiC02.020

Names & Taxonomyi

Protein namesi
Recommended name:
Calpain-13 (EC:3.4.22.-)
Alternative name(s):
Calcium-activated neutral proteinase 13
Short name:
CANP 13
Gene namesi
Name:Capn13
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1562682 Capn13

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002595841 – 668Calpain-13Add BLAST668

Proteomic databases

PaxDbiQ5BK10
PRIDEiQ5BK10

Expressioni

Gene expression databases

BgeeiENSRNOG00000032375 Expressed in 7 organ(s), highest expression level in colon
GenevisibleiQ5BK10 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039021

Structurei

3D structure databases

ProteinModelPortaliQ5BK10
SMRiQ5BK10
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 331Calpain catalyticPROSITE-ProRule annotationAdd BLAST298
Domaini537 – 572EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini635 – 668EF-hand 2PROSITE-ProRule annotationAdd BLAST34

Sequence similaritiesi

Belongs to the peptidase C2 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0037 Eukaryota
KOG0045 Eukaryota
ENOG410XP0B LUCA
GeneTreeiENSGT00760000118971
HOGENOMiHOG000232035
HOVERGENiHBG012645
InParanoidiQ5BK10
KOiK08581
OMAiYLTEMEW
OrthoDBiEOG091G03KK
PhylomeDBiQ5BK10
TreeFamiTF314748

Family and domain databases

CDDicd00044 CysPc, 1 hit
InterProiView protein in InterPro
IPR022684 Calpain_cysteine_protease
IPR022682 Calpain_domain_III
IPR022683 Calpain_III
IPR036213 Calpain_III_sf
IPR029544 CANP13/Calpain-C
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR038765 Papain_like_cys_pep_sf
IPR000169 Pept_cys_AS
IPR001300 Peptidase_C2_calpain_cat
PANTHERiPTHR10183:SF333 PTHR10183:SF333, 1 hit
PfamiView protein in Pfam
PF01067 Calpain_III, 1 hit
PF00648 Peptidase_C2, 1 hit
PRINTSiPR00704 CALPAIN
SMARTiView protein in SMART
SM00720 calpain_III, 1 hit
SM00230 CysPc, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF49758 SSF49758, 1 hit
SSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit
PS50222 EF_HAND_2, 2 hits
PS00139 THIOL_PROTEASE_CYS, 1 hit

Sequencei

Sequence statusi: Complete.

Q5BK10-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHDTEALEE TSVVKFKNQD FRFLRDRCLS RGQLFIDDTF PAEASSIGQK
60 70 80 90 100
LLMGKRLPKL EWKRPQDLSF GPPHFILEGA SRFDIQQGRA GDCWFLAALG
110 120 130 140 150
SLTQNPQCLQ KILMNQSFSY QYAGIFHFRF WQCGQWVEVV IDDRLPVVGN
160 170 180 190 200
NFCFVHPRRG NQEFWPCLME KAYAKLLGSY SQLHYGYLPD ALVDLTGGVV
210 220 230 240 250
TRINLHSSPS DLLMVVKTAV QTGSMVACAT PKWLTEESEV MENGLVSQHA
260 270 280 290 300
YTVTGAEKIQ YRRGWEEIIR LWNPWGNTEW RGRWGDGSQE WWETHGSRKS
310 320 330 340 350
QLYENKDDGE FWMSCRDFHE NFSCLYICSQ FPITMDPGVT PNESWRQMRF
360 370 380 390 400
KNQVISGNTA GGDGRDIQYL FDVQEPMDGN NVIVAFTVMP QSLKTEEWPF
410 420 430 440 450
PLQFQVFKVD SQFQKFQKRL PPAFFSQFRD AAQGIDYVTK RNFTKSFHLS
460 470 480 490 500
PGTYVVVASA HGKEVEFLLR IFLKMPHKDR NPNSSFNLKA LKGSLSENES
510 520 530 540 550
PKSSFHRYMD QGLDIDASQL QSLLNQEYLT GPPGDTFSLD QCQSIMALMD
560 570 580 590 600
LKVNGRLDRE EFARLQSRLI HCQHVFQHIQ RSQGVLRSSD LWEVIESTDF
610 620 630 640 650
LSGVLLSKEL LSLMTLRYSD SSGRLSFPSL VCFLIRLETM SKAFRNLSKD
660
GKSIYLTEME WMKLVMYS
Length:668
Mass (Da):76,939
Last modified:April 12, 2005 - v1
Checksum:i654F7BDEA9D3C6F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091250 mRNA Translation: AAH91250.1
RefSeqiNP_001020304.1, NM_001025133.1
XP_006239839.1, XM_006239777.3
XP_006239840.1, XM_006239778.3
UniGeneiRn.15541

Genome annotation databases

EnsembliENSRNOT00000047853; ENSRNOP00000039021; ENSRNOG00000032375
GeneIDi362701
KEGGirno:362701
UCSCiRGD:1562682 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091250 mRNA Translation: AAH91250.1
RefSeqiNP_001020304.1, NM_001025133.1
XP_006239839.1, XM_006239777.3
XP_006239840.1, XM_006239778.3
UniGeneiRn.15541

3D structure databases

ProteinModelPortaliQ5BK10
SMRiQ5BK10
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000039021

Protein family/group databases

MEROPSiC02.020

Proteomic databases

PaxDbiQ5BK10
PRIDEiQ5BK10

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000047853; ENSRNOP00000039021; ENSRNOG00000032375
GeneIDi362701
KEGGirno:362701
UCSCiRGD:1562682 rat

Organism-specific databases

CTDi92291
RGDi1562682 Capn13

Phylogenomic databases

eggNOGiKOG0037 Eukaryota
KOG0045 Eukaryota
ENOG410XP0B LUCA
GeneTreeiENSGT00760000118971
HOGENOMiHOG000232035
HOVERGENiHBG012645
InParanoidiQ5BK10
KOiK08581
OMAiYLTEMEW
OrthoDBiEOG091G03KK
PhylomeDBiQ5BK10
TreeFamiTF314748

Enzyme and pathway databases

ReactomeiR-RNO-1474228 Degradation of the extracellular matrix

Miscellaneous databases

PROiPR:Q5BK10

Gene expression databases

BgeeiENSRNOG00000032375 Expressed in 7 organ(s), highest expression level in colon
GenevisibleiQ5BK10 RN

Family and domain databases

CDDicd00044 CysPc, 1 hit
InterProiView protein in InterPro
IPR022684 Calpain_cysteine_protease
IPR022682 Calpain_domain_III
IPR022683 Calpain_III
IPR036213 Calpain_III_sf
IPR029544 CANP13/Calpain-C
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR038765 Papain_like_cys_pep_sf
IPR000169 Pept_cys_AS
IPR001300 Peptidase_C2_calpain_cat
PANTHERiPTHR10183:SF333 PTHR10183:SF333, 1 hit
PfamiView protein in Pfam
PF01067 Calpain_III, 1 hit
PF00648 Peptidase_C2, 1 hit
PRINTSiPR00704 CALPAIN
SMARTiView protein in SMART
SM00720 calpain_III, 1 hit
SM00230 CysPc, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF49758 SSF49758, 1 hit
SSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50203 CALPAIN_CAT, 1 hit
PS50222 EF_HAND_2, 2 hits
PS00139 THIOL_PROTEASE_CYS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCAN13_RAT
AccessioniPrimary (citable) accession number: Q5BK10
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: April 12, 2005
Last modified: September 12, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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