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Protein
Submitted name:

Nicotinamide nucleotide transhydrogenase

Gene

Nnt

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-71403 Citric acid cycle (TCA cycle)

Names & Taxonomyi

Protein namesi
Submitted name:
Nicotinamide nucleotide transhydrogenaseImported
Gene namesi
Name:NntImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1587346 Nnt

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei478 – 498HelicalSequence analysisAdd BLAST21
Transmembranei504 – 523HelicalSequence analysisAdd BLAST20
Transmembranei557 – 577HelicalSequence analysisAdd BLAST21
Transmembranei597 – 616HelicalSequence analysisAdd BLAST20
Transmembranei622 – 639HelicalSequence analysisAdd BLAST18
Transmembranei646 – 666HelicalSequence analysisAdd BLAST21
Transmembranei672 – 691HelicalSequence analysisAdd BLAST20
Transmembranei703 – 724HelicalSequence analysisAdd BLAST22
Transmembranei740 – 760HelicalSequence analysisAdd BLAST21
Transmembranei780 – 797HelicalSequence analysisAdd BLAST18
Transmembranei858 – 879HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PRIDEiQ5BJZ3

Expressioni

Gene expression databases

BgeeiENSRNOG00000026842 Expressed in 9 organ(s), highest expression level in heart

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000029578

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 199AlaDh_PNT_NInterPro annotationAdd BLAST140
Domaini208 – 372AlaDh_PNT_CInterPro annotationAdd BLAST165

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IEMU Eukaryota
COG1282 LUCA
COG3288 LUCA
GeneTreeiENSGT00390000004624
HOGENOMiHOG000160623
HOVERGENiHBG006511
KOiK00323
OMAiKPGIPYK
OrthoDBiEOG091G01NO
TreeFamiTF300636

Family and domain databases

InterProiView protein in InterPro
IPR008143 Ala_DH/PNT_CS2
IPR008142 AlaDH/PNT_CS1
IPR007886 AlaDH/PNT_N
IPR007698 AlaDH/PNT_NAD(H)-bd
IPR029035 DHS-like_NAD/FAD-binding_dom
IPR036291 NAD(P)-bd_dom_sf
IPR026255 NADP_transhyd_a
IPR024605 NADP_transhyd_a_C
IPR034300 PNTB-like
PfamiView protein in Pfam
PF01262 AlaDh_PNT_C, 1 hit
PF05222 AlaDh_PNT_N, 1 hit
PF02233 PNTB, 1 hit
PF12769 PNTB_4TM, 1 hit
SMARTiView protein in SMART
SM01002 AlaDh_PNT_C, 1 hit
SM01003 AlaDh_PNT_N, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF52467 SSF52467, 1 hit
TIGRFAMsiTIGR00561 pntA, 1 hit
PROSITEiView protein in PROSITE
PS00836 ALADH_PNT_1, 1 hit
PS00837 ALADH_PNT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5BJZ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHLLKTVVT GCLCPSVSNL GSCKVLPGKK DFLRTFRTHQ ALWCKSPAKP
60 70 80 90 100
GIPYKQLTVG VPKEIFQNEK RVALSPAGVQ ALVKQGFNVV VESGAGEASK
110 120 130 140 150
FPDDLYRAAG AQIQGTKEVL ASDLVVKVRA PMVNPTLGAH EADFLKPSGT
160 170 180 190 200
LISFIYPAQN PDLLNKLSER KTTVLAMDQV PRVTIAQGYD ALSSMANISG
210 220 230 240 250
YKAVVLAANH FGRFFTGQIT AAGKVPPAKI LIVGGGVAGL ASAGAAKSMG
260 270 280 290 300
AVVRGFDTRA AALEQFKSLG AEPLEVDLKE SGEGQGGYAK EMSKEFIEAE
310 320 330 340 350
MKLFAQQCKE VDILISTALI PGKKAPVLFS KEMIESMKEG SVVVDLAAEA
360 370 380 390 400
GGNFETTKPG ELYVHKGITH IGYTDLPSRM ATQASTLYSN NITKLLKAIS
410 420 430 440 450
PDKDNFHFEV KDDFDFGTMS HVIRGTVVMK DGNVIFPAPT PKNIPKEAPA
460 470 480 490 500
KQKTVAELEA EKAGTVSMYT KTLRTASVYS AGLTGMLGLG IVAPNLAFSQ
510 520 530 540 550
MVTTFGLAGI IGYHTVWGVT PALHSPLMSV TNAISGLTAV GGLALMGGHF
560 570 580 590 600
YPSTTSQSLA ALATFISSVN IAGGFLVTQR MLDMFKRPTD PPEYNYLYLL
610 620 630 640 650
PGGTFVGGYL AALYGGYNIE EIMYLGSGLC CVGALGGLST QGTARLGNAL
660 670 680 690 700
GMIGVAGGLA ATLGGLKPDP QLLAQMSGAM AMGGTIGLAI AKRIQISDLP
710 720 730 740 750
QLVAAFHSLV GLAAVLTCMA EYIVEYPHFA MDATSNFTKI VAYIGTYIGG
760 770 780 790 800
VTFSGSLVAY GKLQGILKSA PLLLPGRHAL NAGLLAASVG GIIPFMADPS
810 820 830 840 850
FTTGIMCLGS VSALSTLMGV TLTAAIGGAD MPVVITVLNS YSGWALCAEG
860 870 880 890 900
FLLNNNLLTI VGALIGSSGA ILSYIMCVAM NRSLANVILG GYGTTSTAGG
910 920 930 940 950
KPMEISGTHT EINLDNAVEM IREANSIVIT PGYGLCAAKA QYPIADLVKM
960 970 980 990 1000
LTEQGKKVRF GIHPVAGRMP GQLNVLLAEA GVPYDIVLEM DEINSDFPDT
1010 1020 1030 1040 1050
DLVLVIGAND TVNSAAQEDP NSIIAGMPVL EVWKSKQVIV MKRSLGVGYA
1060 1070 1080
AVDNPIFYKP NTAMLLGDAK KTCDALQAKV RESYQK
Length:1,086
Mass (Da):113,869
Last modified:April 12, 2005 - v1
Checksum:iBFBD8AF1F5502B84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07008294 Genomic DNA No translation available.
AABR07008295 Genomic DNA No translation available.
AABR07008296 Genomic DNA No translation available.
AABR07072708 Genomic DNA No translation available.
AC098186 Genomic DNA No translation available.
BC091271 mRNA Translation: AAH91271.1
RefSeqiNP_001013175.1, NM_001013157.1
XP_006232030.1, XM_006231968.3
XP_006232031.1, XM_006231969.3
XP_006232032.1, XM_006231970.3
XP_006232033.1, XM_006231971.3
XP_006232034.1, XM_006231972.3
XP_008758996.1, XM_008760774.1
UniGeneiRn.3128

Genome annotation databases

EnsembliENSRNOT00000033627; ENSRNOP00000029578; ENSRNOG00000026842
GeneIDi310378
KEGGirno:310378

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07008294 Genomic DNA No translation available.
AABR07008295 Genomic DNA No translation available.
AABR07008296 Genomic DNA No translation available.
AABR07072708 Genomic DNA No translation available.
AC098186 Genomic DNA No translation available.
BC091271 mRNA Translation: AAH91271.1
RefSeqiNP_001013175.1, NM_001013157.1
XP_006232030.1, XM_006231968.3
XP_006232031.1, XM_006231969.3
XP_006232032.1, XM_006231970.3
XP_006232033.1, XM_006231971.3
XP_006232034.1, XM_006231972.3
XP_008758996.1, XM_008760774.1
UniGeneiRn.3128

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000029578

Proteomic databases

PRIDEiQ5BJZ3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000033627; ENSRNOP00000029578; ENSRNOG00000026842
GeneIDi310378
KEGGirno:310378

Organism-specific databases

CTDi23530
RGDi1587346 Nnt

Phylogenomic databases

eggNOGiENOG410IEMU Eukaryota
COG1282 LUCA
COG3288 LUCA
GeneTreeiENSGT00390000004624
HOGENOMiHOG000160623
HOVERGENiHBG006511
KOiK00323
OMAiKPGIPYK
OrthoDBiEOG091G01NO
TreeFamiTF300636

Enzyme and pathway databases

ReactomeiR-RNO-71403 Citric acid cycle (TCA cycle)

Gene expression databases

BgeeiENSRNOG00000026842 Expressed in 9 organ(s), highest expression level in heart

Family and domain databases

InterProiView protein in InterPro
IPR008143 Ala_DH/PNT_CS2
IPR008142 AlaDH/PNT_CS1
IPR007886 AlaDH/PNT_N
IPR007698 AlaDH/PNT_NAD(H)-bd
IPR029035 DHS-like_NAD/FAD-binding_dom
IPR036291 NAD(P)-bd_dom_sf
IPR026255 NADP_transhyd_a
IPR024605 NADP_transhyd_a_C
IPR034300 PNTB-like
PfamiView protein in Pfam
PF01262 AlaDh_PNT_C, 1 hit
PF05222 AlaDh_PNT_N, 1 hit
PF02233 PNTB, 1 hit
PF12769 PNTB_4TM, 1 hit
SMARTiView protein in SMART
SM01002 AlaDh_PNT_C, 1 hit
SM01003 AlaDh_PNT_N, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF52467 SSF52467, 1 hit
TIGRFAMsiTIGR00561 pntA, 1 hit
PROSITEiView protein in PROSITE
PS00836 ALADH_PNT_1, 1 hit
PS00837 ALADH_PNT_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ5BJZ3_RAT
AccessioniPrimary (citable) accession number: Q5BJZ3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2005
Last sequence update: April 12, 2005
Last modified: September 12, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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