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Entry version 127 (29 Sep 2021)
Sequence version 1 (12 Apr 2005)
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Protein

Proton-translocating NAD(P)(+) transhydrogenase

Gene

Nnt

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocaseARBA annotation
LigandNADARBA annotation, NADPARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-71403, Citric acid cycle (TCA cycle)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Proton-translocating NAD(P)(+) transhydrogenaseARBA annotation (EC:7.1.1.1ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NntImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Rat genome database

More...
RGDi
1587346, Nnt

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei478 – 498HelicalSequence analysisAdd BLAST21
Transmembranei504 – 523HelicalSequence analysisAdd BLAST20
Transmembranei557 – 577HelicalSequence analysisAdd BLAST21
Transmembranei597 – 616HelicalSequence analysisAdd BLAST20
Transmembranei622 – 639HelicalSequence analysisAdd BLAST18
Transmembranei646 – 666HelicalSequence analysisAdd BLAST21
Transmembranei672 – 691HelicalSequence analysisAdd BLAST20
Transmembranei703 – 724HelicalSequence analysisAdd BLAST22
Transmembranei740 – 760HelicalSequence analysisAdd BLAST21
Transmembranei780 – 797HelicalSequence analysisAdd BLAST18
Transmembranei858 – 879HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q5BJZ3

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5BJZ3

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q5BJZ3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000026842, Expressed in heart and 20 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000029578

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5BJZ3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini60 – 199AlaDh_PNT_NInterPro annotationAdd BLAST140
Domaini208 – 372AlaDh_PNT_CInterPro annotationAdd BLAST165

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the AlaDH/PNT family.ARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QQ0A, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000004624

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003376_1_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
MSNAFTF

Database of Orthologous Groups

More...
OrthoDBi
220278at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5BJZ3

TreeFam database of animal gene trees

More...
TreeFami
TF300636

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008143, Ala_DH/PNT_CS2
IPR008142, AlaDH/PNT_CS1
IPR007886, AlaDH/PNT_N
IPR007698, AlaDH/PNT_NAD(H)-bd
IPR029035, DHS-like_NAD/FAD-binding_dom
IPR036291, NAD(P)-bd_dom_sf
IPR026255, NADP_transhyd_a
IPR024605, NADP_transhyd_a_C
IPR034300, PNTB-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01262, AlaDh_PNT_C, 1 hit
PF05222, AlaDh_PNT_N, 1 hit
PF02233, PNTB, 1 hit
PF12769, PNTB_4TM, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01002, AlaDh_PNT_C, 1 hit
SM01003, AlaDh_PNT_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51735, SSF51735, 1 hit
SSF52467, SSF52467, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00561, pntA, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00836, ALADH_PNT_1, 1 hit
PS00837, ALADH_PNT_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5BJZ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHLLKTVVT GCLCPSVSNL GSCKVLPGKK DFLRTFRTHQ ALWCKSPAKP
60 70 80 90 100
GIPYKQLTVG VPKEIFQNEK RVALSPAGVQ ALVKQGFNVV VESGAGEASK
110 120 130 140 150
FPDDLYRAAG AQIQGTKEVL ASDLVVKVRA PMVNPTLGAH EADFLKPSGT
160 170 180 190 200
LISFIYPAQN PDLLNKLSER KTTVLAMDQV PRVTIAQGYD ALSSMANISG
210 220 230 240 250
YKAVVLAANH FGRFFTGQIT AAGKVPPAKI LIVGGGVAGL ASAGAAKSMG
260 270 280 290 300
AVVRGFDTRA AALEQFKSLG AEPLEVDLKE SGEGQGGYAK EMSKEFIEAE
310 320 330 340 350
MKLFAQQCKE VDILISTALI PGKKAPVLFS KEMIESMKEG SVVVDLAAEA
360 370 380 390 400
GGNFETTKPG ELYVHKGITH IGYTDLPSRM ATQASTLYSN NITKLLKAIS
410 420 430 440 450
PDKDNFHFEV KDDFDFGTMS HVIRGTVVMK DGNVIFPAPT PKNIPKEAPA
460 470 480 490 500
KQKTVAELEA EKAGTVSMYT KTLRTASVYS AGLTGMLGLG IVAPNLAFSQ
510 520 530 540 550
MVTTFGLAGI IGYHTVWGVT PALHSPLMSV TNAISGLTAV GGLALMGGHF
560 570 580 590 600
YPSTTSQSLA ALATFISSVN IAGGFLVTQR MLDMFKRPTD PPEYNYLYLL
610 620 630 640 650
PGGTFVGGYL AALYGGYNIE EIMYLGSGLC CVGALGGLST QGTARLGNAL
660 670 680 690 700
GMIGVAGGLA ATLGGLKPDP QLLAQMSGAM AMGGTIGLAI AKRIQISDLP
710 720 730 740 750
QLVAAFHSLV GLAAVLTCMA EYIVEYPHFA MDATSNFTKI VAYIGTYIGG
760 770 780 790 800
VTFSGSLVAY GKLQGILKSA PLLLPGRHAL NAGLLAASVG GIIPFMADPS
810 820 830 840 850
FTTGIMCLGS VSALSTLMGV TLTAAIGGAD MPVVITVLNS YSGWALCAEG
860 870 880 890 900
FLLNNNLLTI VGALIGSSGA ILSYIMCVAM NRSLANVILG GYGTTSTAGG
910 920 930 940 950
KPMEISGTHT EINLDNAVEM IREANSIVIT PGYGLCAAKA QYPIADLVKM
960 970 980 990 1000
LTEQGKKVRF GIHPVAGRMP GQLNVLLAEA GVPYDIVLEM DEINSDFPDT
1010 1020 1030 1040 1050
DLVLVIGAND TVNSAAQEDP NSIIAGMPVL EVWKSKQVIV MKRSLGVGYA
1060 1070 1080
AVDNPIFYKP NTAMLLGDAK KTCDALQAKV RESYQK
Length:1,086
Mass (Da):113,869
Last modified:April 12, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBFBD8AF1F5502B84
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07008294 Genomic DNA No translation available.
AABR07008295 Genomic DNA No translation available.
AABR07008296 Genomic DNA No translation available.
AABR07072708 Genomic DNA No translation available.
AC098186 Genomic DNA No translation available.
BC091271 mRNA Translation: AAH91271.1

NCBI Reference Sequences

More...
RefSeqi
NP_001013175.1, NM_001013157.1
XP_006232030.1, XM_006231968.3
XP_006232031.1, XM_006231969.3
XP_006232032.1, XM_006231970.3
XP_006232033.1, XM_006231971.3
XP_006232034.1, XM_006231972.3
XP_008758996.1, XM_008760774.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000033627; ENSRNOP00000029578; ENSRNOG00000026842

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
310378

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:310378

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07008294 Genomic DNA No translation available.
AABR07008295 Genomic DNA No translation available.
AABR07008296 Genomic DNA No translation available.
AABR07072708 Genomic DNA No translation available.
AC098186 Genomic DNA No translation available.
BC091271 mRNA Translation: AAH91271.1
RefSeqiNP_001013175.1, NM_001013157.1
XP_006232030.1, XM_006231968.3
XP_006232031.1, XM_006231969.3
XP_006232032.1, XM_006231970.3
XP_006232033.1, XM_006231971.3
XP_006232034.1, XM_006231972.3
XP_008758996.1, XM_008760774.1

3D structure databases

SMRiQ5BJZ3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000029578

PTM databases

PhosphoSitePlusiQ5BJZ3
SwissPalmiQ5BJZ3

Proteomic databases

PRIDEiQ5BJZ3

Genome annotation databases

EnsembliENSRNOT00000033627; ENSRNOP00000029578; ENSRNOG00000026842
GeneIDi310378
KEGGirno:310378

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23530
RGDi1587346, Nnt

Phylogenomic databases

eggNOGiENOG502QQ0A, Eukaryota
GeneTreeiENSGT00390000004624
HOGENOMiCLU_003376_1_0_1
OMAiMSNAFTF
OrthoDBi220278at2759
PhylomeDBiQ5BJZ3
TreeFamiTF300636

Enzyme and pathway databases

ReactomeiR-RNO-71403, Citric acid cycle (TCA cycle)

Gene expression databases

BgeeiENSRNOG00000026842, Expressed in heart and 20 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR008143, Ala_DH/PNT_CS2
IPR008142, AlaDH/PNT_CS1
IPR007886, AlaDH/PNT_N
IPR007698, AlaDH/PNT_NAD(H)-bd
IPR029035, DHS-like_NAD/FAD-binding_dom
IPR036291, NAD(P)-bd_dom_sf
IPR026255, NADP_transhyd_a
IPR024605, NADP_transhyd_a_C
IPR034300, PNTB-like
PfamiView protein in Pfam
PF01262, AlaDh_PNT_C, 1 hit
PF05222, AlaDh_PNT_N, 1 hit
PF02233, PNTB, 1 hit
PF12769, PNTB_4TM, 1 hit
SMARTiView protein in SMART
SM01002, AlaDh_PNT_C, 1 hit
SM01003, AlaDh_PNT_N, 1 hit
SUPFAMiSSF51735, SSF51735, 1 hit
SSF52467, SSF52467, 1 hit
TIGRFAMsiTIGR00561, pntA, 1 hit
PROSITEiView protein in PROSITE
PS00836, ALADH_PNT_1, 1 hit
PS00837, ALADH_PNT_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ5BJZ3_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5BJZ3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 12, 2005
Last sequence update: April 12, 2005
Last modified: September 29, 2021
This is version 127 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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