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UniProtKB - Q5BJU6 (CRBL2_RAT)
Protein
cAMP-responsive element-binding protein-like 2
Gene
Crebl2
Organism
Rattus norvegicus (Rat)
Status
Functioni
Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle (By similarity).
By similarityGO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity Source: InterPro
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- positive regulation of fat cell differentiation Source: UniProtKB
- positive regulation of glucose import Source: UniProtKB
- positive regulation of lipid biosynthetic process Source: UniProtKB
- positive regulation of peptidyl-serine phosphorylation Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- protein stabilization Source: UniProtKB
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Differentiation, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: cAMP-responsive element-binding protein-like 2 |
Gene namesi | Name:Crebl2 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1309502, Crebl2 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000318194 | 1 – 123 | cAMP-responsive element-binding protein-like 2Add BLAST | 123 |
Post-translational modificationi
Phosphorylated by AMPK.By similarity
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q5BJU6 |
Interactioni
Subunit structurei
Interacts with CREB1; regulates CREB1 phosphorylation, stability and transcriptional activity.
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000009324 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 86 | bZIPAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 24 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 29 – 60 | Basic motifBy similarityAdd BLAST | 32 | |
Regioni | 62 – 69 | Leucine-zipperBy similarity | 8 | |
Regioni | 93 – 123 | DisorderedSequence analysisAdd BLAST | 31 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4515, Eukaryota |
InParanoidi | Q5BJU6 |
OrthoDBi | 1551209at2759 |
PhylomeDBi | Q5BJU6 |
TreeFami | TF323305 |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR046347, bZIP_sf IPR039250, CREBL2/REPTOR-BP |
PANTHERi | PTHR21051, PTHR21051, 1 hit |
Pfami | View protein in Pfam PF07716, bZIP_2, 1 hit |
SUPFAMi | SSF57959, SSF57959, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q5BJU6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDDSKVVGGK VKKPGKRGRK PAKIDLKAKL ERSRQSAREC RARKKLRYQY
60 70 80 90 100
LEELVSSRER AICALREELE MYKQWCMAMD QGKIPSEIRA LLTGEEQNKS
110 120
QQNSSRHPKA GKTDANTNSL VGN
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MXV0 | A0A0A0MXV0_RAT | cAMP-responsive element-binding pro... | Crebl2 | 132 | Annotation score: | ||
A0A8I6ANJ8 | A0A8I6ANJ8_RAT | cAMP responsive element binding pro... | Crebl2 rCG_29896 | 84 | Annotation score: | ||
A0A8I6AC58 | A0A8I6AC58_RAT | cAMP-responsive element-binding pro... | Crebl2 | 121 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC091323 mRNA Translation: AAH91323.1 |
RefSeqi | NP_001015027.1, NM_001015027.1 |
Genome annotation databases
Ensembli | ENSRNOT00000119142; ENSRNOP00000094879; ENSRNOG00000067300 |
GeneIDi | 362453 |
KEGGi | rno:362453 |
UCSCi | RGD:1309502, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC091323 mRNA Translation: AAH91323.1 |
RefSeqi | NP_001015027.1, NM_001015027.1 |
3D structure databases
AlphaFoldDBi | Q5BJU6 |
SMRi | Q5BJU6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000009324 |
Proteomic databases
PaxDbi | Q5BJU6 |
Genome annotation databases
Ensembli | ENSRNOT00000119142; ENSRNOP00000094879; ENSRNOG00000067300 |
GeneIDi | 362453 |
KEGGi | rno:362453 |
UCSCi | RGD:1309502, rat |
Organism-specific databases
CTDi | 1389 |
RGDi | 1309502, Crebl2 |
Phylogenomic databases
eggNOGi | KOG4515, Eukaryota |
InParanoidi | Q5BJU6 |
OrthoDBi | 1551209at2759 |
PhylomeDBi | Q5BJU6 |
TreeFami | TF323305 |
Miscellaneous databases
PROi | PR:Q5BJU6 |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR046347, bZIP_sf IPR039250, CREBL2/REPTOR-BP |
PANTHERi | PTHR21051, PTHR21051, 1 hit |
Pfami | View protein in Pfam PF07716, bZIP_2, 1 hit |
SUPFAMi | SSF57959, SSF57959, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CRBL2_RAT | |
Accessioni | Q5BJU6Primary (citable) accession number: Q5BJU6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | April 12, 2005 | |
Last modified: | May 25, 2022 | |
This is version 87 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families