Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

cAMP-responsive element-binding protein-like 2

Gene

Crebl2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processDifferentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-responsive element-binding protein-like 2
Gene namesi
Name:Crebl2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1309502 Crebl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003181941 – 123cAMP-responsive element-binding protein-like 2Add BLAST123

Post-translational modificationi

Phosphorylated by AMPK.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5BJU6

Interactioni

Subunit structurei

Interacts with CREB1; regulates CREB1 phosphorylation, stability and transcriptional activity.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009324

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 86bZIPAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 60Basic motifBy similarityAdd BLAST32
Regioni62 – 69Leucine-zipperBy similarity8

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Curated

Phylogenomic databases

eggNOGiENOG410J0Q3 Eukaryota
ENOG4111T4Y LUCA
HOGENOMiHOG000111966
HOVERGENiHBG107761
InParanoidiQ5BJU6
PhylomeDBiQ5BJU6
TreeFamiTF323305

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR039250 CREBL2
PANTHERiPTHR21051 PTHR21051, 1 hit
PfamiView protein in Pfam
PF07716 bZIP_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q5BJU6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDDSKVVGGK VKKPGKRGRK PAKIDLKAKL ERSRQSAREC RARKKLRYQY
60 70 80 90 100
LEELVSSRER AICALREELE MYKQWCMAMD QGKIPSEIRA LLTGEEQNKS
110 120
QQNSSRHPKA GKTDANTNSL VGN
Length:123
Mass (Da):14,019
Last modified:April 12, 2005 - v1
Checksum:iF1978A47A582D62C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JYS9A0A0G2JYS9_RAT
cAMP-responsive element-binding pro...
Crebl2
129Annotation score:
A0A0A0MXV0A0A0A0MXV0_RAT
cAMP-responsive element-binding pro...
Crebl2
121Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091323 mRNA Translation: AAH91323.1
RefSeqiNP_001015027.1, NM_001015027.1
UniGeneiRn.107553

Genome annotation databases

GeneIDi362453
KEGGirno:362453
UCSCiRGD:1309502 rat

Similar proteinsi

Entry informationi

Entry nameiCRBL2_RAT
AccessioniPrimary (citable) accession number: Q5BJU6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: April 12, 2005
Last modified: September 12, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again