Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GTP-binding protein Rit2

Gene

Rit2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds and exchanges GTP and GDP.By similarity

Miscellaneous

Shows rapid uncatalyzed guanine nucleotide dissociation rates, which are much faster than those of most Ras subfamily members.By similarity

Activity regulationi

Alternates between an inactive form bound to GDP and an active form bound to GTP.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi27 – 34GTPBy similarity8
Nucleotide bindingi74 – 78GTPBy similarity5
Nucleotide bindingi133 – 136GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein Rit2
Gene namesi
Name:Rit2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 18

Organism-specific databases

RGDi1307654 Rit2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002332611 – 217GTP-binding protein Rit2Add BLAST217

Proteomic databases

PaxDbiQ5BJQ5
PRIDEiQ5BJQ5

Expressioni

Gene expression databases

BgeeiENSRNOG00000017568 Expressed in 6 organ(s), highest expression level in brain
GenevisibleiQ5BJQ5 RN

Interactioni

Subunit structurei

Interacts with AFDN, the C-terminal domain of RALGDS and RLF, but not with RIN1 and PIK3CA. RLF binds exclusively to the active GTP-bound form. Binds calmodulin. Interacts with PLXNB3 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
SLC6A3Q019592EBI-11686902,EBI-6661445From Homo sapiens.

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ5BJQ5, 2 interactors
STRINGi10116.ENSRNOP00000023871

Structurei

3D structure databases

ProteinModelPortaliQ5BJQ5
SMRiQ5BJQ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133678
HOGENOMiHOG000233973
HOVERGENiHBG009351
InParanoidiQ5BJQ5
KOiK07833
OMAiRFLDYHD
OrthoDBiEOG091G0UAU
PhylomeDBiQ5BJQ5
TreeFamiTF315072

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequencei

Sequence statusi: Complete.

Q5BJQ5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAENEAHCC PGSSSGGSRE YKVVMLGAGG VGKSAVTMQF ISHQFPDYHD
60 70 80 90 100
PTIEDAYKTQ VRIDNEPAYL DILDTAGQAE FTAMREQYMR GGEGFIICYS
110 120 130 140 150
VTDRQSFQEA AKFKELIFQV RHTYEIPLVL VGNKIDLEQF RQVSTEEGMT
160 170 180 190 200
LARDYNCAFF ETSAALRFGI DDAFQGLVRE IRRKESMLSL VERKLKRKDS
210
LWKKIKASLK KKRENMI
Length:217
Mass (Da):24,761
Last modified:April 12, 2005 - v1
Checksum:i4D12C7B0D3F46903
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091382 mRNA Translation: AAH91382.1
RefSeqiNP_001013078.1, NM_001013060.1
UniGeneiRn.106719

Genome annotation databases

EnsembliENSRNOT00000023874; ENSRNOP00000023871; ENSRNOG00000017568
GeneIDi291713
KEGGirno:291713
UCSCiRGD:1307654 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC091382 mRNA Translation: AAH91382.1
RefSeqiNP_001013078.1, NM_001013060.1
UniGeneiRn.106719

3D structure databases

ProteinModelPortaliQ5BJQ5
SMRiQ5BJQ5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5BJQ5, 2 interactors
STRINGi10116.ENSRNOP00000023871

Proteomic databases

PaxDbiQ5BJQ5
PRIDEiQ5BJQ5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000023874; ENSRNOP00000023871; ENSRNOG00000017568
GeneIDi291713
KEGGirno:291713
UCSCiRGD:1307654 rat

Organism-specific databases

CTDi6014
RGDi1307654 Rit2

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133678
HOGENOMiHOG000233973
HOVERGENiHBG009351
InParanoidiQ5BJQ5
KOiK07833
OMAiRFLDYHD
OrthoDBiEOG091G0UAU
PhylomeDBiQ5BJQ5
TreeFamiTF315072

Miscellaneous databases

PROiPR:Q5BJQ5

Gene expression databases

BgeeiENSRNOG00000017568 Expressed in 6 organ(s), highest expression level in brain
GenevisibleiQ5BJQ5 RN

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRIT2_RAT
AccessioniPrimary (citable) accession number: Q5BJQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: April 12, 2005
Last modified: September 12, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again