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Entry version 97 (31 Jul 2019)
Sequence version 2 (28 Mar 2018)
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Protein

Transmembrane protein 128

Gene

TMEM128

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.B.202.1.1 the 4 tms tmem128 (tmem128) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 128
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM128
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28201 TMEM128

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q5BJH2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Transmembranei144 – 164HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000132406

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485648

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM128

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74736022

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002545561 – 165Transmembrane protein 128Add BLAST165

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5BJH2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5BJH2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5BJH2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5BJH2

PeptideAtlas

More...
PeptideAtlasi
Q5BJH2

PRoteomics IDEntifications database

More...
PRIDEi
Q5BJH2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
12769
62691 [Q5BJH2-1]
62692 [Q5BJH2-2]

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000132406 Expressed in 206 organ(s), highest expression level in oocyte

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5BJH2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA044809

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124428, 25 interactors

Protein interaction database and analysis system

More...
IntActi
Q5BJH2, 55 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000372201

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IXAQ Eukaryota
ENOG4111NF2 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000012901

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000060333

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5BJH2

Identification of Orthologs from Complete Genome Data

More...
OMAi
CFNVALW

Database of Orthologous Groups

More...
OrthoDBi
1309550at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5BJH2

TreeFam database of animal gene trees

More...
TreeFami
TF328406

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033579 TMEM128

The PANTHER Classification System

More...
PANTHERi
PTHR31134 PTHR31134, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5BJH2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSSRARQQL RRRFLLLPDA EAQLDREGDA GPETSTAVEK KEKPLPRLNI
60 70 80 90 100
HSGFWILASI VVTYYVDFFK TLKENFHTSS WFLCGSALLL VSLSIAFYCI
110 120 130 140 150
VYLEWYCGIG EYDVKYPALI PITTASFIAA GICFNIALWH VWSFFTPLLL
160
FTQFMGVVMF ITLLG
Length:165
Mass (Da):18,822
Last modified:March 28, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC1A4890B243C7AEF
GO
Isoform 2 (identifier: Q5BJH2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: MDSSRARQQLRRRFLLLPDAEAQLDREGDAGP → MPPFGYKT

Note: No experimental confirmation available.
Show »
Length:141
Mass (Da):16,093
Checksum:iDFC33A6E528E3DC4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti43K → E in CAI45928 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08019016L → I2 PublicationsCorresponds to variant dbSNP:rs6854167Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0212291 – 32MDSSR…GDAGP → MPPFGYKT in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK295248 mRNA Translation: BAG58239.1
CR933611 mRNA Translation: CAI45928.1
AC011744 Genomic DNA No translation available.
CH471131 Genomic DNA Translation: EAW82440.1
CH471131 Genomic DNA Translation: EAW82441.1
CH471131 Genomic DNA Translation: EAW82442.1
CH471131 Genomic DNA Translation: EAW82443.1
CH471131 Genomic DNA Translation: EAW82444.1
BC007729 mRNA Translation: AAH07729.1
BC091482 mRNA Translation: AAH91482.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3373.1 [Q5BJH2-2]
CCDS75099.1 [Q5BJH2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001284480.1, NM_001297551.1 [Q5BJH2-1]
NP_001284481.1, NM_001297552.1 [Q5BJH2-1]
NP_116316.1, NM_032927.3 [Q5BJH2-2]
XP_005248091.1, XM_005248034.2 [Q5BJH2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000254742; ENSP00000254742; ENSG00000132406 [Q5BJH2-2]
ENST00000382753; ENSP00000372201; ENSG00000132406 [Q5BJH2-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
85013

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:85013

UCSC genome browser

More...
UCSCi
uc003ghq.2 human [Q5BJH2-1]
uc003ghr.2 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295248 mRNA Translation: BAG58239.1
CR933611 mRNA Translation: CAI45928.1
AC011744 Genomic DNA No translation available.
CH471131 Genomic DNA Translation: EAW82440.1
CH471131 Genomic DNA Translation: EAW82441.1
CH471131 Genomic DNA Translation: EAW82442.1
CH471131 Genomic DNA Translation: EAW82443.1
CH471131 Genomic DNA Translation: EAW82444.1
BC007729 mRNA Translation: AAH07729.1
BC091482 mRNA Translation: AAH91482.1
CCDSiCCDS3373.1 [Q5BJH2-2]
CCDS75099.1 [Q5BJH2-1]
RefSeqiNP_001284480.1, NM_001297551.1 [Q5BJH2-1]
NP_001284481.1, NM_001297552.1 [Q5BJH2-1]
NP_116316.1, NM_032927.3 [Q5BJH2-2]
XP_005248091.1, XM_005248034.2 [Q5BJH2-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi124428, 25 interactors
IntActiQ5BJH2, 55 interactors
STRINGi9606.ENSP00000372201

Protein family/group databases

TCDBi9.B.202.1.1 the 4 tms tmem128 (tmem128) family

Polymorphism and mutation databases

BioMutaiTMEM128
DMDMi74736022

Proteomic databases

EPDiQ5BJH2
jPOSTiQ5BJH2
MaxQBiQ5BJH2
PaxDbiQ5BJH2
PeptideAtlasiQ5BJH2
PRIDEiQ5BJH2
ProteomicsDBi12769
62691 [Q5BJH2-1]
62692 [Q5BJH2-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254742; ENSP00000254742; ENSG00000132406 [Q5BJH2-2]
ENST00000382753; ENSP00000372201; ENSG00000132406 [Q5BJH2-1]
GeneIDi85013
KEGGihsa:85013
UCSCiuc003ghq.2 human [Q5BJH2-1]
uc003ghr.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
85013

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TMEM128
HGNCiHGNC:28201 TMEM128
HPAiHPA044809
neXtProtiNX_Q5BJH2
OpenTargetsiENSG00000132406
PharmGKBiPA143485648

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IXAQ Eukaryota
ENOG4111NF2 LUCA
GeneTreeiENSGT00390000012901
HOGENOMiHOG000060333
InParanoidiQ5BJH2
OMAiCFNVALW
OrthoDBi1309550at2759
PhylomeDBiQ5BJH2
TreeFamiTF328406

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TMEM128 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
85013

Protein Ontology

More...
PROi
PR:Q5BJH2

Gene expression databases

BgeeiENSG00000132406 Expressed in 206 organ(s), highest expression level in oocyte
GenevisibleiQ5BJH2 HS

Family and domain databases

InterProiView protein in InterPro
IPR033579 TMEM128
PANTHERiPTHR31134 PTHR31134, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM128_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5BJH2
Secondary accession number(s): B4DHS7
, D3DVS1, D3DVS3, Q5H9U6, Q96I94
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 28, 2018
Last modified: July 31, 2019
This is version 97 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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