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Protein

Sigma intracellular receptor 2

Gene

TMEM97

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cancer cells (PubMed:28559337). Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation (PubMed:23922215, PubMed:25620095). Under investigation for its potential diagnostic and therapeutic uses (PubMed:23922215, PubMed:25620095). May play a role as a regulator of cellular cholesterol homeostasis (PubMed:19583955). May function as sterol isomerase (PubMed:25566323). May alter the activity of some cytochrome P450 proteins (PubMed:22292588).3 Publications1 Publication2 Publications

Miscellaneous

Sigma receptors are classified into two subtypes (Sigma-1 and Sigma-2) based on their different pharmacological profile. Sigma-2 receptors are identified by radioligand-binding studies as a binding site with high affinity for di-o-tolylguanidine (DTG) and haloperidol.1 Publication
Potentially useful for cancer diagnostics or as target for anticancer therapeutics or adjuvant anticancer treatment agents (PubMed:23922215). Some exogenous ligands display a neuroprotective effect (PubMed:25620095).2 Publications

Caution

The molecular identity of the sigma-2 receptor has been unclear for a long time. It is now identified as TMEM97 (PubMed:28559337). Previously identified as PGRMC1 (AC O00264) (PubMed:22292588, PubMed:28007569).1 Publication2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • cholesterol homeostasis Source: UniProtKB
  • regulation of cell growth Source: UniProtKB

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.93.1.1 the sigma2 receptor or tmem97 (s2r) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sigma intracellular receptor 2Curated
Short name:
Sigma-2 receptor1 Publication
Short name:
Sigma2 receptor1 Publication
Alternative name(s):
Meningioma-associated protein 301 Publication
Transmembrane protein 97Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM97Imported
Synonyms:MAC301 Publication, S2R1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000109084.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28106 TMEM97

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612912 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5BJF2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 9CytoplasmicSequence analysis9
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei10 – 30Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini31 – 68ExtracellularSequence analysisAdd BLAST38
Transmembranei69 – 89Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini90 – 99CytoplasmicSequence analysis10
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 140ExtracellularSequence analysisAdd BLAST20
Transmembranei141 – 161Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini162 – 176CytoplasmicSequence analysisAdd BLAST15

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi11E → Q: Decreases DTG binding. 1 Publication1
Mutagenesisi29D → N: Abolishes DTG binding. 1 Publication1
Mutagenesisi37E → Q: No effect on DTG binding. 1 Publication1
Mutagenesisi42E → Q: No effect on DTG binding. 1 Publication1
Mutagenesisi53E → Q: No effect on DTG binding. 1 Publication1
Mutagenesisi56D → N: Abolishes DTG binding. 1 Publication1
Mutagenesisi61E → Q: No effect on DTG binding. 1 Publication1
Mutagenesisi73E → Q: No effect on DTG binding. 1 Publication1
Mutagenesisi121E → Q: No effect on DTG binding. 1 Publication1
Mutagenesisi122D → N: Decreases DTG binding. 1 Publication1
Mutagenesisi135E → Q: Decreases DTG binding. 1 Publication1
Mutagenesisi139E → Q: Decreases DTG binding. 1 Publication1
Mutagenesisi170E → Q: Decreases DTG binding. 1 Publication1
Mutagenesisi171E → Q: Decreases DTG binding. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
27346

Open Targets

More...
OpenTargetsi
ENSG00000109084

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485635

Chemistry databases

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2553

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM97

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74736009

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002545671 – 176Sigma intracellular receptor 2Add BLAST176

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5BJF2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5BJF2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5BJF2

PeptideAtlas

More...
PeptideAtlasi
Q5BJF2

PRoteomics IDEntifications database

More...
PRIDEi
Q5BJF2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
62679

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q5BJF2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5BJF2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5BJF2

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q5BJF2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed in normal tissues. Expressed in pancreatic, renal, breast, colon, ovarian surface epithelial (OSE) cells. Highly expressed in various proliferating cancer cells (PubMed:23922215).1 Publication3 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in ovarian surface epithelial (OSE) cells with progesterone.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000109084 Expressed in 220 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_TMEM97

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5BJF2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5BJF2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA044795

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NPC1.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
118158, 14 interactors

Protein interaction database and analysis system

More...
IntActi
Q5BJF2, 53 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000226230

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q5BJF2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini10 – 158EXPERAPROSITE-ProRule annotationAdd BLAST149

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM97/sigma-2 receptor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IX1Z Eukaryota
ENOG4111RR6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007149

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000031140

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG079913

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5BJF2

Identification of Orthologs from Complete Genome Data

More...
OMAi
MLRNPYY

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0P5K

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5BJF2

TreeFam database of animal gene trees

More...
TreeFami
TF300241

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033118 EXPERA
IPR016964 Sigma2_recept

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF031032 TMP_97_prd, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51751 EXPERA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q5BJF2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAPATRRCV EWLLGLYFLS HIPITLFMDL QAVLPRELYP VEFRNLLKWY
60 70 80 90 100
AKEFKDPLLQ EPPAWFKSFL FCELVFQLPF FPIATYAFLK GSCKWIRTPA
110 120 130 140 150
IIYSVHTMTT LIPILSTFLF EDFSKASGFK GQRPETLHER LTLVSVYAPY
160 170
LLIPFILLIF MLRSPYYKYE EKRKKK
Length:176
Mass (Da):20,848
Last modified:April 12, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i685248D421877F84
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KTD1J3KTD1_HUMAN
Sigma intracellular receptor 2
TMEM97
118Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q86XC5Q86XC5_HUMAN
Sigma intracellular receptor 2
TMEM97
69Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KT68J3KT68_HUMAN
Sigma intracellular receptor 2
TMEM97
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA16188 differs from that shown. Reason: Frameshift at position 5.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti5A → S in AAA16188 (PubMed:7694637).Curated1
Sequence conflicti34L → V in AAA16188 (PubMed:7694637).Curated1
Sequence conflicti113P → L in AAA16188 (PubMed:7694637).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L19183 mRNA Translation: AAA16188.1 Frameshift.
AK299511 mRNA Translation: BAG61464.1
AC002094 Genomic DNA No translation available.
BC091504 mRNA Translation: AAH91504.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11226.2

Protein sequence database of the Protein Information Resource

More...
PIRi
I65744

NCBI Reference Sequences

More...
RefSeqi
NP_055388.2, NM_014573.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.199695

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000226230; ENSP00000226230; ENSG00000109084

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
27346

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:27346

UCSC genome browser

More...
UCSCi
uc002hat.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19183 mRNA Translation: AAA16188.1 Frameshift.
AK299511 mRNA Translation: BAG61464.1
AC002094 Genomic DNA No translation available.
BC091504 mRNA Translation: AAH91504.1
CCDSiCCDS11226.2
PIRiI65744
RefSeqiNP_055388.2, NM_014573.2
UniGeneiHs.199695

3D structure databases

ProteinModelPortaliQ5BJF2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118158, 14 interactors
IntActiQ5BJF2, 53 interactors
STRINGi9606.ENSP00000226230

Chemistry databases

GuidetoPHARMACOLOGYi2553

Protein family/group databases

TCDBi8.A.93.1.1 the sigma2 receptor or tmem97 (s2r) family

PTM databases

iPTMnetiQ5BJF2
PhosphoSitePlusiQ5BJF2
SwissPalmiQ5BJF2

Polymorphism and mutation databases

BioMutaiTMEM97
DMDMi74736009

Proteomic databases

EPDiQ5BJF2
MaxQBiQ5BJF2
PaxDbiQ5BJF2
PeptideAtlasiQ5BJF2
PRIDEiQ5BJF2
ProteomicsDBi62679
TopDownProteomicsiQ5BJF2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000226230; ENSP00000226230; ENSG00000109084
GeneIDi27346
KEGGihsa:27346
UCSCiuc002hat.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
27346
DisGeNETi27346
EuPathDBiHostDB:ENSG00000109084.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TMEM97
HGNCiHGNC:28106 TMEM97
HPAiHPA044795
MIMi612912 gene
neXtProtiNX_Q5BJF2
OpenTargetsiENSG00000109084
PharmGKBiPA143485635

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IX1Z Eukaryota
ENOG4111RR6 LUCA
GeneTreeiENSGT00390000007149
HOGENOMiHOG000031140
HOVERGENiHBG079913
InParanoidiQ5BJF2
OMAiMLRNPYY
OrthoDBiEOG091G0P5K
PhylomeDBiQ5BJF2
TreeFamiTF300241

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TMEM97 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
27346

Protein Ontology

More...
PROi
PR:Q5BJF2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000109084 Expressed in 220 organ(s), highest expression level in testis
CleanExiHS_TMEM97
ExpressionAtlasiQ5BJF2 baseline and differential
GenevisibleiQ5BJF2 HS

Family and domain databases

InterProiView protein in InterPro
IPR033118 EXPERA
IPR016964 Sigma2_recept
PIRSFiPIRSF031032 TMP_97_prd, 1 hit
PROSITEiView protein in PROSITE
PS51751 EXPERA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSGMR2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5BJF2
Secondary accession number(s): B4DS02, Q07823
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: April 12, 2005
Last modified: November 7, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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