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Protein

F-box/LRR-repeat protein 7

Gene

Fbxl7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • cell proliferation Source: UniProtKB
  • G2/M transition of mitotic cell cycle Source: UniProtKB
  • mitotic cell cycle Source: UniProtKB
  • protein ubiquitination Source: UniProtKB
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB

Keywordsi

Biological processCell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayi
UPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/LRR-repeat protein 7
Alternative name(s):
F-box and leucine-rich repeat protein 7
Gene namesi
Name:Fbxl7
Synonyms:Kiaa0840
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:3052506 Fbxl7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003077201 – 491F-box/LRR-repeat protein 7Add BLAST491

Proteomic databases

MaxQBiQ5BJ29
PaxDbiQ5BJ29
PeptideAtlasiQ5BJ29
PRIDEiQ5BJ29

PTM databases

iPTMnetiQ5BJ29
PhosphoSitePlusiQ5BJ29

Expressioni

Gene expression databases

BgeeiENSMUSG00000043556 Expressed in 34 organ(s), highest expression level in thymus
CleanExiMM_FBXL7
GenevisibleiQ5BJ29 MM

Interactioni

Subunit structurei

Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complex SCF(FBXL7) composed of CUL1, SKP1, RBX1 and FBXL7. Interacts with AURKA; interaction takes place during mitosis but not in interphase.1 Publication

Protein-protein interaction databases

BioGridi243078, 2 interactors
IntActiQ5BJ29, 1 interactor
STRINGi10090.ENSMUSP00000061305

Structurei

3D structure databases

ProteinModelPortaliQ5BJ29
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini111 – 157F-boxPROSITE-ProRule annotationAdd BLAST47
Repeati185 – 210LRR 1Add BLAST26
Repeati211 – 236LRR 2Add BLAST26
Repeati237 – 262LRR 3Add BLAST26
Repeati271 – 296LRR 4Add BLAST26
Repeati297 – 322LRR 5Add BLAST26
Repeati323 – 348LRR 6Add BLAST26
Repeati349 – 374LRR 7Add BLAST26
Repeati375 – 400LRR 8Add BLAST26
Repeati401 – 426LRR 9Add BLAST26
Repeati427 – 452LRR 10Add BLAST26

Sequence similaritiesi

Belongs to the FBXL7 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IT22 Eukaryota
ENOG410YA1Y LUCA
GeneTreeiENSGT00760000119059
HOGENOMiHOG000116328
HOVERGENiHBG051591
InParanoidiQ5BJ29
KOiK10273
OMAiLMLETVI
OrthoDBiEOG091G06QE
PhylomeDBiQ5BJ29
TreeFamiTF313434

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR001611 Leu-rich_rpt
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF13516 LRR_6, 5 hits
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SM00367 LRR_CC, 10 hits
SUPFAMiSSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit

Sequencei

Sequence statusi: Complete.

Q5BJ29-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGANNGKQYG SEGKGSSSVS SDVSSSTDHT PTKAQRNVAT SEDSDLSMRT
60 70 80 90 100
LSTPSPALIC PPTLPGFQNG RGSSTSSSSI TGETVAMVHS PPPTRLTHPL
110 120 130 140 150
IRLASRPQKE QASIDRLPDH SMVQIFSFLP TNQLCRCARV CRRWYNLAWD
160 170 180 190 200
PRLWRTIRLT GETINVDRAL KVLTRRLCQD TPNVCLMLET VIVSGCRRLT
210 220 230 240 250
DRGLYTIAQC CPELRRLEVS GCYNISNEAV FDVVSLCPNL EHLDVSGCSK
260 270 280 290 300
VTCISLTREA SIKLSPLHGK QISIRYLDMT DCFVLEDEGL HTIAAHCTQL
310 320 330 340 350
THLYLRRCVR LTDEGLRYLV IYCTSIKELS VSDCRFVSDF GLREIAKLES
360 370 380 390 400
RLRYLSIAHC GRITDVGIRY VAKYCSKLRY LNARGCEGIT DHGVEYLAKN
410 420 430 440 450
CTKLKSLDIG KCPLVSDTGL ESLALNCFNL KRLSLKSCES ITGQGLQIVA
460 470 480 490
ANCFDLQMLN VQDCEVSVEA LRFVKRHCKR CVIEHTNPAF F
Length:491
Mass (Da):54,646
Last modified:April 12, 2005 - v1
Checksum:i52EC5B2A00EDC1E6
GO

Sequence cautioni

The sequence BAC98037 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129227 mRNA Translation: BAC98037.1 Different initiation.
BC091646 mRNA Translation: AAH91646.1
CCDSiCCDS37052.1
RefSeqiNP_795933.2, NM_176959.3
UniGeneiMm.253378

Genome annotation databases

EnsembliENSMUST00000059204; ENSMUSP00000061305; ENSMUSG00000043556
GeneIDi448987
KEGGimmu:448987
UCSCiuc007vjn.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129227 mRNA Translation: BAC98037.1 Different initiation.
BC091646 mRNA Translation: AAH91646.1
CCDSiCCDS37052.1
RefSeqiNP_795933.2, NM_176959.3
UniGeneiMm.253378

3D structure databases

ProteinModelPortaliQ5BJ29
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi243078, 2 interactors
IntActiQ5BJ29, 1 interactor
STRINGi10090.ENSMUSP00000061305

PTM databases

iPTMnetiQ5BJ29
PhosphoSitePlusiQ5BJ29

Proteomic databases

MaxQBiQ5BJ29
PaxDbiQ5BJ29
PeptideAtlasiQ5BJ29
PRIDEiQ5BJ29

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059204; ENSMUSP00000061305; ENSMUSG00000043556
GeneIDi448987
KEGGimmu:448987
UCSCiuc007vjn.1 mouse

Organism-specific databases

CTDi23194
MGIiMGI:3052506 Fbxl7
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IT22 Eukaryota
ENOG410YA1Y LUCA
GeneTreeiENSGT00760000119059
HOGENOMiHOG000116328
HOVERGENiHBG051591
InParanoidiQ5BJ29
KOiK10273
OMAiLMLETVI
OrthoDBiEOG091G06QE
PhylomeDBiQ5BJ29
TreeFamiTF313434

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-MMU-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-MMU-8951664 Neddylation
R-MMU-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

PROiPR:Q5BJ29
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043556 Expressed in 34 organ(s), highest expression level in thymus
CleanExiMM_FBXL7
GenevisibleiQ5BJ29 MM

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR001611 Leu-rich_rpt
IPR006553 Leu-rich_rpt_Cys-con_subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF13516 LRR_6, 5 hits
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SM00367 LRR_CC, 10 hits
SUPFAMiSSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFBXL7_MOUSE
AccessioniPrimary (citable) accession number: Q5BJ29
Secondary accession number(s): Q6ZQ36
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: April 12, 2005
Last modified: September 12, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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