UniProtKB - Q5BFH3 (XRN2_EMENI)
Protein
5'-3' exoribonuclease 2
Gene
rat1
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Functioni
Possesses 5'->3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote termination of transcription by RNA polymerase II (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 267 – 284 | CCHC-typePROSITE-ProRule annotationAdd BLAST | 18 |
GO - Molecular functioni
- 5'-3' exoribonuclease activity Source: GO_Central
- RNA binding Source: GO_Central
- rRNA binding Source: EnsemblFungi
- zinc ion binding Source: InterPro
GO - Biological processi
- cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: EnsemblFungi
- mRNA processing Source: UniProtKB-KW
- negative regulation of phosphorylation of RNA polymerase II C-terminal domain Source: EnsemblFungi
- negative regulation of transcription elongation from RNA polymerase II promoter Source: EnsemblFungi
- nuclear mRNA surveillance Source: EnsemblFungi
- nuclear polyadenylation-dependent rRNA catabolic process Source: EnsemblFungi
- nuclear-transcribed mRNA catabolic process Source: GO_Central
- nuclear-transcribed mRNA catabolic process, exonucleolytic, 5'-3' Source: EnsemblFungi
- positive regulation of chromosome segregation Source: EnsemblFungi
- snoRNA processing Source: EnsemblFungi
- termination of RNA polymerase II transcription, exosome-dependent Source: EnsemblFungi
- termination of RNA polymerase II transcription, poly(A)-coupled Source: EnsemblFungi
Keywordsi
Molecular function | Exonuclease, Hydrolase, Nuclease |
Biological process | mRNA processing, rRNA processing, Transcription, Transcription regulation, Transcription termination |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:rat1 ORF Names:AN0707 |
Organismi | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) |
Taxonomic identifieri | 227321 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Aspergillus › Aspergillus subgen. Nidulantes › |
Proteomesi |
|
Subcellular locationi
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000249925 | 2 – 1032 | 5'-3' exoribonuclease 2Add BLAST | 1031 |
Proteomic databases
PRIDEi | Q5BFH3 |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 120 – 152 | Sequence analysisAdd BLAST | 33 | |
Coiled coili | 406 – 442 | Sequence analysisAdd BLAST | 37 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 868 – 1030 | Gly-richAdd BLAST | 163 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 267 – 284 | CCHC-typePROSITE-ProRule annotationAdd BLAST | 18 |
Keywords - Domaini
Coiled coil, Zinc-fingerPhylogenomic databases
eggNOGi | KOG2044, Eukaryota |
HOGENOMi | CLU_006038_1_1_1 |
InParanoidi | Q5BFH3 |
OMAi | GEHFDSN |
OrthoDBi | 685597at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR027073, 5_3_exoribonuclease IPR004859, Put_53exo IPR041412, Xrn1_helical IPR017151, Xrn2/3/4 IPR001878, Znf_CCHC |
PANTHERi | PTHR12341, PTHR12341, 1 hit |
Pfami | View protein in Pfam PF17846, XRN_M, 1 hit PF03159, XRN_N, 1 hit |
PIRSFi | PIRSF037239, Exonuclease_Xrn2, 1 hit |
SMARTi | View protein in SMART SM00343, ZnF_C2HC, 1 hit |
PROSITEi | View protein in PROSITE PS50158, ZF_CCHC, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q5BFH3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGVPALFRWL SKKYPKIISS VIEELPQEVN GEEIPVDITG PNPNGEEMDN
60 70 80 90 100
LYLDMNGIVH PCTHPEGKPP PANEQEMMIE IFKYTDRVVN MVRPRKLLMI
110 120 130 140 150
AVDGVAPRAK MNQQRARRFR SAQEAREQDE KKQEFQRMLA KQNGDKEQML
160 170 180 190 200
QEEVIQKTWD SNVITPGTPF MDILAASLRY WIAYKLNTDP AWEKLKIIIS
210 220 230 240 250
DATVPGEGEH KIMEFIRSQR ASPEHDPNAR HVIYGLDADL IMLGLATHEP
260 270 280 290 300
HFRVLREDVF FQESKQRTCH LCGQPGHKAE ECRGQAKEKN GEFDEKGKGA
310 320 330 340 350
TLKPFIWLHV SILREYLAAE LYVPHQPFPF DLERALDDWV FMCFFVGNDF
360 370 380 390 400
LPHLPSLDIR EDGIDTLIAI WRDNIPLMGG YLTQDGRVDL KKAQLILQGL
410 420 430 440 450
AKQEDAIFRR RRQAEERKLA NEKRRKQEEK ARNEERARKR RRSSPSYDAI
460 470 480 490 500
ESPTHAKPRS AGAAAAPPAG LELITPARGE LARQTRELTH SMVVNRGNVY
510 520 530 540 550
RANMANKSAA AVLKSKLLGG QDGQPSDDGE STAESDAQLD AAGPVLGKRK
560 570 580 590 600
ADEAEVGQLG TETPDKPEPA KADELPPDTV RLWEEGYADR YYEQKFGVDP
610 620 630 640 650
QDKEFRHKVA RAYAEGLAWV LLYYFQGCPS WTWYYPYHYA PFAADFVDIG
660 670 680 690 700
DMELSFEKGT PFKPYEQLMG VLPASSNHAI PKVFHSLMTE PDSEIIDFYP
710 720 730 740 750
EDFPVDLNGK KFAWQGVVLL PFIDEKRLLA AMSKKYPLLT EDEKARNTVG
760 770 780 790 800
RDVLLLSESH PLYQDLVSNF YSKKQGAPKY KLNMRVSDGL AGKVEKNEAY
810 820 830 840 850
IPHSSLVSSL EEYGMPSLED DRSIMVNYEI PKSTNIHKSM LLRGVKFGPP
860 870 880 890 900
ALDNADIQAT KSRAQHSGRS YGGAPFRGGR GGRMNYAGDR QSHGNDRPNP
910 920 930 940 950
FAAHLDPKFM PGANPGAPMG MPSGWVPPSG NFSRGPPPPP RGGTSYGYGS
960 970 980 990 1000
QQYGSYGGYG QQQSYQQSSH SQSDYYGRGP PAPYNNGPAD YYSGRPSGYG
1010 1020 1030
PQESRGGGYN RGGYRGGRDT YSSSGHGGYG RY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AACD01000010 Genomic DNA Translation: EAA65483.1 BN001308 Genomic DNA Translation: CBF88946.1 |
RefSeqi | XP_658311.1, XM_653219.1 |
Genome annotation databases
EnsemblFungii | CBF88946; CBF88946; ANIA_00707 EAA65483; EAA65483; AN0707.2 |
GeneIDi | 2876473 |
KEGGi | ani:AN0707.2 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AACD01000010 Genomic DNA Translation: EAA65483.1 BN001308 Genomic DNA Translation: CBF88946.1 |
RefSeqi | XP_658311.1, XM_653219.1 |
3D structure databases
SMRi | Q5BFH3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 162425.CADANIAP00001962 |
Proteomic databases
PRIDEi | Q5BFH3 |
Genome annotation databases
EnsemblFungii | CBF88946; CBF88946; ANIA_00707 EAA65483; EAA65483; AN0707.2 |
GeneIDi | 2876473 |
KEGGi | ani:AN0707.2 |
Phylogenomic databases
eggNOGi | KOG2044, Eukaryota |
HOGENOMi | CLU_006038_1_1_1 |
InParanoidi | Q5BFH3 |
OMAi | GEHFDSN |
OrthoDBi | 685597at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR027073, 5_3_exoribonuclease IPR004859, Put_53exo IPR041412, Xrn1_helical IPR017151, Xrn2/3/4 IPR001878, Znf_CCHC |
PANTHERi | PTHR12341, PTHR12341, 1 hit |
Pfami | View protein in Pfam PF17846, XRN_M, 1 hit PF03159, XRN_N, 1 hit |
PIRSFi | PIRSF037239, Exonuclease_Xrn2, 1 hit |
SMARTi | View protein in SMART SM00343, ZnF_C2HC, 1 hit |
PROSITEi | View protein in PROSITE PS50158, ZF_CCHC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | XRN2_EMENI | |
Accessioni | Q5BFH3Primary (citable) accession number: Q5BFH3 Secondary accession number(s): C8VRD3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2006 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 88 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families