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UniProtKB - Q5BFH3 (XRN2_EMENI)

Entry version 88 (02 Dec 2020)
Sequence version 3 (23 Jan 2007)
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Protein

5'-3' exoribonuclease 2

Gene

rat1

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Possesses 5'->3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote termination of transcription by RNA polymerase II (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri267 – 284CCHC-typePROSITE-ProRule annotationAdd BLAST18

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionExonuclease, Hydrolase, Nuclease
Biological processmRNA processing, rRNA processing, Transcription, Transcription regulation, Transcription termination
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
5'-3' exoribonuclease 2 (EC:3.1.13.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rat1
ORF Names:AN0707
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri227321 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Aspergillus › Aspergillus subgen. Nidulantes ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000560 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VIII
  • UP000005890 Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002499252 – 10325'-3' exoribonuclease 2Add BLAST1031

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		Q5BFH3

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		162425.CADANIAP00001962

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5BFH3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili120 – 152Sequence analysisAdd BLAST33
Coiled coili406 – 442Sequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi868 – 1030Gly-richAdd BLAST163

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri267 – 284CCHC-typePROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2044, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006038_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5BFH3

Identification of Orthologs from Complete Genome Data

More...OMAi		GEHFDSN

Database of Orthologous Groups

More...OrthoDBi		685597at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027073, 5_3_exoribonuclease
IPR004859, Put_53exo
IPR041412, Xrn1_helical
IPR017151, Xrn2/3/4
IPR001878, Znf_CCHC

The PANTHER Classification System

More...PANTHERi		PTHR12341, PTHR12341, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF17846, XRN_M, 1 hit
PF03159, XRN_N, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF037239, Exonuclease_Xrn2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00343, ZnF_C2HC, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50158, ZF_CCHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q5BFH3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGVPALFRWL SKKYPKIISS VIEELPQEVN GEEIPVDITG PNPNGEEMDN 
        60         70         80         90        100
LYLDMNGIVH PCTHPEGKPP PANEQEMMIE IFKYTDRVVN MVRPRKLLMI 
       110        120        130        140        150
AVDGVAPRAK MNQQRARRFR SAQEAREQDE KKQEFQRMLA KQNGDKEQML 
       160        170        180        190        200
QEEVIQKTWD SNVITPGTPF MDILAASLRY WIAYKLNTDP AWEKLKIIIS 
       210        220        230        240        250
DATVPGEGEH KIMEFIRSQR ASPEHDPNAR HVIYGLDADL IMLGLATHEP 
       260        270        280        290        300
HFRVLREDVF FQESKQRTCH LCGQPGHKAE ECRGQAKEKN GEFDEKGKGA 
       310        320        330        340        350
TLKPFIWLHV SILREYLAAE LYVPHQPFPF DLERALDDWV FMCFFVGNDF 
       360        370        380        390        400
LPHLPSLDIR EDGIDTLIAI WRDNIPLMGG YLTQDGRVDL KKAQLILQGL 
       410        420        430        440        450
AKQEDAIFRR RRQAEERKLA NEKRRKQEEK ARNEERARKR RRSSPSYDAI 
       460        470        480        490        500
ESPTHAKPRS AGAAAAPPAG LELITPARGE LARQTRELTH SMVVNRGNVY 
       510        520        530        540        550
RANMANKSAA AVLKSKLLGG QDGQPSDDGE STAESDAQLD AAGPVLGKRK 
       560        570        580        590        600
ADEAEVGQLG TETPDKPEPA KADELPPDTV RLWEEGYADR YYEQKFGVDP 
       610        620        630        640        650
QDKEFRHKVA RAYAEGLAWV LLYYFQGCPS WTWYYPYHYA PFAADFVDIG 
       660        670        680        690        700
DMELSFEKGT PFKPYEQLMG VLPASSNHAI PKVFHSLMTE PDSEIIDFYP 
       710        720        730        740        750
EDFPVDLNGK KFAWQGVVLL PFIDEKRLLA AMSKKYPLLT EDEKARNTVG 
       760        770        780        790        800
RDVLLLSESH PLYQDLVSNF YSKKQGAPKY KLNMRVSDGL AGKVEKNEAY 
       810        820        830        840        850
IPHSSLVSSL EEYGMPSLED DRSIMVNYEI PKSTNIHKSM LLRGVKFGPP 
       860        870        880        890        900
ALDNADIQAT KSRAQHSGRS YGGAPFRGGR GGRMNYAGDR QSHGNDRPNP 
       910        920        930        940        950
FAAHLDPKFM PGANPGAPMG MPSGWVPPSG NFSRGPPPPP RGGTSYGYGS 
       960        970        980        990       1000
QQYGSYGGYG QQQSYQQSSH SQSDYYGRGP PAPYNNGPAD YYSGRPSGYG 
      1010       1020       1030 
PQESRGGGYN RGGYRGGRDT YSSSGHGGYG RY
Length:1,032
Mass (Da):115,795
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7E5F419573EE6E6D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AACD01000010 Genomic DNA Translation: EAA65483.1
BN001308 Genomic DNA Translation: CBF88946.1

NCBI Reference Sequences

More...RefSeqi		XP_658311.1, XM_653219.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		CBF88946; CBF88946; ANIA_00707
EAA65483; EAA65483; AN0707.2

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2876473

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ani:AN0707.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000010 Genomic DNA Translation: EAA65483.1
BN001308 Genomic DNA Translation: CBF88946.1
RefSeqiXP_658311.1, XM_653219.1

3D structure databases

SMRiQ5BFH3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi162425.CADANIAP00001962

Proteomic databases

PRIDEiQ5BFH3

Genome annotation databases

EnsemblFungiiCBF88946; CBF88946; ANIA_00707
EAA65483; EAA65483; AN0707.2
GeneIDi2876473
KEGGiani:AN0707.2

Phylogenomic databases

eggNOGiKOG2044, Eukaryota
HOGENOMiCLU_006038_1_1_1
InParanoidiQ5BFH3
OMAiGEHFDSN
OrthoDBi685597at2759

Family and domain databases

InterProiView protein in InterPro
IPR027073, 5_3_exoribonuclease
IPR004859, Put_53exo
IPR041412, Xrn1_helical
IPR017151, Xrn2/3/4
IPR001878, Znf_CCHC
PANTHERiPTHR12341, PTHR12341, 1 hit
PfamiView protein in Pfam
PF17846, XRN_M, 1 hit
PF03159, XRN_N, 1 hit
PIRSFiPIRSF037239, Exonuclease_Xrn2, 1 hit
SMARTiView protein in SMART
SM00343, ZnF_C2HC, 1 hit
PROSITEiView protein in PROSITE
PS50158, ZF_CCHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiXRN2_EMENI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5BFH3
Secondary accession number(s): C8VRD3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: January 23, 2007
Last modified: December 2, 2020
This is version 88 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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