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Entry version 109 (17 Jun 2020)
Sequence version 1 (26 Apr 2005)
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Protein

Nonribosomal peptide synthase nlsA

Gene

nlsA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nonribosomal peptide synthase involved in the synthesis of nidulanin A and derived compounds (PubMed:23248299). Nidulanin A is a tetracyclopeptide with the sequence L-Phe-L-Kyn-L-Val-D-Val and an isoprene unit N-linked to the amino group of L-kynurenine (PubMed:23248299). The NRPS nlsA is responsible of the synthesis of the cyclopeptide and the prenyltransferase nptA adds the isoprene unit on the L-kynurenine residue of nidulanin A (PubMed:23248299). Further modifications lead to additional oxygenated related compounds (PubMed:23248299).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Secondary metabolite biosynthesis

This protein is involved in Secondary metabolite biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in Secondary metabolite biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase, Ligase, Multifunctional enzyme

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nonribosomal peptide synthase nlsA1 Publication (EC:6.3.2.-1 Publication)
Alternative name(s):
Nidulanin A synthaseCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nlsA1 Publication
ORF Names:ANIA_01242
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri227321 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillusNidulantes
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000560 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VIII

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Impairs the biosynthesis of nidulanin A and related compounds (PubMed:23248299).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004441981 – 6077Nonribosomal peptide synthase nlsAAdd BLAST6077

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei788O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3334O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei4398O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei5371O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
162425.CADANIAP00001381

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5BDY8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini751 – 827Carrier 1PROSITE-ProRule annotationAdd BLAST77
Domaini3297 – 3373Carrier 2PROSITE-ProRule annotationAdd BLAST77
Domaini4361 – 4437Carrier 3PROSITE-ProRule annotationAdd BLAST77
Domaini5334 – 5410Carrier 4PROSITE-ProRule annotationAdd BLAST77
Domaini5921 – 6004Carrier 5PROSITE-ProRule annotationAdd BLAST84

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni417 – 618Adenylation 1Sequence analysisAdd BLAST202
Regioni842 – 1267Condensation 1Sequence analysisAdd BLAST426
Regioni1309 – 1737Condensation 2Sequence analysisAdd BLAST429
Regioni1757 – 2149Adenylation 2Sequence analysisAdd BLAST393
Regioni2755 – 3157Adenylation 3Sequence analysisAdd BLAST403
Regioni3524 – 3779Condensation 3Sequence analysisAdd BLAST256
Regioni3816 – 4213Adenylation 4Sequence analysisAdd BLAST398
Regioni4451 – 4869Condensation 4Sequence analysisAdd BLAST419
Regioni4916 – 5260Condensation 5Sequence analysisAdd BLAST345
Regioni5476 – 5885Condensation 6Sequence analysisAdd BLAST410

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module (By similarity). Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product (By similarity). Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme (By similarity). Occasionally, methyltransferase domains (responsible for amino acid methylation) are present within the NRP synthetase (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NRP synthase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000022_60_6_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5BDY8

Identification of Orthologs from Complete Genome Data

More...
OMAi
DIVSWRI

Database of Orthologous Groups

More...
OrthoDBi
4243at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 5 hits
3.30.559.10, 6 hits
3.40.50.12780, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010071 AA_adenyl_domain
IPR036736 ACP-like_sf
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
IPR023213 CAT-like_dom_sf
IPR001242 Condensatn
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501 AMP-binding, 4 hits
PF00668 Condensation, 8 hits
PF00550 PP-binding, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336 SSF47336, 5 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01733 AA-adenyl-dom, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455 AMP_BINDING, 1 hit
PS50075 CARRIER, 5 hits
PS00012 PHOSPHOPANTETHEINE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5BDY8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQQAQCLLP SFGTISDGPK RPVSITTKTT PSQSAKLLSA YKNDSLDPLL
60 70 80 90 100
KTAWGLLLYR YTGLQDVCFG YKHDDAGALV SQTSDAGRLL TFRLTINEHD
110 120 130 140 150
TIKTILEKSG GGYGCQTDIG VSGSSNANND NYSSFNTVVM VRVCGDSTKE
160 170 180 190 200
ETFVRPVFQS ILPEECRARL HVKVLQEDIC IFLEWWNTDI STAQMESVAR
210 220 230 240 250
YFEHILNQVL YSDDTVVANA DCFLEQDWAR ICKFNSVIPE TYDRCIHDVI
260 270 280 290 300
SEQVRLHPQR EAVCAWDGSF TYGELDVLAS ELSYRLKGYG VRPETFVALC
310 320 330 340 350
FDKSKWNIVA MLGVLKAGGA FVPLDPTHPT PRLRSLVDSV NVNIMLCSRN
360 370 380 390 400
RAEHLSKVVN NLIPLDEQSF GKISFPPRGY LRQEVKSNNA AYLIFTSGST
410 420 430 440 450
GKPKGTLLEH RAFVSCVFAY APLIHGGCVC VPSEEERLND IVQAINRMNV
460 470 480 490 500
NFICLTPSFA RFVNPSSIPQ VNTALLVGEA MSRTDLEAWS HIKLLNGYGP
510 520 530 540 550
TEAAVCAAIN STMDINSDCR DIGLATGTHF WVVKPNNHDQ LVPVGCPGEL
560 570 580 590 600
LLEGPTLARC YINNPEKTDE VFIYNPTWAR HDPKRGDRRF YKTGDLVRYN
610 620 630 640 650
SDLGSLTFLG RKDSQIKLHG QRIELGEIEH NISTLPLVKH GMAFLCESGP
660 670 680 690 700
AKGRLMAVVS LNGELSSNTV PFKLLPPAER TYAVTELRQQ LSKRLPTYMI
710 720 730 740 750
PAVWLCVEAL PLLPSGKLNR REIISWATNK TDDFQGGASE SSGVETPKAA
760 770 780 790 800
HSEVTVEDRL KSIWSRVLAI PRDRISLDES FLALGGDSIA AITCMGYCKK
810 820 830 840 850
QGMGVTVQDV LQSKSIRDLV TRVQEIKHLV KYQEETEEPF GLSPIQKLHF
860 870 880 890 900
MIRKEGQGYF NQSVRTRLSR RLSADDLRHA IQVIIERHSM LRVRLIKDTL
910 920 930 940 950
VGNLRQRITR DIDSSYRLRV HNINHQAQME SAISVSQSCI NAFQGPIMAV
960 970 980 990 1000
DIFYTEDDCF LSMVAHHLAI DIVSWRIILE DLEDILLRSE DKTIYTSSLP
1010 1020 1030 1040 1050
FSTWCHLQDE RTQTFGSYLE DLPIPDAAYW GVENRVATYG DAICETFELG
1060 1070 1080 1090 1100
LDDSKSILME CHKSLATEPV DILLASLLHA FGQTFRDRSL PAIYNEGHGR
1110 1120 1130 1140 1150
EAWDSSIDIS RTVGWFTTVF PIFIREQIPD DPVETVVLVK DIRRSVSDNG
1160 1170 1180 1190 1200
RQRFASLMSA STKDEKREFL CPMEISFNYV GQHRDLQRQD GLFQLMNQMA
1210 1220 1230 1240 1250
GETGQGGGAS DFGKETPRFG LFEISALAVN GRLRFIFSFS KYMRHQKRIR
1260 1270 1280 1290 1300
AWIASCGDVL RSLGKRLQTH AKRPTLSDFP MLSLTYPDIE SMLAKTLPSL
1310 1320 1330 1340 1350
GVSSPELIED IYPCSRMQQG ILLARSRDSS LYAVHDTYEV RGFNGKPDVA
1360 1370 1380 1390 1400
RLAEAWRMVV SRHAMLRTLF VENLTSRDLF SQLVLRNCEP SILYLSCPTD
1410 1420 1430 1440 1450
DDVVSTFNSQ RPEIYNEYQP HHRLTFCETA SGRVFFRLEL SHAAMDGVSI
1460 1470 1480 1490 1500
SVILRDLQLA YDGKLDQNKP LFKNYIQYLR NTPQDASIVY WKNYLADVKP
1510 1520 1530 1540 1550
CLFPTLTDGK IIAQKQLKVL RPKFNLFNDL QTACEERRLT LSSAFTAAWG
1560 1570 1580 1590 1600
LTLSLFCGSN DVCFSYMTSL RDALVDDIES VVGPVINLLA CRVKISEGDT
1610 1620 1630 1640 1650
LRDIMQKVQN DCMEQLAYNT LSLIDIVHEL RLSEQALINT GISYQRVTKM
1660 1670 1680 1690 1700
QMHHTTGINL SRVCAIQDPA EYPLFVNVVA SDKAAEIEVN YWTDTLSDEQ
1710 1720 1730 1740 1750
AESVSSTFFK CLENIVRHLK EQVGQLEVLS DWNKQRIRKW NKQLPEEVDM
1760 1770 1780 1790 1800
LVQDIIQEKM ASQPDKPAII AWDGTLTYAE LEYLSSCFAA YLQQLGVRRG
1810 1820 1830 1840 1850
TLMPIYVGKS VWQIVAILAV FKTGAICVPR DEAQLGDSVD KWLVDHGAHI
1860 1870 1880 1890 1900
VVTLPSLAGS LERQFPVVVP INKSLFEFLP SSSQENLPQV YPHDDSFIAF
1910 1920 1930 1940 1950
DSSDPHESSA VLDQRAIIAR AASFASTINS NSGTKTFQYA PCTSDMFLQE
1960 1970 1980 1990 2000
VMGTFMSGGC LCIPRSDSLS QLSRSINETS ANLICLTPLV ASFIRPSDVP
2010 2020 2030 2040 2050
SIQVLVLFGE QSARNVRNIW SEKVQLYTFY GRTECSSTCI QVSGLDDLDT
2060 2070 2080 2090 2100
QSSIGTSVGC CSWVVDPQDF TRLVPVGCIG ELVIEGPSVS RGYFCHEKQK
2110 2120 2130 2140 2150
KERFTEQDRG LMEPAKRPYT LFPGSRRKMF RTGYLVRYNA DGTLVYLGEK
2160 2170 2180 2190 2200
VDSMDQTLQM IAFKIEQLLD VQGSAGYRCV AEILDLRIEE YPEPCIAVFI
2210 2220 2230 2240 2250
LSTEKQQSNT IKQSTVIARK TNNSHMLMAK LHASLAASLP ASQVPSLYFP
2260 2270 2280 2290 2300
VFGLPMTSLG KVNRPLLRKA VKSLSADSLT EYDLKKFGEF WRHQLEKPSL
2310 2320 2330 2340 2350
SGQHLLQPFP IQESPALKMV DKGELLVNAK ESSNSAEQFL PQATMIPRRV
2360 2370 2380 2390 2400
QVNNSTSISG LLDQTASCLV KARPYEKTPL SSIRSLNADT SQASDFDSAL
2410 2420 2430 2440 2450
SISSMTSQQQ SQYLRSLENA ERLHSRFSAC PIVVFCALEE TGVSLEIRYD
2460 2470 2480 2490 2500
DRAVYRSQAD RLLALFGECL NIFKSTTGLE EKVADLSKRG GNLQIFNDTI
2510 2520 2530 2540 2550
DYWKVQLTDI ESCLFPDLSP KKGESRLGTE TLRLSNASKM QSACKALSIN
2560 2570 2580 2590 2600
PNILLQTVWA LVLRCYTGLE DVCFGYHVST KKDSVNILPC RFNLNDDLRL
2610 2620 2630 2640 2650
QDVMQKRKED MESASKYQMP LFEILRAIGS ENSPIFNTAF RYRKSSSNAA
2660 2670 2680 2690 2700
VFNNAVLDPV NEGLNEYLIS VNASVSGSSA EISFDYQSTS LSETDIGHII
2710 2720 2730 2740 2750
DCFECILNSI LTLLGPSRVI RDVEFFGRQS CQKVSAWNAS LPERPKRCAH
2760 2770 2780 2790 2800
TIIQDRVIAQ PSAPAICSWD ENFTYSELDS LTTKLAYHLM DWGVGPEVFV
2810 2820 2830 2840 2850
GLCFEKSAWA VIAQVAVLKA GGAFASLDPA HPESRLRGLV DDIAAPIVLC
2860 2870 2880 2890 2900
STRYLDKSSR ICMAALAVSH YTLEQIPDSP ATRSLPTLSV ENAAYAIFTS
2910 2920 2930 2940 2950
GTTGKPKITV LEHAALDVAS SCFAKTLGID SNTRALQFSS YTFDVSILET
2960 2970 2980 2990 3000
IITLMTGGCV CTPSDDERMN DLAGAIKRME ANSISCTPSV ISTLDPSSVP
3010 3020 3030 3040 3050
TLKTIFTGGE KLTEAQIMRW ADRRFYNAYG PSEATIIATA SLKVNRDGIR
3060 3070 3080 3090 3100
LDDDCNSIGT AVCGRAWIVD PYNHHRLLPV GAVGELVLEG YNIARGYLNN
3110 3120 3130 3140 3150
DKKTKEVFIT LPRWLRDSGL RDVPKPTGRM YRTGDLVRYK SDKNISFISR
3160 3170 3180 3190 3200
MDTQVKLNGQ RIELEEIEQQ CTFISPANTQ VAVDIVVPET KTVAKALAAF
3210 3220 3230 3240 3250
ITIAGHEAQS ATPGLGVSSS LLLPLSDSIQ RTIGQLHNSL GQVLPQVMIP
3260 3270 3280 3290 3300
RLYFPVRYLP LGTTGKLDRK GLRAMVQALP KEQLISYMIS NVGSGRAVER
3310 3320 3330 3340 3350
AAESTLRDLW AKALEIEPGS ISAEDSFFAL GGDSFAAMKL VGAARSQNIS
3360 3370 3380 3390 3400
LSFATIYEHP VLVDMAKCCD DTEKPAERQR ADLRPFTLVP GSIPLHDIME
3410 3420 3430 3440 3450
EVSEQCSVTK DSIADIYPCT AVQEGLITLS IKSPGSYVAR IPYRLAASID
3460 3470 3480 3490 3500
LQRFKAAWQQ VTDEFDILRT RIVHIENTGF LQVVLKKERI SWTLETSLDN
3510 3520 3530 3540 3550
VTDDTAEGSG ALLAKYAIVQ LGTDSRYRQC LYKLFIHHLL QRDMQQSDEF
3560 3570 3580 3590 3600
WKSYLDGLSC EPFPPKKNKD LSCSGAGSIH RASVDISRKV GTTDTTVPEL
3610 3620 3630 3640 3650
VRSAWAIVLS VHTGSGDVCF GETLMGRNID MPGITDVVGP VLTTVPMRIR
3660 3670 3680 3690 3700
VDNKLPINQY LRDVRQIITT MIPHQHSGLQ RIQKLSGDAA LACNFQNLLV
3710 3720 3730 3740 3750
IQSDDSQLND DIWSPVEQDT RGDFFTHPLV VQCQISGPRL LILANYDELV
3760 3770 3780 3790 3800
LDDWQTERLI GQFSFVLEQL LSVPRDSLMT VGDIDITGPL DKRDIASWNQ
3810 3820 3830 3840 3850
RQVTCVNKCV HEIIRENAIM HPQATAICSW DGEITYEEMF QLASSFAAYL
3860 3870 3880 3890 3900
VICGVGPETL VPVCLGKSLW TMVTVLSVLL AGGAFVPLDP SHPTSRHKEI
3910 3920 3930 3940 3950
LEEIEADMIL CSPQLRSRYL GSVSTIIPVS EDTIKAYSTV TTSEKANASP
3960 3970 3980 3990 4000
TPENMAYAIF TSGSTGRPKG IIIEHRAVCS SVIGFAPVVG LNKESRVFQF
4010 4020 4030 4040 4050
ASLTFDAAIL EVLGTLMLGG CICVPSDDER LNDIPGAMQR MNVSWSFLTP
4060 4070 4080 4090 4100
SVACILEPST VPSLQILTCG GEALSSEVVK KWTGHVKFYG GYGPTETVVF
4110 4120 4130 4140 4150
AVVARDFVDH DFTCIGYGVP STLTWVVQPD DHDRLAPLGA VGELVLEGPA
4160 4170 4180 4190 4200
LAREYLKNPS KTTDVFINEP AWIKSFPSSL PSPRRIYKTG DLVRYNPDGS
4210 4220 4230 4240 4250
IEYLGRKDHQ VKLHGQRMEL GEIEHRLLAS ENIRNAVVIL PQKGPLRQKL
4260 4270 4280 4290 4300
VAVLSLKSLT VESSTIMTGS CELASQKDML ETGYRQIRTS QKSIEEQLPV
4310 4320 4330 4340 4350
YMVPQAWAVV KSIPMLVSGK LDRKRICTWL EQIDKSAYDR IMQDYDNVDQ
4360 4370 4380 4390 4400
VIVEEENKGE REGDATPAII RDIFAQVLNL PLNKVDPSRS FIYLGGDSIS
4410 4420 4430 4440 4450
GMAVVSKARK RGLNLPLNRI LQAKSIEELA VSCGTKPLPT KNVKESGSLF
4460 4470 4480 4490 4500
PLSPIQELFF RSASVLPKAL GRFNQSITVR LARRTEPNVL EDAVRAVVQK
4510 4520 4530 4540 4550
HAMFRARFSK SSDGTWRQRI TDEVDSSYKF CTHPVKNAGN MLSIIADTQS
4560 4570 4580 4590 4600
SLDIQRGPVI AADLFDKNGE QILFLVASHI CVDVVSWRIV LQELEDFVDT
4610 4620 4630 4640 4650
GSIPSDVPLS FKSWCNVQFE ESKRLNKSIE IPCQQADLNY WGMSRAPNNY
4660 4670 4680 4690 4700
GHVKMDSFAL DKQATAFISG HFHEILGTET MEVLLAAVMY SFNRVFPDRD
4710 4720 4730 4740 4750
APTIYNEGHG REPWNYSDPS GTIGWFTTLN PLHVEASSDL LELLKQVKDT
4760 4770 4780 4790 4800
RRRISEHSRA FFAHNVLHSD STDRTHMFSI PLEILFNYLG QLQQLERGGS
4810 4820 4830 4840 4850
TFQHYGDVFS AETMDSASDM GPETPRFSLF EITALILKEQ LHISFTYNRN
4860 4870 4880 4890 4900
MRHQARIQAW MAECKRVLEV ELPKFRNVAP QPTLSDYPLL PITYHGLEEL
4910 4920 4930 4940 4950
TASVLPRLGL ESWRQVEDIY PCSPVQEGIL FSQLRDPHEY IFNAIFELRQ
4960 4970 4980 4990 5000
SGNKGSFDLA RLKKAWSTVV VRHPVLRTVF IDSCCEEGSF DQVVLKEASD
5010 5020 5030 5040 5050
ATVLIECDDL DALNKLEAVS LRSNKSLNLY HQLVLCKTST GRVLMKLEMN
5060 5070 5080 5090 5100
HVIIDGGSTS ILLRELALAY SNQHPPGPGP LFSEYIKYLR EQPTAEALEY
5110 5120 5130 5140 5150
WKRRLSDMPP CHLPINASEN GARQLGTHLV AFNRFAALQS FCEANSITFA
5160 5170 5180 5190 5200
NLILAVWAIV LRSHTKSDDV CFGYPSTGRD LPVPGIQDAV GIFINTLCCR
5210 5220 5230 5240 5250
VRFDTNQTLK GTVKSVQEDH IASLAYQRSS LAEIQHALGR KGEPLFNTCI
5260 5270 5280 5290 5300
SIQNRSEDKT EIAGISYEFQ KAHDPCEMLG KGKPVTSWVK SHGAESPSDF
5310 5320 5330 5340 5350
PDIRNDVEES LQDLVVMMEK TPASSTQTLN TDYRAPNDSE KQLWRLWSIT
5360 5370 5380 5390 5400
LGLPPHPVKY HDSFFRLGGD SITAMRLVRA ARDEGLKLSV ADVLKNPVFE
5410 5420 5430 5440 5450
NMMALINDRK KSIPTTVTEK RADSIEKRVE DKPILTKCES SQDISILRPM
5460 5470 5480 5490 5500
SLEFDDTSLR AAISPKVGVF KGGIVDVLPV TDFQALSLTA TMFESRWMLN
5510 5520 5530 5540 5550
YFYLDGKGSL DIRRLRESFL RVVDAFDILR TVFVCFHGQF YQVVLRKIKP
5560 5570 5580 5590 5600
DIFVHETEKG LDEYTNSLQQ RDREQSPGQG QQCVQFYVVR KTNSDEHRIL
5610 5620 5630 5640 5650
VRMSHAQFDG VCLSKIMTAI KMAYEGSPVS PSSFLNYMRL LPGNITPEHY
5660 5670 5680 5690 5700
QHWGNLLKGS KMTQIVQRDR PNTFQHIGGF TQQSKVIEIP STATENVTIA
5710 5720 5730 5740 5750
TVMQSAWAVT LAKICAQDDV VFGLTVNGRN AVPGAENTIG PCLNFIPIRV
5760 5770 5780 5790 5800
TFKDCWTGLD LFRFLQDQQV ANMTYESLGF REIVRRCTDW PESTFFTTSV
5810 5820 5830 5840 5850
LHQNVDYEGH MQLDNNTYKM GGVGVIDNLT DLTLFSKPVA GQPAQINVAL
5860 5870 5880 5890 5900
GYSTKGPIHP SFVSTVLDMV CDTAQSLVAN PNVALPSPST IRSLPPQLVE
5910 5920 5930 5940 5950
DIPTTGSTDS LLSSLNNHSL SEILVHSDLI TRIWQQVLPP KLNTGKPPSS
5960 5970 5980 5990 6000
YQLDSSFFGL GGDIVNVAQV VWILEQETGL HIRLEDLLAH STFLGHMAVL
6010 6020 6030 6040 6050
ALNMTKRDSA GVDSDAAPAP AYAPVDARAS RNVSTSRQQQ EGLPLPAANA
6060 6070
KSEWSALDRA RVLAKKITRL GGLGTRV
Length:6,077
Mass (Da):677,235
Last modified:April 26, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3397E5B0A5E5A7E0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BN001308 Genomic DNA Translation: CBF87869.1

NCBI Reference Sequences

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RefSeqi
XP_658846.1, XM_653754.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
CBF87869; CBF87869; ANIA_01242
EAA65835; EAA65835; AN1242.2

Database of genes from NCBI RefSeq genomes

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GeneIDi
2877020

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ani:AN1242.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BN001308 Genomic DNA Translation: CBF87869.1
RefSeqiXP_658846.1, XM_653754.1

3D structure databases

SMRiQ5BDY8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi162425.CADANIAP00001381

Genome annotation databases

EnsemblFungiiCBF87869; CBF87869; ANIA_01242
EAA65835; EAA65835; AN1242.2
GeneIDi2877020
KEGGiani:AN1242.2

Phylogenomic databases

HOGENOMiCLU_000022_60_6_1
InParanoidiQ5BDY8
OMAiDIVSWRI
OrthoDBi4243at2759

Family and domain databases

Gene3Di1.10.1200.10, 5 hits
3.30.559.10, 6 hits
3.40.50.12780, 5 hits
InterProiView protein in InterPro
IPR010071 AA_adenyl_domain
IPR036736 ACP-like_sf
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
IPR023213 CAT-like_dom_sf
IPR001242 Condensatn
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
PfamiView protein in Pfam
PF00501 AMP-binding, 4 hits
PF00668 Condensation, 8 hits
PF00550 PP-binding, 4 hits
SUPFAMiSSF47336 SSF47336, 5 hits
TIGRFAMsiTIGR01733 AA-adenyl-dom, 2 hits
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit
PS50075 CARRIER, 5 hits
PS00012 PHOSPHOPANTETHEINE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNLSA_EMENI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5BDY8
Secondary accession number(s): C8VSP8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 23, 2018
Last sequence update: April 26, 2005
Last modified: June 17, 2020
This is version 109 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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