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UniProtKB - Q5BAE9 (NTE1_EMENI)
Protein
Lysophospholipase nte1
Gene
nte1
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Functioni
Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).
By similarityCatalytic activityi
- EC:3.1.1.5
Activity regulationi
Inhibited by organophosphorus esters.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 1257 | NucleophilePROSITE-ProRule annotation | 1 | |
Active sitei | 1375 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 682 – 809 | cNMP 1Add BLAST | 128 | |
Nucleotide bindingi | 846 – 966 | cNMP 2Add BLAST | 121 |
GO - Molecular functioni
- lysophospholipase activity Source: GO_Central
- phosphatidyl phospholipase B activity Source: UniProtKB-EC
GO - Biological processi
- lipid catabolic process Source: UniProtKB-KW
- phosphatidylcholine metabolic process Source: InterPro
Keywordsi
Molecular function | Hydrolase |
Biological process | Lipid degradation, Lipid metabolism |
Names & Taxonomyi
Protein namesi | Recommended name: Lysophospholipase nte1 (EC:3.1.1.5)Alternative name(s): Intracellular phospholipase B Neuropathy target esterase homolog |
Gene namesi | Name:nte1 ORF Names:AN2481 |
Organismi | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) |
Taxonomic identifieri | 227321 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Aspergillus › Aspergillus subgen. Nidulantes › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | FungiDB:AN2481 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 73 | CytoplasmicBy similarityAdd BLAST | 73 | |
Transmembranei | 74 – 94 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 95 – 116 | LumenalBy similarityAdd BLAST | 22 | |
Transmembranei | 117 – 137 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 138 – 1527 | CytoplasmicBy similarityAdd BLAST | 1390 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000295320 | 1 – 1527 | Lysophospholipase nte1Add BLAST | 1527 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1224 – 1388 | PNPLAPROSITE-ProRule annotationAdd BLAST | 165 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 299 – 387 | DisorderedSequence analysisAdd BLAST | 89 | |
Regioni | 567 – 596 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 765 – 785 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 1504 – 1527 | DisorderedSequence analysisAdd BLAST | 24 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 1228 – 1233 | GXGXXGPROSITE-ProRule annotation | 6 | |
Motifi | 1255 – 1259 | GXSXGPROSITE-ProRule annotation | 5 | |
Motifi | 1375 – 1377 | DGA/GPROSITE-ProRule annotation | 3 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 299 – 315 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 577 – 596 | Basic and acidic residuesSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the NTE family.Curated
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2968, Eukaryota |
HOGENOMi | CLU_000960_1_1_1 |
InParanoidi | Q5BAE9 |
OrthoDBi | 253518at2759 |
Family and domain databases
CDDi | cd00038, CAP_ED, 2 hits |
Gene3Di | 2.60.120.10, 3 hits |
InterProi | View protein in InterPro IPR016035, Acyl_Trfase/lysoPLipase IPR018490, cNMP-bd-like IPR000595, cNMP-bd_dom IPR001423, LysoPLipase_patatin_CS IPR002641, PNPLA_dom IPR014710, RmlC-like_jellyroll |
Pfami | View protein in Pfam PF00027, cNMP_binding, 1 hit PF01734, Patatin, 1 hit |
SMARTi | View protein in SMART SM00100, cNMP, 2 hits |
SUPFAMi | SSF51206, SSF51206, 3 hits SSF52151, SSF52151, 1 hit |
PROSITEi | View protein in PROSITE PS50042, CNMP_BINDING_3, 2 hits PS51635, PNPLA, 1 hit PS01237, UPF0028, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5BAE9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADSGASVPS PDLPDLDSLH ASLSLPDIPS VAATSLSTSL PAISAKVSGF
60 70 80 90 100
PSFSSHLPPP PLLSPPTPTT MVGWIGWVFS LVFQTIPSVL YWVITFSTIT
110 120 130 140 150
LPTWLFTLFS MSLTFTMNFT TLLLIVLGLV STVSWFIRYR FLNMYSRLPP
160 170 180 190 200
EPQRKEPQLD LFPDVQEGDS KPGLANYLDE FLSAIKVFGY LERPVFHELT
210 220 230 240 250
RTMQTRKLIA GETLQLEEEK GFCLVVDGLV QIFVKSMRSG KHGLNGEVIE
260 270 280 290 300
GSSDEDDQAR DGKQGYQLLT EVKNGASMSS LFSILSLFTE DIRLRASEGS
310 320 330 340 350
SSSMSSVQPS PARTTPAPFL DSPGEMLNGS PMVLPRDSEV DSSAINGEAE
360 370 380 390 400
PLPPVPPLHL GESRASSYHP NGQSTASERV RGNRRKSVHP DIVARAMVDT
410 420 430 440 450
TIAIIPASAF RRLTRLYPRA TAHIVQVILT RLQRVTFATA HSYLGLTNEV
460 470 480 490 500
LGIEKQMTKF TTYDLPNDIR GAALDRLKDK FLKEKDRLGS EEVTRGIALH
510 520 530 540 550
NPYAGRRRRS MSFVRKEAAL KAKMPLPKRP NSLINPERPF HGYDTAGVSP
560 570 580 590 600
GDLLSTIQLS RFGPRHDQFA TTPRLHSPLT EKERSPLRRS SLQRKDSVDE
610 620 630 640 650
DALFRESILD CIMKGIGLTP SSHNALRKGS HSGELSPKLV SYDSRRQKAV
660 670 680 690 700
FSNNAFGFID AYEGSGDGDT ESMMSMSVTS AGGTSPIVYL REDLLNDIEI
710 720 730 740 750
VYFPKGAVLV EQGERHPGLY YVIDGFLDVG VQVNEKGDDL VGASRPGHAQ
760 770 780 790 800
PDEELFPTLK RTQTATSRGA TAAAPINESK RKKPSRKSLY MIKPGGMQGY
810 820 830 840 850
VGAMASYRSY TDVVAKTDVY VGFLPRASLE RLAERYPIAL LTLAKRLTGL
860 870 880 890 900
LPRLLLHIDF ALEWVQVNAG QVIYHQGDES DAIYITLNGR LRSVHEGKGG
910 920 930 940 950
KMTVVGEHGQ GESVGELEVM TESTRPATLH AIRDTELAKF PRSLFNSLAQ
960 970 980 990 1000
EHTGITIQVS KLIAQRMRDL VENPMTEQGE PGNTGSVKTA TSTLNLRTVG
1010 1020 1030 1040 1050
ILPITTGVPV VEFGNRLLSA LQQIGVTDGV TSLNQAAILN HLGRHAFSRM
1060 1070 1080 1090 1100
GKLKLSQYLA DLEEKYGMVL YIADTNVNSP WTQTCISQAD CILLVGLAES
1110 1120 1130 1140 1150
SPNVGEYERF LLGMKTTARK ELVLLHADRY CPPGLTRKWL KNRVWINGGH
1160 1170 1180 1190 1200
HHIQMAFRLT AEPSHPQTKR LGTVLKQRVQ ILQAEIQKYT SRRIRQTPIY
1210 1220 1230 1240 1250
SAQTPFKGDF HRLARRLCGR AVGLVLGGGG ARGIAHVGVI KALEEAGIPV
1260 1270 1280 1290 1300
DIVGGTSIGA FIGGLYARDA DVVPMYGRAK KFAGRMGSIW RFALDLTYPS
1310 1320 1330 1340 1350
VSYTTGHEFN RGIFKTFGDS QIEDFWLEFY CNTTNISRSR AEYHSSGYVW
1360 1370 1380 1390 1400
RYVRASMSLA GLLPPICDEG SMLLDGGYID NLTVAHMKTL GADVIFAIDV
1410 1420 1430 1440 1450
GSIDDNTPQG YGDSLSGMWS VINRWNPFSS IPNPPTLSEI QARLAYVSSI
1460 1470 1480 1490 1500
DNLERAKNIP GCLYMRPPID RYGTLEFGNF DEIYQVGYAY GKEYLQKLKS
1510 1520
QGSLPLPEEN EEKKKLQRTL APRRASI
Sequence cautioni
The sequence CBF86943 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence EAA63799 differs from that shown. Reason: Erroneous gene model prediction.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AACD01000041 Genomic DNA Translation: EAA63799.1 Sequence problems. BN001307 Genomic DNA Translation: CBF86943.1 Sequence problems. |
RefSeqi | XP_660085.1, XM_654993.1 |
Genome annotation databases
EnsemblFungii | EAA63799; EAA63799; AN2481.2 |
GeneIDi | 2875190 |
KEGGi | ani:AN2481.2 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AACD01000041 Genomic DNA Translation: EAA63799.1 Sequence problems. BN001307 Genomic DNA Translation: CBF86943.1 Sequence problems. |
RefSeqi | XP_660085.1, XM_654993.1 |
3D structure databases
AlphaFoldDBi | Q5BAE9 |
SMRi | Q5BAE9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 162425.CADANIAP00009202 |
Genome annotation databases
EnsemblFungii | EAA63799; EAA63799; AN2481.2 |
GeneIDi | 2875190 |
KEGGi | ani:AN2481.2 |
Organism-specific databases
VEuPathDBi | FungiDB:AN2481 |
Phylogenomic databases
eggNOGi | KOG2968, Eukaryota |
HOGENOMi | CLU_000960_1_1_1 |
InParanoidi | Q5BAE9 |
OrthoDBi | 253518at2759 |
Family and domain databases
CDDi | cd00038, CAP_ED, 2 hits |
Gene3Di | 2.60.120.10, 3 hits |
InterProi | View protein in InterPro IPR016035, Acyl_Trfase/lysoPLipase IPR018490, cNMP-bd-like IPR000595, cNMP-bd_dom IPR001423, LysoPLipase_patatin_CS IPR002641, PNPLA_dom IPR014710, RmlC-like_jellyroll |
Pfami | View protein in Pfam PF00027, cNMP_binding, 1 hit PF01734, Patatin, 1 hit |
SMARTi | View protein in SMART SM00100, cNMP, 2 hits |
SUPFAMi | SSF51206, SSF51206, 3 hits SSF52151, SSF52151, 1 hit |
PROSITEi | View protein in PROSITE PS50042, CNMP_BINDING_3, 2 hits PS51635, PNPLA, 1 hit PS01237, UPF0028, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NTE1_EMENI | |
Accessioni | Q5BAE9Primary (citable) accession number: Q5BAE9 Secondary accession number(s): C8VPA5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 24, 2007 |
Last sequence update: | July 24, 2007 | |
Last modified: | May 25, 2022 | |
This is version 103 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families