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Protein

Iron-sulfur clusters transporter atm1, mitochondrial

Gene

atm1

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins. Hydrolyzes ATP. Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei410Glutathione; via amide nitrogenBy similarity1
Binding sitei462ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi486 – 497ATPPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Iron transport, Transport
LigandATP-binding, Iron, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-sulfur clusters transporter atm1, mitochondrial
Gene namesi
Name:atm1
ORF Names:AN5528
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome V
  • UP000005890 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 127Mitochondrial matrixBy similarityAdd BLAST110
Transmembranei128 – 149HelicalPROSITE-ProRule annotationAdd BLAST22
Topological domaini150 – 172Mitochondrial intermembraneBy similarityAdd BLAST23
Transmembranei173 – 196HelicalPROSITE-ProRule annotationAdd BLAST24
Topological domaini197 – 245Mitochondrial matrixBy similarityAdd BLAST49
Transmembranei246 – 269HelicalPROSITE-ProRule annotationAdd BLAST24
Topological domaini270Mitochondrial intermembraneBy similarity1
Transmembranei271 – 291HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini292 – 357Mitochondrial matrixBy similarityAdd BLAST66
Transmembranei358 – 376HelicalPROSITE-ProRule annotationAdd BLAST19
Topological domaini377 – 391Mitochondrial intermembraneBy similarityAdd BLAST15
Transmembranei392 – 413HelicalPROSITE-ProRule annotationAdd BLAST22
Topological domaini414 – 721Mitochondrial matrixBy similarityAdd BLAST308

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 17MitochondrionSequence analysisAdd BLAST17
ChainiPRO_000025544518 – 721Iron-sulfur clusters transporter atm1, mitochondrialAdd BLAST704

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi162425.CADANIAP00003554

Structurei

3D structure databases

SMRiQ5B1Q2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini128 – 418ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST291
Domaini453 – 689ABC transporterPROSITE-ProRule annotationAdd BLAST237

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni297 – 301Glutathione bindingBy similarity5
Regioni360 – 363Glutathione bindingBy similarity4

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ5B1Q2
KOiK05663
OMAiYEAQRYD
OrthoDBiEOG092C3H79

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF90123 SSF90123, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5B1Q2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRQAAQTRC WRTPARFVSH RPAFPRSNPV SAALGGTQFR KLSVKTQTDK
60 70 80 90 100
NTLSDKKTAE ADTSSSSSSA KSAAPSQQKT QNATTAQKNL LSESTVANKE
110 120 130 140 150
QRKADWAIMR EMAKYLWPKG DWGTKLRVGT ALSLLVGAKV LNVEVPFYFK
160 170 180 190 200
SIVDSMNVDF AAVGGTAYTV AGSMIIAYGA TRIGATFFQE LRNAVFASVA
210 220 230 240 250
QKAIRKVARN VFEHLLRLDL NFHLSRQTGG LTRAIDRGTK GISFLLTSMV
260 270 280 290 300
FHVVPTALEI SLVCGILTHQ YGIKFAAITA TTMLAYSAFT IATTAWRTKF
310 320 330 340 350
RKQANAADNR GATVAVDSLI NYEAVKYFNN EKFEVARYDK ALKAYEDASI
360 370 380 390 400
KVTTSLAFLN SGQNMIFSSA LAAMMYLAAD GVATGSLTVG DLVMVNQLVF
410 420 430 440 450
QLSVPLNFLG SVYRELRQSL LDMETLFNLQ KVNVNIKEKP DAKPLELKQG
460 470 480 490 500
GQIRFENVTF GYHPERPILK NASFTIPAGQ KFAIVGPSGC GKSTILRLLF
510 520 530 540 550
RYYDVQEGRI LVDGQDIRHV TIESLRKAIG VVPQDTPLFN DTIEHNIRYG
560 570 580 590 600
RLDASDEEVR KAARRAHIHE LVERLPEGYR TAVGERGMMI SGGEKQRLAI
610 620 630 640 650
SRLLLKDPQL LFFDEATSAL DTYTEQALMQ NINSILKEKG RTSVFVAHRL
660 670 680 690 700
RTIYDCDQIL VLKDGQVAEL GSHRELLDLD GIYAELWSAQ ETSLAQDPEY
710 720
ERNAGLEGET AGEVEDKAPR Q
Length:721
Mass (Da):79,800
Last modified:November 16, 2011 - v2
Checksum:i1A68759955638EF9
GO

Sequence cautioni

The sequence EAA62688 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000094 Genomic DNA Translation: EAA62688.1 Sequence problems.
BN001305 Genomic DNA Translation: CBF81731.1
RefSeqiXP_663132.1, XM_658040.1

Genome annotation databases

EnsemblFungiiCBF81731; CBF81731; ANIA_05528
EAA62688; EAA62688; AN5528.2
GeneIDi2871817
KEGGiani:AN5528.2

Similar proteinsi

Entry informationi

Entry nameiATM1_EMENI
AccessioniPrimary (citable) accession number: Q5B1Q2
Secondary accession number(s): C8VG84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 16, 2011
Last modified: June 20, 2018
This is version 99 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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