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UniProtKB - Q5AWD4 (BGLM_EMENI)
Protein
Probable beta-glucosidase M
Gene
bglM
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Functioni
Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose (By similarity).
By similarityCatalytic activityi
- Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose. EC:3.2.1.21
: cellulose degradation Pathwayi
This protein is involved in the pathway cellulose degradation, which is part of Glycan metabolism.View all proteins of this organism that are known to be involved in the pathway cellulose degradation and in Glycan metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 287 | By similarity | 1 |
GO - Molecular functioni
- beta-glucosidase activity Source: GO_Central
- scopolin beta-glucosidase activity Source: UniProtKB-EC
GO - Biological processi
- cellulose catabolic process Source: UniProtKB-UniPathway
- glucan catabolic process Source: GO_Central
Keywordsi
Molecular function | Glycosidase, Hydrolase |
Biological process | Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation |
Enzyme and pathway databases
UniPathwayi | UPA00696 |
Protein family/group databases
CAZyi | GH3, Glycoside Hydrolase Family 3 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable beta-glucosidase M (EC:3.2.1.21)Alternative name(s): Beta-D-glucoside glucohydrolase M Cellobiase M Gentiobiase M |
Gene namesi | Name:bglM ORF Names:AN7396 |
Organismi | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) |
Taxonomic identifieri | 227321 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Aspergillus › Aspergillus subgen. Nidulantes › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | FungiDB:AN7396 |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000394909 | 21 – 772 | Probable beta-glucosidase MAdd BLAST | 752 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 259 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 315 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 322 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 438 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 523 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 547 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 574 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 586 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PRIDEi | Q5AWD4 |
Family & Domainsi
Sequence similaritiesi
Belongs to the glycosyl hydrolase 3 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502SMNU, Eukaryota |
HOGENOMi | CLU_004542_2_1_1 |
InParanoidi | Q5AWD4 |
OMAi | NFPGLCV |
OrthoDBi | 321444at2759 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.20.20.300, 1 hit 3.40.50.1700, 1 hit |
InterProi | View protein in InterPro IPR026891, Fn3-like IPR002772, Glyco_hydro_3_C IPR036881, Glyco_hydro_3_C_sf IPR001764, Glyco_hydro_3_N IPR036962, Glyco_hydro_3_N_sf IPR017853, Glycoside_hydrolase_SF IPR013783, Ig-like_fold |
Pfami | View protein in Pfam PF14310, Fn3-like, 1 hit PF00933, Glyco_hydro_3, 1 hit PF01915, Glyco_hydro_3_C, 1 hit |
PRINTSi | PR00133, GLHYDRLASE3 |
SMARTi | View protein in SMART SM01217, Fn3_like, 1 hit |
SUPFAMi | SSF51445, SSF51445, 1 hit SSF52279, SSF52279, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q5AWD4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLTSWGKTGF VLALALGGRA AENVITSDTF FYGESPPVYP SPEGTGAGDW
60 70 80 90 100
ASAYTKARAF VAQLSDDEKI QLTAGVSSNT ACSGFIQPID RLGFPGICMS
110 120 130 140 150
DAGNGLRGTD YVNGWSSGIS VGASWNRDLA HSRGAYMGQE YRKKGVNMIL
160 170 180 190 200
GPVVGPLGRV ALGGRNWEGY AADPYLSGVL VSESVKGLQS QKVATSVKHF
210 220 230 240 250
IANEQETNRN PTTDSERNVV QSVSSNIDDK TMHELYLWPF QDAVLAGATN
260 270 280 290 300
LMCSYNRVNN SYACQNSKLL NGVLKTELGF QGYVVTDWGA QHAGIASANA
310 320 330 340 350
GLDVVMPRSS TWNSNLTTAI ANGTMEASRL DDMITRLMAT WYYLDQDTEF
360 370 380 390 400
PSPGVGMPSS PSAAHQAVIA TSPEAKPILL QSAIESHVLV KNTDGALPLK
410 420 430 440 450
SPKLISVFGY DAYAPLTYDL GNNFDFSSTR VRSDLYKNGT LYVGGGSGLN
460 470 480 490 500
SPAYIDAPID AIKRRAYEDG SSVLWDFTSE NPSVDYTSDV CLVFINAYAT
510 520 530 540 550
EGYDRQALSD THSDSVVENI AGNCSNTIVV VHNAGIRTAE AWVDHANVTA
560 570 580 590 600
IIYAHLPGQD IGRALVRLLY GESNFSGRLP YTVAKNSSDY GSLLEPSQPE
610 620 630 640 650
GKYQYFPQSD FSEGVYIDYR AFDKDGIVPQ YAFGYGLSYT TFEYSDLKIS
660 670 680 690 700
KNSDGVPSIY PAKASILPGG NPHLFDELVT VTAKIRNTGN VDGQEVAQLY
710 720 730 740 750
VGIPDGPVRQ LRGFDKVLIE SGSSATVTFS LTRRDLSTWD ANAQEWSLQR
760 770
GTYKIFVGRD SRDLPLEETL VF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AACD01000128 Genomic DNA Translation: EAA61767.1 BN001304 Genomic DNA Translation: CBF78465.1 |
RefSeqi | XP_680665.1, XM_675573.1 |
Genome annotation databases
EnsemblFungii | CBF78465; CBF78465; ANIA_07396 EAA61767; EAA61767; AN7396.2 |
GeneIDi | 2869858 |
KEGGi | ani:AN7396.2 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AACD01000128 Genomic DNA Translation: EAA61767.1 BN001304 Genomic DNA Translation: CBF78465.1 |
RefSeqi | XP_680665.1, XM_675573.1 |
3D structure databases
AlphaFoldDBi | Q5AWD4 |
SMRi | Q5AWD4 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 162425.CADANIAP00000031 |
Protein family/group databases
CAZyi | GH3, Glycoside Hydrolase Family 3 |
Proteomic databases
PRIDEi | Q5AWD4 |
Genome annotation databases
EnsemblFungii | CBF78465; CBF78465; ANIA_07396 EAA61767; EAA61767; AN7396.2 |
GeneIDi | 2869858 |
KEGGi | ani:AN7396.2 |
Organism-specific databases
VEuPathDBi | FungiDB:AN7396 |
Phylogenomic databases
eggNOGi | ENOG502SMNU, Eukaryota |
HOGENOMi | CLU_004542_2_1_1 |
InParanoidi | Q5AWD4 |
OMAi | NFPGLCV |
OrthoDBi | 321444at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00696 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.20.20.300, 1 hit 3.40.50.1700, 1 hit |
InterProi | View protein in InterPro IPR026891, Fn3-like IPR002772, Glyco_hydro_3_C IPR036881, Glyco_hydro_3_C_sf IPR001764, Glyco_hydro_3_N IPR036962, Glyco_hydro_3_N_sf IPR017853, Glycoside_hydrolase_SF IPR013783, Ig-like_fold |
Pfami | View protein in Pfam PF14310, Fn3-like, 1 hit PF00933, Glyco_hydro_3, 1 hit PF01915, Glyco_hydro_3_C, 1 hit |
PRINTSi | PR00133, GLHYDRLASE3 |
SMARTi | View protein in SMART SM01217, Fn3_like, 1 hit |
SUPFAMi | SSF51445, SSF51445, 1 hit SSF52279, SSF52279, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | BGLM_EMENI | |
Accessioni | Q5AWD4Primary (citable) accession number: Q5AWD4 Secondary accession number(s): C8VCE8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 15, 2010 |
Last sequence update: | April 26, 2005 | |
Last modified: | May 25, 2022 | |
This is version 89 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families