UniProtKB - Q5ASA5 (SET2_EMENI)
Protein
Histone-lysine N-methyltransferase, H3 lysine-36 specific
Gene
set2
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Functioni
Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression.By similarity
Catalytic activityi
- L-lysyl36-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl36-[histone H3] + 3 S-adenosyl-L-homocysteinePROSITE-ProRule annotationBy similarityEC:2.1.1.359PROSITE-ProRule annotationBy similarity
GO - Molecular functioni
- histone methyltransferase activity (H3-K36 specific) Source: GO_Central
GO - Biological processi
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | Methyltransferase, Repressor, Transferase |
Biological process | Transcription, Transcription regulation |
Ligand | S-adenosyl-L-methionine |
Names & Taxonomyi
Protein namesi | Recommended name: Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC:2.1.1.359By similarity)Alternative name(s): SET domain-containing protein 2 |
Gene namesi | Name:set2 ORF Names:AN8825 |
Organismi | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) |
Taxonomic identifieri | 227321 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Aspergillus › Aspergillus subgen. Nidulantes › |
Proteomesi |
|
Subcellular locationi
Nucleus
- Nucleus By similarity
Other locations
- Chromosome By similarity
Keywords - Cellular componenti
Chromosome, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000269788 | 1 – 980 | Histone-lysine N-methyltransferase, H3 lysine-36 specificAdd BLAST | 980 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 167 – 239 | AWSPROSITE-ProRule annotationAdd BLAST | 73 | |
Domaini | 241 – 358 | SETPROSITE-ProRule annotationAdd BLAST | 118 | |
Domaini | 365 – 381 | Post-SETPROSITE-ProRule annotationAdd BLAST | 17 | |
Domaini | 630 – 661 | WWPROSITE-ProRule annotationAdd BLAST | 32 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 662 – 670 | Poly-Pro | 9 | |
Compositional biasi | 726 – 818 | Lys-richAdd BLAST | 93 | |
Compositional biasi | 890 – 942 | Pro-richAdd BLAST | 53 |
Domaini
The AWS and SET domains are necessary for transcription repression.By similarity
Sequence similaritiesi
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG4442, Eukaryota |
HOGENOMi | CLU_008492_0_1_1 |
InParanoidi | Q5ASA5 |
OMAi | NHACGED |
OrthoDBi | 453286at2759 |
Family and domain databases
CDDi | cd19172, SET_SETD2, 1 hit |
Gene3Di | 1.10.1740.100, 1 hit |
InterProi | View protein in InterPro IPR006560, AWS_dom IPR003616, Post-SET_dom IPR025788, Set2_fungi IPR001214, SET_dom IPR044437, SETD2/Set2_SET IPR013257, SRI IPR038190, SRI_sf IPR001202, WW_dom IPR036020, WW_dom_sf |
Pfami | View protein in Pfam PF17907, AWS, 1 hit PF00856, SET, 1 hit PF08236, SRI, 1 hit |
SMARTi | View protein in SMART SM00570, AWS, 1 hit SM00508, PostSET, 1 hit SM00317, SET, 1 hit |
SUPFAMi | SSF51045, SSF51045, 1 hit |
PROSITEi | View protein in PROSITE PS51215, AWS, 1 hit PS50868, POST_SET, 1 hit PS51568, SAM_MT43_SET2_1, 1 hit PS50280, SET, 1 hit PS01159, WW_DOMAIN_1, 1 hit PS50020, WW_DOMAIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5ASA5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTHDNADRQ SEFVADAVTA MKLEQSENNT DAPILNGGGA AMKPDSKAAS
60 70 80 90 100
PEPLIKDERA SSTFMKSRSS SRTPSSRTPL KKEHSDSEDI QEKRGDDASG
110 120 130 140 150
TEKVGGGISV KMEPGQPPKL ARSSSQKVVP RPPQLFLDLP DSTEEAQKTF
160 170 180 190 200
EVIETCQYAN KYMGYTEHAM ECDCAEEWVL VVVLAPSPSF RVPSQNPASS
210 220 230 240 250
TNRACGEDSD CINRATKIEC MGDCGCGPDC QNQRFQRREY ANVAVIKTEK
260 270 280 290 300
KGYGLRAEED LRPHQFIFEY VGEVINEGPF HRRMRQYDAE GIKHFYFMSL
310 320 330 340 350
SKGEFVDATK KGNLGRFCNH SCNPNCYVDK WVVGEKLRMG IFAERHIQAG
360 370 380 390 400
EELVFNYNVD RYGADPQPCY CGEPNCTGFI GGKTQTERAT KLSNATIEAL
410 420 430 440 450
GIEDADGWDT AVAKRPRKKK MGEEDEEYVD SVQPKSLDES GVTKVMAALM
460 470 480 490 500
QCKEKWIAVK LLGRIQRCDD ERVRNRVVKM HGYQILNSQL AMWKDDFNVV
510 520 530 540 550
LQILDILDKF PRLTRNKIID SKIESTIQPL TSCGDERVEQ KATVLLQLWS
560 570 580 590 600
TLEIGYRIPR MKRDPNAATP TVSQFHRRDD ISDERQQRPR SRSRSRSIEA
610 620 630 640 650
PRGPAAQKRG GQGPRNQHHQ GPRTFRRRFD PLPQGWFAAE SNGRTYYYSA
660 670 680 690 700
RGDTTWTRPT KPAPQPPPPP KESRDKALQS IIDGIMNAKE QTPKEKSGTP
710 720 730 740 750
TTPQPSKPTP EGKDRQEKWR SYSEEKQKKL YENTLYPHIK YVVDKFKHKL
760 770 780 790 800
PKDDLKRYAK DVAKKLVNSD FKNNRVTDPT KIDDKQQKKV KKFCKEFFDK
810 820 830 840 850
AVAKHQAHEK RKAEKLAKEG SSDNKLATPV GGQSEGDGTP DVKMSDDEGS
860 870 880 890 900
TGREGTGSLK RKRDELSVGN TNTPDDTPTS STKRQRSSTP PPPPPPAMNT
910 920 930 940 950
NDNNNDNDDM SVRSDEPDAD ADADEVVLVG NPTPPPPPPP PPQEDMRIPD
960 970 980
ADAETNGHNF EGYGEMNRSH QAQIGIEGNV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AACD01000162 Genomic DNA Translation: EAA60113.1 BN001303 Genomic DNA Translation: CBF77940.1 |
RefSeqi | XP_682094.1, XM_677002.1 |
Genome annotation databases
EnsemblFungii | CBF77940; CBF77940; ANIA_08825 EAA60113; EAA60113; AN8825.2 |
GeneIDi | 2868338 |
KEGGi | ani:AN8825.2 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AACD01000162 Genomic DNA Translation: EAA60113.1 BN001303 Genomic DNA Translation: CBF77940.1 |
RefSeqi | XP_682094.1, XM_677002.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 162425.CADANIAP00006232 |
Genome annotation databases
EnsemblFungii | CBF77940; CBF77940; ANIA_08825 EAA60113; EAA60113; AN8825.2 |
GeneIDi | 2868338 |
KEGGi | ani:AN8825.2 |
Phylogenomic databases
eggNOGi | KOG4442, Eukaryota |
HOGENOMi | CLU_008492_0_1_1 |
InParanoidi | Q5ASA5 |
OMAi | NHACGED |
OrthoDBi | 453286at2759 |
Family and domain databases
CDDi | cd19172, SET_SETD2, 1 hit |
Gene3Di | 1.10.1740.100, 1 hit |
InterProi | View protein in InterPro IPR006560, AWS_dom IPR003616, Post-SET_dom IPR025788, Set2_fungi IPR001214, SET_dom IPR044437, SETD2/Set2_SET IPR013257, SRI IPR038190, SRI_sf IPR001202, WW_dom IPR036020, WW_dom_sf |
Pfami | View protein in Pfam PF17907, AWS, 1 hit PF00856, SET, 1 hit PF08236, SRI, 1 hit |
SMARTi | View protein in SMART SM00570, AWS, 1 hit SM00508, PostSET, 1 hit SM00317, SET, 1 hit |
SUPFAMi | SSF51045, SSF51045, 1 hit |
PROSITEi | View protein in PROSITE PS51215, AWS, 1 hit PS50868, POST_SET, 1 hit PS51568, SAM_MT43_SET2_1, 1 hit PS50280, SET, 1 hit PS01159, WW_DOMAIN_1, 1 hit PS50020, WW_DOMAIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SET2_EMENI | |
Accessioni | Q5ASA5Primary (citable) accession number: Q5ASA5 Secondary accession number(s): C8V9K8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 9, 2007 |
Last sequence update: | April 26, 2005 | |
Last modified: | April 7, 2021 | |
This is version 111 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families