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Entry version 96 (31 Jul 2019)
Sequence version 2 (16 Nov 2011)
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Protein

Helicase swr1

Gene

swr1

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi850 – 857ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Chromatin regulator, DNA-binding, Helicase, Hydrolase
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Helicase swr1 (EC:3.6.4.12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:swr1
ORF Names:AN9077
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri227321 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000560 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome VI
  • UP000005890 Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000743681 – 1698Helicase swr1Add BLAST1698

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q5ARK3

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the SWR1 chromatin-remodeling complex.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
162425.CADANIAP00009538

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5ARK3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini329 – 403HSAPROSITE-ProRule annotationAdd BLAST75
Domaini837 – 1002Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST166
Domaini1377 – 1527Helicase C-terminalPROSITE-ProRule annotationAdd BLAST151

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi953 – 956DEAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi470 – 609Asp-richAdd BLAST140

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000186095

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5ARK3

KEGG Orthology (KO)

More...
KOi
K11681

Identification of Orthologs from Complete Genome Data

More...
OMAi
RQGWNND

Database of Orthologous Groups

More...
OrthoDBi
188211at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10810, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR014012 HSA_dom
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00271 Helicase_C, 1 hit
PF07529 HSA, 1 hit
PF00176 SNF2_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51204 HSA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5ARK3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQNGTTIGIP PENERVTERA EPVPSDLLPN NSPVNSPTID PTLSEIKDVA
60 70 80 90 100
ADHNEEPPSK RRKVAGSTPS RRSHSRAASP PWKKAGADGP TSKIVDGKRR
110 120 130 140 150
STRVSNVGPV EQPPSDAKPT RSSQKQYVSK AVSSQRNAAV SSPLPMSPSR
160 170 180 190 200
SGINRRSLAG VAVNGSPSTT AKGSIGRRRR ESPSPVSKRA STRTRPDNMD
210 220 230 240 250
AYHPSNGVTP RSNSTKTRST RSFQLASSDF REETADDIGN DGQDEHGQRI
260 270 280 290 300
QRLRIKVKKP ALSIQHPSHV LPTRKYGSFK EWLENEGTGP GRMLTMTDAL
310 320 330 340 350
EEAQKRRQVT EAMEPGGLLS SEVCSAFLPE PQEELPQQFS HQDHLVAHAL
360 370 380 390 400
YFKKLLDKEH RAHRQAAKSL AAACAEVWRK RNKDPEDILR EQQEEMRGKR
410 420 430 440 450
KQLAKDLKKM FELARAEIDR VRLARWEEEQ KAKDQRALDR AIKQSTMLFE
460 470 480 490 500
KRRLEILGET GSDAPETTTD DEEVETDNGS ENDDEEGESN MSTETEEEDG
510 520 530 540 550
DDRDDDVGLT AEELRLKYAN LPDTNPHPDQ SPYSDEDSED SDDIAADNTP
560 570 580 590 600
GDTSGGVNRS PPPDSSGQVE LDEVDPVLID DSDESTDMDD DMGDSDDDGY
610 620 630 640 650
SEAESDDEDG GEPGLLGFFS AKDLSLSNLH QTNSGEGDTH QTGADGDRNE
660 670 680 690 700
DSSFDESEFG SEDPDEVTLV PTGPTNKDLS TPATVTASAE LEPAAMTPSI
710 720 730 740 750
DQTSTEEPIA IGTETPIETV AEDAAALADT EPVDVDVLDT STNDSVPPVM
760 770 780 790 800
SPATNLLKQI ERQQHEPYHS RAASSEASPG TVATKPSEPE SVSSIEAPAE
810 820 830 840 850
KHAQPSESPG PGLKTPIPHL LRGTLREYQH FGLDWLAGLY SNHINGILAD
860 870 880 890 900
EMGLGKTIQT IALLAHLAVE HGVWGPHLVV VPTSVILNWE MEFKKWCPGF
910 920 930 940 950
KIMTYYGNQE ERRQKRRGWM DDNSWNVLIT SYQLVLQDQQ VLKRRSWHYM
960 970 980 990 1000
ILDEAHNIKN FRSQRWQALL TFRTRARLLL TGTPLQNNLT ELWSLLFFLM
1010 1020 1030 1040 1050
PTDGDEAGIE GFADLRNFSE WFRRPVEQIL EHGRETMDDE AKQVVTKLHT
1060 1070 1080 1090 1100
VLRPYILRRL KADVEKQMPG KYEHVVYCRL SKRQRYLYDG FMSRAQTKET
1110 1120 1130 1140 1150
LASGNYLSII NCLMQLRKVC NHPDLFETRP ISTSFAMPRS VATEFETSEA
1160 1170 1180 1190 1200
LVRRRLLYQH PLEKLDLDFL NLVPISREDI SRRLADDSAR IMAYAPFNTL
1210 1220 1230 1240 1250
RERQYHRTNW EMKFNGSTVQ STLEALENDC RKRRMAELER SLYFESKRHG
1260 1270 1280 1290 1300
RRPVYGSSLI EFLTADSKQR PTAHGPLRKR SYADWLSSQS SVLASMMMSL
1310 1320 1330 1340 1350
EERSQAMDGY IQRFACVTPA AVAAGVTEAA LTPISTRHLT NKERFPPHDP
1360 1370 1380 1390 1400
FHEAQMRLSI AFPDKRLLQY DCGKLQRLDK LLRDLKAGGH RALIFTQMTK
1410 1420 1430 1440 1450
MLDVLEQFLN IHGHRYLRLD GTTKVEQRQI LTDRFNNDNR ILAFILSSRS
1460 1470 1480 1490 1500
GGLGINLTGA DTVIFYDLDW NPAMDKQCQD RCHRIGQTRD VHIYRFVSEY
1510 1520 1530 1540 1550
TIESNILRKA NQKRMLDDVV IQEGEFTTDY FTKLDVRDMI GNDEALKDEA
1560 1570 1580 1590 1600
SAAMDRVLEN RVTNTSRVFE QAEDKEDIDA AKNAQKELEH ADDGDFDDRA
1610 1620 1630 1640 1650
NANASGVTAA SASASGAGQT PTQAGTPLPD EAQQSLNANN AEVAEDTADS
1660 1670 1680 1690
DPSVGHIDDY LLRFMEWNMK DEPLVLPVDK SMKKSKKGKE HRLRKRRR
Length:1,698
Mass (Da):190,547
Last modified:November 16, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFB023CCEF1AADA9D
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence EAA61910 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AACD01000169 Genomic DNA Translation: EAA61910.1 Sequence problems.
BN001306 Genomic DNA Translation: CBF82596.1

NCBI Reference Sequences

More...
RefSeqi
XP_682346.1, XM_677254.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
CBF82596; CBF82596; ANIA_09077
EAA61910; EAA61910; AN9077.2

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2868023

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ani:AN9077.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AACD01000169 Genomic DNA Translation: EAA61910.1 Sequence problems.
BN001306 Genomic DNA Translation: CBF82596.1
RefSeqiXP_682346.1, XM_677254.1

3D structure databases

SMRiQ5ARK3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi162425.CADANIAP00009538

Proteomic databases

PRIDEiQ5ARK3

Genome annotation databases

EnsemblFungiiCBF82596; CBF82596; ANIA_09077
EAA61910; EAA61910; AN9077.2
GeneIDi2868023
KEGGiani:AN9077.2

Phylogenomic databases

HOGENOMiHOG000186095
InParanoidiQ5ARK3
KOiK11681
OMAiRQGWNND
OrthoDBi188211at2759

Family and domain databases

Gene3Di3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR014012 HSA_dom
IPR027417 P-loop_NTPase
IPR038718 SNF2-like_sf
IPR000330 SNF2_N
PfamiView protein in Pfam
PF00271 Helicase_C, 1 hit
PF07529 HSA, 1 hit
PF00176 SNF2_N, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51204 HSA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSWR1_EMENI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5ARK3
Secondary accession number(s): C8VH70
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: November 16, 2011
Last modified: July 31, 2019
This is version 96 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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