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UniProtKB - Q5ANB1 (WOR2_CANAL)
Protein
White-opaque regulator 2
Gene
WOR2
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Functioni
Transcriptional regulator of the switch between 2 heritable states, the white and opaque states. These 2 cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically, at low frequency. WOR2 is necessary for the stability of the opaque state phenotypic switching from the white to the opaque phase is a necessary step for mating. Plays a role in cell adhesion and pseudohyphal growth.
3 PublicationsRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 305 – 332 | Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd BLAST | 28 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: InterPro
- zinc ion binding Source: InterPro
GO - Biological processi
- filamentous growth Source: CGD
- growth of unicellular organism as a thread of attached cells Source: CGD
- negative regulation of growth of unicellular organism as a thread of attached cells Source: CGD
- phenotypic switching Source: CGD
- positive regulation of phenotypic switching Source: CGD
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation, Virulence |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: White-opaque regulator 2 |
Gene namesi | Name:WOR2 Ordered Locus Names:CAALFM_C305170WA ORF Names:CaO19.13413, CaO19.5992 |
Organismi | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
Taxonomic identifieri | 237561 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Candida/Lodderomyces clade › Candida › |
Proteomesi |
|
Organism-specific databases
CGDi | CAL0000177394, WOR2 |
VEuPathDBi | FungiDB:C3_05170W_A |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000420155 | 1 – 446 | White-opaque regulator 2Add BLAST | 446 |
Expressioni
Inductioni
Expression is induced by HAP43 under low iron conditions.1 Publication
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 203 | DisorderedSequence analysisAdd BLAST | 203 | |
Regioni | 336 – 402 | DisorderedSequence analysisAdd BLAST | 67 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 146 | Polar residuesSequence analysisAdd BLAST | 146 | |
Compositional biasi | 153 – 170 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 171 – 188 | Pro residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 189 – 203 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 353 – 402 | Polar residuesSequence analysisAdd BLAST | 50 |
Phylogenomic databases
HOGENOMi | CLU_613927_0_0_1 |
InParanoidi | Q5ANB1 |
OMAi | LDFNEHF |
OrthoDBi | 1607569at2759 |
Family and domain databases
CDDi | cd00067, GAL4, 1 hit |
Gene3Di | 4.10.240.10, 1 hit |
InterProi | View protein in InterPro IPR001138, Zn2-C6_fun-type_DNA-bd IPR036864, Zn2-C6_fun-type_DNA-bd_sf |
Pfami | View protein in Pfam PF00172, Zn_clus, 1 hit |
SMARTi | View protein in SMART SM00066, GAL4, 1 hit |
SUPFAMi | SSF57701, SSF57701, 1 hit |
PROSITEi | View protein in PROSITE PS00463, ZN2_CY6_FUNGAL_1, 1 hit PS50048, ZN2_CY6_FUNGAL_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5ANB1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTQLPSVSEL INRTGSIGSS SNITRVPPMT TTSATNTTTA ATATTVTSTT
60 70 80 90 100
PRSENSYSPN SPYSLPTRPS NTSLTNYSAG SGITVASSSF QFSQPSPGRS
110 120 130 140 150
KHNSTSSQSS SGDSFQQHQS NPSGVSMSSN TSPRTSIVQS MSSVPTPPST
160 170 180 190 200
GPAPQQFVYQ ESQLPVQPPP QQQQLQQPPP PPPQQQQHIY PQQQPNFPYH
210 220 230 240 250
NNFVSPPTYT TAYPQYYYQP VMTPPHHQPH QQAPIHLANN VSILQSQAVM
260 270 280 290 300
QNAYPTTHYL QHVGPHHIYA NVNSQVYYQD MAREEANKAL INKRRIIKRR
310 320 330 340 350
TRTGCLTCRK RRIKCDERKP TCFNCERSKK SCLGYQDLSK LPPRKRNRDT
360 370 380 390 400
SLDLPDGNQQ QQQQQQNQQS IVGGAGNVSD EPHNETHQIT SISGSSTNSR
410 420 430 440
NLDMMIPQSF RNNISSQPIN FYGPVATTAS GASAVINRVS VADLLK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP017625 Genomic DNA Translation: AOW28532.1 |
RefSeqi | XP_723202.1, XM_718109.1 |
Genome annotation databases
GeneIDi | 3635230 |
KEGGi | cal:CAALFM_C305170WA |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP017625 Genomic DNA Translation: AOW28532.1 |
RefSeqi | XP_723202.1, XM_718109.1 |
3D structure databases
AlphaFoldDBi | Q5ANB1 |
SMRi | Q5ANB1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 1218324, 1 interactor |
Genome annotation databases
GeneIDi | 3635230 |
KEGGi | cal:CAALFM_C305170WA |
Organism-specific databases
CGDi | CAL0000177394, WOR2 |
VEuPathDBi | FungiDB:C3_05170W_A |
Phylogenomic databases
HOGENOMi | CLU_613927_0_0_1 |
InParanoidi | Q5ANB1 |
OMAi | LDFNEHF |
OrthoDBi | 1607569at2759 |
Miscellaneous databases
PROi | PR:Q5ANB1 |
Family and domain databases
CDDi | cd00067, GAL4, 1 hit |
Gene3Di | 4.10.240.10, 1 hit |
InterProi | View protein in InterPro IPR001138, Zn2-C6_fun-type_DNA-bd IPR036864, Zn2-C6_fun-type_DNA-bd_sf |
Pfami | View protein in Pfam PF00172, Zn_clus, 1 hit |
SMARTi | View protein in SMART SM00066, GAL4, 1 hit |
SUPFAMi | SSF57701, SSF57701, 1 hit |
PROSITEi | View protein in PROSITE PS00463, ZN2_CY6_FUNGAL_1, 1 hit PS50048, ZN2_CY6_FUNGAL_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | WOR2_CANAL | |
Accessioni | Q5ANB1Primary (citable) accession number: Q5ANB1 Secondary accession number(s): A0A1D8PK50 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 31, 2012 |
Last sequence update: | April 26, 2005 | |
Last modified: | May 25, 2022 | |
This is version 102 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Candida albicans
Candida albicans: entries and gene names