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Protein

Filamentous growth regulator 23

Gene

FGR23

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Putative adhesin which may be involved in cell adhesion and virulence (By similarity). Involved in the regulation of filamentous growth.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Filamentous growth regulator 23
Alternative name(s):
Predicted GPI-anchored protein 40
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FGR23
Synonyms:PGA40
Ordered Locus Names:CAALFM_C302300WA
ORF Names:CaO19.1616, CaO19.9183
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri237561 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000559 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Candida Genome Database

More...
CGDi
CAL0000178630 FGR23

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Affects filamentous growth.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000042494322 – 1089Filamentous growth regulator 23Add BLAST1068
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00004249441090 – 1114Removed in mature formSequence analysisAdd BLAST25

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi382N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi397N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi475N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi490N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi506N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi539N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi565N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi591N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi637N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi687N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi739N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi831N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi957N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi966N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1070N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi1089GPI-anchor amidated asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q5AJV5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced in biofilms and by alpha factor. Repressed by HAP43.3 Publications

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi71 – 1049Thr-richPROSITE-ProRule annotationAdd BLAST979
Compositional biasi103 – 129Ser-richPROSITE-ProRule annotationAdd BLAST27
Compositional biasi250 – 1072Ser-richPROSITE-ProRule annotationAdd BLAST823

Keywords - Domaini

Signal

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
EOG092C5HDM

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q5AJV5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFASYLLLVL WIIRLVPTTH AHTGNDAEYL LNTVLKRDAT SLSRNAYLDS
60 70 80 90 100
EATSGATNYC SDCDNDEVIV TVDGTSTIWT ILLDSTISTL VTTTSTEKTT
110 120 130 140 150
LTSCGQSCTK SKDASSVSSS SASSSTSRSL IFRTSTKTVT DTTTLPTVTE
160 170 180 190 200
INTFTTTDSH IVLVYTDINS ESTITGDYTF IKNKNTRTVI ITDYVTSTVG
210 220 230 240 250
GETQIVTQTT TSVVYELVVT CPDHDFATTL TGSETFVPPT TAPKPVETPS
260 270 280 290 300
PEPSTTILSI KSESSVPSAT TSVLDTSITL ETSSSSIEFS TSTQESSSIG
310 320 330 340 350
PSSSSSIGSC TSSSISTEES LSTTKLSSSF TSISSWEELS SSFTQSTTSS
360 370 380 390 400
NAEPSSSFAE SFTTESLSST IEATSSMEDI SNNSVLTSSI FSETTTNESS
410 420 430 440 450
SYTDEPSSSE EITNTYEPSS STESSTTDQF SSLLSSSLPV TSTSSTTISS
460 470 480 490 500
ATPITTVLST SITSQDTNCE ATITNISTNT LIETITVNGN TTIYTETQLS
510 520 530 540 550
TYLTSNTSIN CPNTNSATTT TTQVIPTATT EQIHTTTLNG SIIVSTETAT
560 570 580 590 600
LKTTVIITHC PECTNESSTS EYSSSLKAES SQQSIPTIES NLSELSVSST
610 620 630 640 650
LSLVESTASG KCSGLTTTTF TSIVSTTTES IYTITSNEST FEMTTTVTNI
660 670 680 690 700
GTIVITTCPT ITPVSSSYSS SESLSSSVST SLLTESNSTI SQSTVSTDKS
710 720 730 740 750
SLTNDNQIST VSTETPLTSI TIIETTSKTT ESLYTTTSND STHIFTTTII
760 770 780 790 800
DVQTNTIVTC PTTTSTLTSS HTSDNEKPAS LSSSSLIESD HIADGTTTST
810 820 830 840 850
TFQSTSTTTV DHHCSSCSEI LLSTSSSIIG NKSTSTSISS IETSASSSYH
860 870 880 890 900
SSEPEVMSSS SSTSIKQSSD SIPSTSQTHV STTSSSVSSL ETTTTTTENS
910 920 930 940 950
PTSNGFSSSS IVTSVNVPDY VSSSVSSTSS TTSSPSTESS SNGLVSTVTE
960 970 980 990 1000
SSTANENTSE ITTIDNTSIT SEKVTGTNSN PKTSEIIKDA TITTSGNVES
1010 1020 1030 1040 1050
LHSTTPISST SIISTNAISS SDTTTLTITN TLTYSIDSIT TMKTSSITTA
1060 1070 1080 1090 1100
PPPPQQKESS SVLSSSLIIN SSTPTIIPTI NIPITFEGNA NSLGLKNGDN
1110
SWIIGIMMIG LLMI
Length:1,114
Mass (Da):116,305
Last modified:May 10, 2017 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD38B9832E72FCA56
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP017625 Genomic DNA Translation: AOW28267.1

NCBI Reference Sequences

More...
RefSeqi
XP_721695.2, XM_716602.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3636555

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cal:CAALFM_C302300WA

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017625 Genomic DNA Translation: AOW28267.1
RefSeqiXP_721695.2, XM_716602.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Proteomic databases

PRIDEiQ5AJV5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3636555
KEGGical:CAALFM_C302300WA

Organism-specific databases

CGDiCAL0000178630 FGR23

Phylogenomic databases

OrthoDBiEOG092C5HDM

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q5AJV5

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFGR23_CANAL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5AJV5
Secondary accession number(s): A0A1D8PJI3, Q5AJH8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 22, 2014
Last sequence update: May 10, 2017
Last modified: December 5, 2018
This is version 55 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
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