Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 103 (12 Aug 2020)
Sequence version 2 (10 May 2017)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Actin cytoskeleton-regulatory complex protein PAN1

Gene

PAN1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding
Biological processEndocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Actin cytoskeleton-regulatory complex protein PAN1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PAN1
Ordered Locus Names:CAALFM_C203380WA
ORF Names:CaO19.8505, CaO19.886
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri237561 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000559 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Candida Genome Database

More...
CGDi
CAL0000184200, PAN1

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:C2_03380W_A

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Endosome, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003494711 – 1396Actin cytoskeleton-regulatory complex protein PAN1Add BLAST1396

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q5AHB1

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the PAN1 actin cytoskeleton-regulatory complex.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
1220357, 1 interactor

STRING: functional protein association networks

More...
STRINGi
5476.C4YJT5

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5AHB1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini122 – 211EH 1PROSITE-ProRule annotationAdd BLAST90
Domaini472 – 561EH 2PROSITE-ProRule annotationAdd BLAST90
Domaini1365 – 1382WH2PROSITE-ProRule annotationAdd BLAST18

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1037 – 1093Sequence analysisAdd BLAST57

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi6 – 91Gln-richPROSITE-ProRule annotationAdd BLAST86
Compositional biasi310 – 413Gln-richPROSITE-ProRule annotationAdd BLAST104
Compositional biasi1284 – 1351Pro-richPROSITE-ProRule annotationAdd BLAST68

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PAN1 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0998, Eukaryota
KOG1029, Eukaryota
KOG2056, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001619_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5AHB1

KEGG Orthology (KO)

More...
KOi
K20047

Database of Orthologous Groups

More...
OrthoDBi
597979at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00052, EH, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013182, DUF1720
IPR011992, EF-hand-dom_pair
IPR002048, EF_hand_dom
IPR000261, EH_dom
IPR003124, WH2_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08226, DUF1720, 2 hits
PF12763, EF-hand_4, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00054, EFh, 2 hits
SM00027, EH, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473, SSF47473, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50222, EF_HAND_2, 2 hits
PS50031, EH, 2 hits
PS51082, WH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5AHB1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYNPYQQQQQ GMGYNPQQQT GYGYNNYQMP QQPQFNQQPM YPQATGFVPQ
60 70 80 90 100
QPNLYGSNFQ TSGGSGMAPQ QTGFSQQQTM QPQQTGYIQT QPTGFGGTAP
110 120 130 140 150
IVTENSELKI PSIRLSFISA EDQKKFEHLF RTAVPKGEQS ISGDSASGIL
160 170 180 190 200
LRSGLSAVTL AEIWNLSDID KTGSLLFPEF ALSLHLCSMA KRGEPLPGIL
210 220 230 240 250
PEKWLNEVRS FVDQINFTVP DDPSKILANT PFANFAPKKE SDWLAPQSTG
260 270 280 290 300
YLQNQSAPPM TSFQPQVTGF GGQGLVSQAT GGVPMPSTTF GNAAGLTAQR
310 320 330 340 350
TGGGTLIPLQ PQQTAGLIPA QKTGPLNPQT TGFNQQSLQQ QRTGGLPQQL
360 370 380 390 400
TGYQGPPQGQ GQQLQQQRTG GFPQVQSQPT GGFVPQTSFQ QPQLVSQRTG
410 420 430 440 450
PMQAQPTGSL QAQPTGRPGE WGFVSMPTGG IPGLNAMQQH FLPNNQLPTS
460 470 480 490 500
NLHSAMDNKL KENVTWAITK QEKQIYDGLF QAWDNQKKGY VDSNVALNVF
510 520 530 540 550
TKSGLSRSDL ESIWTLVDTD DTGKLNKNQF AVAMHLIYRR LNGYDIPLRL
560 570 580 590 600
PPELIPPADR TLKDTMDSLK NSLKGGVNNK PTKPPKPQSK PDGTRFKNDD
610 620 630 640 650
NNFGYVSNVR HRRKSTSDES HKSSVKSSSD YDLSIEDMKK LIHEKRILLD
660 670 680 690 700
ALDTEDQANN YSRSSSSMHE KQIIENLKKE IMAVQTKLDE RGNDGPSSDE
710 720 730 740 750
RNKLLATLDH LTRDVVPRLI SDIHKVNQEI SRKKAEVFKL ELLKKNPSWN
760 770 780 790 800
PEDDESQIQG TGPNGEVTDY DRIKYQSRQK LKQRMAALTG KSTGGNSDLD
810 820 830 840 850
LELKQATEKA QDEASRQSEM IQDIAAGIKT MEDECAAKLS SSVTEDVGHE
860 870 880 890 900
KWEQGKGISS EVAKFVKELE AFSKEQRRNI AKSQKQEQTR EPLAKQQTNA
910 920 930 940 950
SLVSDSGAAK SAYATPEERA AYIKQQAEKR MNERLAKLGI TRKSKSTEQK
960 970 980 990 1000
PPVESKSVSN HSPVPDSEVK SVTRNANEVE VQKPKPDSQP VSKNREPAEQ
1010 1020 1030 1040 1050
PNSKADTNSV GSQNVVSNTN DDTSGDDDDE EYKAILKQKQ EMEARERERK
1060 1070 1080 1090 1100
LRKQKAKEER LAKIKKEMEE MKKREMEESQ DEEEEEAKQV TSVHVSRAQS
1110 1120 1130 1140 1150
SNANSNVIPQ QETATENVNT VSQPTSTDTA KQSYHPHESN PFSKMNNNTS
1160 1170 1180 1190 1200
QNSTVTNTGT NPFFKSTSQE TKIDPHKAEA QRASQRGVAS SGGWSDSEEE
1210 1220 1230 1240 1250
ESEEESPNRA GAAKLASLLF GGMPQPPTTS SSSLNNDAEK VSEQEHENAK
1260 1270 1280 1290 1300
QVASTPLSND DNGKTDSGPS GFAGENESSF SQAPPIPVDA PPAPNSIPPP
1310 1320 1330 1340 1350
PPPPPQFSNE APPVPDSIPP PPPPPSVPST VPALPDSMPP PPPPPPPPAA
1360 1370 1380 1390
PNNTSSSQQA SGAPNIGALL GQITGGASLR KVETKVSSGA TVGRVL
Length:1,396
Mass (Da):152,369
Last modified:May 10, 2017 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE61D9B421CB1CA29
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP017624 Genomic DNA Translation: AOW27374.1

NCBI Reference Sequences

More...
RefSeqi
XP_721009.2, XM_715916.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3637386

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cal:CAALFM_C203380WA

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017624 Genomic DNA Translation: AOW27374.1
RefSeqiXP_721009.2, XM_715916.2

3D structure databases

SMRiQ5AHB1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi1220357, 1 interactor
STRINGi5476.C4YJT5

Proteomic databases

PRIDEiQ5AHB1

Genome annotation databases

GeneIDi3637386
KEGGical:CAALFM_C203380WA

Organism-specific databases

CGDiCAL0000184200, PAN1
EuPathDBiFungiDB:C2_03380W_A

Phylogenomic databases

eggNOGiKOG0998, Eukaryota
KOG1029, Eukaryota
KOG2056, Eukaryota
HOGENOMiCLU_001619_0_0_1
InParanoidiQ5AHB1
KOiK20047
OrthoDBi597979at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q5AHB1

Family and domain databases

CDDicd00052, EH, 2 hits
InterProiView protein in InterPro
IPR013182, DUF1720
IPR011992, EF-hand-dom_pair
IPR002048, EF_hand_dom
IPR000261, EH_dom
IPR003124, WH2_dom
PfamiView protein in Pfam
PF08226, DUF1720, 2 hits
PF12763, EF-hand_4, 2 hits
SMARTiView protein in SMART
SM00054, EFh, 2 hits
SM00027, EH, 2 hits
SUPFAMiSSF47473, SSF47473, 2 hits
PROSITEiView protein in PROSITE
PS50222, EF_HAND_2, 2 hits
PS50031, EH, 2 hits
PS51082, WH2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPAN1_CANAL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5AHB1
Secondary accession number(s): A0A1D8PGW1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: May 10, 2017
Last modified: August 12, 2020
This is version 103 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again