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UniProtKB - Q5AD78 (DCW1_CANAL)
Protein
Mannan endo-1,6-alpha-mannosidase DCW1
Gene
DCW1
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Functioni
Probable mannosidase required for normal synthesis of the cell wall.
1 PublicationCatalytic activityi
- Random hydrolysis of (1->6)-alpha-D-mannosidic linkages in unbranched (1->6)-mannans. EC:3.2.1.101
GO - Molecular functioni
- mannan endo-1,6-alpha-mannosidase activity Source: UniProtKB-EC
GO - Biological processi
- budding cell bud growth Source: GO_Central
- carbohydrate catabolic process Source: InterPro
- cell wall organization Source: UniProtKB-KW
- fungal-type cell wall biogenesis Source: GO_Central
Keywordsi
Molecular function | Glycosidase, Hydrolase |
Biological process | Cell wall biogenesis/degradation |
Names & Taxonomyi
Protein namesi | Recommended name: Mannan endo-1,6-alpha-mannosidase DCW1 (EC:3.2.1.101)Alternative name(s): Defective cell wall 1 Endo-alpha-1->6-D-mannanase DCW1 GPI-anchored protein 51 |
Gene namesi | Name:DCW1 Synonyms:PGA51 Ordered Locus Names:CAALFM_C201360CA ORF Names:CaO19.1989, CaO19.9540 |
Organismi | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
Taxonomic identifieri | 237561 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Candida/Lodderomyces clade › Candida › |
Proteomesi |
|
Organism-specific databases
CGDi | CAL0000197643, DCW1 |
VEuPathDBi | FungiDB:C2_01360C_A |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; GPI-anchor By similarity
Plasma Membrane
- anchored component of plasma membrane Source: EnsemblFungi
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000424805 | 19 – 431 | Mannan endo-1,6-alpha-mannosidase DCW1Add BLAST | 413 | |
PropeptideiPRO_0000424806 | 432 – 452 | Removed in mature formSequence analysisAdd BLAST | 21 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 25 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 81 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 106 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 130 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 200 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 237 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 240 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 262 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 271 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 286 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 431 | GPI-anchor amidated glycineSequence analysis | 1 |
Keywords - PTMi
Glycoprotein, GPI-anchor, LipoproteinExpressioni
Inductioni
Induced by HAP43 and up-regulated in absence of CYR1.2 Publications
Family & Domainsi
Sequence similaritiesi
Belongs to the glycosyl hydrolase 76 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QSWP, Eukaryota |
HOGENOMi | CLU_025694_1_2_1 |
InParanoidi | Q5AD78 |
OMAi | IMSEVAC |
OrthoDBi | 844700at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR008928, 6-hairpin_glycosidase_sf IPR005198, Glyco_hydro_76 IPR014480, Mannan-1_6-alpha_mannosidase |
PANTHERi | PTHR12145, PTHR12145, 1 hit |
Pfami | View protein in Pfam PF03663, Glyco_hydro_76, 1 hit |
PIRSFi | PIRSF016302, Man_a_manosd, 1 hit |
SUPFAMi | SSF48208, SSF48208, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q5AD78-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKFSIYLIIS LFSSFSHAIW LDTNNETTIR EDCNIIAKGL LDYYEGTKYG
60 70 80 90 100
GVIGMFSWPY YWWEAGGAWG SLIDYTFYFD NDTLVPLITD ALLYQTGDDD
110 120 130 140 150
NYIPLNQSTT EGNDDQAFWG IAVMAAAERN FTNPKDPTKA WLTLAQAVFN
160 170 180 190 200
TMQARWDTET CNGGLRWQIF QWNSGYDYKN SVSNGALFHL AARLARYTGN
210 220 230 240 250
DSYVVWAERV WDWMYGVGLL TEQNWWFVYD GVKIANNCSN ITKYQWSYNQ
260 270 280 290 300
GLMLAGCAYL YNYTEEEKWY NYTIKLLESA QVFFKNISGS MVMYEAACQP
310 320 330 340 350
SNSCNNDQRS FKAYFSRFLG LTSVLVPQTE PVITKWLVDS ANGAAGSCSG
360 370 380 390 400
GSDGVTCGLS WTDWSQGWDG KWGLGEQMSA LEVMQNLMVH KRPAPYTADT
410 420 430 440 450
GGSSIGNPAA GYGKLTSDAT PLSIDGGDKA GAGIITAIIG ASLVGSCVWL
IL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP017624 Genomic DNA Translation: AOW27182.1 |
RefSeqi | XP_719439.1, XM_714346.1 |
Genome annotation databases
GeneIDi | 3638842 |
KEGGi | cal:CAALFM_C201360CA |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP017624 Genomic DNA Translation: AOW27182.1 |
RefSeqi | XP_719439.1, XM_714346.1 |
3D structure databases
SMRi | Q5AD78 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 237561.Q5AD78 |
Genome annotation databases
GeneIDi | 3638842 |
KEGGi | cal:CAALFM_C201360CA |
Organism-specific databases
CGDi | CAL0000197643, DCW1 |
VEuPathDBi | FungiDB:C2_01360C_A |
Phylogenomic databases
eggNOGi | ENOG502QSWP, Eukaryota |
HOGENOMi | CLU_025694_1_2_1 |
InParanoidi | Q5AD78 |
OMAi | IMSEVAC |
OrthoDBi | 844700at2759 |
Miscellaneous databases
PROi | PR:Q5AD78 |
Family and domain databases
InterProi | View protein in InterPro IPR008928, 6-hairpin_glycosidase_sf IPR005198, Glyco_hydro_76 IPR014480, Mannan-1_6-alpha_mannosidase |
PANTHERi | PTHR12145, PTHR12145, 1 hit |
Pfami | View protein in Pfam PF03663, Glyco_hydro_76, 1 hit |
PIRSFi | PIRSF016302, Man_a_manosd, 1 hit |
SUPFAMi | SSF48208, SSF48208, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DCW1_CANAL | |
Accessioni | Q5AD78Primary (citable) accession number: Q5AD78 Secondary accession number(s): A0A1D8PGD3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 11, 2013 |
Last sequence update: | April 26, 2005 | |
Last modified: | February 23, 2022 | |
This is version 92 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Candida albicans
Candida albicans: entries and gene names - Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries - SIMILARITY comments
Index of protein domains and families