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Protein

Multiple drug resistance-associated protein-like transporter 1

Gene

MLT1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Vacuolar multi-drug resistance ABC transporter that may be involved in the transport of bilirubin and glutathione conjugates (By similarity). Plays an important role in virulence.1 PublicationBy similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi704 – 711ATPPROSITE-ProRule annotation8
Nucleotide bindingi1379 – 1386ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport, Virulence
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Multiple drug resistance-associated protein-like transporter 11 Publication
Short name:
MRP-like transporter 11 Publication
Alternative name(s):
Vacuolar multi-drug resistance ABC transporter MTL1Curated
Gene namesi
Name:MLT1
Synonyms:ABC1, BPT1, YCF11 Publication
Ordered Locus Names:CAALFM_C108210CA
ORF Names:CaO19.12566, CaO19.5100
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 1

Organism-specific databases

CGDiCAL0000178329 MLT1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei67 – 87Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei111 – 131Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei134 – 154Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei159 – 179Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei196 – 216Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei325 – 345Helical; Name=6Sequence analysisAdd BLAST21
Transmembranei365 – 385Helical; Name=7Sequence analysisAdd BLAST21
Transmembranei438 – 458Helical; Name=8Sequence analysisAdd BLAST21
Transmembranei470 – 490Helical; Name=9Sequence analysisAdd BLAST21
Transmembranei548 – 568Helical; Name=10Sequence analysisAdd BLAST21
Transmembranei588 – 608Helical; Name=11Sequence analysisAdd BLAST21
Transmembranei1015 – 1035Helical; Name=12Sequence analysisAdd BLAST21
Transmembranei1071 – 1091Helical; Name=13Sequence analysisAdd BLAST21
Transmembranei1132 – 1152Helical; Name=14Sequence analysisAdd BLAST21
Transmembranei1154 – 1174Helical; Name=15Sequence analysisAdd BLAST21
Transmembranei1252 – 1272Helical; Name=16Sequence analysisAdd BLAST21
Transmembranei1276 – 1296Helical; Name=17Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Vacuole

Pathology & Biotechi

Disruption phenotypei

Leads to decreased sublethal intraperitoneal infection in mice.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004305551 – 1606Multiple drug resistance-associated protein-like transporter 1Add BLAST1606

Expressioni

Inductioni

Is 10-fold down-regulated during log phase and strongly induced at the diauxic shift. Expression remains high during the postdiauxic phase and continues into stationary phase. Is also up-regulated during the presence of cadmium ions.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ5A762
SMRiQ5A762
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini326 – 613ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST288
Domaini672 – 905ABC transporter 1PROSITE-ProRule annotationAdd BLAST234
Domaini1042 – 1308ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST267
Domaini1345 – 1600ABC transporter 2PROSITE-ProRule annotationAdd BLAST256

Sequence similaritiesi

Belongs to the ABC transporter superfamily.UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ5A762
OrthoDBiEOG092C0QQU

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

Sequencei

Sequence statusi: Complete.

Q5A762-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNESNRELIL GLSPVHLSLF NSESLLHTFN FFGVGDGQAN IASNYVTASK
60 70 80 90 100
FVIPQPLYSP HGNALNPAFV ELIGQAVNTF FAIFMLFQLT RLLLTKKKSH
110 120 130 140 150
RIYTPTPFSQ TLKISLVLLQ VILVASLYFL NKNSYFIGGI AATVLALILH
160 170 180 190 200
LVEFRRSPIA IESLLTYWSA NTAFTFAVFI QDSYSKHKIY ANSGPAYVIE
210 220 230 240 250
IISLVNSFLI FVFEVGYYKP GFEITNEKFL DTVNLFSYFT FYYLQPLINK
260 270 280 290 300
IYATDDVQLT DLPDILGNIT CDDTKAKVAK AWEEELKRTK KPGLVSKVWS
310 320 330 340 350
FVTRRKVNSK PQMFLAIAKA FFDKFAISIT LAIIVTGLSF LQPFLLRKFI
360 370 380 390 400
QFFSTYFYSV EKPPIIIGYF WASVMFLTSV ANFIAFNQAF KTQFDLGYEI
410 420 430 440 450
QSSLTTLIYE KALRLSPQSR KNKPTGDIIN HITMDIDIIF WFCWQLGEYL
460 470 480 490 500
ASPLKLAVCL AALYKLFSNA TWAGVITAII VAPLATLVNA SMSKNYIQLM
510 520 530 540 550
KDKDERTSLI TEILNSAKSI KFYSWEKPML ARLSHIRNDR ELNNIKKIGV
560 570 580 590 600
VSALAQFLWS CIPFFISCAT YATYAYFYNV PLTPDIVFPA LALFDLLSEP
610 620 630 640 650
MLLIPSFIVE VIEVSTSLAR IGELLCLDEL ADDQHGYVKR DPEPNDNSIY
660 670 680 690 700
SVIVKDATFV WSEETQQKQY TDEESEVQEV PASNVALKNI NFSARKGELA
710 720 730 740 750
CIVGKVGSGK STLIKAILGD VPIKIPSYSD DSTNPTPSVE TFGSIAYCPQ
760 770 780 790 800
NPWILNGTVK ENILFGHKYD AEFYQKTIDA CELISDFKNL PDGDQTVVGE
810 820 830 840 850
KGISLSGGQK ARISLARSVY TRADIYLLDD ILSAVDAHVG KNIIKKVLSN
860 870 880 890 900
EGLIGNRCRI LATNSVPVLH EANDIYLIAG GAFVEHGKFK EVMKRNGDLA
910 920 930 940 950
KLIKEYGRKK DEPTEEETTE ASTEPKEEDH SNGKSDTAVH DELDTDELVD
960 970 980 990 1000
EIVDYVGEQN RGVVEQAILR RASVVSYGHN YENDEADNGQ IRKTRHEQEE
1010 1020 1030 1040 1050
SRKGTVPWDI FKQYIIACDY KYFSFYVAAT FSVVLISAGE KYLLSYWSQL
1060 1070 1080 1090 1100
NSEQNDTVEP VFFLGTYATL GVVSGFLTYM GALVIWSYCI VKGSTYFHNK
1110 1120 1130 1140 1150
MAESVLRSPM SFFDTTPIGR ILNRFTEDIG KIDMNLPWTI ISFITTLLNG
1160 1170 1180 1190 1200
FVTFGVILSF LPLMLVVIVS LLFVYNYFRI RFVPTTRELK RLESIAKSPV
1210 1220 1230 1240 1250
LATIQESING VETIKAFHQR ERFVYKSKKL IDEKTLIGVV QQNCNRWLSM
1260 1270 1280 1290 1300
RLQTISSSIM FFTALLAVVT LGGKHPILPS ILGFVMTYSM SITYILNSLV
1310 1320 1330 1340 1350
RIWAEMQAGG VAIERIIEYC DLPSEAPMII EDKRPQDSWP AHGVVKFKKY
1360 1370 1380 1390 1400
STAYRKHLDP VLREIELTIN SKEKVGIVGR TGAGKSSLTL ALFRIIEATG
1410 1420 1430 1440 1450
GNIEIDGVDT SQIGLYDLRH HLTIIPQEAH TFRASVRENL DPFGEYSDDK
1460 1470 1480 1490 1500
LWKVLELAHL KEHVTKMETD PTEEEKKASK NPDELSKKVG LDAQIEEGGS
1510 1520 1530 1540 1550
NLSSGQKQLL CLARALLNET SKILVLDEAT AAVDFQTDKI IQETIRTEFK
1560 1570 1580 1590 1600
DKTILTIAHR IDTIMDSDKI LVLDSGKVAE FDSPQNLLKN KDSIFYSLAK

EGGYID
Length:1,606
Mass (Da):180,693
Last modified:April 26, 2005 - v1
Checksum:i8A22999D3B480EA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017623 Genomic DNA Translation: AOW26461.1
RefSeqiXP_717637.1, XM_712544.2

Genome annotation databases

EnsemblFungiiAOW26461; AOW26461; CAALFM_C108210CA
GeneIDi3640748
KEGGical:CAALFM_C108210CA

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017623 Genomic DNA Translation: AOW26461.1
RefSeqiXP_717637.1, XM_712544.2

3D structure databases

ProteinModelPortaliQ5A762
SMRiQ5A762
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAOW26461; AOW26461; CAALFM_C108210CA
GeneIDi3640748
KEGGical:CAALFM_C108210CA

Organism-specific databases

CGDiCAL0000178329 MLT1

Phylogenomic databases

InParanoidiQ5A762
OrthoDBiEOG092C0QQU

Miscellaneous databases

PROiPR:Q5A762

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMLT1_CANAL
AccessioniPrimary (citable) accession number: Q5A762
Secondary accession number(s): A0A1D8PEB9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 29, 2014
Last sequence update: April 26, 2005
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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