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Protein

Multiple drug resistance-associated protein-like transporter 1

Gene

MLT1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Vacuolar multi-drug resistance ABC transporter that may be involved in the transport of bilirubin and glutathione conjugates (By similarity). Plays an important role in virulence.1 PublicationBy similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi704 – 711ATPPROSITE-ProRule annotation8
Nucleotide bindingi1379 – 1386ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport, Virulence
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Multiple drug resistance-associated protein-like transporter 11 Publication
Short name:
MRP-like transporter 11 Publication
Alternative name(s):
Vacuolar multi-drug resistance ABC transporter MTL1Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MLT1
Synonyms:ABC1, BPT1, YCF11 Publication
Ordered Locus Names:CAALFM_C108210CA
ORF Names:CaO19.12566, CaO19.5100
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri237561 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000559 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Candida Genome Database

More...
CGDi
CAL0000178329 MLT1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei67 – 87Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei111 – 131Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei134 – 154Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei159 – 179Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei196 – 216Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei325 – 345Helical; Name=6Sequence analysisAdd BLAST21
Transmembranei365 – 385Helical; Name=7Sequence analysisAdd BLAST21
Transmembranei438 – 458Helical; Name=8Sequence analysisAdd BLAST21
Transmembranei470 – 490Helical; Name=9Sequence analysisAdd BLAST21
Transmembranei548 – 568Helical; Name=10Sequence analysisAdd BLAST21
Transmembranei588 – 608Helical; Name=11Sequence analysisAdd BLAST21
Transmembranei1015 – 1035Helical; Name=12Sequence analysisAdd BLAST21
Transmembranei1071 – 1091Helical; Name=13Sequence analysisAdd BLAST21
Transmembranei1132 – 1152Helical; Name=14Sequence analysisAdd BLAST21
Transmembranei1154 – 1174Helical; Name=15Sequence analysisAdd BLAST21
Transmembranei1252 – 1272Helical; Name=16Sequence analysisAdd BLAST21
Transmembranei1276 – 1296Helical; Name=17Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Vacuole

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Leads to decreased sublethal intraperitoneal infection in mice.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004305551 – 1606Multiple drug resistance-associated protein-like transporter 1Add BLAST1606

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Is 10-fold down-regulated during log phase and strongly induced at the diauxic shift. Expression remains high during the postdiauxic phase and continues into stationary phase. Is also up-regulated during the presence of cadmium ions.1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q5A762

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5A762

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini326 – 613ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST288
Domaini672 – 905ABC transporter 1PROSITE-ProRule annotationAdd BLAST234
Domaini1042 – 1308ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST267
Domaini1345 – 1600ABC transporter 2PROSITE-ProRule annotationAdd BLAST256

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ABC transporter superfamily.UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5A762

Database of Orthologous Groups

More...
OrthoDBi
138195at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5A762-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNESNRELIL GLSPVHLSLF NSESLLHTFN FFGVGDGQAN IASNYVTASK
60 70 80 90 100
FVIPQPLYSP HGNALNPAFV ELIGQAVNTF FAIFMLFQLT RLLLTKKKSH
110 120 130 140 150
RIYTPTPFSQ TLKISLVLLQ VILVASLYFL NKNSYFIGGI AATVLALILH
160 170 180 190 200
LVEFRRSPIA IESLLTYWSA NTAFTFAVFI QDSYSKHKIY ANSGPAYVIE
210 220 230 240 250
IISLVNSFLI FVFEVGYYKP GFEITNEKFL DTVNLFSYFT FYYLQPLINK
260 270 280 290 300
IYATDDVQLT DLPDILGNIT CDDTKAKVAK AWEEELKRTK KPGLVSKVWS
310 320 330 340 350
FVTRRKVNSK PQMFLAIAKA FFDKFAISIT LAIIVTGLSF LQPFLLRKFI
360 370 380 390 400
QFFSTYFYSV EKPPIIIGYF WASVMFLTSV ANFIAFNQAF KTQFDLGYEI
410 420 430 440 450
QSSLTTLIYE KALRLSPQSR KNKPTGDIIN HITMDIDIIF WFCWQLGEYL
460 470 480 490 500
ASPLKLAVCL AALYKLFSNA TWAGVITAII VAPLATLVNA SMSKNYIQLM
510 520 530 540 550
KDKDERTSLI TEILNSAKSI KFYSWEKPML ARLSHIRNDR ELNNIKKIGV
560 570 580 590 600
VSALAQFLWS CIPFFISCAT YATYAYFYNV PLTPDIVFPA LALFDLLSEP
610 620 630 640 650
MLLIPSFIVE VIEVSTSLAR IGELLCLDEL ADDQHGYVKR DPEPNDNSIY
660 670 680 690 700
SVIVKDATFV WSEETQQKQY TDEESEVQEV PASNVALKNI NFSARKGELA
710 720 730 740 750
CIVGKVGSGK STLIKAILGD VPIKIPSYSD DSTNPTPSVE TFGSIAYCPQ
760 770 780 790 800
NPWILNGTVK ENILFGHKYD AEFYQKTIDA CELISDFKNL PDGDQTVVGE
810 820 830 840 850
KGISLSGGQK ARISLARSVY TRADIYLLDD ILSAVDAHVG KNIIKKVLSN
860 870 880 890 900
EGLIGNRCRI LATNSVPVLH EANDIYLIAG GAFVEHGKFK EVMKRNGDLA
910 920 930 940 950
KLIKEYGRKK DEPTEEETTE ASTEPKEEDH SNGKSDTAVH DELDTDELVD
960 970 980 990 1000
EIVDYVGEQN RGVVEQAILR RASVVSYGHN YENDEADNGQ IRKTRHEQEE
1010 1020 1030 1040 1050
SRKGTVPWDI FKQYIIACDY KYFSFYVAAT FSVVLISAGE KYLLSYWSQL
1060 1070 1080 1090 1100
NSEQNDTVEP VFFLGTYATL GVVSGFLTYM GALVIWSYCI VKGSTYFHNK
1110 1120 1130 1140 1150
MAESVLRSPM SFFDTTPIGR ILNRFTEDIG KIDMNLPWTI ISFITTLLNG
1160 1170 1180 1190 1200
FVTFGVILSF LPLMLVVIVS LLFVYNYFRI RFVPTTRELK RLESIAKSPV
1210 1220 1230 1240 1250
LATIQESING VETIKAFHQR ERFVYKSKKL IDEKTLIGVV QQNCNRWLSM
1260 1270 1280 1290 1300
RLQTISSSIM FFTALLAVVT LGGKHPILPS ILGFVMTYSM SITYILNSLV
1310 1320 1330 1340 1350
RIWAEMQAGG VAIERIIEYC DLPSEAPMII EDKRPQDSWP AHGVVKFKKY
1360 1370 1380 1390 1400
STAYRKHLDP VLREIELTIN SKEKVGIVGR TGAGKSSLTL ALFRIIEATG
1410 1420 1430 1440 1450
GNIEIDGVDT SQIGLYDLRH HLTIIPQEAH TFRASVRENL DPFGEYSDDK
1460 1470 1480 1490 1500
LWKVLELAHL KEHVTKMETD PTEEEKKASK NPDELSKKVG LDAQIEEGGS
1510 1520 1530 1540 1550
NLSSGQKQLL CLARALLNET SKILVLDEAT AAVDFQTDKI IQETIRTEFK
1560 1570 1580 1590 1600
DKTILTIAHR IDTIMDSDKI LVLDSGKVAE FDSPQNLLKN KDSIFYSLAK

EGGYID
Length:1,606
Mass (Da):180,693
Last modified:April 26, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8A22999D3B480EA3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP017623 Genomic DNA Translation: AOW26461.1

NCBI Reference Sequences

More...
RefSeqi
XP_717637.1, XM_712544.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3640748

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cal:CAALFM_C108210CA

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017623 Genomic DNA Translation: AOW26461.1
RefSeqiXP_717637.1, XM_712544.2

3D structure databases

ProteinModelPortaliQ5A762
SMRiQ5A762
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3640748
KEGGical:CAALFM_C108210CA

Organism-specific databases

CGDiCAL0000178329 MLT1

Phylogenomic databases

InParanoidiQ5A762
OrthoDBi138195at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q5A762

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMLT1_CANAL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5A762
Secondary accession number(s): A0A1D8PEB9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 29, 2014
Last sequence update: April 26, 2005
Last modified: January 16, 2019
This is version 115 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Candida albicans
    Candida albicans: entries and gene names
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