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Protein

Ceramide very long chain fatty acid hydroxylase

Gene

SCS7

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Ceramide hydroxylase involved in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids. Hydroxylates the very long chain fatty acid of ceramides at C2 and C3.UniRule annotation

Cofactori

Fe cationUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
Biological processFatty acid biosynthesisUniRule annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandHemeSAAS annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ceramide very long chain fatty acid hydroxylaseUniRule annotation (EC:1.-.-.-UniRule annotation)
Gene namesi
Name:SCS7Imported
Ordered Locus Names:orf19.3822Imported
ORF Names:CAALFM_C404590WAImported
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)Imported
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 4

Organism-specific databases

CGDiCAL0000201815 SCS7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei196 – 215HelicalSequence analysisAdd BLAST20
Transmembranei221 – 241HelicalSequence analysisAdd BLAST21
Transmembranei300 – 320HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, Membrane

Structurei

3D structure databases

ProteinModelPortaliQ5A668
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sterol desaturase family. SCS7 subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

KOiK19703
OMAiRWLEQYY
OrthoDBiEOG092C3MYJ

Family and domain databases

Gene3Di3.10.120.10, 1 hit
InterProiView protein in InterPro
IPR001199 Cyt_B5-like_heme/steroid-bd
IPR036400 Cyt_B5-like_heme/steroid_sf
IPR018506 Cyt_B5_heme-BS
IPR006694 Fatty_acid_hydroxylase
IPR014430 Scs7
PfamiView protein in Pfam
PF00173 Cyt-b5, 1 hit
PF04116 FA_hydroxylase, 1 hit
PIRSFiPIRSF005149 IPC-B_HD, 1 hit
PRINTSiPR00363 CYTOCHROMEB5
SMARTiView protein in SMART
SM01117 Cyt-b5, 1 hit
SUPFAMiSSF55856 SSF55856, 1 hit
PROSITEiView protein in PROSITE
PS00191 CYTOCHROME_B5_1, 1 hit
PS50255 CYTOCHROME_B5_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5A668-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKNLPLLSI QEVSKHNHVK DCWVTLYQRK IYNVTGFLEE HPGGGEIILP
60 70 80 90 100
YAGKDITEIM ADIQSHQHSE SAYEILDEGM LVGYLATEQE EKGLLRNKNN
110 120 130 140 150
TPVEVKLVNK DDKDFDMYEF HDHLPAEEKL SIQTDFEEDS KKHRFLDLNK
160 170 180 190 200
PLLMQLLTSN FSKEFYLDQV HRPRHYGKGS APLFGNFLEP ISLTPWWVIP
210 220 230 240 250
LVWLPPNFYL FYVGFVNQSP ITALSLWVMG LFIWTLVEYC LHRFLFHLDY
260 270 280 290 300
FLPDHPYAFA LHFLLHGIHH YLPMDGYRLV LPPTLFLVLA YPFYKLIFSI
310 320 330 340 350
FPFYMACSGF AGGTLGYIMY DITHYVLHHT KLPKYFQTVK RLHLEHHYKN
360 370
YELGFGVTSP FWDVVFGTEL TNTFEKRR
Length:378
Mass (Da):44,426
Last modified:April 26, 2005 - v1
Checksum:i361C944030A58417
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017626 Genomic DNA Translation: AOW29206.1
RefSeqiXP_717227.1, XM_712134.1

Genome annotation databases

EnsemblFungiiAOW29206; AOW29206; CAALFM_C404590WA
GeneIDi3641157
KEGGical:CAALFM_C404590WA

Similar proteinsi

Entry informationi

Entry nameiQ5A668_CANAL
AccessioniPrimary (citable) accession number: Q5A668
Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: March 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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