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UniProtKB - Q5A5N6 (ALG14_CANAL)
Protein
UDP-N-acetylglucosamine transferase subunit ALG14
Gene
ALG14
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Functioni
Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER (By similarity).
By similarityGO - Biological processi
- dolichol-linked oligosaccharide biosynthetic process Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: UDP-N-acetylglucosamine transferase subunit ALG14Alternative name(s): Asparagine-linked glycosylation protein 14 |
Gene namesi | Name:ALG14 Ordered Locus Names:CAALFM_C210790CA ORF Names:CaO19.12823, CaO19.5363 |
Organismi | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
Taxonomic identifieri | 237561 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Candida/Lodderomyces clade › Candida › |
Proteomesi |
|
Organism-specific databases
CGDi | CAL0000178538, orf19.5363 |
VEuPathDBi | FungiDB:C2_10790C_A |
Subcellular locationi
Nucleus
- Nucleus membrane By similarity; Single-pass membrane protein Sequence analysis
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Single-pass membrane protein Sequence analysis
Endoplasmic reticulum
- UDP-N-acetylglucosamine transferase complex Source: GO_Central
Nucleus
- nuclear membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 8 | LumenalBy similarity | 8 | |
Transmembranei | 9 – 29 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 30 – 219 | CytoplasmicBy similarityAdd BLAST | 190 |
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000123811 | 1 – 219 | UDP-N-acetylglucosamine transferase subunit ALG14Add BLAST | 219 |
Interactioni
Subunit structurei
Heterodimer with ALG13 to form a functional enzyme.
By similarityProtein-protein interaction databases
STRINGi | 237561.Q5A5N6 |
Family & Domainsi
Sequence similaritiesi
Belongs to the ALG14 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3339, Eukaryota |
HOGENOMi | CLU_064541_2_0_1 |
InParanoidi | Q5A5N6 |
OMAi | GPGTCCI |
OrthoDBi | 1449763at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR013969, Oligosacch_biosynth_Alg14 |
PANTHERi | PTHR12154, PTHR12154, 1 hit |
Pfami | View protein in Pfam PF08660, Alg14, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5A5N6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDIETAACFS IAFIATPILI VLVRLLFILP SLRLPTSVKK KKKLIQECQL
60 70 80 90 100
SILLGSGGHT GEMMRIISKL DMGKVSRTWI YTSGDNASLA KAQDYERKSG
110 120 130 140 150
TSSQYIPIPR ARTVGQSYIS SIPTTIYSFL FSAIAMLKHR PAVILLNGPG
160 170 180 190 200
TCVPVAYILF LYKLLGLCNT KIIYIESLAR VNKLSLSGLL LLPISDRFIV
210
QWESLYQQYS RVEYYGILI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP017624 Genomic DNA Translation: AOW28047.1 |
RefSeqi | XP_717165.1, XM_712072.1 |
Genome annotation databases
GeneIDi | 3641242 |
KEGGi | cal:CAALFM_C210790CA |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP017624 Genomic DNA Translation: AOW28047.1 |
RefSeqi | XP_717165.1, XM_712072.1 |
3D structure databases
SMRi | Q5A5N6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 237561.Q5A5N6 |
Genome annotation databases
GeneIDi | 3641242 |
KEGGi | cal:CAALFM_C210790CA |
Organism-specific databases
CGDi | CAL0000178538, orf19.5363 |
VEuPathDBi | FungiDB:C2_10790C_A |
Phylogenomic databases
eggNOGi | KOG3339, Eukaryota |
HOGENOMi | CLU_064541_2_0_1 |
InParanoidi | Q5A5N6 |
OMAi | GPGTCCI |
OrthoDBi | 1449763at2759 |
Miscellaneous databases
PROi | PR:Q5A5N6 |
Family and domain databases
InterProi | View protein in InterPro IPR013969, Oligosacch_biosynth_Alg14 |
PANTHERi | PTHR12154, PTHR12154, 1 hit |
Pfami | View protein in Pfam PF08660, Alg14, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ALG14_CANAL | |
Accessioni | Q5A5N6Primary (citable) accession number: Q5A5N6 Secondary accession number(s): A0A1D8PIT0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 22, 2005 |
Last sequence update: | April 26, 2005 | |
Last modified: | February 23, 2022 | |
This is version 87 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Candida albicans
Candida albicans: entries and gene names - SIMILARITY comments
Index of protein domains and families