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UniProtKB - Q5A477 (GMT_CANAL)
Protein
GDP-mannose transporter
Gene
VRG4
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Functioni
Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen. Involved in hyphal formation.
1 PublicationGO - Molecular functioni
- antiporter activity Source: GO_Central
- GDP-mannose transmembrane transporter activity Source: CGD
GO - Biological processi
- carbohydrate transport Source: UniProtKB-KW
- GDP-mannose transmembrane transport Source: CGD
- hyphal growth Source: CGD
- protein glycosylation Source: CGD
Keywordsi
Biological process | Sugar transport, Transport |
Protein family/group databases
TCDBi | 2.A.7.13.2, the drug/metabolite transporter (dmt) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: GDP-mannose transporterShort name: GMT |
Gene namesi | Name:VRG4 Ordered Locus Names:CAALFM_C107700CA ORF Names:CaO19.1232, CaO19.8817 |
Organismi | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
Taxonomic identifieri | 237561 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Debaryomycetaceae › Candida/Lodderomyces clade › Candida › |
Proteomesi |
|
Organism-specific databases
CGDi | CAL0000182900, VRG4 |
VEuPathDBi | FungiDB:C1_07700C_A |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane 1 Publication; Multi-pass membrane protein 1 Publication
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication
Other locations
- Cytoplasmic vesicle membrane 1 Publication; Multi-pass membrane protein 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Golgi apparatus
- Golgi apparatus Source: CGD
- Golgi membrane Source: UniProtKB-SubCell
Other locations
- cytoplasmic vesicle membrane Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 51 | CytoplasmicBy similarityAdd BLAST | 51 | |
Transmembranei | 52 – 72 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 73 – 80 | LumenalBy similarity | 8 | |
Transmembranei | 81 – 101 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 102 – 121 | CytoplasmicBy similarityAdd BLAST | 20 | |
Transmembranei | 122 – 138 | HelicalSequence analysisAdd BLAST | 17 | |
Topological domaini | 139 – 145 | LumenalBy similarity | 7 | |
Transmembranei | 146 – 162 | HelicalSequence analysisAdd BLAST | 17 | |
Topological domaini | 163 – 171 | CytoplasmicBy similarity | 9 | |
Transmembranei | 172 – 192 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 193 – 206 | LumenalBy similarityAdd BLAST | 14 | |
Transmembranei | 207 – 227 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 228 – 241 | CytoplasmicBy similarityAdd BLAST | 14 | |
Transmembranei | 242 – 262 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 263 – 281 | LumenalBy similarityAdd BLAST | 19 | |
Transmembranei | 282 – 302 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 303 – 309 | CytoplasmicBy similarity | 7 | |
Transmembranei | 310 – 329 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 330 – 332 | LumenalBy similarity | 3 | |
Transmembranei | 333 – 355 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 356 – 371 | CytoplasmicBy similarityAdd BLAST | 16 |
Keywords - Cellular componenti
Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000333515 | 1 – 371 | GDP-mannose transporterAdd BLAST | 371 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 268 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinInteractioni
Subunit structurei
Homooligomer.
By similarityProtein-protein interaction databases
STRINGi | 237561.Q5A477 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1444, Eukaryota |
HOGENOMi | CLU_025360_1_2_1 |
InParanoidi | Q5A477 |
OrthoDBi | 1093260at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR038736, Vrg4-like |
PANTHERi | PTHR11132:SF251, PTHR11132:SF251, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5A477-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGVISFYLIG QLLYLIRKKY TTTYRQQQQH QYNMDSKHST SSSSSGSLAT
60 70 80 90 100
RISNSGPISI AAYCLSSILM TVTNKYVLSG FSFNLNFFLL AVQSIVCIVT
110 120 130 140 150
IGSLKSLNII TYRQFNKDEA KKWSPIAFLL VAMIYTSSKA LQYLSIPVYT
160 170 180 190 200
IFKNLTIILI AYGEVIWFGG KVTTMALSSF LLMVLSSVIA YYGDNAAVKS
210 220 230 240 250
HDDAFALYLG YFWMLTNCFA SAAFVLIMRK RIKLTNFKDF DTMYYNNLLS
260 270 280 290 300
IPILLICSFI FEDWSSANVS LNFPADNRVT TITAMILSGA SSVGISYCSA
310 320 330 340 350
WCVRVTSSTT YSMVGALNKL PIALSGLIFF EAAVNFWSVS SIFVGFGAGL
360 370
VYAVAKQKQQ KEQSQQLPTT K
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 30 | H → Y in AAK74075 (PubMed:11741841). | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF164627 Genomic DNA Translation: AAK74075.1 CP017623 Genomic DNA Translation: AOW26417.1 |
RefSeqi | XP_716540.2, XM_711447.2 |
Genome annotation databases
GeneIDi | 3641768 |
KEGGi | cal:CAALFM_C107700CA |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF164627 Genomic DNA Translation: AAK74075.1 CP017623 Genomic DNA Translation: AOW26417.1 |
RefSeqi | XP_716540.2, XM_711447.2 |
3D structure databases
SMRi | Q5A477 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 237561.Q5A477 |
Protein family/group databases
TCDBi | 2.A.7.13.2, the drug/metabolite transporter (dmt) superfamily |
Genome annotation databases
GeneIDi | 3641768 |
KEGGi | cal:CAALFM_C107700CA |
Organism-specific databases
CGDi | CAL0000182900, VRG4 |
VEuPathDBi | FungiDB:C1_07700C_A |
Phylogenomic databases
eggNOGi | KOG1444, Eukaryota |
HOGENOMi | CLU_025360_1_2_1 |
InParanoidi | Q5A477 |
OrthoDBi | 1093260at2759 |
Miscellaneous databases
PROi | PR:Q5A477 |
Family and domain databases
InterProi | View protein in InterPro IPR038736, Vrg4-like |
PANTHERi | PTHR11132:SF251, PTHR11132:SF251, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GMT_CANAL | |
Accessioni | Q5A477Primary (citable) accession number: Q5A477 Secondary accession number(s): A0A1D8PE59, Q96WN8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 20, 2008 |
Last sequence update: | March 15, 2017 | |
Last modified: | February 23, 2022 | |
This is version 98 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Candida albicans
Candida albicans: entries and gene names - SIMILARITY comments
Index of protein domains and families