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Protein

Probable GPI-anchored adhesin-like protein PGA55

Gene

PGA55

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Predicted GPI-ancored adhesin-like protein which may be involved in filamentous growth and chlamydospore formation.1 Publication

Miscellaneous

The PGA55 mRNA is transported by SHE3 to bud in yeast cells, as well as to the hyphal tips during filamentous growth.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable GPI-anchored adhesin-like protein PGA55
Alternative name(s):
Predicted GPI-anchored protein 55
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PGA55
Ordered Locus Names:CAALFM_C208980CA
ORF Names:CaO19.207, CaO19.7838
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri237561 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000559 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Candida Genome Database

More...
CGDi
CAL0000189083 PGA55

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000042491720 – 1382Probable GPI-anchored adhesin-like protein PGA55Add BLAST1363
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00004249181383 – 1404Removed in mature formSequence analysisAdd BLAST22

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi817N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi994N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1074N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi1382GPI-anchor amidated asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q59SG9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced during chlamydospore formation and filamentous growth. Expression is regulated by the NRG1 and TUP1 transcription factors.2 Publications

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati104 – 1091-16
Repeati136 – 1411-26
Repeati156 – 1611-36
Repeati162 – 1671-46
Repeati183 – 1881-56
Repeati196 – 2011-66
Repeati203 – 2081-76
Repeati209 – 2141-86
Repeati216 – 2211-96
Repeati222 – 2271-106
Repeati228 – 2331-116
Repeati234 – 2391-126
Repeati247 – 2521-136
Repeati253 – 2581-146
Repeati261 – 2661-156
Repeati267 – 2721-166
Repeati274 – 2791-176
Repeati280 – 2851-186
Repeati286 – 2911-196
Repeati292 – 2971-206
Repeati298 – 3031-216
Repeati304 – 3091-226
Repeati317 – 3221-236
Repeati324 – 3291-246
Repeati330 – 3351-256
Repeati336 – 3411-266
Repeati343 – 3481-276
Repeati349 – 3541-286
Repeati355 – 3601-296
Repeati361 – 3661-306
Repeati374 – 3791-316
Repeati380 – 3851-326
Repeati388 – 3931-336
Repeati394 – 3991-346
Repeati401 – 4061-356
Repeati407 – 4121-366
Repeati413 – 4181-376
Repeati419 – 4241-386
Repeati425 – 4301-396
Repeati431 – 4361-406
Repeati444 – 4491-416
Repeati450 – 4551-426
Repeati457 – 4621-436
Repeati463 – 4681-446
Repeati469 – 4741-456
Repeati475 – 4801-466
Repeati488 – 4931-476
Repeati494 – 5001-487
Repeati502 – 5071-496
Repeati508 – 5131-506
Repeati515 – 5201-516
Repeati521 – 5261-526
Repeati527 – 5321-536
Repeati533 – 5381-546
Repeati546 – 5511-556
Repeati552 – 5571-566
Repeati560 – 5651-576
Repeati566 – 5711-586
Repeati573 – 5781-596
Repeati579 – 5841-606
Repeati585 – 5901-616
Repeati591 – 5961-626
Repeati604 – 6091-636
Repeati611 – 6161-646
Repeati617 – 6221-656
Repeati623 – 6281-666
Repeati629 – 6341-676
Repeati635 – 6401-686
Repeati641 – 6461-696
Repeati654 – 6591-706
Repeati660 – 6651-716
Repeati668 – 6731-726
Repeati674 – 6791-736
Repeati681 – 6861-746
Repeati687 – 6921-756
Repeati693 – 6981-766
Repeati699 – 7041-776
Repeati712 – 7171-786
Repeati719 – 7241-796
Repeati725 – 7301-806
Repeati731 – 7361-816
Repeati737 – 7421-826
Repeati743 – 7481-836
Repeati749 – 7541-846
Repeati771 – 7761-856
Repeati777 – 7821-866
Repeati797 – 8021-876
Repeati824 – 8291-886

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni104 – 54188 X 6 AA approximate tandem repeatsAdd BLAST438

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi93 – 940Ser/Val-richAdd BLAST848
Compositional biasi932 – 1183Thr-richAdd BLAST252

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
EOG092C2YWL

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q59SG9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLLCKYKVS WVFVLSVAGS SLIRDFLFGQ DDSLSIEKRT NEYTTPEYGG
60 70 80 90 100
TSHCNGGDKN CYPQCFDHRG QPKKDKCCFD KHNKVLYPYP CTSSSSSSSS
110 120 130 140 150
SSTVSSSSSE VISSSSEEAS SSEITSSSEI SSSSEVSSSS EVLSSSEIIS
160 170 180 190 200
SSSEVVSSSS KVSSSSEATS SSSEIISSSS EVVSSSSQVT SSSEVVSSSS
210 220 230 240 250
EVVSSSSEVS SSSEVVSSSS EVSSSSEVSS SSEVSSSSQV TSSSEIVSSS
260 270 280 290 300
SEVSSSSSEV VSSSSEVSSS SEVVSSSSEV SSSSEVSSSS EVSSSSEVSS
310 320 330 340 350
SSEVSSSSQV ISSSEVVSSS SEVVSSSSEV SSSSEVSSSS EVVSSSSEVS
360 370 380 390 400
SSSEVSSSSE VSSSSQVTSS SEIVSSSSEV SSSSSEVVSS SSEVSSSSEV
410 420 430 440 450
VSSSSEVSSS SEVSSSSEVS SSSEVSSSSE VSSSSQVTSS SEVVSSSSEV
460 470 480 490 500
SSSSEVVSSS SEVSSSSEVS SSSEVSSSSQ VTSSSEIVSS SSEVSSSSSE
510 520 530 540 550
VVSSSSEVSS SSEVVSSSSE VSSSSEVSSS SEVSSSSQVT SSSEIVSSSS
560 570 580 590 600
EVSSSSSEVV SSSSEVSSSS EVVSSSSEVS SSSEVSSSSE VSSSSQVTSS
610 620 630 640 650
SEVVSSSSEV VSSSSEVSSS SEVSSSSEVS SSSEVSSSSE VSSSSQVTSS
660 670 680 690 700
SEIVSSSSEV SSSSSEVVSS SSEVSSSSEV VSSSSEVSSS SEVSSSSEVS
710 720 730 740 750
SSSQVTSSSE VVSSSSEVVS SSSEVSSSSE VSSSSEVSSS SEVSSSSEVS
760 770 780 790 800
SSSEVTSSSS EIISSSSSSE VTSSSEVSSS SQATSSSSEI ISSSSKVSSS
810 820 830 840 850
SEITSSSECI SSTSEVNSSS SEVVSSSSAS SEVVSSSTEC ISSSSEAISS
860 870 880 890 900
SSQVTSSSTE CISSSSEVIS SSEVTSCSSE VVSSSETCIS SKEMSSSEQI
910 920 930 940 950
SSSESTSSCS EFVSKSSEHS SLSSESCPSE ETSTVSETSS ETVTCKHHGC
960 970 980 990 1000
SKTKTHHSTP TKCVTKTIET SVYVTTCPDK SITTETAVVI VVTNESTATT
1010 1020 1030 1040 1050
YTEIIKTTVI EGNTLTTNIP IKHVETETAE IIEYTTICPT TLPNGHKTTV
1060 1070 1080 1090 1100
IAGIAVGTNG QGQKVTKTVP LEYNESTLAN GHVTRVASGI VKATGENGEE
1110 1120 1130 1140 1150
ITKTIPIEYR KTTERIEFIT VCPTTLANGQ VIETTAGIVI TTNKQGEKVT
1160 1170 1180 1190 1200
KPVPLEFTST IEFSHHLTTH PVTLPNGQIT VTTEGVIITR KGEQQFTKTV
1210 1220 1230 1240 1250
EVGNLPSKPI EVVQKISVVP KTLPNSQVTS ETVAILVTVG EELQPITKTI
1260 1270 1280 1290 1300
PIGTSAQETE PSFASYSEIV FTTCSEGGCN TYTTNVEVIG NKVITKQSGK
1310 1320 1330 1340 1350
PIVEEQTTNG IEHQSDKVYY TVVSGETKTI QTPGSIVSTS PAAIPVVTSK
1360 1370 1380 1390 1400
GSPNIVGSSV VAGSSVTTSE VSTSTAGVLQ GNAASRQSFN YKFIVGLILA

YIIA
Length:1,404
Mass (Da):142,167
Last modified:March 15, 2017 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD8693E3089E9F04A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP017624 Genomic DNA Translation: AOW27886.1

NCBI Reference Sequences

More...
RefSeqi
XP_712591.2, XM_707498.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3645784

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cal:CAALFM_C208980CA

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP017624 Genomic DNA Translation: AOW27886.1
RefSeqiXP_712591.2, XM_707498.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Proteomic databases

PRIDEiQ59SG9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3645784
KEGGical:CAALFM_C208980CA

Organism-specific databases

CGDiCAL0000189083 PGA55

Phylogenomic databases

OrthoDBiEOG092C2YWL

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q59SG9

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPGA55_CANAL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q59SG9
Secondary accession number(s): A0A1D8PIB4, Q59SD7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 22, 2014
Last sequence update: March 15, 2017
Last modified: December 5, 2018
This is version 51 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
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