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Protein

Glycerophosphoinositol permease 1

Gene

GIT1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Glycerophosphodiester transporter that mediates uptake of glycerophosphoinositol (GroPIns) as a source of inositol and phosphate (PubMed:21984707, PubMed:24114876). Does not possess detectable glycerophosphocholine (GroPCho) transport activity (PubMed:21984707). Although no glycerophosphoinositol transport activity occurs in the absence of GIT1, C.albicans is still able to use glycerophosphoinositol as a phosphate source at pH 7.5, albeit slowly (PubMed:21984707). Thus, a second, GIT1-independent, mechanism must exist for utilizing glycerophosphoinositol as a phosphate source at physiological pH (PubMed:21984707, PubMed:24114876). The expanded ability to utilize GroPIns and GroPCho results from the organism's pathogenic nature and its need to occupy a variety of environments within its host organism (PubMed:21984707). This possibility is buttressed by the fact that GroPIns and GroPCho are present and abundant in human fluids (PubMed:21984707, PubMed:24114876).2 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=28 µM for glycerophosphoinositol transport1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • carbohydrate:proton symporter activity Source: GO_Central
    • glycerol-3-phosphate transmembrane transporter activity Source: EnsemblFungi
    • glycerophosphodiester transmembrane transporter activity Source: CGD

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Biological processTransport, Virulence

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Glycerophosphoinositol permease 11 Publication
    Alternative name(s):
    Glycerophosphodiester transporter GIT1Curated
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:GIT11 Publication
    Synonyms:GIT99
    Ordered Locus Names:CAALFM_C206590CA
    ORF Names:orf19.341 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri237561 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000559 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

    Organism-specific databases

    Candida Genome Database

    More...
    CGDi
    CAL0000193792 GIT1

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
    Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
    Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
    Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
    Transmembranei186 – 206HelicalSequence analysisAdd BLAST21
    Transmembranei216 – 236HelicalSequence analysisAdd BLAST21
    Transmembranei273 – 293HelicalSequence analysisAdd BLAST21
    Transmembranei313 – 333HelicalSequence analysisAdd BLAST21
    Transmembranei337 – 357HelicalSequence analysisAdd BLAST21
    Transmembranei363 – 383HelicalSequence analysisAdd BLAST21
    Transmembranei404 – 424HelicalSequence analysisAdd BLAST21
    Transmembranei432 – 452HelicalSequence analysisAdd BLAST21

    Keywords - Cellular componenti

    Cell membrane, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

    Abolished the utilization of glycerophosphoinositol(GroPIns) as a phosphate source (PubMed:21984707).1 Publication

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004397981 – 519Glycerophosphoinositol permease 1Add BLAST519

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi93N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
    Glycosylationi175N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
    Glycosylationi506N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

    Keywords - PTMi

    Glycoprotein

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Phosphate levels regulate glycerophosphoinositol transport activity and transcription factor PHO4 is required for GIT1 expression (PubMed:21984707). Expression profile differs significantly in isolates of high, medium, and low virulence, being the highest in the most virulent strains (PubMed:19151328).2 Publications

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    Q59Q30

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi20 – 24Poly-AsnSequence analysis5

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    IMVTNFV

    Database of Orthologous Groups

    More...
    OrthoDBi
    EOG092C241Y

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd06174 MFS, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR020846 MFS_dom
    IPR005828 MFS_sugar_transport-like
    IPR036259 MFS_trans_sf
    IPR005829 Sugar_transporter_CS

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00083 Sugar_tr, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF103473 SSF103473, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50850 MFS, 1 hit
    PS00216 SUGAR_TRANSPORT_1, 2 hits

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q59Q30-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MSDLVKSSEV IETTEVPPHN NNNNKRHFKY DSEQRKQRLA GGVKLKDALM
    60 70 80 90 100
    ILCAGFALIS DGYQNNVMSM MNKVFALEYP KEYTASLSTQ VSNASLVGTI
    110 120 130 140 150
    FGQVIIGLTA DYIGRKWSIV TATCFLIFGT MMCAASHGKT VNGMFWMLTI
    160 170 180 190 200
    FRGVTGFGIG AEYPSSSVTA SEAANESVKR RGGAFILATN LPLSFGGPFA
    210 220 230 240 250
    LCIFLIVRRI CGNHLDAIWR TMFAIGCFWP LSVFYFRLKM VTSELYTKSA
    260 270 280 290 300
    IKQRAPYWLA LKYYWPRLIG TCVAWFLYDF VTFPNGIFSA GIISNVIPKS
    310 320 330 340 350
    EKNNLEKIAE WNLLLGAIAL PGVFVGAYVV DILGRKYTMM IGFCGYIVFG
    360 370 380 390 400
    LIVGCGYHQI KPITGLFIVF YGLMMSCGNF GPGNNMGLTS SESFATPIRG
    410 420 430 440 450
    TAYGISAAIG KVGAVVGTKT FSPIQKNLGD KWTFIIAAIC GLAGVLVTFI
    460 470 480 490 500
    FIPHLKDEDL LEEDVKFKNY LIDNGWKGKF GIQEYDEEED LEGSSEDSSD
    510
    GEIVKNNTKN DVEKVDALK
    Length:519
    Mass (Da):57,163
    Last modified:April 26, 2005 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i896615C246109D9D
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    CP017624 Genomic DNA Translation: AOW27660.1

    NCBI Reference Sequences

    More...
    RefSeqi
    XP_711841.1, XM_706749.1

    Genome annotation databases

    Ensembl fungal genome annotation project

    More...
    EnsemblFungii
    KHC81693; KHC81693; W5Q_02082
    KHC88024; KHC88024; I503_02096

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    3646562

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    cal:CAALFM_C206590CA

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    CP017624 Genomic DNA Translation: AOW27660.1
    RefSeqiXP_711841.1, XM_706749.1

    3D structure databases

    ProteinModelPortaliQ59Q30
    ModBaseiSearch...
    MobiDBiSearch...

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsemblFungiiKHC81693; KHC81693; W5Q_02082
    KHC88024; KHC88024; I503_02096
    GeneIDi3646562
    KEGGical:CAALFM_C206590CA

    Organism-specific databases

    CGDiCAL0000193792 GIT1

    Phylogenomic databases

    OMAiIMVTNFV
    OrthoDBiEOG092C241Y

    Family and domain databases

    CDDicd06174 MFS, 1 hit
    InterProiView protein in InterPro
    IPR020846 MFS_dom
    IPR005828 MFS_sugar_transport-like
    IPR036259 MFS_trans_sf
    IPR005829 Sugar_transporter_CS
    PfamiView protein in Pfam
    PF00083 Sugar_tr, 1 hit
    SUPFAMiSSF103473 SSF103473, 1 hit
    PROSITEiView protein in PROSITE
    PS50850 MFS, 1 hit
    PS00216 SUGAR_TRANSPORT_1, 2 hits

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGIT1_CANAL
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q59Q30
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2017
    Last sequence update: April 26, 2005
    Last modified: December 5, 2018
    This is version 108 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Candida albicans
      Candida albicans: entries and gene names
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