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Entry version 82 (02 Jun 2021)
Sequence version 1 (26 Apr 2005)
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Protein

DNA polymerase

Gene
N/A
Organism
Trachemys scripta (Red-eared slider turtle) (Pseudemys scripta)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

[4Fe-4S] clusterUniRule annotationARBA annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingUniRule annotation, DNA-directed DNA polymeraseUniRule annotationARBA annotation, Nucleotidyltransferase, Transferase
Biological processDNA replicationUniRule annotation
Ligand4Fe-4SUniRule annotationARBA annotation, Iron, Iron-sulfur, Metal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA polymeraseUniRule annotation (EC:2.7.7.7UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTrachemys scripta (Red-eared slider turtle) (Pseudemys scripta)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri34903 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaTestudinesCryptodiraDurocryptodiraTestudinoideaEmydidaeTrachemys

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusUniRule annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 43DNA_pol_alpha_NInterPro annotationAdd BLAST41
Domaini342 – 680DNA_pol_B_exo1InterPro annotationAdd BLAST339
Domaini745 – 1196DNA_pol_BInterPro annotationAdd BLAST452
Domaini1236 – 1424zf-DNA_PolInterPro annotationAdd BLAST189

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni46 – 72DisorderedSequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi48 – 72Basic and acidic residuesSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-B family.UniRule annotationARBA annotation

Keywords - Domaini

Zinc-fingerUniRule annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.132.60, 1 hit
1.10.3200.20, 1 hit
3.30.420.10, 1 hit
3.90.1600.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006172, DNA-dir_DNA_pol_B
IPR017964, DNA-dir_DNA_pol_B_CS
IPR006133, DNA-dir_DNA_pol_B_exonuc
IPR006134, DNA-dir_DNA_pol_B_multi_dom
IPR043502, DNA/RNA_pol_sf
IPR024647, DNA_pol_a_cat_su_N
IPR042087, DNA_pol_B_C
IPR023211, DNA_pol_palm_dom_sf
IPR038256, Pol_alpha_znc_sf
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf
IPR015088, Znf_DNA-dir_DNA_pol_B_alpha

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12254, DNA_pol_alpha_N, 1 hit
PF00136, DNA_pol_B, 1 hit
PF03104, DNA_pol_B_exo1, 1 hit
PF08996, zf-DNA_Pol, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00106, DNAPOLB

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00486, POLBc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53098, SSF53098, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00116, DNA_POLYMERASE_B, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q59J89-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
FTSVYEEVDE AQYSKMVRER QDDDWIVDDD GIGYVEDGRE IFDEDLEDDV
60 70 80 90 100
LGSKKKGKGD KTSTNDKKNV KKSVVSKPNT IKSMFMASAG KKNTDKTVDL
110 120 130 140 150
SKDDLLGDIL QDLNAETIQI TPPPVVKLRK KRPVGASLNP FSVQSPAHMV
160 170 180 190 200
VTPIVRKAPT TVKKEVISPT TADPKHTTYA AKPVAVHKEN GAEYTIKTAE
210 220 230 240 250
NEELVKAKPE KAIQENDQGM MDFEDGDFDE PMEADIPETA GALKKEQKLE
260 270 280 290 300
KKETQQVDSV KEDASFLSSF LPDMSCWTRM DKDETDLVAS EVQVDPSCLP
310 320 330 340 350
LVNGEDGDQV FRFYWLDAYE DQYSQPGVVF LFGKVWIESA ETYVSCCVTV
360 370 380 390 400
KNIERIIYLL PREMQMDLTS GKETENPVTM MNIYQEFNDQ IAVKYKIMKF
410 420 430 440 450
RSKKVEKNYA FEIPDVPAKS DYLEVRYSAE FPRLPQDLKG ETFSHVFGTN
460 470 480 490 500
TSSLELLLMS RKIKGPSWLE IKNPQPLSHP VSWCKVEATA LKPDLVNIVK
510 520 530 540 550
DLPPPPLVIM SLSMRTIQNV KTHQHEVMAV AALVHQRFCL DKAPPQPPFQ
560 570 580 590 600
THFCVISKPN DCIFPYDFKE IIKSKNSNVE IAATERTLLG FFLAKVHKID
610 620 630 640 650
PDIIVGHNIY GFDLEVLLQR INVSKVPHWS KIGRLRRSIM PKLGGRGGFA
660 670 680 690 700
ERNAACGRMI CDVEISAKEL IRCKSYHLSE LVHQILKTER ITIPPEEIRN
710 720 730 740 750
MYSDSSHLLY MLENTWTDAR FILQIMCELN VLPLALQITN ISGNVMSRTM
760 770 780 790 800
MGGRSERNEF LLLHAFYERD YIVPDKQVFK KPQQKLVDED EGVEDQNKSK
810 820 830 840 850
IGRKKAAYAG GLVLDPKVGF YDTFILLLDF NSLYPSIIQE FNICFTTVQR
860 870 880 890 900
ESSDAQKRAE DGVQEEIPEL PDPSLEMGIL PKEIRKLVER RRQVKQLMKQ
910 920 930 940 950
PDLNPDLYLQ YDIRQKALKL TANSMYGCLG FSYSRFYAKP LAALVTHKGR
960 970 980 990 1000
EILMHTKEMV QKMNLEVIYG DTDSIMINTN STNLEEVFKL GNKIKSEVNK
1010 1020 1030 1040 1050
LYKLLEIDID GVFKSLLLLK KKKYAALTVE PTGDGKYVTK QELKGLDIVR
1060 1070 1080 1090 1100
RDWCDLAKET GNYVIGQILS DQSRDTIVEN IQRRLIEIGE NVINGRVPIS
1110 1120 1130 1140 1150
QFEINKALTK DPQDYPDKKS LPHVHVAMWI NSQEGRKVKA GDTVSYVICQ
1160 1170 1180 1190 1200
DGSNLSASQR AYAPEQLQKQ ENLTVDTQYY LSQQIHPVVA RICEPIDGID
1210 1220 1230 1240 1250
SVLIATWLGL DPSQFKIHHH YHKDEENDAL LGGPAQLTDE EKYRDCERFK
1260 1270 1280 1290 1300
FSCPRCGTEN IYDNVFDGSG KLMEPSLQQC SKKECDESPF NYTIQMNNKL
1310 1320 1330 1340 1350
LLDIRRYLKS YYNSWLICEE PTCQNRTRRL PLSFSQNGAL CQACKKAILR
1360 1370 1380 1390 1400
PEYSDKALYT QLCFYRYIFD VDYAMDKVIT DQEKESMKRK LTINETEVYR
1410 1420 1430 1440
KLKNTVDKFL SMSGYSEVNL SKLFQTFSIV KSVGDPSNER Q
Length:1,441
Mass (Da):164,619
Last modified:April 26, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8F5D217B8855B182
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB178526 mRNA Translation: BAD92008.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB178526 mRNA Translation: BAD92008.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di1.10.132.60, 1 hit
1.10.3200.20, 1 hit
3.30.420.10, 1 hit
3.90.1600.10, 1 hit
InterProiView protein in InterPro
IPR006172, DNA-dir_DNA_pol_B
IPR017964, DNA-dir_DNA_pol_B_CS
IPR006133, DNA-dir_DNA_pol_B_exonuc
IPR006134, DNA-dir_DNA_pol_B_multi_dom
IPR043502, DNA/RNA_pol_sf
IPR024647, DNA_pol_a_cat_su_N
IPR042087, DNA_pol_B_C
IPR023211, DNA_pol_palm_dom_sf
IPR038256, Pol_alpha_znc_sf
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf
IPR015088, Znf_DNA-dir_DNA_pol_B_alpha
PfamiView protein in Pfam
PF12254, DNA_pol_alpha_N, 1 hit
PF00136, DNA_pol_B, 1 hit
PF03104, DNA_pol_B_exo1, 1 hit
PF08996, zf-DNA_Pol, 1 hit
PRINTSiPR00106, DNAPOLB
SMARTiView protein in SMART
SM00486, POLBc, 1 hit
SUPFAMiSSF53098, SSF53098, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS00116, DNA_POLYMERASE_B, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ59J89_TRASC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q59J89
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: June 2, 2021
This is version 82 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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