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UniProtKB - Q59H94 (Q59H94_HUMAN)

Entry version 79 (02 Dec 2020)
Sequence version 1 (26 Apr 2005)
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Protein
Submitted name:

Gamma filamin variant

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Gamma filamin variantImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28174

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...PeptideAtlasi		Q59H94

PRoteomics IDEntifications database

More...PRIDEi		Q59H94

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q59H94, HS

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q59H94

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1 – 54FilaminPROSITE-ProRule annotationAdd BLAST54
Repeati55 – 150FilaminPROSITE-ProRule annotationAdd BLAST96
Repeati151 – 247FilaminPROSITE-ProRule annotationAdd BLAST97
Repeati260 – 351FilaminPROSITE-ProRule annotationAdd BLAST92
Repeati402 – 471FilaminPROSITE-ProRule annotationAdd BLAST70
Repeati471 – 563FilaminPROSITE-ProRule annotationAdd BLAST93
Repeati561 – 650FilaminPROSITE-ProRule annotationAdd BLAST90
Repeati653 – 745FilaminPROSITE-ProRule annotationAdd BLAST93
Repeati838 – 923FilaminPROSITE-ProRule annotationAdd BLAST86
Repeati926 – 1018FilaminPROSITE-ProRule annotationAdd BLAST93
Repeati1020 – 1113FilaminPROSITE-ProRule annotationAdd BLAST94
Repeati1117 – 1209FilaminPROSITE-ProRule annotationAdd BLAST93
Repeati1247 – 1341FilaminPROSITE-ProRule annotationAdd BLAST95

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni357 – 382DisorderedSequence analysisAdd BLAST26
Regioni857 – 877DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi857 – 875PolarSequence analysisAdd BLAST19

Phylogenomic databases

Database of Orthologous Groups

More...OrthoDBi		35998at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 13 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR017868, Filamin/ABP280_repeat-like
IPR001298, Filamin/ABP280_rpt
IPR013783, Ig-like_fold
IPR014756, Ig_E-set

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00630, Filamin, 12 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00557, IG_FLMN, 13 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF81296, SSF81296, 13 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50194, FILAMIN_REPEAT, 13 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q59H94-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
GLAIEGPSEA KMSCKDNKDG SCTVEYIPFT PGDYDVNITF GGRPIPGSPF 
        60         70         80         90        100
RVPVKDVVDP GKVKCSGPGL GAGVRARVPQ TFTVDCSQAG RAPLQVAVLG 
       110        120        130        140        150
PTGVAEPVEV RDNGDGTHTV HYTPATDGPY TVAVKYADQE VPRSPFKIKV 
       160        170        180        190        200
LPAHDASKVR ASGPGLNASG IPASLPVEFT IDARDAGEGL LTVQILDPEG 
       210        220        230        240        250
KPKKANIRDN GDGTYTVSYL PDMSGRYTIT IKYGGDEIPY SPFRIHALPT 
       260        270        280        290        300
GDASKCLVTV SIGGHGLGAC LGPRIQIGQE TVITVDAKAA GEGKVTCTVS 
       310        320        330        340        350
TPDGAELDVD VVENHDGTFD IYYTAPEPGK YVITIRFGGE HIPNSPFHVL 
       360        370        380        390        400
ACDPLPHEEE PSEVPQLRQP YAPPRPGARP THWATEEPVV PVEPMESMLR 
       410        420        430        440        450
PFNLVIPFAV QKGELTGEVR MPSGKTARPN ITDNKDGTIT VRYAPTEKGL 
       460        470        480        490        500
HQMGIKYDGN HIPGSPLQFY VDAINSRHVS AYGPGLSHGM VNKPATFTIV 
       510        520        530        540        550
TKDAGEGGLS LAVEGPSKAE ITCKDNKDGT CTVSYLPTAP GDYSIIVRFD 
       560        570        580        590        600
DKHIPGSPFT AKITGDDSMR TSQLNVGTST DVSLKITESD LSQLTASIRA 
       610        620        630        640        650
PSGNEEPCLL KRLPNRHIGI SFTPKEVGEH VVSVRKSGKH VTNSPFKILV 
       660        670        680        690        700
GPSEIGDASK VRVWGKGLSE GHTFQVAEFI VDTRNAGYGG LGLSIEGPSK 
       710        720        730        740        750
VDINCEDMED GTCKVTYCPT EPGTYIINIK FADKHVPGSP FTVKVTGEGR 
       760        770        780        790        800
MKESITRRRQ APSIATIGST CDLNLKIPGN WFQMVSAQER LTRTFTRSSH 
       810        820        830        840        850
TYTRTERTEI SKTRGGETKR EVRVEESTQV GGDPFPAVFG DFLGRERLGS 
       860        870        880        890        900
FGSITRQQEG EASSQDMTAQ VTSPSGKVEA AEIVEGEDSA YSVRFVPQEM 
       910        920        930        940        950
GPHTVAVKYR GQHVPGSPFQ FTVGPLGEGG AHKVRAGGTG LERGVAGVPA 
       960        970        980        990       1000
EFSIWTREAG AGGLSIAVEG PSKAEIAFED RKDGSCGVSY VVQEPGDYEV 
      1010       1020       1030       1040       1050
SIKFNDEHIP DSPFVVPVAS LSDDARRLTV TSLQETGLKV NQPASFAVQL 
      1060       1070       1080       1090       1100
NGARGVIDAR VHTPSGAVEE CYVSELDSDK HTIRFIPHEN GVHSIDVKFN 
      1110       1120       1130       1140       1150
GAHIPGSPFK IRVGEQSQAG DPGLVSAYGP GLEGGTTGVS SEFIVNTLNA 
      1160       1170       1180       1190       1200
GSGALSVTID GPSKVQLDCR ECPEGHVVTY TPMAPGNYLI AIKYGGPQHI 
      1210       1220       1230       1240       1250
VGSPFKAKVT GPRLSGGHSL HETSTVLVET VTKSSSSRGS SYSSIPKFSS 
      1260       1270       1280       1290       1300
DASKVVTRGP GLSQAFVGQK NSFTVDCSKA GTNMMMVGVH GPKTPCEEVY 
      1310       1320       1330       1340 
VKHMGNRVYN VTYTVKEKGD YILIVKWGDE SVPGSPFKVK VP
Length:1,342
Mass (Da):142,815
Last modified:April 26, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCE776D873FA591CA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB208865 mRNA Translation: BAD92102.1

NCBI Reference Sequences

More...RefSeqi		NP_001120959.1, NM_001127487.1
NP_001449.3, NM_001458.4

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2318

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2318

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB208865 mRNA Translation: BAD92102.1
RefSeqiNP_001120959.1, NM_001127487.1
NP_001449.3, NM_001458.4

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Proteomic databases

PeptideAtlasiQ59H94
PRIDEiQ59H94

Genome annotation databases

GeneIDi2318
KEGGihsa:2318

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2318
PharmGKBiPA28174

Phylogenomic databases

OrthoDBi35998at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2318, 7 hits in 844 CRISPR screens
EvolutionaryTraceiQ59H94

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2318

Gene expression databases

GenevisibleiQ59H94, HS

Family and domain databases

Gene3Di2.60.40.10, 13 hits
InterProiView protein in InterPro
IPR017868, Filamin/ABP280_repeat-like
IPR001298, Filamin/ABP280_rpt
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
PfamiView protein in Pfam
PF00630, Filamin, 12 hits
SMARTiView protein in SMART
SM00557, IG_FLMN, 13 hits
SUPFAMiSSF81296, SSF81296, 13 hits
PROSITEiView protein in PROSITE
PS50194, FILAMIN_REPEAT, 13 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ59H94_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q59H94
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: December 2, 2020
This is version 79 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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