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Entry version 100 (31 Jul 2019)
Sequence version 1 (26 Apr 2005)
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Protein

Integrin beta

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIntegrinUniRule annotationImported
Biological processCell adhesionUniRule annotation

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q59H46

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Integrin betaUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q59H46

PRoteomics IDEntifications database

More...
PRIDEi
Q59H46

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1161 – 1250Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini1254 – 1353Fibronectin type-IIIInterPro annotationAdd BLAST100
Domaini1492 – 1515Fibronectin type-IIIInterPro annotationAdd BLAST24

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 37DisorderedSequence analysisAdd BLAST37
Regioni1145 – 1172DisorderedSequence analysisAdd BLAST28
Regioni1456 – 1487DisorderedSequence analysisAdd BLAST32

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the integrin beta chain family.UniRule annotation

Keywords - Domaini

TransmembraneUniRule annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 2 hits
2.60.40.2030, 1 hit
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038081 CalX-like_sf
IPR003644 Calx_beta
IPR013032 EGF-like_CS
IPR013111 EGF_extracell
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR040622 I-EGF_1
IPR013783 Ig-like_fold
IPR033760 Integrin_beta_N
IPR015812 Integrin_bsu
IPR012013 Integrin_bsu-4
IPR012896 Integrin_bsu_tail
IPR036349 Integrin_bsu_tail_dom_sf
IPR002369 Integrin_bsu_VWA
IPR016201 PSI
IPR036465 vWFA_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10082 PTHR10082, 3 hits
PTHR10082:SF42 PTHR10082:SF42, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03160 Calx-beta, 1 hit
PF07974 EGF_2, 1 hit
PF00041 fn3, 2 hits
PF18372 I-EGF_1, 1 hit
PF07965 Integrin_B_tail, 1 hit
PF00362 Integrin_beta, 1 hit
PF17205 PSI_integrin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01186 INTEGRINB

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00237 Calx_beta, 1 hit
SM00060 FN3, 2 hits
SM00187 INB, 1 hit
SM01242 Integrin_B_tail, 1 hit
SM00423 PSI, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF141072 SSF141072, 1 hit
SSF49265 SSF49265, 1 hit
SSF53300 SSF53300, 1 hit
SSF69687 SSF69687, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 1 hit
PS50853 FN3, 3 hits
PS00243 INTEGRIN_BETA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q59H46-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
GSPGAEGASP PRGRSRTGAQ QQPRLAGRGR KRMAGPRPSP WARLLLAALI
60 70 80 90 100
SVSLSGTLAN RCKKAPVKSC TECVRVDKDC AYCTDEMFRD RRCNTQAELL
110 120 130 140 150
AAGCQRESIV VMESSFQITE ETQIDTTLRR SQMSPQGLRV RLRPGEERHF
160 170 180 190 200
ELEVFEPLES PVDLYILMDF SNSMSDDLDN LKKMGQNLAR VLSQLTSDYT
210 220 230 240 250
IGFGKFVDKV SVPQTDMRPE KLKEPWPNSD PPFSFKNVIS LTEDVDEFRN
260 270 280 290 300
KLQGERISGN LDAPEGGFDA ILQTAVCTRD IGWRPDSTHL LVFSTESAFH
310 320 330 340 350
YEADGANVLA GIMSRNDERC HLDTTGTYTQ YRTQDYPSVP TLVRLLAKHN
360 370 380 390 400
IIPIFAVTNY SYSYYEKLHT YFPVFSLGVL QEDSSNIVEL LEEAFNRIRS
410 420 430 440 450
NLDIRALDSP RGLRTEVTSK MFQKTRTGSF HIRRGEVGIY QVQLRALEHV
460 470 480 490 500
DGTHVCQLPE DQKGNIHLKP SFSDGLKMDA GIICDVCTCE LQKEVRSARC
510 520 530 540 550
SFNGDFVCGQ CVCSEGWSGQ TCNCSTGSLS DIQPCLREGE DKPCSGRGEC
560 570 580 590 600
QCGHCVCYGE GRYEGQFCEY DNFQCPRTSG FLCNDRGRCS MGQCVCEPGW
610 620 630 640 650
TGPSCDCPLS NATCIDSNGG ICNGRGHCEC GRCHCHQQSL YTDTICEINY
660 670 680 690 700
SAIHPGLCED LRSCVQCQAW GTGEKKGRTC EECNFKVKMV DELKRAEEVV
710 720 730 740 750
VRCSFRDEDD DCTYSYTMEG DGAPGPNSTV LVHKKKDCPP GSFWWLIPLL
760 770 780 790 800
LLLLPLLALL LLLCWKYCAC CKACLALLPC CNRGHMVGFK EDHYMLRENL
810 820 830 840 850
MASDHLDTPM LRSGNLKGRD VVRWKVTNNM QRPGFATHAA SINPTELVPY
860 870 880 890 900
GLSLRLARLC TENLLKPDTR ECAQLRQEVE ENLNEVYRQI SGVHKLQQTK
910 920 930 940 950
FRQQPNAGKK QDHTIVDTVL MAPRSAKPAL LKLTEKQVEQ RAFHDLKVAP
960 970 980 990 1000
GYYTLTADQD ARGMVEFQEG VELVDVRVPL FIRPEDDDEK QLLVEAIDVP
1010 1020 1030 1040 1050
AGTATLGRRL VNITIIKEQA RDVVSFEQPE FSVSRGDQVA RIPVIRRVLD
1060 1070 1080 1090 1100
GGKSQVSYRT QDGTAQGNRD YIPVEGELLF QPGEAWKELQ VKLLELQEVD
1110 1120 1130 1140 1150
SLLRGRQVRR FHVQLSNPKF GAHLGQPHST TIIIRDPDEL DRSFTSQMLS
1160 1170 1180 1190 1200
SQPPPHGDLG APQNPNAKAA GSRKIHFNWL PPSGKPMGYR VKYWIQGDSE
1210 1220 1230 1240 1250
SEAHLLDSKV PSVELTNLYP YCDYEMKVCA YGAQGEGPYS SLVSCRTHQE
1260 1270 1280 1290 1300
VPSEPGRLAF NVVSSTVTQL SWAEPAETNG EITAYEVCYG LVNDDNRPIG
1310 1320 1330 1340 1350
PMKKVLVDNP KNRMLLIENL RESQPYRYTV KARNGAGWGP EREAIINLAT
1360 1370 1380 1390 1400
QPKRPMSIPI IPDIPIVDAQ SGEDYDSFLM YSDDVLRSPS GSQRPSVSDD
1410 1420 1430 1440 1450
TEHLVNGRMD FAFPGSTNSL HRMTTTSAAA YGTHLSPHVP HRVLSTSSTL
1460 1470 1480 1490 1500
TRDYNSLTRS EHSHSTTLPR DYSTLTSVSS HDSRLTAGVP DTPTRLVFSA
1510
LGPTSLRVSW QEPRC
Length:1,515
Mass (Da):169,147
Last modified:April 26, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4232F4D2D60FB6FE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1
Non-terminal residuei1515Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB208913 mRNA Translation: BAD92150.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB208913 mRNA Translation: BAD92150.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiQ59H46
PRIDEiQ59H46

Enzyme and pathway databases

SignaLinkiQ59H46

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 2 hits
2.60.40.2030, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR038081 CalX-like_sf
IPR003644 Calx_beta
IPR013032 EGF-like_CS
IPR013111 EGF_extracell
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR040622 I-EGF_1
IPR013783 Ig-like_fold
IPR033760 Integrin_beta_N
IPR015812 Integrin_bsu
IPR012013 Integrin_bsu-4
IPR012896 Integrin_bsu_tail
IPR036349 Integrin_bsu_tail_dom_sf
IPR002369 Integrin_bsu_VWA
IPR016201 PSI
IPR036465 vWFA_dom_sf
PANTHERiPTHR10082 PTHR10082, 3 hits
PTHR10082:SF42 PTHR10082:SF42, 3 hits
PfamiView protein in Pfam
PF03160 Calx-beta, 1 hit
PF07974 EGF_2, 1 hit
PF00041 fn3, 2 hits
PF18372 I-EGF_1, 1 hit
PF07965 Integrin_B_tail, 1 hit
PF00362 Integrin_beta, 1 hit
PF17205 PSI_integrin, 1 hit
PRINTSiPR01186 INTEGRINB
SMARTiView protein in SMART
SM00237 Calx_beta, 1 hit
SM00060 FN3, 2 hits
SM00187 INB, 1 hit
SM01242 Integrin_B_tail, 1 hit
SM00423 PSI, 1 hit
SUPFAMiSSF141072 SSF141072, 1 hit
SSF49265 SSF49265, 1 hit
SSF53300 SSF53300, 1 hit
SSF69687 SSF69687, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS50853 FN3, 3 hits
PS00243 INTEGRIN_BETA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ59H46_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q59H46
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 26, 2005
Last sequence update: April 26, 2005
Last modified: July 31, 2019
This is version 100 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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