UniProtKB - Q59H18 (TNI3K_HUMAN)
Serine/threonine-protein kinase TNNI3K
TNNI3K
Functioni
Catalytic activityi
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 490 | ATP | 1 | |
Active sitei | 588 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 469 – 477 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- protein C-terminus binding Source: UniProtKB
- protein kinase activity Source: UniProtKB
- protein serine kinase activity Source: UniProtKB-EC
- protein threonine kinase activity Source: UniProtKB-EC
- troponin I binding Source: UniProtKB
GO - Biological processi
- bundle of His cell to Purkinje myocyte communication Source: BHF-UCL
- protein phosphorylation Source: UniProtKB
- regulation of cardiac conduction Source: BHF-UCL
- regulation of cardiac muscle contraction Source: BHF-UCL
- regulation of heart rate Source: BHF-UCL
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q59H18 |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein kinase TNNI3K (EC:2.7.11.1)Alternative name(s): Cardiac ankyrin repeat kinase Cardiac troponin I-interacting kinase TNNI3-interacting kinase |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19661, TNNI3K |
MIMi | 613932, gene |
neXtProti | NX_Q59H18 |
VEuPathDBi | HostDB:ENSG00000116783.14 |
Pathology & Biotechi
Involvement in diseasei
Cardiac conduction disease with or without dilated cardiomyopathy (CCDD)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_072650 | 526 | G → D in CCDD; the mutation results in decreased protein solubility; causes abnormal aggregation; markedly reduced protein expression is observed in the sarcoplasm and nuclei of patient cardiomyocytes. 1 PublicationCorresponds to variant dbSNP:rs606231469EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 490 | K → R: Loss of autophosphorylation activity. 1 Publication | 1 |
Keywords - Diseasei
Cardiomyopathy, Disease variantOrganism-specific databases
DisGeNETi | 100526835 51086 |
MalaCardsi | TNNI3K |
MIMi | 616117, phenotype |
OpenTargetsi | ENSG00000116783 ENSG00000259030 |
Orphaneti | 436242, Familial atrial tachyarrhythmia-infra-Hisian cardiac conduction disease |
PharmGKBi | PA134976654 |
Miscellaneous databases
Pharosi | Q59H18, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5260 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | Q59H18 |
Genetic variation databases
BioMutai | TNNI3K |
DMDMi | 300669705 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086757 | 1 – 835 | Serine/threonine-protein kinase TNNI3KAdd BLAST | 835 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q59H18 |
MassIVEi | Q59H18 |
PaxDbi | Q59H18 |
PeptideAtlasi | Q59H18 |
PRIDEi | Q59H18 |
ProteomicsDBi | 62665 [Q59H18-2] 62666 [Q59H18-1] 62667 [Q59H18-3] 62668 [Q59H18-4] |
PTM databases
iPTMneti | Q59H18 |
PhosphoSitePlusi | Q59H18 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000116783, Expressed in heart and 113 other tissues |
ExpressionAtlasi | Q59H18, baseline and differential |
Genevisiblei | Q59H18, HS |
Organism-specific databases
HPAi | ENSG00000116783, Tissue enriched (heart) |
Interactioni
Subunit structurei
Interacts with TNNI3, ACTC1, ACTA1, MYBPC3, AIP, FABP3 and HADHB.
1 PublicationBinary interactionsi
Hide detailsQ59H18
With | #Exp. | IntAct |
---|---|---|
FBXO4 [Q9UKT5] | 3 | EBI-704142,EBI-960409 |
TNNI3 [P19429] | 2 | EBI-704142,EBI-704146 |
Isoform 2 [Q59H18-2]
With | #Exp. | IntAct |
---|---|---|
TNNI3 [P19429] | 2 | EBI-10762055,EBI-704146 |
GO - Molecular functioni
- protein C-terminus binding Source: UniProtKB
- troponin I binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 119276, 13 interactors |
IntActi | Q59H18, 8 interactors |
STRINGi | 9606.ENSP00000322251 |
Chemistry databases
BindingDBi | Q59H18 |
Miscellaneous databases
RNActi | Q59H18, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q59H18 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 66 – 96 | ANK 1Add BLAST | 31 | |
Repeati | 100 – 129 | ANK 2Add BLAST | 30 | |
Repeati | 133 – 162 | ANK 3Add BLAST | 30 | |
Repeati | 166 – 195 | ANK 4Add BLAST | 30 | |
Repeati | 199 – 228 | ANK 5Add BLAST | 30 | |
Repeati | 234 – 263 | ANK 6Add BLAST | 30 | |
Repeati | 269 – 298 | ANK 7Add BLAST | 30 | |
Repeati | 304 – 335 | ANK 8Add BLAST | 32 | |
Repeati | 339 – 368 | ANK 9Add BLAST | 30 | |
Repeati | 381 – 410 | ANK 10Add BLAST | 30 | |
Domaini | 463 – 723 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 261 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 21 – 51 | Sequence analysisAdd BLAST | 31 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 733 – 746 | Poly-SerAdd BLAST | 14 |
Sequence similaritiesi
Keywords - Domaini
ANK repeat, Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG0192, Eukaryota |
GeneTreei | ENSGT00940000159131 |
HOGENOMi | CLU_017658_0_0_1 |
InParanoidi | Q59H18 |
OMAi | WAYERGH |
OrthoDBi | 173077at2759 |
PhylomeDBi | Q59H18 |
Family and domain databases
Gene3Di | 1.25.40.20, 4 hits |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF12796, Ank_2, 3 hits PF07714, PK_Tyr_Ser-Thr, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 10 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 6 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGNYKSRPTQ TCTDEWKKKV SESYVITIER LEDDLQIKEK ELTELRNIFG
60 70 80 90 100
SDEAFSKVNL NYRTENGLSL LHLCCICGGK KSHIRTLMLK GLRPSRLTRN
110 120 130 140 150
GFTALHLAVY KDNAELITSL LHSGADIQQV GYGGLTALHI ATIAGHLEAA
160 170 180 190 200
DVLLQHGANV NIQDAVFFTP LHIAAYYGHE QVTRLLLKFG ADVNVSGEVG
210 220 230 240 250
DRPLHLASAK GFLNIAKLLM EEGSKADVNA QDNEDHVPLH FCSRFGHHDI
260 270 280 290 300
VKYLLQSDLE VQPHVVNIYG DTPLHLACYN GKFEVAKEII QISGTESLTK
310 320 330 340 350
ENIFSETAFH SACTYGKSID LVKFLLDQNV ININHQGRDG HTGLHSACYH
360 370 380 390 400
GHIRLVQFLL DNGADMNLVA CDPSRSSGEK DEQTCLMWAY EKGHDAIVTL
410 420 430 440 450
LKHYKRPQDE LPCNEYSQPG GDGSYVSVPS PLGKIKSMTK EKADILLLRA
460 470 480 490 500
GLPSHFHLQL SEIEFHEIIG SGSFGKVYKG RCRNKIVAIK RYRANTYCSK
510 520 530 540 550
SDVDMFCREV SILCQLNHPC VIQFVGACLN DPSQFAIVTQ YISGGSLFSL
560 570 580 590 600
LHEQKRILDL QSKLIIAVDV AKGMEYLHNL TQPIIHRDLN SHNILLYEDG
610 620 630 640 650
HAVVADFGES RFLQSLDEDN MTKQPGNLRW MAPEVFTQCT RYTIKADVFS
660 670 680 690 700
YALCLWEILT GEIPFAHLKP AAAAADMAYH HIRPPIGYSI PKPISSLLIR
710 720 730 740 750
GWNACPEGRP EFSEVVMKLE ECLCNIELMS PASSNSSGSL SPSSSSDCLV
760 770 780 790 800
NRGGPGRSHV AALRSRFELE YALNARSYAA LSQSAGQYSS QGLSLEEMKR
810 820 830
SLQYTPIDKY GYVSDPMSSM HFHSCRNSSS FEDSS
The sequence of this isoform differs from the canonical sequence as follows:
1-13: MGNYKSRPTQTCT → MAAARDPPEV...NSFTILLIHS
The sequence of this isoform differs from the canonical sequence as follows:
1-13: MGNYKSRPTQTCT → MAAARDPPEV...NSFTILLIHS
591-596: SHNILL → RYFFPK
597-835: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-13: MGNYKSRPTQTCT → MAAARDPPEV...NSFTILLIHS
708-742: GRPEFSEVVMKLEECLCNIELMSPASSNSSGSLSP → AKSRPSHYPVSSVYTETLKKKNEDRFGMWIEYLRR
743-835: Missing.
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YCE9 | H0YCE9_HUMAN | Serine/threonine-protein kinase TNN... | TNNI3K | 150 | Annotation score: | ||
H0YE48 | H0YE48_HUMAN | Serine/threonine-protein kinase TNN... | TNNI3K | 188 | Annotation score: | ||
H0YDG1 | H0YDG1_HUMAN | Serine/threonine-protein kinase TNN... | TNNI3K | 113 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 127 | I → V in AAH32865 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 250 | I → M in CAE45949 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 367 | N → S in CAE45949 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 629 | R → L in AAH32865 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041223 | 151 | D → H1 PublicationCorresponds to variant dbSNP:rs34874695EnsemblClinVar. | 1 | |
Natural variantiVAR_041224 | 263 | P → L1 PublicationCorresponds to variant dbSNP:rs34521608EnsemblClinVar. | 1 | |
Natural variantiVAR_041225 | 309 | F → L1 Publication | 1 | |
Natural variantiVAR_041226 | 430 | S → L in a colorectal adenocarcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_041227 | 510 | V → L1 PublicationCorresponds to variant dbSNP:rs34335537Ensembl. | 1 | |
Natural variantiVAR_072650 | 526 | G → D in CCDD; the mutation results in decreased protein solubility; causes abnormal aggregation; markedly reduced protein expression is observed in the sarcoplasm and nuclei of patient cardiomyocytes. 1 PublicationCorresponds to variant dbSNP:rs606231469EnsemblClinVar. | 1 | |
Natural variantiVAR_035639 | 629 | R → G in a colorectal cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_041228 | 637 | T → M1 PublicationCorresponds to variant dbSNP:rs2274260EnsemblClinVar. | 1 | |
Natural variantiVAR_041229 | 686 | I → T1 PublicationCorresponds to variant dbSNP:rs3737564Ensembl. | 1 | |
Natural variantiVAR_038821 | 785 | A → G1 PublicationCorresponds to variant dbSNP:rs45578635Ensembl. | 1 | |
Natural variantiVAR_041230 | 798 | M → I in a head & Neck squamous cell carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs201613442Ensembl. | 1 | |
Natural variantiVAR_038822 | 833 | D → Y1 PublicationCorresponds to variant dbSNP:rs45614933Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_039403 | 1 – 13 | MGNYK…TQTCT → MAAARDPPEVSLREATQRKL RRFSELRGKLVARGEFWDIV AITAADEKQELAYNQQLSEK LKRKELPLGVQYHVFVDPAG AKIGNGGSTLCALQCLEKLY GDKWNSFTILLIHS in isoform 1, isoform 3 and isoform 4. 3 PublicationsAdd BLAST | 13 | |
Alternative sequenceiVSP_051882 | 591 – 596 | SHNILL → RYFFPK in isoform 3. 1 Publication | 6 | |
Alternative sequenceiVSP_051883 | 597 – 835 | Missing in isoform 3. 1 PublicationAdd BLAST | 239 | |
Alternative sequenceiVSP_051884 | 708 – 742 | GRPEF…GSLSP → AKSRPSHYPVSSVYTETLKK KNEDRFGMWIEYLRR in isoform 4. 1 PublicationAdd BLAST | 35 | |
Alternative sequenceiVSP_051885 | 743 – 835 | Missing in isoform 4. 1 PublicationAdd BLAST | 93 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF116826 mRNA Translation: AAD29632.1 AY303691 mRNA Translation: AAP72030.1 AB208941 Transcribed RNA Translation: BAD92178.1 Different initiation. BX640903 mRNA Translation: CAE45949.1 Different initiation. DQ822519 Genomic DNA Translation: ABG46944.1 AC093158 Genomic DNA No translation available. AC098692 Genomic DNA No translation available. AC105271 Genomic DNA No translation available. AC119672 Genomic DNA No translation available. BX470253 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06415.1 BC032865 mRNA Translation: AAH32865.1 BC113539 mRNA Translation: AAI13540.1 BC117262 mRNA Translation: AAI17263.1 |
CCDSi | CCDS664.1 [Q59H18-2] |
RefSeqi | NP_001186256.2, NM_001199327.1 [Q59H18-4] NP_057062.1, NM_015978.2 [Q59H18-2] |
Genome annotation databases
Ensembli | ENST00000326637; ENSP00000322251; ENSG00000116783 [Q59H18-2] |
GeneIDi | 100526835 51086 |
KEGGi | hsa:100526835 hsa:51086 |
UCSCi | uc001dgf.3, human [Q59H18-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF116826 mRNA Translation: AAD29632.1 AY303691 mRNA Translation: AAP72030.1 AB208941 Transcribed RNA Translation: BAD92178.1 Different initiation. BX640903 mRNA Translation: CAE45949.1 Different initiation. DQ822519 Genomic DNA Translation: ABG46944.1 AC093158 Genomic DNA No translation available. AC098692 Genomic DNA No translation available. AC105271 Genomic DNA No translation available. AC119672 Genomic DNA No translation available. BX470253 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06415.1 BC032865 mRNA Translation: AAH32865.1 BC113539 mRNA Translation: AAI13540.1 BC117262 mRNA Translation: AAI17263.1 |
CCDSi | CCDS664.1 [Q59H18-2] |
RefSeqi | NP_001186256.2, NM_001199327.1 [Q59H18-4] NP_057062.1, NM_015978.2 [Q59H18-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4YFF | X-ray | 3.07 | A/B/C/D | 420-730 | [»] | |
4YFI | X-ray | 2.70 | A/B/C/D | 402-730 | [»] | |
6B5J | X-ray | 2.97 | A/B/C/D | 420-730 | [»] | |
SMRi | Q59H18 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119276, 13 interactors |
IntActi | Q59H18, 8 interactors |
STRINGi | 9606.ENSP00000322251 |
Chemistry databases
BindingDBi | Q59H18 |
ChEMBLi | CHEMBL5260 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | Q59H18 |
PTM databases
iPTMneti | Q59H18 |
PhosphoSitePlusi | Q59H18 |
Genetic variation databases
BioMutai | TNNI3K |
DMDMi | 300669705 |
Proteomic databases
jPOSTi | Q59H18 |
MassIVEi | Q59H18 |
PaxDbi | Q59H18 |
PeptideAtlasi | Q59H18 |
PRIDEi | Q59H18 |
ProteomicsDBi | 62665 [Q59H18-2] 62666 [Q59H18-1] 62667 [Q59H18-3] 62668 [Q59H18-4] |
Protocols and materials databases
Antibodypediai | 2103, 147 antibodies |
DNASUi | 51086 |
Genome annotation databases
Ensembli | ENST00000326637; ENSP00000322251; ENSG00000116783 [Q59H18-2] |
GeneIDi | 100526835 51086 |
KEGGi | hsa:100526835 hsa:51086 |
UCSCi | uc001dgf.3, human [Q59H18-2] |
Organism-specific databases
CTDi | 100526835 51086 |
DisGeNETi | 100526835 51086 |
GeneCardsi | TNNI3K |
HGNCi | HGNC:19661, TNNI3K |
HPAi | ENSG00000116783, Tissue enriched (heart) |
MalaCardsi | TNNI3K |
MIMi | 613932, gene 616117, phenotype |
neXtProti | NX_Q59H18 |
OpenTargetsi | ENSG00000116783 ENSG00000259030 |
Orphaneti | 436242, Familial atrial tachyarrhythmia-infra-Hisian cardiac conduction disease |
PharmGKBi | PA134976654 |
VEuPathDBi | HostDB:ENSG00000116783.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0192, Eukaryota |
GeneTreei | ENSGT00940000159131 |
HOGENOMi | CLU_017658_0_0_1 |
InParanoidi | Q59H18 |
OMAi | WAYERGH |
OrthoDBi | 173077at2759 |
PhylomeDBi | Q59H18 |
Enzyme and pathway databases
PathwayCommonsi | Q59H18 |
Miscellaneous databases
BioGRID-ORCSi | 100526835, 38 hits in 840 CRISPR screens 51086, 5 hits in 618 CRISPR screens |
Pharosi | Q59H18, Tchem |
PROi | PR:Q59H18 |
RNActi | Q59H18, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000116783, Expressed in heart and 113 other tissues |
ExpressionAtlasi | Q59H18, baseline and differential |
Genevisiblei | Q59H18, HS |
Family and domain databases
Gene3Di | 1.25.40.20, 4 hits |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF12796, Ank_2, 3 hits PF07714, PK_Tyr_Ser-Thr, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 10 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 6 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TNI3K_HUMAN | |
Accessioni | Q59H18Primary (citable) accession number: Q59H18 Secondary accession number(s): Q17RN0 Q9Y2V6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 22, 2005 |
Last sequence update: | July 13, 2010 | |
Last modified: | April 7, 2021 | |
This is version 170 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families