UniProtKB - Q59GL5 (Q59GL5_HUMAN)
Protein
Glutamate receptor
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.UniRule annotation
GO - Molecular functioni
- ionotropic glutamate receptor activity Source: InterPro
Keywordsi
Molecular function | Ion channel, Ligand-gated ion channelUniRule annotationARBA annotation, ReceptorUniRule annotationImportedARBA annotation |
Biological process | Ion transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Glutamate receptorUniRule annotation |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Plasma membrane
- Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
- postsynaptic cell membrane UniRule annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- postsynaptic membrane Source: UniProtKB-KW
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 462 – 484 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 545 – 567 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 735 – 757 | HelicalUniRule annotationAdd BLAST | 23 |
Keywords - Cellular componenti
Cell junction, Cell membraneUniRule annotationARBA annotation, Membrane, Postsynaptic cell membraneUniRule annotationARBA annotation, SynapseFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 335 – 710 | PBPeInterPro annotationAdd BLAST | 376 | |
Domaini | 345 – 410 | Lig_chan-Glu_bdInterPro annotationAdd BLAST | 66 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 788 – 807 | DisorderedSequence analysisAdd BLAST | 20 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 788 – 802 | PolarSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. [View classification]UniRule annotation
Keywords - Domaini
SignalARBA annotation, Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
OrthoDBi | 188544at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR019594, Glu/Gly-bd IPR001508, Iono_rcpt_met IPR001320, Iontro_rcpt IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF01094, ANF_receptor, 1 hit PF00060, Lig_chan, 1 hit PF10613, Lig_chan-Glu_bd, 1 hit |
PRINTSi | PR00177, NMDARECEPTOR |
SMARTi | View protein in SMART SM00918, Lig_chan-Glu_bd, 1 hit SM00079, PBPe, 1 hit |
SUPFAMi | SSF53822, SSF53822, 1 hit |
i Sequence
Sequence statusi: Fragment.
Q59GL5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
ICSQFSKGVY AIFGFYERRT VNMLTSFCGA LHVCFITPSF PVDTSNQFVL
60 70 80 90 100
QLRPELQDAL ISIIDHYKWQ KFVYIYDADR GLSVLQKVLD TAAEKNWQVT
110 120 130 140 150
AVNILTTTEE GYRMLFQDLE KKKERLVVVD CESERLNAIL GQIIKLEKNG
160 170 180 190 200
IGYHYILANL GFMDIDLNKF KESGANVTGF QLVNYTDTIP AKIMQQWKNS
210 220 230 240 250
DARDHTRVDW KRPKYTSALT YDGVKVMAEA FQSLRRQRID ISRRGNAGDC
260 270 280 290 300
LANPAVPWGQ GIDIQRALQQ VRFEGLTGNV QFNEKGRRTN YTLHVIEMKH
310 320 330 340 350
DGIRKIGYWN EDDKFVPAAT DAQAGGDNSS VQNRTYIVTT ILEDPYVMLK
360 370 380 390 400
KNANQFEGND RYEGYCVELA AEIAKHVGYS YRLEIVSDGK YGARDPDTKA
410 420 430 440 450
WNGMVGELVY GRADVAVAPL TITLVREEVI DFSKPFMSLG ISIMIKKPQK
460 470 480 490 500
SKPGVFSFLD PLAYEIWMCI VFAYIGVSVV LFLVSRFSPY EWHSEEFEEG
510 520 530 540 550
RDQTTSDQSN EFGIFNSLWF SLGAFMQQGC DISPRSLSGR IVGGVWWFFT
560 570 580 590 600
LIIISSYTAN LAAFLTVERM VSPIESAEDL AKQTEIAYGT LEAGSTKEFF
610 620 630 640 650
RRSKIAVFEK MWTYMKSAEP SVFVRTTEEG MIRVRKSKGK YAYLLESTMN
660 670 680 690 700
EYIEQRKPCD TMKVGGNLDS KGYGIATPKG SALRGPVNLA VLKLSEQGVL
710 720 730 740 750
DKLKSKWWYD KGECGSKDSG SKDKTSALSL SNVAGVFYIL IGGLGLAMLV
760 770 780 790 800
ALIEFCYKSR SESKRMKGFC LIPQQSINEA IRTSTLPRNS GAGASSGGSG
810 820 830
ENGRVVSHDF PKSMQSIPCM SHSSGMPLGA TGL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB209094 mRNA Translation: BAD92331.1 |
RefSeqi | NP_000818.2, NM_000827.3 NP_001107655.1, NM_001114183.1 NP_001244948.1, NM_001258019.1 NP_001244949.1, NM_001258020.1 NP_001244950.1, NM_001258021.1 NP_001244951.1, NM_001258022.1 NP_001244952.1, NM_001258023.1 |
Genome annotation databases
GeneIDi | 2890 |
KEGGi | hsa:2890 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB209094 mRNA Translation: BAD92331.1 |
RefSeqi | NP_000818.2, NM_000827.3 NP_001107655.1, NM_001114183.1 NP_001244948.1, NM_001258019.1 NP_001244949.1, NM_001258020.1 NP_001244950.1, NM_001258021.1 NP_001244951.1, NM_001258022.1 NP_001244952.1, NM_001258023.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | Q59GL5 |
Genome annotation databases
GeneIDi | 2890 |
KEGGi | hsa:2890 |
Organism-specific databases
CTDi | 2890 |
PharmGKBi | PA28966 |
Phylogenomic databases
OrthoDBi | 188544at2759 |
Miscellaneous databases
BioGRID-ORCSi | 2890, 2 hits in 842 CRISPR screens |
GenomeRNAii | 2890 |
Gene expression databases
Genevisiblei | Q59GL5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR019594, Glu/Gly-bd IPR001508, Iono_rcpt_met IPR001320, Iontro_rcpt IPR028082, Peripla_BP_I |
Pfami | View protein in Pfam PF01094, ANF_receptor, 1 hit PF00060, Lig_chan, 1 hit PF10613, Lig_chan-Glu_bd, 1 hit |
PRINTSi | PR00177, NMDARECEPTOR |
SMARTi | View protein in SMART SM00918, Lig_chan-Glu_bd, 1 hit SM00079, PBPe, 1 hit |
SUPFAMi | SSF53822, SSF53822, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q59GL5_HUMAN | |
Accessioni | Q59GL5Primary (citable) accession number: Q59GL5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 26, 2005 |
Last sequence update: | April 26, 2005 | |
Last modified: | December 2, 2020 | |
This is version 96 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |